ライフサイエンスコーパス: Marburg virus

1 responses than Zaire Ebola virus (ZEBOV) or Marburg virus.

2 entified in Ebola virus GP1 are conserved in Marburg virus.

3 se caused by the filoviruses Ebola virus and Marburg virus.

4 osure of rhesus macaques to a lethal dose of Marburg virus.

5 ected primates respond following exposure to Marburg virus.

6 strategies against infections with Ebola and Marburg viruses.

7 for the largest outbreak ever documented for Marburg viruses.

8 Marburg virus, a cousin of Ebola virus, causes severe he

9 completely protect nonhuman primates against Marburg virus and 3 different species of Ebola virus.

10 t virus, Bundibugyo virus, Reston virus, and Marburg virus and differentiated between the genera Ebol

11 The filoviruses Marburg virus and Ebola virus cause severe hemorrhagic f

12 typed with Marburg virus GP(1,2), as well as Marburg virus and Ebola virus infection in a dose-depend

13 sembled using filovirus matrix proteins from Marburg virus and Ebola virus is also sensitive to inhib

14 The filoviruses, Marburg virus and Ebola virus, cause severe hemorrhagic

15 ope glycoproteins (GPs) from the filoviruses Marburg virus and Ebola virus.

16 re likely induced in response to exposure to Marburg virus and further suggested that the early immun

17 ndibugyo virus (BDBV), Sudan virus, and even Marburg virus and Lloviu virus, which belong to the hete

18 VP24 is only 30% identical between Marburg virus and the ebolaviruses.

19 Filoviruses, which include Marburg viruses and Ebola viruses, are zoonotic pathogen

20 n, Tai Forest, Bundibugyo, Zaire, Sudan, and Marburg viruses and found two antibodies that showed pan

21 ae contains three genera, Ebolavirus (EBOV), Marburg virus, and Cuevavirus.

22 dengue virus, West Nile virus, Ebola virus, Marburg virus, and Zika virus.

23 In addition, we showed that Marburg virus Angola and Ebola virus Makona-WPGC07 effic

24 The filoviruses Ebola Zaire virus and Marburg virus are believed to infect target cells throug

25 uctures and visual images of the proteins of Marburg virus are essential for the development of antiv

26 while the ebolaviruses Sudan and Reston and Marburg virus are not.

27 onstrate that the VP35s from Ebola virus and Marburg virus are the major suppressors of DC maturation

28 Ebola and Marburg viruses are believed to enter host cells by rece

29 Ebola and Marburg viruses are filoviruses: filamentous, enveloped

30 The filoviruses, Ebola virus and Marburg virus, are zoonotic pathogens that cause severe

31 re resistant to infection by Ebola virus and Marburg virus, but remain fully susceptible to a suite o

32 Marburg virus can cause severe disease, with up to 90% h

33 Infection of Ebola virus and Marburg virus can cause severe illness in humans with a

34 Infection by Ebola virus and Marburg virus can cause severe illness in humans, with a

35 Ebola and Marburg viruses can cause hemorrhagic fever (HF) outbrea

36 Ebola virus and Marburg virus cause serious disease outbreaks with high

37 Filoviruses, including Ebola and Marburg viruses, cause rapidly fatal diseases in humans

38 Marburg virus causes a severe infection that is associat

39 To better understand the overall response to Marburg virus challenge, we undertook a transcriptomic a

40 the Ravn strain (RAVV VP40)-from a distinct Marburg virus clade-is demonstrated to also inhibit IFN

41 ganda and was confirmed to be an outbreak of Marburg virus disease (MVD).

42 of BCX4430 protects against Ebola virus and Marburg virus disease in rodent models.

43 fever, Ebola virus disease, Lassa fever, and Marburg virus disease.

44 he trafficking and subsequent release of the Marburg virus from infected cells.

45 d Sudan glycoproteins and one (MAR) encoding Marburg virus glycoprotein.

46 e, we present the 3.6 A crystal structure of Marburg virus GP in complex with a cross-reactive antibo

47 bited entry of retroviruses pseudotyped with Marburg virus GP(1,2), as well as Marburg virus and Ebol

48 tro potency of CV-N to inhibit EboZV GP- and Marburg virus GP-pseudotyped viruses (EC50 approximately

49 s highly similar to those of Ebola virus and Marburg virus GP2 despite CASV genome homology to arenav

50 ructure has been observed in Ebola virus and Marburg virus GP2, as well as other viruses that enter v

51 uring mouse adaptation of the Ravn strain of Marburg virus have impacted the budding function of the

52 filoviruses including Sudan, Bundibugyo, and Marburg viruses have caused human outbreaks with mortali

53 herapeutics are licensed to counter Ebola or Marburg viruses, highly pathogenic filoviruses that are

54 omologous protection against Ebola virus and Marburg virus in a prophylactic setting against in macaq

55 EV) demonstrated protective efficacy against Marburg virus in nonhuman primates.

56 are currently no approved interventions for Marburg virus, in part because a small-animal model that

57 ar requirements of nucleocapsid transport in Marburg virus-infected cells under biosafety level 4 con

58 nes whose disruption allowed the survival of Marburg virus-infected cells, suggesting that Rab9 is ut

59 ngs demonstrate very early host responses to Marburg virus infection and provide a rich data set for

60 were tested for evidence of acute or recent Marburg virus infection by reverse transcription-polymer

61 study, we carefully analyzed the timeline of Marburg virus infection in nonhuman primates in order to

62 We evaluated the susceptibility to Ebola and Marburg virus infection of mice that cannot respond to i

63 completely protects cynomolgus macaques from Marburg virus infection when administered as late as 48

64 significantly increased survival time after Marburg virus infection.

65 own to protect macaques from Ebola virus and Marburg virus infections, both prophylactically and post

66 showing their utility in combating Ebola and Marburg virus infections.

67 development of life-saving measures against Marburg virus infections.

68 The findings imply that reservoir hosts of Marburg virus inhabit caves, mines, or similar habitats.

69 Marburg virus is a genetically simple RNA virus that cau

70 aviruses is immunosuppressive, while that of Marburg virus is not.

71 One key protein in the Marburg virus life cycle is VP40, which both assembles t

72 ve different viruses, including Ebola virus, Marburg virus, lymphocytic choriomeningitis virus (LCMV)

73 Ebola virus (EboV) and Marburg virus (MarV) (filoviruses) are the causative age

74 Infections with Marburg virus (MARV) and Ebola virus (EBOV) cause severe

75 Marburg virus (MARV) and Ebola virus (EBOV), members of

76 members of the Marburgvirus genus, including Marburg virus (MARV) and Ravn virus (RAVV), is difficult

77 Marburg virus (MARV) and the ebolaviruses belong to the

78 Ebola virus (EBOV) and Marburg virus (MARV) are among the deadliest human patho

79 sms by which neutralizing antibodies inhibit Marburg virus (MARV) are not known.

80 The filoviruses Ebola virus (EBOV) and Marburg virus (MARV) are responsible for devastating hem

81 Ebola virus (EBOV) and Marburg virus (MARV) belong to the Filoviridae family an

82 Ebola virus (EBOV) and Marburg virus (MARV) cause rapidly progressive hemorrhag

83 Here we report rescue of a recombinant Marburg virus (MARV) expressing EGFP from an additional

84 In the seven protein-coding genes in the Marburg virus (MARV) genome, the synonymous nucleotide d

85 ll as the addition of Sudan virus (SUDV) and Marburg virus (MARV) GP containing virions.

86 Marburg virus (MARV) has been associated with sporadic e

87 Marburg virus (MARV) has caused outbreaks of filoviral h

88 n virus (SUDV), Bundibugyo virus (BDBV), and Marburg virus (MARV) have also caused sizeable human out

89 dated as an inhibitor of infectious EBOV and Marburg virus (MARV) in cell-based assays, with 50% inhi

90 Marburg virus (MARV) infection causes a severe and often

91 Marburg virus (MARV) infection causes severe morbidity a

92 The 2005 outbreak of Marburg virus (MARV) infection in Angola was the most le

93 Marburg virus (MARV) infection is a lethal hemorrhagic f

94 of cynomolgus monkeys against Lake Victoria Marburg virus (MARV) infection.

95 Marburg virus (MARV) is a highly pathogenic filovirus th

96 Marburg virus (MARV) is a lipid-enveloped filamentous vi

97 Marburg virus (MARV) is a lipid-enveloped virus from the

98 Marburg virus (MARV) is an emerging zoonotic pathogen th

99 targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein.

100 e particles (VLPs) of Ebola virus (EBOV) and Marburg virus (MARV) produced in human 293T embryonic ki

101 2 closely related plaque-derived variants of Marburg virus (MARV) species Lake Victoria marburgvirus,

102 Phylogenetic comparisons of known Marburg virus (MARV) strains reveal 2 distinct genetic l

103 that the filoviruses Ebola virus (EBOV) and Marburg virus (MARV) suppress DC maturation in vitro Bot

104 s, we delivered an antigen-capture assay for Marburg virus (MARV) that was based on llama single-doma

105 Marburg virus (MARV), a close relative of Ebola virus, i

106 Marburg virus (MARV), a member of the Filoviridae family

107 Marburg virus (MARV), a member of the filovirus family,

108 iruses, consisting of Ebola virus (EBOV) and Marburg virus (MARV), are among the most lethal infectio

109 ruses, including both Ebola virus (EBOV) and Marburg virus (MARV), can infect humans and other animal

110 Immune responses to Marburg virus (MARV), however, remain almost entirely un

111 y lethal filoviruses, Ebola virus (EBOV) and Marburg virus (MARV), in humans.

112 re highly conserved among filoviruses except Marburg virus (MARV), suggesting that MARV may not bind

113 oding the glycoprotein (GP) gene from Angola Marburg virus (MARV), were compared for their ability to

114 Marburg virus (MARV), which belongs to the virus family

115 In the first study, Marburg virus (MARV)-infected NHPs were treated 15 to 30

116 hogenic and biological threat agents such as Marburg virus (MARV).

117 were inoculated subcutaneously (n = 22) with Marburg virus (MARV).

118 ette bat (ERB) is a known reservoir host for Marburg virus (MARV).

119 te bat (ERB) is a natural reservoir host for Marburg virus (MARV); however, the mechanisms by which M

120 f lethal infection with the Angola strain of Marburg virus (MARV-Ang) in rhesus macaques and tested t

121 The Angola strain of Marburg virus (MARV/Ang) was responsible for the largest

122 ) and nucleoprotein (NP) of Ebola (EBOV) and Marburg viruses (MARV) play key roles during virion asse

123 Marburg viruses (MARVs) cause highly lethal infections i

124 Recombinant Ebola and Marburg virus matrix VP40 and glycoprotein (GP) antigens

125 r hosts of highly virulent pathogens such as Marburg virus, Nipah virus, and SARS coronavirus.

126 he putative matrix protein of both Ebola and Marburg viruses, possesses a conserved proline-rich moti

127 ]R downward arrow), and one is predicted for Marburg viruses (R[R/K]KR downward arrow), although in a

128 that the VP40 protein of the Ravn strain of Marburg virus (Ravn virus [RAVV]) failed to block IFN si

129 lecular automaton able to diagnose Ebola and Marburg virus sequences.

130 A comparison with the closely related Marburg virus shows that the N-terminal region of nucleo

131 e ZEBOV and Sudan Ebolavirus and 4 different Marburg virus strains produced severe, but more slowly p

132 roup received the same dose of the VSV-based Marburg virus vaccine at both time points; another group

133 cluding the group treated with the VSV-based Marburg virus vaccine.

134 The crystal structure of Marburg virus VP24, presented here, reveals that althoug

135 ays, including Ebola virus VP35 and VP24 and Marburg virus VP35, VP40, and VP24, on DC maturation and

136 the corresponding (84)LPLGIM(89) sequence of Marburg virus VP40 (mVP40) are critical for efficient re

137 The Marburg virus VP40 protein is a viral matrix protein tha

138 Here we provide the molecular structure of Marburg virus VP40, illustrate differences from VP40 of

139 The host response to aerosolized Marburg virus was evident at 1 day postexposure.

140 using in vitro affinity reagent selection on Marburg virus we rapidly established monoclonal affinity

141 an completely protect rhesus monkeys against Marburg virus when administered after exposure and can p

142 virus, Lassa virus, LCMV, rabies virus, and Marburg virus, which was substituted for the VSV glycopr