ライフサイエンスコーパス: MTHFR

1 MTHFR 1298A>C and RFC1 intron 5A>G polymorphisms were as

2 MTHFR 677C>T genotype and folate status were generally n

3 MTHFR and TYMS genotypes were determined on 365 HCC case

4 MTHFR genotype was a determinant of vascular 5-MTHF (not

5 MTHFR genotype was an independent predictor of plasma an

6 MTHFR genotyping was performed to identify a C-->T mutat

7 MTHFR is unusual among flavin oxidoreductases because it

8 MTHFR null mutants (mthfr(-)) lacked 5-methyltetrahydrof

9 MTHFR protein and mRNA were reduced in embryonic liver,

10 MTHFR protein levels were reduced in FASD pup livers, wi

11 MTHFR TT was associated with lower folate concentrations

12 MTHFR variants may be involved in SS non-MALT NHL develo

13 MTHFR was not inhibited by S-adenosylmethionine and, uni

14 (P = 1 x 10(-21)), SH2B3 (P = 3 x 10(-18)), MTHFR (P = 2 x 10(-13)), c10orf107 (P = 1 x 10(-9)), ZNF

15 1.46; 95% CI, 1.26-1.68; P = 2.5 x 10(-7)), MTHFR C677T and gastric cancer (OR, 1.52; 95% CI, 1.31-1

16 in S/P and RBC folate concentrations across MTHFR C677T genotypes.

17 ctions to a variety of pharmacologic agents (MTHFR) and an immunological transcription factor (IRF1)

18 endelian randomisation the association among MTHFR C677T, homocysteine levels and WMH, approached, bu

19 and P1054R (OR=1.42; 95% CI: 1.14-1.77) and MTHFR A222V (OR=0.82; 95% CI: 0.69-0.97).

20 evels are significantly elevated in CBS- and MTHFR-deficient patients.

21 stent with epistatic effects of the COMT and MTHFR polymorphisms on prefrontal dopamine signaling, an

22 tive synergistic effect between the CPS1 and MTHFR SNPs in the offspring (interaction P = 0.0046), th

23 For bipolar disorder and MTHFR C677T, the fixed-effects odds ratio for TT versus

24 the brain results from OCM dysfunction, and MTHFR mutations such as Mthfr 677C-->T, common in human

25 blood cell folate, plasma homocysteine, and MTHFR 677C>T genotype and colonic tissue biopsies for me

26 iations were found for IL2, CTLA4, HPSE, and MTHFR but were inconsistent with original publications.

27 ylation of only two studied genes, LTB4R and MTHFR, which were appreciably methylated even in control

28 ne and vitamin B12 levels were measured, and MTHFR C677T and A1298C genotyped.

29 10(-8) and 4.09 x 10(-8), respectively) and MTHFR in the African ancestry sample (P=1.72 x 10(-6)).

30 For schizophrenia and MTHFR C677T, the fixed-effects odds ratio for TT versus

31 upplementation among different age, sex, and MTHFR genotype groups are required to provide evidence f

32 or by combinations of the MTHFR 677C-->T and MTHFR 1298A-->C genotypes.

33 interactive effect of the MTHFR 677C-->T and MTHFR 1298A-->C polymorphisms on tHcy concentrations.

34 acid inhibited MTHFR activity in vitro, and MTHFR protein was reduced in FASD-fed mice.

35 assess a causal relationship between WMH and MTHFR.

36 acid supplements, particularly those who are MTHFR deficient.

37 and replicated a SNP at LSP1/TNNT3, a SNP at MTHFR-NPPB independent (r(2) = 0.33) of previous reports

38 late status modifies the association between MTHFR 677C-->T and stroke in a genetic analysis and meta

39 e genetic studies of the association between MTHFR 677C-->T and stroke in low folate settings are nee

40 tudies have examined the association between MTHFR C677T (a proxy for high homocysteine concentration

41 there was no evidence of association between MTHFR C677T genotype and CHD risk (odds ratio [OR], 0.96

42 We assessed the association between MTHFR C677T genotypes and blood folate concentrations am

43 There was no significant association between MTHFR genotype and CHD risk in large studies from region

44 We investigated the associations between MTHFR 677C>T genotype, folate status, and DNA methylatio

45 We found a significant interaction between MTHFR 677C-->T and MTRR 66A-->G on serum homocysteine co

46 No interactions between MTHFR and child folate and homocysteine levels were obse

47 Both MTHFR genotype and vascular 5-MTHF were associated with

48 Phosphatidylcholine was modified by MTHFR genotype (P = 0.035; 677TT < 677CC).

49 s; 5,068 cases, 7,876 controls) of the C677T MTHFR polymorphism and CRC, with stratification by racia

50 ort (TCN1, TCN2), or metabolism (BHMT2, CBS, MTHFR, MUT, SHMT1).

51 rders were diagnosed (mutations in PAH, CBS, MTHFR, CYP27A1, and HIBCH), and in 1 family, 2 disease-c

52 % CI, 6.5 to 26.4; P=0.002) lower than in CC MTHFR subjects.

53 ation was found in subjects with either [CC] MTHFR or [CT/TT] cSHMT genotypes.

54 e potential links between maternal and child MTHFR polymorphisms and child neurodevelopment in a lead

55 d with maternal MTHFR 1298 genotype or child MTHFR genotypes.

56 tructures of the Ala177Val mutant of E. coli MTHFR and of its complex with the 5,10-dideazafolate ana

57 In both human and E. coli MTHFR, the A --> V mutation increases the rate of dissoc

58 gh Phe223 contacts each substrate in E. coli MTHFR, this residue is not invariant; for example, a leu

59 23 in the oxidative half-reaction of E. coli MTHFR.

60 initial X-ray structure of Escherichia coli MTHFR revealed that this 33-kDa polypeptide is a (betaal

61 lent Ala to Val mutation in Escherichia coli MTHFR, which is 30% identical to the catalytic domain of

62 synthesis is highly sensitive to the common MTHFR C677T polymorphism and that the effect of the poly

63 DNF, OXTR, RORA, GRM8, CHRNA4, IL-1A, CRHR1, MTHFR, DRD2, APOE) and loneliness were replicated (p>0.0

64 Mexican American men (n = 60) with different MTHFR C677T genotypes (29 677TT, 31 677CC) consumed a di

65 (P for interaction = 0.08) but not by either MTHFR genotype.

66 nd Trypanosoma cruzi, contain genes encoding MTHFR and two distinct methionine synthases.

67 ymorphisms in key folate metabolism enzymes (MTHFR 677 C>T, MTHFR 1298 A>C, SHMT1 1420 C>T, MTR 2756

68 Although 3 fetal MTHFR and DHFR genetic variants had no effect, the fetal

69 FR genetic variants had no effect, the fetal MTHFR 677TT genotype was associated with significantly l

70 ia and hypomethioninemia, reduced fibroblast MTHFR enzymatic activity (18%-52% of control participant

71 , mutagenic lesions, we suggest that, as for MTHFR C677T, the GGH -124 T>G SNP may modulate the risk

72 lementation with riboflavin-the cofactor for MTHFR.

73 Hence, this study demonstrates a role for MTHFR in lignin biosynthesis.

74 ten primary glaucoma cases were studied for MTHFR C677T polymorphism and compared with 280 controls

75 en homozygote variants and the wild type for MTHFR C677T and A1298C.

76 ntly potentiated in platelets harvested from MTHFR++ carriers, and it was reversed by the inhibition

77 ), the finding that bm2 encodes a functional MTHFR is consistent with its lignin phenotype.

78 show that the bm2 gene encodes a functional MTHFR.

79 Although the homocysteine remethylation gene MTHFR has emerged as a risk factor in some human populat

80 with a C677T polymorphism of the MTHFR gene (MTHFR++).

81 e methylene tetrahydrofolate reductase gene (MTHFR) appreciably increases homocysteine levels, so "Me

82 The region includes a gene, MTHFR, that in previous studies has been associated with

83 Seven polymorphisms in 6 genes (MTHFR, MTRR, FOLH1, CbetaS, RFC1, SHMT) involved in fola

84 ligand-free Phe223Leu and Phe223Leu/Glu28Gln MTHFR in complex with CH(3)-H(4)folate have been determi

85 MTHFR deficiency, methionine, homocysteine, MTHFR enzyme activity in fibroblasts, or mutations (in t

86 genes (ACE, CHRNB2, CST3, ESR1, GAPDHS, IDE, MTHFR, NCSTN, PRNP, PSEN1, TF, TFAM and TNF) with statis

87 RD2, DRD4, DTNBP1, GABRB2, GRIN2B, HP, IL1B, MTHFR, PLXNA2, SLC6A4, TP53 and TPH1) showed nominally s

88 se A2 expression was significantly higher in MTHFR++ carriers compared with healthy volunteers.

89 The genetic mutations in MTHFR and TYMS genes may have influences on their respec

90 In children carrying C677T mutations in MTHFR, higher folate levels were associated with an incr

91 pport the role of the A1298C polymorphism in MTHFR as prognostic marker in female patients with metas

92 Polymorphisms in MTHFR may offer potential for treatment individualizatio

93 Similarly, in MTHFR++ carriers, the content of H2S was significantly h

94 We identified 5 SNPs in MTHFR that altered the slope of the intake-metabolite co

95 ydrofolate reductase (MTHFR) gene, including MTHFR C677T and A1298C, and common psychiatric disorders

96 enetic variants had been measured, including MTHFR C677T.

97 High folic acid inhibited MTHFR activity in vitro, and MTHFR protein was reduced i

98 We investigated MTHFR C677T genotypes and alleles frequencies in primary

99 ealthy adults 18 to 65 years of age of known MTHFR 677C-->T genotype, we identified 35 with the homoz

100 Leishmania MTHFR differed from those in other eukaryotes by the abs

101 Moderate alcohol intake and low MTHFR activity have adverse effects on tHcy, but those e

102 SH2B3/ATXN2, CSK, CYP17A1, FURIN, HFE, LSP1, MTHFR, SOX6) at array-wide significance (P < 2.4 x 10(-6

103 ay, six of the 55 examined gene loci (LTB4R, MTHFR, CDH13, PGR, CDH1, and IGSF4) were significantly h

104 L. major MTHFR was expressed in yeast and recombinant enzyme was

105 Maternal MTHFR haplotype also predicted MDI-24 scores (mean +/- S

106 tion (chi(2) = 8.82, p = 0.003) and maternal MTHFR 677C>T genotype with IGF2 methylation (chi(2) = 2.

107 2) status, infant MTRR genotype and maternal MTHFR genotype, all of which may influence the supply of

108 ed to plasma folate concentrations, maternal MTHFR genotype did not explain the association of folate

109 acid supplement use or variation in maternal MTHFR genotype.

110 variate-adjusted regression models, maternal MTHFR 677 genotype predicted MDI-24 scores, in which eac

111 The maternal MTHFR 677T allele is an independent predictor of poorer

112 4 scores, in which each copy of the maternal MTHFR 677T variant allele was associated with lower MDI-

113 -24 scores were not associated with maternal MTHFR 1298 genotype or child MTHFR genotypes.

114 Mild MTHFR deficiency (677C > T polymorphism) increases risk

115 In the Cox proportional hazards model, MTHFR Glu429Ala variant genotypes were associated with s

116 Neither CYP11B2 T(-344)C nor MTHFR C677T were significantly associated when tested in

117 choline between betaine and CDP-PC among NP (MTHFR rs1801133 and MTR rs1805087 WT) and lactating (MTH

118 he frequency of the genotypes and alleles of MTHFR C677T differ significantly between cases and contr

119 Alteration of MTHFR function is expected to influence accumulation of

120 iod of follow-up, the inverse association of MTHFR with CVD mortality was significant only in the per

121 The inverse association of MTHFR with CVD mortality was unexpected and highlights t

122 The association of MTHFR, a gene consistently associated with homocysteine,

123 The objective was to examine associations of MTHFR C677T, a proxy for high homocysteine concentration

124 bjective: To investigate the associations of MTHFR polymorphisms and serum homocysteine levels with i

125 on prefrontal function within the context of MTHFR genotype.

126 dicates that the allele T and genotype CT of MTHFR C677T polymorphism are significantly associated wi

127 controls were genotyped for the detection of MTHFR polymorphisms.

128 authors assessed whether the distribution of MTHFR C677T genotypes was independent of potential confo

129 The effect of MTHFR 677C-->T on homocysteine concentrations was reduce

130 vity genotype, each low-activity genotype of MTHFR was associated with a statistically nonsignificant

131 measured confounders appeared independent of MTHFR genotype within the largest ethnically homogenous

132 mutant alleles in the 3 polymorphic loci of MTHFR/TYMS (range, 0-4), there was a monotonic decrease

133 s performed to explore a possible pathway of MTHFR polymorphisms via homocysteine levels to cortical

134 The functional polymorphism of MTHFR gene, C677T has been shown to impact various disea

135 udies are warranted to establish the role of MTHFR variants in these associations.

136 correlated with the phosphorylation state of MTHFR, with more severe mutations resulting in lower abu

137 Genetic polymorphism 677 C>T on MTHFR affects vascular 5-MTHF (but not homocysteine) and

138 tivity nor the growth of mthfr(-) mutants or MTHFR overexpressors were differentially affected by ant

139 ontrol participants), and 3 novel pathogenic MTHFR mutations, 2 as compound heterozygotes in one fami

140 lenetetrahydrofolate reductase polymorphism (MTHFR 677C>T) may influence risk by modifying DNA methyl

141 otein and activity levels, creating a pseudo-MTHFR deficiency.

142 late intake during pregnancy leads to pseudo-MTHFR deficiency, disturbed choline/methyl metabolism, e

143 s study supports the hypothesis that reduced MTHFR activity and enhanced TYMS activity, both of which

144 est that high folic acid consumption reduces MTHFR protein and activity levels, creating a pseudo-MTH

145 ant of methylenetetrahydro-folate reductase (MTHFR), rather than the AA variant, were less likely to

146 rphism, methylenetetrahydrofolate reductase (MTHFR) 677C --> T (rs1801133), has been associated with

147 The methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism is a risk factor for neural t

148 n 1-CM, methylenetetrahydrofolate reductase (MTHFR) 677C>T, rs1801133, and phosphatidylethanolamineN-

149 es 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C-->T and 1298A-->C, methionine synthase reduc

150 ypes in methylenetetrahydrofolate reductase (MTHFR) 677TT, thymidylate synthase (TSER) *2/*2 (variabl

151 he 5,10-methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR) genes were ass

152 Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS) are known to play

153 m (SNP) methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) was used as proxy for homocyste

154 of the methylenetetrahydrofolate reductase (MTHFR) C677T genotype on choline status was also examine

155 he 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T genotype, a correlate of plasma homocystein

156 severe methylenetetrahydrofolate reductase (MTHFR) deficiency is presently unclear.

157 severe methylenetetrahydrofolate reductase (MTHFR) deficiency manifesting a complicated form of adul

158 he 5,10-methylenetetrahydrofolate reductase (MTHFR) gene has been associated with a lower risk of CRC

159 in the methylenetetrahydrofolate reductase (MTHFR) gene increases the requirement for folate and may

160 The methylenetetrahydrofolate reductase (MTHFR) gene is important for folate metabolism, and 2 co

161 CBS) or methylenetetrahydrofolate reductase (MTHFR) gene lead to markedly elevated levels of circulat

162 in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C-->T and 1298A-->C.

163 he 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, including MTHFR C677T and A1298C, and commo

164 utative methylenetetrahydrofolate reductase (MTHFR) gene, which is down-regulated in bm2 mutant plant

165 Methylenetetrahydrofolate reductase (MTHFR) generates methyltetrahydrofolate for methylation

166 The methylenetetrahydrofolate reductase (MTHFR) genotype is associated with modification of disea

167 ith the methylenetetrahydrofolate reductase (MTHFR) genotype.

168 isms of methylenetetrahydrofolate reductase (MTHFR) have been associated with diastolic blood pressur

169 enzyme, methylenetetrahydrofolate reductase (MTHFR) in Mthfr(+/-) mice, exaggerated the ethanol effec

170 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of the tetrahydrofolate (THF)-med

171 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating intracellular folate l

172 Methylenetetrahydrofolate reductase (MTHFR) is central to folate metabolism and has two commo

173 Methylenetetrahydrofolate reductase (MTHFR) is involved in intracellular folate homeostasis a

174 rtance: Methylenetetrahydrofolate reductase (MTHFR) polymorphisms have been shown to influence homocy

175 The methylenetetrahydrofolate reductase (MTHFR) protein and methylation potential [ratio of S-ade

176 Methylenetetrahydrofolate reductase (MTHFR) provides methyl donors for S-adenosylmethionine (

177 bolism, methylenetetrahydrofolate reductase (MTHFR) rs1801133, methionine synthase (MTR) rs1805087 [w

178 n human methylenetetrahydrofolate reductase (MTHFR) the Ala222Val (677C-->T) polymorphism encodes a h

179 dent of methylenetetrahydrofolate reductase (MTHFR) variants.

180 ncoding methylenetetrahydrofolate reductase (MTHFR) was responsive to supplementation with riboflavin

181 Methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in folate metabolism is involv

182 nthase, methylenetetrahydrofolate reductase (MTHFR), and VEGF.

183 enzyme, methylenetetrahydrofolate reductase (MTHFR), from 564 individuals of diverse ethnicities.

184 genes: methylenetetrahydrofolate reductase (MTHFR), reduced folate carrier 1 (RFC1), and glutamate c

185 (MTRR), methylenetetrahydrofolate reductase (MTHFR), serine hydroxymethyltransferase (SHMT), and cyst

186 of 5,10 methylenetetrahydrofolate reductase (MTHFR).

187 in the methylenetetrahydrofolate reductase (MTHFR)gene was associated with the risk ofAEin both tria

188 Methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) is the sole enzyme responsible for g

189 P 5,10-methylene tetrahydrofolate reductase (MTHFR) Ala222Val (dbSNP ID: rs1801133; P-value=1.27 x 10

190 , 5,10 methylene tetrahydrofolate reductase (MTHFR) C677T genotype, folate and vitamin B12 status, an

191 of the methylene tetrahydrofolate reductase (MTHFR) gene and congenital heart disease (CHD) is conten

192 used the methyl tetrahydrofolate reductase (MTHFR) gene polymorphism 677C>T as a model of chronic ex

193 of the methylene-tetrahydrofolate reductase (MTHFR) gene, an enzyme essential in DNA synthesis and me

194 (GGH), methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), proton-coupled folate

195 WMH to methylene tetrahydrofolate reductase (MTHFR).

196 ulated methylene tetrahydrofolate reductase (MTHFR).

197 (C677T methylenetetrahydrofolate reductase [MTHFR] and C1420T cytoplasmic serine hydroxymethyltransf

198 thway (methylene tetrahydrofolate reductase; MTHFR:C677T), and the vitamin D pathway (vitamin D recep

199 Methylenetetrahydrofolate reductases (MTHFRs; EC 1.7.99.5) catalyze the NAD(P)H-dependent redu

200 Data regarding MTHFR polymorphisms C677T and A1298C, peri- and postnata

201 Conclusions and Relevance: MTHFR polymorphism and elevated homocysteine levels cont

202 Severe MTHFR deficiency results in homocystinuria and neurologi

203 Although severe MTHFR deficiency is a rare cause of complicated spastic

204 To define severe MTHFR deficiency, methionine, homocysteine, MTHFR enzyme

205 betaine, or (2) single patients with severe MTHFR deficiency treated with betaine.

206 chomotor development in patients with severe MTHFR deficiency, highlighting the importance of timely

207 families with 2 or more patients with severe MTHFR deficiency, of whom at least 1 received betaine, o

208 Further, significant MTHFR x COMT genotype interactions were observed, which

209 We did not observe significant MTHFR genotype x lead interactions with respect to any o

210 The widely studied MTHFR C677T SNP (rs1801133) was also highly significant

211 or V Leiden, G20210A prothrombin, and 677C>T MTHFR polymorphisms.

212 ey folate metabolism enzymes (MTHFR 677 C>T, MTHFR 1298 A>C, SHMT1 1420 C>T, MTR 2756 A>G, TS 1494del

213 -2000), and genetic variation (MTHFR 677C>T, MTHFR 1298A>C, MTR 2756A>G, SHMT1 1420C>T, TYMS 1494del6

214 ects and interactions of the MTHFR 677C-->T, MTHFR 1298A-->C, RFC1 80G-->A, and GCPII 1561C-->T polym

215 hat manipulating tobacco (Nicotiana tabacum) MTHFR gene (NtMTHFR1) expression dramatically alters the

216 Herein, we tested the hypothesis that MTHFR variants contribute to pSS-related lymphomagenesis

217 Our observations indicate that MTHFR 677TT homozygous individuals are more likely to de

218 Our findings suggest that MTHFR genotype is linked to a woman's potential to produ

219 The MTHFR 1298A-->C, RFC1 80G-->A, and GCPII 1561C-->T polym

220 The MTHFR 677C-->T polymorphism has been associated with rai

221 The MTHFR 677C-->T polymorphism was associated with signific

222 The MTHFR 677C-->T variant is associated with reduced enzyme

223 The MTHFR 677TT genotype was associated with a approximately

224 The MTHFR 677TT genotype was associated with increased plasm

225 The MTHFR 677TT polymorphism seems to be associated with a r

226 The MTHFR A1298G polymorphism was not associated with altere

227 The MTHFR C677T polymorphism, which directly influences plas

228 The MTHFR C677T SNP was strongly associated with Hcy (P = 1.

229 The MTHFR gene was amplified using specific primers.

230 The MTHFR TT genotype was not associated with genomic or gen

231 ce of coronary artery disease (n = 331), the MTHFR CC genotype increased coronary artery disease risk

232 For unipolar depression and the MTHFR C677T polymorphism, the fixed-effects odds ratio f

233 potential gene regulatory mechanisms at the MTHFR and NOS3 loci.

234 An interaction between the MTHFR 677TT and RFC1 80GG genotypes was observed whereby

235 eraction (P = 0.05) was observed between the MTHFR 677TT and RFC1 80GG genotypes, whereby persons wit

236 The inverse association between the MTHFR 677TT polymorphism and CRC was not significantly m

237 ysis demonstrates an association between the MTHFR C677T variant and depression, schizophrenia, and b

238 ations were not affected individually by the MTHFR 1298A-->C, RFC1 80G-->A, or GCPII 1561C-->T polymo

239 tamins showed that individuals who carry the MTHFR 677TT_1298AA or 677CC_1298CC combination were sign

240 Individuals carrying the MTHFR 677T allele had a marked increase in risk of SCC (

241 the rise in plasma homocysteine, as did the MTHFR 677TT genotype (P < 0.001).

242 ethnic group and other CVD risk factors, the MTHFR C677T TT genotype was associated with significantl

243 s of European descent were genotyped for the MTHFR 677 C-->T polymorphism.

244 For the MTHFR A1298C (rs1801131) single nucleotide polymorphisms

245 stroke among individuals homozygous for the MTHFR T allele is close to that predicted from the diffe

246 We assessed 2 polymorphisms in the MTHFR gene (C677T and A1298C) in relation to colorectal

247 ctivity in fibroblasts, or mutations (in the MTHFR gene) had to be described as well as the effect of

248 homozygous for a common polymorphism in the MTHFR gene.

249 ment that identified genetic variants in the MTHFR-CLCN6-NPPA-NPPB cluster to be significantly associ

250 leotide polymorphisms were identified in the MTHFR-CLCN6-NPPA-NPPB locus and were all replicated.

251 variants previously reported at or near the MTHFR, MTR, CPS1, MUT, NOX4, DPEP1, and CBS genes.

252 -->T polymorphisms or by combinations of the MTHFR 677C-->T and MTHFR 1298A-->C genotypes.

253 There was no interactive effect of the MTHFR 677C-->T and MTHFR 1298A-->C polymorphisms on tHcy

254 f this study was to assess the effect of the MTHFR 677C-->T polymorphism on the current folate RDA fo

255 The effect of the MTHFR 677C-->T variant on homocysteine concentration was

256 e individual effects and interactions of the MTHFR 677C-->T, MTHFR 1298A-->C, RFC1 80G-->A, and GCPII

257 Data on the association studies of the MTHFR and TYMS genetic polymorphisms and risk of hepatoc

258 to determine the differential effects of the MTHFR C677T genotype and the effect of various choline i

259 cysteinemia with a C677T polymorphism of the MTHFR gene (MTHFR++).

260 We propose that the effect of the MTHFR genotypes on increasing risk of adenoma recurrence

261 gest that the rs13306560 polymorphism of the MTHFR may be part of the observed hypertension process i

262 of CpGs reduced the promoter activity of the MTHFR regulatory region.

263 s, and Mexican Americans irrespective of the MTHFR TT genotype, and, from a population perspective, t

264 effect of the rs13306560 polymorphism on the MTHFR promoter region by means of luciferase reporter ge

265 suggest that in schizophrenia patients, the MTHFR 677T allele exacerbates prefrontal dopamine defici

266 ype, and, from a population perspective, the MTHFR 677C-->T variant does not warrant modifications to

267 vo PtdCho biosynthesis and indicate that the MTHFR 677TT genotype favors the use of choline as a meth

268 Computational simulations indicate that the MTHFR C677T polymorphism and folate deficiency interact

269 We conclude that the MTHFR C677T polymorphism increases the risk for POAG dev

270 d analysis of all samples confirmed that the MTHFR variant was more strongly associated with Hcy in t

271 entrations were significantly related to the MTHFR 677C-->T genotype but not to the other polymorphis

272 We sought to determine whether the MTHFR 677C-->T genotype modifies the response to folic a

273 randomized trials have examined whether the MTHFR genotype modifies the observed response.

274 steine concentrations between those with the MTHFR 677 CC and TT genotypes.

275 Persons with the MTHFR 677 TT genotype had a 22.1% (95% CI: 14.6%, 28.9%)

276 tHcy concentrations than did those with the MTHFR 677CC genotype (P < 0.001), and this effect was gr

277 Men with the MTHFR 677TT genotype had a higher urinary enrichment rat

278 Subjects with the MTHFR 677TT genotype had higher serum tHcy concentration

279 omocysteine concentrations in those with the MTHFR TT genotype.

280 riants (rs1801133 and rs13306560) within the MTHFR are associated with hypertension in Mexican-Mestiz

281 pidemiologic studies demonstrated that these MTHFR polymorphisms were associated with cancer risk in

282 fr null mice do not develop NTDs even though MTHFR mutations increase human NTD risk.

283 In carriers of [CT/TT] MTHFR genotypes, the SD of normal-to-normal intervals wa

284 In the same [CT/TT] MTHFR subjects, each 10-mug/m(3) increase in PM(2.5) in

285 Two MTHFR gene polymorphisms (C677T and A1298C) were tested

286 Two MTHFR gene polymorphisms, C677T and A1298C, are linked t

287 Two MTHFR polymorphisms, C677T (rs1801133) and A1298C (rs180

288 red to controls, individuals with one or two MTHFR 677T alleles were at 42% increased cancer risk (OR

289 Candidate genes (TYMS, MTHFR, ABCB1, BGLAP, ACP5, LRP5, ESR1, PAI-1, VDR, PTH,

290 necticut, 1997-2000), and genetic variation (MTHFR 677C>T, MTHFR 1298A>C, MTR 2756A>G, SHMT1 1420C>T,

291 Neither in vitro MTHFR activity nor the growth of mthfr(-) mutants or MTH

292 e effects in the central nervous system were MTHFR 677TT (OR 3.3, P < 0.01) and SHMT1 1420CC (OR 2.4,

293 When MTHFR C677T genotype frequencies in MSS CRC cases were c

294 d with reduced DNA methylation levels, while MTHFR c. 1298A > C AC genotype with reduced DNA double-s

295 Risk of MA is associated with MTHFR C674T homozygosity, independent of other cardiovas

296 Although ethnicity was associated with MTHFR genotype distribution within the entire cohort (p

297 cysteine concentrations were associated with MTHFR genotype throughout the supplementation trial, reg

298 No evidence of an association with MTHFR 677 was observed for ALL or AML, either in childre

299 was strongest for mothers and children with MTHFR 677 C>T variant genotypes.

300 homozygous wild-type individuals, those with MTHFR 677TT genotype were more likely to have MSI than m