ライフサイエンスコーパス: Marburgvirus

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1 of nonadapted wild-type (wt) Ebolavirus and Marburgvirus.

2 appears to be the major virulence factor for marburgviruses.

3 of the secreted ebolavirus glycoproteins on marburgvirus and ebolavirus cell entry, using Fc-tagged

4 inct from that of Ebola virus (EBOV) (genera Marburgvirus and Ebolavirus, respectively).

5 Viruses within Marburg marburgvirus and Sudan ebolavirus species can be traced

6 m Ebolavirus Zaire and Sudan species and the Marburgvirus Angola strain expressed in a DNA vaccine.

7 Marburgviruses are zoonotic pathogens that cause lethal

8 Ebolaviruses and marburgviruses belong to the family Filoviridae and caus

9 Ebolavirus and Marburgvirus cause severe hemorrhagic fever with high mo

10 irus vaccine vectors using wt Ebolavirus and Marburgvirus challenge strains.

11 s protected naive animals from EBOV, but not Marburgvirus, challenge.

12 n of Reston and Lloviu viruses, filoviruses (marburgviruses, ebolaviruses, and "cuevaviruses") cause

13 While the marburgviruses exhibit high overall genetic diversity (u

14 1,2), ebolaviruses and cuevaviruses, but not marburgviruses, express two secreted glycoproteins, solu

15 Viruses in the Ebolavirus and Marburgvirus genera (family Filoviridae) have been assoc

16 ad-spectrum therapies against members of the Marburgvirus genus, including Marburg virus (MARV) and R

17 Neither the marburgvirus GP1 fragment nor that of ebolavirus bound a

18 151-amino acid fragment of the Lake Victoria marburgvirus GP1 subunit bound filovirus-permissive cell

19 or for the deadly filoviruses Ebolavirus and Marburgvirus has yet to be identified and characterized.

20 These studies provide insights into how marburgviruses manipulate the host for enzymes, metaboli

21 Filoviruses, marburgvirus (MARV) and ebolavirus (EBOV), are causative

22 Marburgvirus (MARV) infections are generally lethal in h

23 s Zaire ebolavirus (ZEBOV) and Lake Victoria marburgvirus (MARV) were not affected by these condition

24 morrhagic fever (MHF), the disease caused by marburgvirus (MARV), and has created a bottleneck in the

25 irus (ZEBOV), Reston Ebolavirus (REBOV), and Marburgvirus (MARV), using transcriptional profiling and

26 The filoviruses, Marburg marburgvirus (MARV), Zaire ebolavirus (ZEBOV), and Sudan

27 BOV), Cote d'Ivoire ebolavirus (CIEBOV), and Marburgvirus (MARV).

28 In primate cells, the Lake Victoria marburgvirus Musoke strain (MARV) VP40 matrix protein an

29 hat is both captor and tracer for polyvalent Marburgvirus nucleoprotein.

30 iruses pseudotyped with either Lake Victoria marburgvirus or Zaire ebolavirus GP(1,2).

31 This is in contrast to the 1998 to 2000 marburgvirus outbreak, where evidence of several virus g

32 Partial marburgvirus RNA sequence analysis revealed up to 21% nu

33 ope within the fusion loop of ebolavirus and marburgvirus species.

34 f Marburg virus (MARV) species Lake Victoria marburgvirus, strain Musoke, indicate only a few regions

35 potential of all filovirus species: Marburg marburgvirus, Tai Forest ebolavirus, Reston ebolavirus,

36 tely 7%) from the main group of East African marburgviruses than one might expect given the large geo

37 erentiated between the genera Ebolavirus and Marburgvirus The amount of filovirus RNA that could be d

38 species of Ebolavirus and several strains of marburgvirus, the current immunotherapeutics primarily t

39 leotide sequences may confer activity across marburgvirus variants.

40 In contrast, structures of marburgvirus VP35 show that it primarily coats the dsRNA

41 Marburgvirus was also included despite the fact that the

42 Surprisingly, marburgvirus was confirmed (12 of 15 specimens) as the c

43 The investigational Ebolavirus and Marburgvirus WT GP DNA vaccines were safe, well tolerate

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