ライフサイエンスコーパス: MTP

1 MTP and MTPv1 efficiently transferred phosphatidylethano

2 MTP bind to the extracellular matrix protein laminin in

3 MTP deficiency had no effect on ceramide and sphingomyel

4 MTP deficiency significantly reduced triglyceride absorp

5 MTP inhibition in Western diet fed mice decreased plasma

6 MTP inhibition increases plasma transaminases and tissue

7 MTP inhibition is a valuable therapeutic approach for ho

8 MTP was covalently modified when cells were incubated wi

9 MTP was induced in fasted animals soon after refeeding.

10 MTP was recently suggested to directly regulate the bios

11 MTP-B does not encode a protein; MTP-C encodes the same

12 MTP-B has a unique first exon (Ex1B) located 10.5 kb ups

13 MTP-B represents approximately 90% of total MTP mRNA in

14 MTP-B was found in a number of tissues, whereas MTP-C wa

15 MTP-inhibited FTOCs produced negligible numbers of CD1d

16 MTPs and HTPs were sufficiently effective to decrease AP

17 5-MTP blocked cancer cell COX-2 overexpression and suppres

18 5-MTP was synthesized from L-tryptophan via tryptophan hyd

19 9 and other cancer cells were defective in 5-MTP production.

20 ryptophan metabolite, 5-methoxytryptophan (5-MTP).

21 Furthermore, i.p. infusion of 5-MTP reduced tumor growth and cancer metastasis in a muri

22 hat normal fibroblasts produce and release 5-MTP into the extracellular milieu whereas A549 and other

23 We conclude that 5-MTP synthesis represents a mechanism for endogenous cont

24 first exon (Ex1A) for canonical MTP (MTP-A); MTP-C contains both first exons for MTP-A and MTP-B.

25 tein-secreting cells, such as the adipocyte, MTP-B may have different localization properties, perhap

26 CCl(4) did not affect MTP synthesis but induced post-translational degradation

27 outinely generated from oleylamine-capped Ag MTPs, we obtained very few hollow structures by using a

28 ion of alloy nanorings and nanocages from Ag MTPs of decahedral or icosahedral shape.

29 anorings and nanocages derived from 11-nm Ag MTPs, the surface plasmon resonance (SPR) peak can be co

30 When the size of Ag MTPs was increased to 14 nm, the SPR peak can be further

31 All MTP orthologues shared similar secondary and tertiary st

32 the same protein encoded by MTP-A, although MTP-C translation is strongly inhibited by regulatory el

33 s were randomized to be managed either by an MTP goal directed by TEG or by CCA (ie, international no

34 l trial (RCT) to test the hypothesis that an MTP goal directed by the viscoelastic assay thrombelasto

35 patients improves survival compared with an MTP guided by CCA and utilizes less plasma and platelet

36 phy (TEG) improves survival compared with an MTP guided by conventional coagulation assays (CCA).

37 TP-C contains both first exons for MTP-A and MTP-B.

38 e, we found that hepatic FoxO1 abundance and MTP production were increased in mice with abnormal trig

39 human tissues, which we have named MTP-B and MTP-C.

40 free cholesterol or triglyceride or both and MTP activity, specific inhibition of phospholipid or tri

41 egulating forkhead transcription factors and MTP and that inhibition of apoAIV expression might reduc

42 des were substantially lower in Gaa(-/-) and MTP mice vs. controls.

43 L production by regulating LysoPC levels and MTP expression.

44 vertase subtilisin/kexin type 9 (PCSK9), and MTP genes result in low or absent levels of apoB and LDL

45 4) decreased apoB-lipoprotein production and MTP activity but had no effect on mRNA levels in primary

46 he specific binding of substrates TPP(+) and MTP(+) to EmrE reconstituted into 1,2-dimyristoyl-sn-gly

47 ulation of MTP production and that augmented MTP levels may be a causative factor for VLDL overproduc

48 ctivities, and targeting of apolipoprotein B-MTP protein-protein interactions might be pursued to avo

49 f addressing the causal relationship between MTP inhibition and aberrant elevations in plasma liver e

50 The anti-LCN2 Ab-bound MTPs were stable for 6 weeks when stored in 0.1M PBS, pH

51 The anti-HFA Ab-bound MTPs, stored at 4 degrees C in 0.1M PBS, pH 7.4, retaine

52 The anti-HFA antibody-bound MTPs, stored at 4 degrees C in 0.1M PBS, were highly sta

53 isition of triglyceride transfer activity by MTP provided for a significant advantage in the evolutio

54 isition of triglyceride transfer activity by MTP, we evaluated amino acid sequences, protein structur

55 n; MTP-C encodes the same protein encoded by MTP-A, although MTP-C translation is strongly inhibited

56 on CD4(+)CD8(+) FTOC cells was unaffected by MTP inhibition.

57 tream of the first exon (Ex1A) for canonical MTP (MTP-A); MTP-C contains both first exons for MTP-A a

58 ximately 2.7 kilobases upstream of canonical MTP (MTP-A) exon 1.

59 ion Facilitator/Metal Tolerance Protein (CDF/MTP) family of metal cation transporters in Oryza sativa

60 In HepG2 cells, MTP expression was induced by FoxO1 and inhibited by exp

61 MTP, FoxA2, and FoxO1 mRNA levels, cellular MTP activity, and media apoB.

62 cing plays a key role in regulating cellular MTP levels by introducing distinct promoter regions and

63 was evaluated and compared with a commercial MTP reader (MTPR) for three model assays: our recently d

64 o group in MTR) as well as of the natural DK-MTP 1-P substrate, we determined that the "enolase"-cata

65 The 2-carbonyl group of DK-MTP 1-P is rapidly hydrated and can undergo enolization

66 t studied the structure and reactivity of DK-MTP 1-P that was reported to decompose rapidly.

67 3-diketo-5-methylthiopentane 1-phosphate (DK-MTP 1-P) "enolase" reaction in the well-known "methionin

68 3-diketo-5-methylthiopentane 1-phosphate (DK-MTP 1-P) in the methionine salvage pathway in which 5-me

69 o confirm that this RuBisCO catalyzes the DK-MTP 1-P "enolase" reaction either in vitro or in vivo.

70 by abstraction of a proton from C1 of the DK-MTP 1-P substrate to form the tautomerized product, a co

71 th respect to distinct domains in Drosophila MTP (dMTP) and human MTP (hMTP) are not obvious because

72 Previously we reported that the Drosophila MTP transfers phospholipids but does not transfer trigly

73 ells with truncated forms of apoB and either MTP-A or MTP-B demonstrated that both isoforms are effec

74 Elamipretide (MTP-131), a novel mitochondria-targeting peptide, was sh

75 FoxO1 activity was associated with enhanced MTP expression, augmented VLDL production, and elevated

76 All of the analogues, except MTP, and their products were substrates for the three co

77 n mice were subjected to restricted feeding, MTP expression was high at the expected time of food ava

78 c level-1 trauma center meeting criteria for MTP activation.

79 (MTP-A); MTP-C contains both first exons for MTP-A and MTP-B.

80 d formin 1 (DIAPH1), as a candidate gene for MTP using exome sequencing, ontological phenotyping, and

81 Liver and enterocyte microsomes from MTP-deficient animals synthesize lesser amounts of chole

82 The antibody-bound GNP-functionalized MTPs retained its original activity after 6 weeks of sto

83 Utilization of a goal-directed, TEG-guided MTP to resuscitate severely injured patients improves su

84 . investigate the events controlling hepatic MTP expression and VLDL production and secretion (see th

85 Similar to the small intestine, hepatic MTP activity, protein, and mRNA levels also changed sign

86 the underlying mechanism, we studied hepatic MTP regulation by forkhead box O1 (FoxO1), a transcripti

87 These data highlight MTP as a unique regulator of human metabolic and immune

88 At higher concentrations, however, MTP inhibitors blocked apoE expression and secretion and

89 aphragmatic contractile properties; however, MTP mice had ventilation similar to the Gaa(-/-) mice du

90 t domains in Drosophila MTP (dMTP) and human MTP (hMTP) are not obvious because both proteins have ve

91 Splice variants of human MTP have not been reported.

92 We identified MTP variant 1 (MTPv1), a novel splice variant of mouse M

93 These studies identify MTP as a major target of CCl(4) and its degradation as a

94 Replacement with a low dose of CORT in MTP-treated animals reversed these effects in brain.

95 ro-interfering RNA led to 60-70% decrease in MTP mRNA and protein levels, but it had no detectable ef

96 It is associated with defects in MTP-mediated lipid transfer onto apolipoprotein B (APOB)

97 nemia patients with deleterious mutations in MTP and absence of B-lps had significantly lower plasma

98 Characterization of mutations in MTP causing abetalipoproteinemia has revealed that the c

99 es its degradation, leading to reductions in MTP activity and in apolipoprotein B (APOB) secretion.

100 and dark completely abolished rhythmicity in MTP expression and plasma lipid levels.

101 as food and light, play an important role in MTP regulation.

102 Diurnal variations in MTP expression and its induction by food availability ha

103 Moreover, LysoPC increased MTP mRNA, protein, and activity.

104 Conversely, apoAIV overexpression increased MTP mRNA in hepatoma cells, indicating transcriptional r

105 t of therapies for dyslipidemia that inhibit MTP.

106 Adenoviral overexpression of SHP inhibits MTP activity as well as VLDL-apoB protein secretion, and

107 nses, we measured MTP expression; intestinal MTP was low at night, and its induction after food entra

108 These studies show that intestinal MTP and ABCA1 are critical for lipid absorption and are

109 MTPs transferred triglyceride, invertebrate MTPs lacked this activity.

110 This isoform, MTP-B, has a unique first exon located approximately 2.7

111 noviruses in liver-specific MTP-deficient (L-MTP(-/-)) mice that have low plasma and high hepatic lip

112 Hepatosteatosis in L-MTP(-/-) mice was ameliorated to similar levels by both.

113 other pathways, we generated mice that lack MTP and ABCA1, individually and in combination, in the i

114 e--the Gaa(-/-) mouse and a transgenic line (MTP) expressing GAA only in skeletal muscle, as well as

115 We further speculate that short-lived MTP antagonists may be useful in controlling plasma and

116 and high-temperature pasteurisations (LTPs, MTPs and HTPs): 65, 80 and 90 degrees C for 30 or 60s.

117 Macrothrombocytopenia (MTP) is a heterogeneous group of disorders characterized

118 NOD2 received intravitreal injection of MDP, MTP, or PGN.

119 asons for these lower responses, we measured MTP expression; intestinal MTP was low at night, and its

120 of FoxA2 and FoxO1 abolished apoAIV-mediated MTP induction.

121 ted with the VPT at the metatarsophalangeal (MTP) joint (Spearman's rho=0.384, P=0.033), indicating t

122 rticosteroid synthesis inhibitor metyrapone (MTP) also significantly reduced GR-ir in the POA, mp, Me

123 In most MTP, this phenotype arises because of altered regulation

124 t 1 (MTPv1), a novel splice variant of mouse MTP, by polymerase chain reaction and Northern analysis

125 ely 2.7 kilobases upstream of canonical MTP (MTP-A) exon 1.

126 of the first exon (Ex1A) for canonical MTP (MTP-A); MTP-C contains both first exons for MTP-A and MT

127 riants in human tissues, which we have named MTP-B and MTP-C.

128 red with 20 amino acids encoded by exon 1 of MTP-A.

129 Ablation of MTP abolishes triglyceride absorption and results in mas

130 Conditional genetic ablation of MTP reduces cholesteryl esters and enhances free cholest

131 epatic iNKT cell abundance in the absence of MTP is associated with susceptibility to severe iNKT cel

132 regulate FoxO1 transcriptional activation of MTP.

133 utral and polar lipid transfer activities of MTP are critical for lipoprotein assembly.

134 nce of the phospholipid transfer activity of MTP in the lipidation of apolipoprotein B and CD1d has b

135 Phospholipid transfer activity of MTP promoted biogenesis of both apoB48 and apoB100-conta

136 ibition of triglyceride transfer activity of MTP.

137 trend toward better EFS with the addition of MTP (P = .08).

138 The addition of MTP to chemotherapy improved 6-year overall survival fro

139 The addition of MTP to chemotherapy resulted in a statistically signific

140 io for overall survival with the addition of MTP was 0.71 (95% CI, 0.52 to 0.96).

141 cific regions corresponding to the bottom of MTP's wells.

142 Conversely, coexpression of MTP and apoB in AC29 cells stably transfected with ACAT1

143 Yet, the development of MTP inhibitors to lower plasma lipid concentrations has

144 Thus, the N-terminal domain of MTP is also important for its lipid transfer activity.

145 1B is quite adequate to drive expression of MTP.

146 A new function of MTP in cholesterol ester biosynthesis has been reported.

147 ve knowledge about the structure-function of MTP might help design new molecules that avoid steatosis

148 lated primary hepatocytes, heterozygosity of MTP caused an approximately 50% reduction in mitochondri

149 However, we found that the major impact of MTP deficiency occurred distal to the ER and Golgi compa

150 lipoprotein assembly occur independently of MTP lipid transfer activity.

151 lso reduces lipid synthesis independently of MTP.

152 ion of the MTP promoter and the induction of MTP mRNA by LRH-1 in hepatocytes.

153 apoE expression, as well as the influence of MTP inhibitors on the formation of HCV particles.

154 Chemical inhibition of MTP also decreases esterification of cholesterol in Caco

155 s, we posit that the selective inhibition of MTP triglyceride transfer activity might reduce hyperlip

156 Intestine-specific inhibitors of MTP decrease chylomicron biogenesis and improve insulin

157 Mice with hepatocyte-specific loss of MTP exhibit defects in the function of CD1d and show inc

158 times and suggest that diurnal modulation of MTP is a major determinant of daily changes in plasma li

159 Cotranslational presence of MTP can dramatically promote the folding of B6.4-20.5 an

160 The presence of MTP prolongs this window of time by acting as a chaperon

161 thermore, apoB translated in the presence of MTP retains its phospholipid recruitment capability post

162 Adenovirus-mediated reconstitution of MTP expression proportionately restored CREBH processing

163 interacts with the 3' untranslated region of MTP mRNA and induces its degradation, leading to reducti

164 of the biology and therapeutic regulation of MTP and their significance for lipid metabolism and card

165 abolition of insulin-dependent regulation of MTP expression.

166 st that FoxO1 mediates insulin regulation of MTP production and that augmented MTP levels may be a ca

167 d as a novel intestine-specific regulator of MTP.

168 roRNA-30c (miR-30c) as a potent repressor of MTP that controls plasma apoB-containing lipoprotein lev

169 findings suggest a novel, unexpected role of MTP at a late stage of CD1d trafficking in the lysosomal

170 investigated the putative functional role of MTP in the initial lipidation of apoB:1000 in stable tra

171 ent, participants with the LCHADD subtype of MTP disorder continue to demonstrate visually disabling

172 Suppression of MTP gene expression in stable transformants of McA-RH777

173 However, the clinical use of MTP inhibitors has been uncertain because of the gastroi

174 identification of a novel splice variant of MTP in mice.

175 udies in mice identified a splice variant of MTP with an alternate first exon.

176 and this process is critically dependent on MTP.

177 To study the effect of this mutation on MTP function, we created mutants via site-directed mutag

178 on efficiency, enabling the cell to optimize MTP activity.

179 truncated forms of apoB and either MTP-A or MTP-B demonstrated that both isoforms are effective in t

180 receive or not to receive ifosfamide and/or MTP in a 2 x 2 factorial design.

181 absence of either proper lipid substrate or MTP may result in the improper folding of apoB and, cons

182 Partial MTP inhibition using small molecule inhibitors, such as

183 en 11- and 14-nm multiply twinned particles (MTPs) of Ag and HAuCl4 in chloroform.

184 (BES) derived from three minimum tile paths (MTP) to examine the extent and homogeneity of polyploid-

185 dendritic cells isolated from ABL patients, MTP deficiency was associated with increased proteasomal

186 ncept that mitochondrial targeting peptides (MTP) can interact and disrupt bacterial membranes, actin

187 sphate (EP), D-3-methylthrietol-4-phosphate (MTP), D-3-ethylerythritol-4-phosphate (EEP), D-1-amino-3

188 Purified M. tuberculosis pili (MTP) are composed of low-molecular-weight protein subuni

189 A 96- or 24-well microtiter plate (MTP) was positioned on the gadget's screensaver that pro

190 hed to a polystyrene based-microtiter plate (MTP), pretreated with KOH.

191 pensed in a KOH-pretreated microtiter plate (MTP).

192 ve cellphone-based 96-well microtiter-plate (MTP) reader, capable of performing AST without the need

193 96-well chemiluminescent microtiter plates (MTP) using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimid

194 osterior (ITP) > medium turbinate posterior (MTP) > medium turbinate anterior (MTA).

195 As predicted, a decrease in spectral power (MTP) at 40 Hz was observed in the cannabis group (p<0.01

196 formed using Fourier-based mean trial power (MTP) and phase-locking (inter-trial coherence; ITC).

197 formed using Fourier-based mean trial power (MTP).

198 nd, microsomal triglycerol transfer protein (MTP) activity and apolipoprotein B (ApoB) secretion were

199 in microsomal triglyceride transfer protein (MTP) activity, hepatic TG content increased dramatically

200 al microsomal triglyceride transfer protein (MTP) activity, protein, mRNA, and gene transcription sho

201 ested that both microsomal transfer protein (MTP) and apoB are important for HCV production.

202 on microsomal triglyceride transfer protein (MTP) and ATP-binding cassette family A protein 1, respec

203 of microsomal triglyceride transfer protein (MTP) and ATP-binding cassette transporter A1 (ABCA1) in

204 Microsomal triglyceride transfer protein (MTP) has been studied extensively, primarily because of

205 by microsomal triglyceride transfer protein (MTP) in a rate-limiting step that is regulated by insuli

206 A microsomal triglyceride transfer protein (MTP) inhibitor nearly deleted apoB100 secretion from hep

207 a microsomal triglyceride transfer protein (MTP) inhibitor to block beta-lipoprotein particle format

208 of microsomal triglyceride transfer protein (MTP) inhibitors is limited to severe hyperlipidemias bec

209 Microsomal triglyceride transfer protein (MTP) is a key protein in the secretion of apolipoprotein

210 Microsomal triglyceride transfer protein (MTP) is a target to reduce plasma lipids because of its

211 Microsomal triglyceride transfer protein (MTP) is a unique lipid transfer protein essential for th

212 Microsomal triglyceride transfer protein (MTP) is an endoplasmic reticulum (ER)-resident lipid tra

213 Microsomal triglyceride transfer protein (MTP) is essential for the assembly of neutral-lipid-rich

214 er microsomal triglyceride transfer protein (MTP) mRNA and protein levels.

215 ed microsomal triglyceride transfer protein (MTP) mRNA and protein levels.

216 Microsomal triglyceride transfer protein (MTP) plays a key role in the lipidation of nascent apoB

217 ed microsomal triglyceride transfer protein (MTP) without diminishing mRNA levels.

218 Microsomal triglyceride transfer protein (MTP), a chaperone for the biosynthesis of apolipoprotein

219 at microsomal triglyceride transfer protein (MTP), a protein involved in the transfer of lipids onto

220 Microsomal triglyceride transfer protein (MTP), an endoplasmic reticulum lipid transfer protein cr

221 k, microsomal triglyceride transfer protein (MTP), and nocturnin are involved in the circadian regula

222 or microsomal triglyceride transfer protein (MTP), as well as deletion of HSP110 in the radioresistan

223 on microsomal triglyceride transfer protein (MTP), can contribute to hyperlipidemia.

224 Microsomal triglyceride transfer protein (MTP), essential for apolipoprotein B (apoB) biosynthesis

225 to the ER by microsomal TG transfer protein (MTP), inducing ER stress.

226 of microsomal triglyceride transfer protein (MTP), required for B-lp assembly and secretion, in sphin

227 he microsomal triglyceride transfer protein (MTP), the product of the MTTP gene, is essential for the

228 in microsomal triglyceride transfer protein (MTP).

229 nd microsomal triglyceride transfer protein (MTP).

230 by microsomal triglyceride transfer protein (MTP).

231 on microsomal triglyceride transfer protein (MTP).

232 or microsomal triglyceride transfer protein (MTP).

233 ) for a mitochondrial trifunctional protein (MTP) gene defect to determine if a primary defect in mit

234 such as mitochondrial trifunctional protein (MTP) that catalyses beta-oxidation of fatty acids in L.

235 of the mitochondrial trifunctional protein (MTP), an enzyme complex which catalyzes the last 3 steps

236 MTP-B does not encode a protein; MTP-C encodes the same protein encoded by MTP-A, althoug

237 Metal tolerance proteins (MTPs) are plant members of the cation diffusion facilita

238 Massive transfusion protocols (MTPs) have become standard of care in the management of

239 yl esters in vitro, but addition of purified MTP and low density lipoprotein corrects this deficiency

240 Recently, MTP was shown to regulate the CD1 family of lipid antige

241 three unique residues; however, recombinant MTP and MTPv1 had an equivalent protein disulfide isomer

242 poAIV in differentiated Caco-2 cells reduced MTP, FoxA2, and FoxO1 mRNA levels, cellular MTP activity

243 of hepatic FoxO1 was associated with reduced MTP and VLDL production in adult mice.

244 e Au and Ag form alloys rapidly within small MTPs rich in vacancy and grain boundary defects, a compl

245 s were seen in liver- and intestine-specific MTP knock-out (L,I-Mttp(-/-)) mice, suggesting that MTP

246 ing and apoA-IV expression in liver-specific MTP knock-out mice.

247 thologs using adenoviruses in liver-specific MTP-deficient (L-MTP(-/-)) mice that have low plasma and

248 h the ability of FoxO1 to bind and stimulate MTP promoter activity.

249 Lomitapide, a systemic MTP inhibitor, significantly reduces LDL-C in homozygous

250 CCl(3)(.) generated by these enzymes targets MTP for degradation.

251 We conclude that MTP triglyceride transfer activity first appeared in fis

252 We conclude that MTP-B functions similarly to MTP-A in lipoprotein assemb

253 We confirmed that MTP mice had normal diaphragmatic contractile properties

254 They demonstrate that MTP is a target of the transcription factor FoxO1 and th

255 We also found that MTP transferred these lipids between vesicles in vitro.

256 We hypothesized that MTP deficiency may affect either their synthesis or secr

257 Thus, we propose that MTP are previously unidentified host-colonization factor

258 Therefore, we propose that MTP might regulate plasma ceramide and sphingomyelin lev

259 Mechanistic studies revealed that MTP inhibition increased transcription of the GPT/GOT1 g

260 ed fusions of the two proteins revealed that MTP-A is localized to the endoplasmic reticulum, whereas

261 These studies show that MTP expression and plasma lipid undergo diurnal regulati

262 The proposed approaches may show that MTP targeting is a viable approach to lower plasma lipid

263 A loss-of-function study showed that MTP depletion rendered cells less responsive to alpha in

264 Gene-ablation studies showed that MTP function and chylomicron assembly is essential for t

265 Recent studies have suggested that MTP may also play key roles in other cellular processes.

266 ix protein laminin in vitro, suggesting that MTP possess adhesive properties.

267 ck-out (L,I-Mttp(-/-)) mice, suggesting that MTP specifically plays a role in the regulation of plasm

268 The MTP (minimal tiling path) module uses sequence and finge

269 was directly associated with the VPT at the MTP joint and lateral femoral condyle, after adjustment

270 Simulation results are provided for the MTP, DSI and parallelization.

271 ne attachment that holds and illuminates the MTP using a light-emitting-diode array.

272 inding to the identified cis elements in the MTP promoter at night.

273 d that sequences between -204/-775 bp in the MTP promoter respond to apoAIV and that apoAIV enhances

274 SHP represses the transactivation of the MTP promoter and the induction of MTP mRNA by LRH-1 in h

275 mutation of the FoxO1 target site within the MTP promoter disabled FoxO1 binding and resulted in abol

276 Therefore, MTP is involved in ceramide and sphingomyelin secretion

277 Therefore, MTP plays a novel role in regulating cholesteryl ester b

278 Therefore, MTPs represent alternative sources to design new potenti

279 Consistently with this, MTP protein and mRNA levels were suppressed by HCV infec

280 Thus, MTP enhances cellular cholesterol esterification by remo

281 abolished ocular inflammation in response to MTP but not to PGN treatment.

282 e conclude that MTP-B functions similarly to MTP-A in lipoprotein assembly.

283 MTP-B represents approximately 90% of total MTP mRNA in mouse adipocytes and 3T3-L1 cells and <5% in

284 whether the addition of muramyl tripeptide (MTP) to chemotherapy enhances event-free survival (EFS)

285 amyl dipeptide (MDP) and muramyl tripeptide (MTP).

286 Additionally, two MTP inhibitors, CP-346086 and BMS-2101038, efficiently b

287 Lactacystin increased ubiquitinylated MTP and prevented lipid accumulation in tissues.

288 Upon MTP activation, patients were randomized to be managed e

289 We tested this mobile-reader using MTPs prepared with 17 antibiotics targeting Gram-negativ

290 ochemical and cellular properties of various MTP orthologues obtained from species that diverged duri

291 While vertebrate MTPs transferred triglyceride, invertebrate MTPs lacked

292 of ABCA1, and it was reduced by 92-95% when MTP was deleted in the intestine alone or together with

293 We hypothesize that, when MTP is inactive, CD1d traffics to the cell surface and p

294 t affecting lipid transfer activity, whereas MTP antagonist inhibits lipid transfer activity without

295 alized to the endoplasmic reticulum, whereas MTP-B localizes primarily to the Golgi complex in these

296 -B was found in a number of tissues, whereas MTP-C was prominent in brain and testis.

297 But it is unknown whether MTP directly transfers lipids onto apoB in vivo and, if

298 onsequently absence of Ufm1 conjugation with MTP resulted in diminished acetyl-CoA, the end-product o

299 We describe 2 unrelated pedigrees with MTP and sensorineural hearing loss that segregate with a

300 tal thymic organ culture (FTOC) treated with MTP antagonists.