ライフサイエンスコーパス: Mb

1 Mb rebinding was detected by direct electrocatalytic red

2 Mb rebinding was examined in Mb-free diluted human serum

3 affold N50 of 8.7 Mb and the longest of 19.0 Mb.

4 3 Gb (contig N50: 8.3 Mb, scaffold N50: 22.0 Mb, including 39.3 Mb N-bases), together with 206 Mb of

5 ning a total of 55 848 composite parts (71.0 Mb).

6 s and structural variants, as well as 137.02-Mb sequences harboring 1737 protein-coding genes that we

7 ic gaps in the reference genome, adding 1.03 Mb of previously intractable sequence.

8 ntig N50 of 45.7 kb and scaffold N50 of 4.06 Mb.

9 f 13,588 scaffolds covering 725 of the 1,084 Mb genome, was generated using ~133-fold Illumina sequen

10 his method to efficiently deliver large (1.1 Mb) synthetic yeast centromeric plasmids (YCps) to cultu

11 DB1-dependent loop formations bypassed 0.2-1 Mb of linear genome and radiated from the TAD(cPcdh) fri

12 genome, coldspots have a median size of 2.1 Mb and are spatially clustered.

13 gies produced a draft nuclear genome of 36.1 Mb, organized into 321 scaffolds with L50 of 31 and N50

14 ing approximately 3.6 Mb, in addition to 4.1 Mb of nonreference sequence, mostly originating from dup

15 Mb of HX1-specific sequences, including 4.1 Mb that are not present in previously reported Asian gen

16 3,365 genotyped and imputed SNPs across a 1 Mb region (positions 44,394,495-45,364,167; NCBI build 3

17 ession is regulated by the ( approximately 1 Mb distant) ZRS enhancer.

18 one of the two genes in the approximately 1 Mb interval and the only gene disruption shared between

19 uencing to fine map it to an approximately 1 Mb interval.

20 f self-interacting domains ( approximately 1 Mb) resembling mammalian topologically associating domai

21 pared with SZ, most notably for deletions >1 Mb (P=9 x 10(-4)).

22 CNV burden that was prominent for large (> 1 Mb), singleton events (OR = 2.28, 95% CI [1.39-3.79], p

23 with global ROH measurements (12.38 ROHs >1 Mb in cases vs 12.11 in controls; 2.986 Mb average size

24 Consistently, active transcription units >1 Mb were robust cell-type-specific predictors of induced

25 24e-05) among 115 duplication carriers (>/=1 Mb).

26 .9%) carriers of a duplication of at least 1 Mb (OR, 3.67; 95% CI, 1.29-8.54; P = .008) had an intell

27 ct with smoking were in close vicinity (</=1 Mb) to SNPs previously associated with IBD; many were lo

28 A shared haplotype of 1 Mb around LMNA suggested a common founder.

29 220 candidate genes (within a distance of 1 Mb).

30 osed for analyzing data at low resolution (1 Mb).

31 d a haplotype of 14 rare variants spanning 1 Mb of the disease-causing allele.

32 We identified 32 rare CNVs larger than 1 Mb in 31 patients.

33 of operator sequences, can be placed up to 1 Mb from the origin with no loss of penetrance.

34 igs encompass a 1.5-Mb genomic region with 1 Mb of sequence containing 82 S-linked genes anchored to

35 ulated by Lmx1b and found 292 PCRMs within 1 Mb of 254 Lmx1b-regulated genes.

36 ic disease architecture in which >/=71% of 1-Mb genomic regions harbor >/=1 variant influencing schiz

37 This study i) provided a 10 Mb targeted genome assembly; ii) demonstrated NGS of BAC

38 When imputing 10 Mb of sequence data from 200,000 reference samples in VC

39 When imputing 10 Mb of sequence data from 50,000 reference samples, Beagl

40 highly concordant with large-scale (order 10 Mb) features of previously reported genetic maps for mou

41 ht, with the Igf2r cluster extending over 10 Mb in placenta.

42 ate the expression of genes located up to 10 Mb from the telomeres (Telomere Position Effect-Over Lon

43 ponding to perfect phase in a majority of 10-Mb segments).

44 his genetic map enabled the anchoring of 100 Mb of WGS and 420 Mb of BAC sequences, an exploration of

45 umans, and was used to produce more than 100 Mb of additional annotation of TE-derived regions in the

46 ed by alternative alleles at a balanced >100-Mb inversion-based supergene, providing a unique system

47 s occupying 74 Mb of the A subgenome and 104 Mb of the D subgenome, and identified 19 candidate loci

48 ngal pathogenicity, we present here the 116 Mb de novo assembled high-quality genome of Ophiocordyce

49 We have assembled 117 Mb of the A. thaliana Landsberg erecta (Ler) genome into

50 previously described improvement of the 117-Mb sequence in the euchromatic portion of the genome and

51 re chromosomes in fission yeast and up to 12 Mb fragments in human cells.

52 ome assemblies, of which sizes vary from 120 Mb to 3.5 Gb.

53 a draft H. dujardini genome assembly of 135 Mb with superior assembly metrics to the previously publ

54 Here, we introduce the 18.14-Mb genome of Peltaster fructicola, one of the most preva

55 guingly, we found an exceptionally large (14-Mb) region with a low recombination rate on the X chromo

56 Two QTL, one on SSC12 at 15 Mb and the other on SSC7 at 75 Mb, explained 16.87% of t

57 er than 2.5 Mb, and scaffolds longer than 15 Mb.

58 A 15-Mb subset of this sequence was assembled, revealing two

59 Like many draft genomes, however, the 158-Mb Spirodela genome sequence has not been resolved to ch

60 ackground ratios peaking at 24 (IgG) and 16 (Mb) h after injection.

61 The genome (161 Mb) is smaller than those of related bursate nematodes a

62 The genome size is ca. 163 Mb with 19,222 predicted protein-coding genes.

63 Here we report the 169- and 168-Mb draft genomes of T. saginata and T. asiatica.

64 Here we investigate a paracentric 1.17-Mb inversion on chromosome 4 of Arabidopsis thaliana wit

65 kage analysis identified an approximately 18 Mb disease-associated locus on chromosome 4 (maximal log

66 An approximately 19 Mb critical region on X chromosome was identified throug

67 he mechanism as resulting from a balanced 19-Mb chromosomal inversion on chromosome 10q.

68 tent of 27.4% and an approximate size of 3.2 Mb.

69 panded the C. elegans reference genome by >2 Mb due to a more accurate determination of repetitive se

70 ontrols) and detected 124 mosaic X events >2 Mb in 97 (0.25%) women.

71 n controls; 2.986 Mb average size of ROHs >2 Mb in cases vs 2.889 Mb in controls; and 22% of cases wi

72 y of large clonal autosomal mosaic events >2 Mb in size in the aging population.

73 Restricting to events >2 Mb in size, we observed an increase in event frequency a

74 hr4q31.3 (empirical P value 2 = .04; ROHs >2 Mb).

75 re positioning because many of its large ( 2 Mb) centromeres are not dominated by satellite DNA.

76 e of regulation, deletion of one such site 2 Mb upstream of IL6 induces expression of the gene.

77 proportion of cases with ROHs greater than 2 Mb (P = .004) or greater than 3 Mb (P = .02), as well as

78 ted expanses of chromatin that reach up to 2 Mb in size.

79 cluding a large topologically associated 1.2-Mb domain conserved in humans and mice that encompasses

80 Using a 1.2-Mb inversion as an example, we show that such rearrangem

81 We used it to interrogate the 2-Mb POU5F1 locus in human embryonic stem cells, and ident

82 Each pool consists of approximately 20 Mb of up to 5000 unique and sequence-verified composite

83 ncluding 39.3 Mb N-bases), together with 206 Mb of alternative haplotypes.

84 the euchromatic portion of the genome and 21 Mb in the heterochromatic portion, using a whole-genome

85 633 bp in 347 scaffolds, with an N50 of 1.24 Mb.

86 Here we report a 243 Mb draft genome of black raspberry that will serve as a

87 (kgp) gene cluster was identified in a 5.26 Mb draft genome of Microcystis aeruginosa NIES-88.

88 udicots with a relatively small genome ( 260 Mb).

89 Despite possessing the smallest genome (0.27 Mb) of any organism not subsisting within a host cell, t

90 f this species (1.37 Gb, scaffold N50 = 1.28 Mb) that covers 93.8% of the genome (1.47 Gb) and harbou

91 .3 Mb, scaffold N50: 22.0 Mb, including 39.3 Mb N-bases), together with 206 Mb of alternative haploty

92 a mouse model of autism that duplicates 6.3 Mb region of chromosome 7 (Dp/+) corresponding to a regi

93 sion contains 4943 scaffolds totalling 691.3 Mb of which 88.6% were captured by the 11 chromosomes.

94 de novo assembly of 2.93 Gb (contig N50: 8.3 Mb, scaffold N50: 22.0 Mb, including 39.3 Mb N-bases), t

95 odal ( approximately 0.3 and approximately 3 Mb) size distribution and overlapping microhomology at t

96 l verbal dyspraxia, we identify a deletion 3 Mb away from the FOXP2 gene, which impacts FOXP2 gene ex

97 b in controls; and 22% of cases with ROHs >3 Mb vs 19% of controls) and a gene-cluster on Chr3p21.31

98 .31 (empirical P value 2 = .006-.04; ROHs >3 Mb).

99 rate that parents transmitting the de novo 3 Mb LCR22A-D 22q11.2 deletion, the reciprocal duplication

100 eater than 2 Mb (P = .004) or greater than 3 Mb (P = .02), as well as a significant 114-kilobase cons

101 typical distal nested deletions within the 3 Mb region that do not include TBX1 including 20 with LCR

102 n substitution, forming the [ZnMb(-6), Fe(3+)Mb(+6)] complex.

103 lbug Armadillidium vulgare We identified a 3-Mb insert of a feminizing Wolbachia genome that was rece

104 ter results in deletion of a approximately 3-Mb interstitial region containing genes with unexplored

105 hes, with scaffold N50 values approaching 30 Mb, and we identified complex structural variants (SVs)

106 evealed a large shared homozygous region (31 Mb) spanning PTF1A Sanger sequencing of PTF1A identified

107 nd assembled the pomegranate genome with 328 Mb anchored into nine pseudo-chromosomes and annotated 2

108 e also identified coldspots encompassing 329 Mb, or [Formula: see text] of observable genome, in whic

109 The 353 Mb genome contains 35 597 predicted protein-coding genes

110 We conducted a de novo assembly for the 375 Mb genome of the perennial model plant, Arabis alpina.

111 yte development gene FSIP2 (15.3%) and a 0.4 Mb region at Xq28 (15.3%).

112 zygous for c.2005C>T (p.Arg669Cys) and a 2.4 Mb deletion involving PIGG.

113 resenting 24% of the total size, and an 81.4 Mb transcriptome, were also obtained.

114 on chromosome 8 (P=1.5 x 10(-15)) spanning 4 Mb and containing at least 36 genes.

115 (PMP22) gene, which is located within a 1.4-Mb duplication on chromosome 17 associated with the most

116 n this study, we report a high-quality 313.4-Mb genome sequence of a bottle gourd inbred line, USVL1V

117 In this study, we report the 34.41 Mb genome sequence of strain Z7 of the tangerine pathoty

118 abled the anchoring of 100 Mb of WGS and 420 Mb of BAC sequences, an exploration of genetic diversity

119 Among them, approximately 71.43 Mb of novel CNVRs were detected in the Chinese cattle po

120 Its rapid life cycle, small (440-Mb) genome, and advanced germplasm resources make birch

121 genealogy of modern horses by screening 1.46 Mb of the male-specific region of the Y chromosome (MSY)

122 (LOH) across the genome (median 913 vs. 460 Mb in LOH, P < 0.05), with significant recurrent LOH on

123 ully determined the linkage interval to 9.47 Mb region on chromosome 12q13.13-q14.1, which was unexpe

124 The 479 Mb medfly genome is sequenced from adult flies from line

125 e traits; of these, 168 reside more than 0.5 Mb away from any previously reported GWAS significant va

126 or less while 4 regions were larger than 0.5 Mb.

127 reciprocal duplication, and the smaller 1.5 Mb LCR22A-B 22q11.2 deletion carry inversions of LCR22B-

128 We previously identified a ~1.5 Mb locus on canine chromosome 27 associated with CAD in

129 pe-methylation correlations within a 1.0-1.5 Mb region surrounding each of 16 OA-associated single-nu

130 hed both at short (<500 kb) and longer (>1.5 Mb) genomic distances.

131 ic distance range ( approximately 700 kb-1.5 Mb), while interactions involving actively marked DNase

132 er than 100 kb, phase blocks longer than 2.5 Mb, and scaffolds longer than 15 Mb.

133 enced the genomes of T. cruzi Y strain (35.5 Mb) and three benznidazole-resistant clones derived from

134 rom which an algorithm-guided 192-member 4.5 Mb library is built.

135 10(-8)) with at least five genes located >5 Mb away.

136 BAC contigs encompass a 1.5-Mb genomic region with 1 Mb of sequence containing 82 S-

137 tion and duplication, respectively, of a 1.5-Mb region that includes several genes with a role in epi

138 Of these DMCs, 52% were located in one 15.5-Mb locus on chromosome 13, which encompassed the Bhmt ge

139 alleles at a single locus encompassing a 4.5-Mb inversion in the genome.

140 aeder alleles are both associated with a 4.5-Mb inversion that occurred about 3.8 million years ago.

141 ype, although it was inherited on a unique 5-Mb genetic backbone.

142 n about expression in moderately-sized (1-50 Mb) segmental duplications, and about the response of sm

143 expression, whereas large duplications (>50 Mb) are more often dosage compensated.

144 ns separated by large genomic distances (>50 Mb) have yet to be characterized.

145 ing the Agilent SureSelect Human all Exon 51 Mb version 5 capture kit.

146 N. viennensis is a soil organism with a 2.52-Mb genome and 3,123 predicted protein-coding genes.

147 A total of 114 scaffolds consisting of 573 Mb are anchored on 24 linkage groups.

148 eving phased blocks with an N50 size of 11.6 Mb.

149 d 47 inversions comprising approximately 3.6 Mb, in addition to 4.1 Mb of nonreference sequence, most

150 constructed directed assemblies of the 4.6 Mb E. coli genome, 48.5 kb lambda genome, and a represe

151 tations with allele frequency (AF) 1% in 4.6 Mb-sized genome, the sensitivity and specificity of o2n-

152 ents involving up to 65 breakpoints and 60.6 Mb across four chromosomes, further defining rare catego

153 ) samples with pathogenic rearrangements > 6 Mb but only 2/10 samples with rearrangements < 6 Mb, unl

154 T can only detect the majority of larger (>6 Mb) chromosomal rearrangements and requires knowledge of

155 ut only 2/10 samples with rearrangements < 6 Mb, unless they were maternally inherited.

156 eviously developed positive mutant, Mb(+6) = Mb(D44K/D60K/E85K), led to construction of the complemen

157 f the complementary negative mutant Mb(-6) = Mb(K45E, K63E, K95E).

158 ts with two, three, and four doses of a 14.6-Mb segment of chromosome 1 that contains approximately 3

159 coli K-12 MG1655 chromosome in a single 4.6-Mb contig using only nanopore data.

160 before exome sequencing (Illumina Nextera 62 Mb capture) with variants called by FreeBayes; copy numb

161 torial library just varying expression (0.64 Mb of DNA assembly).

162 of the C. lectularius sequenced genome (650 Mb) and 14,220 predicted protein-coding genes provide a

163 addition, each genome carries on average 0.7 Mb of sequence that is not found in the main build of th

164 Correspondingly, carriers of 1.7 Mb BP1-BP5 rearrangements that encompass both the BP2-BP

165 Resequencing of 3.7 Mb of MSY DNA in 334 males, comprising 17 European and M

166 line, USVL1VR-Ls, with a scaffold N50 of 8.7 Mb and the longest of 19.0 Mb.

167 ads, resulting in 187 sequences covering 9.7 Mb.

168 to haplotype contigs with N50 greater than 7 Mb.

169 titutions, an intragenic deletion, and a 4.7-Mb multigene deletion involved the DNA-binding domain of

170 he size of the exome-CDS to approximately 71 Mb.

171 scanned 93 domestication sweeps occupying 74 Mb of the A subgenome and 104 Mb of the D subgenome, and

172 n SSC12 at 15 Mb and the other on SSC7 at 75 Mb, explained 16.87% of the total genetic variance.

173 plex gene family, the DNA sequence of a 1.75-Mb genomic region spanning the Gli-2 locus was analyzed

174 ference sequence of wheat chromosome 3B (774 Mb), which provides an excellent opportunity to study th

175 cific tandem DNA repeats ( approximately 1.8 Mb in maize).

176 Comparison to GRCh38 reveals 12.8 Mb of HX1-specific sequences, including 4.1 Mb that are

177 mic datasets, ranging from ca. 25 Kb to 16.8 Mb and inferred topologies using both concatenated gene

178 we performed a focused 5C analysis of a 2.8 Mb chromosome 7 region surrounding CFTR in a panel of ce

179 e of 17.9 Mb and a scaffold N50 size of 44.8 Mb, resolving 8 chromosomal arms into single scaffolds.

180 A locus was mapped to an approximately 5.8 Mb region at 12p13.1 but no candidate gene was identifie

181 lti-gene families, the DNA sequence of a 2.8-Mb genomic region, representing an 8.8 cM genetic interv

182 In the mouse, the approximately 2.8-Mb IgH and IgL loci require long-range, differential act

183 with the high recombination rate in the 2.8-Mb region with nine-fold higher than the genome-wide ave

184 etable MSY sequence ranges from 2.61 to 3.80 Mb.

185 We present an analysis of the closed 1.86 Mb genome of the ant-associated bacterium, for which we

186 oximately 1.2-Gb genome (scaffold N50 = 1.88 Mb) with at least 26 723 predicted genes for E. ulmoides

187 average size of ROHs >2 Mb in cases vs 2.889 Mb in controls; and 22% of cases with ROHs >3 Mb vs 19%

188 every CpG analyzed across approximately 1.9 Mb of the 15q11-q13 Prader-Willi/Angelman syndrome regio

189 ous assembly, with a contig N50 size of 17.9 Mb and a scaffold N50 size of 44.8 Mb, resolving 8 chrom

190 hogenic or likely pathogenic CNVs (0.08-18.9 Mb).

191 T 97-6194-5, consisting of approximately 2.9 Mb with a G+C content of 35% and 2,704 genes, was annota

192 Its genome sequence was 5.9 Mb with a G+C content of 39.2% and encompassed a total o

193 with 392 traits and diseases, covering 73.9 Mb (2.2%) of the human genome.

194 n ovarian cancer cell line and as small as 9 Mb in two high-grade serous ovarian cancer samples using

195 The new 143.9-Mb reference sequence, designated Release 6, effectively

196 tation and phylogenetic mapping of the 697.9-Mb Cimex lectularius genome, with an N50 of 971 kb, usin

197 refined the chromosome 12E signal to a 1.95 Mb linkage disequilibrium block containing only one gene

198 s >1 Mb in cases vs 12.11 in controls; 2.986 Mb average size of ROHs >2 Mb in cases vs 2.889 Mb in co

199 taining 48 contigs (N50 contig length = 3.99 Mb) covering >99% of the 100,286,401-base reference geno

200 We identify a Mb-scale genomic region present in weedy rice but not cu

201 , were employed to "break the symmetry" of a Mb homodimer by pairing Mb constructs with complementary

202 Adducted Mb promoted lipid oxidation in washed muscle more effect

203 ed muscle more effectively than non-adducted Mb.

204 g of alpha,beta-unsaturated aldehydes affect Mb oxidation and the onset of lipid oxidation are discus

205 alphaLA-RL and Mb-RL form surfactant-saturated complexes above 5.6 and

206 gh sequence conservation known as Myc boxes (Mb).

207 cle mitochondrial respiration is improved by Mb overexpression via up-regulation of complex IV activi

208 sts in which Mb expression was suppressed by Mb-siRNA transfection (Mb vector transfected vs. Mb vect

209 gG and its small-molecular-weight derivative Mb.

210 aptasensor was effectively applied to detect Mb in human serum.

211 and increase in BMI by 0.14 kg/m(2) for each Mb of total deletion burden (P = 2.5 x 10(-10), 6.0 x 10

212 NE and HHE (4-hydroxy-2-hexenal) facilitated Mb-mediated lipid oxidation similarly.

213 For Mb-RL, the analysis gives complexes of two connected mic

214 on for Db-IR700 and 24 h after injection for Mb-IR700 and IgG-IR700 as well as 24 h after the peak up

215 se range between 1 ng/mL and 4 microg/mL for Mb.

216 nce-trained muscle, the O2 release rate from Mb increased because of the increased Mb concentration a

217 Results using H97A Mb suggested that the combination of HNE and low hemin a

218 complex IV activity was solely activated in Mb-overexpressing myoblasts, and complex IV activity was

219 ondrial DNA copy numbers were not altered in Mb-overexpressing myotubes, O2 consumption was greater i

220 ius prefactors associated with CO binding in Mb and Hb.

221 y play an important role in fuel delivery in Mb-rich muscle fibers (e.g. type I fibers and cardiomyoc

222 Mb rebinding was examined in Mb-free diluted human serum spiked with Mb as well as in

223 -chain acylcarnitine and fatty acid pools in Mb-rich tissues.

224 e enhancer chromatin regions inside PTPRQ in Mb were also seen in PTPRQ mRNA-expressing non-myogenic

225 e from Mb increased because of the increased Mb concentration and faster decremental rate in SmbO2 at

226 omosomes, and specific segments at megabase (Mb) and kilobase (kb) resolutions of single average and

227 enotypes can be linked to long (>1-megabase [Mb]) runs of homozygosity (ROHs) detectable by single-nu

228 roduced, going from the initial 1 Megabases (Mb) resolution to the current 10 Kilobases (Kb) or even

229 f tandem duplications of up to 10 megabases (Mb) in size.

230 uence generated here comprises 30 megabases (Mb).

231 91 antibody (IgG; 150 kDa) and its minibody (Mb; 80 kDa) format were functionalized with the chelator

232 the biological significance of mitochondrial Mb as a potential modulator of mitochondrial respiratory

233 The precise roles of mitochondrial Mb remain unclear.

234 Combing multi-Mb-scale DNA molecules revealed previously undetected or

235 ruction of the complementary negative mutant Mb(-6) = Mb(K45E, K63E, K95E).

236 sing a previously developed positive mutant, Mb(+6) = Mb(D44K/D60K/E85K), led to construction of the

237 PyV-positive tumors (0.40 +/- 0.09 mutations/Mb) and lacked a UV signature.

238 high mutation burden (median of 62 mutations/Mb) ranked desmoplastic melanoma among the most highly m

239 ighest mutation rate in cancer (65 mutations/Mb).

240 s alpha-Lactalbumin (alphaLA) and myoglobin (Mb) with the biosurfactant rhamnolipid (RL).

241 ing in other heme systems such as myoglobin (Mb) and hemoglobin (Hb).

242 t long-chain fatty acids can bind myoglobin (Mb) in an oxygen-dependent manner.

243 At onset of muscle contraction, myoglobin (Mb) immediately releases its bound O2 to the mitochondri

244 thin a "charge-disproportionated" myoglobin (Mb) dimer with greatly enhanced affinity.

245 ase, glucose oxidase, hemoglobin, myoglobin (Mb), conjugation with metals e.g. gold (Au), chitosan (C

246 ional model of HCOs engineered in myoglobin (Mb).

247 Electroanalysis of myoglobin (Mb) in 10 plasma samples of healthy donors (HDs) and 14

248 Monitoring of myoglobin (Mb) in human blood serum is highly in demand for early d

249 structure or redox properties of myoglobin (Mb).

250 that the muscle-specific protein myoglobin (Mb) interacts with complex IV.

251 scle specific O2 binding protein, Myoglobin (Mb), is localized in mitochondria and interacts with res

252 ashion, CN(-), CO, and O2 bind to myoglobin (Mb).

253 nted polymer (MIP) templated with myoglobin (Mb) and the reference non-imprinted polymer (NIP) was ex

254 or naturally occurring mammalian myoglobins (Mb).

255 In the absence of Mb, the Y-shape structure remains intact.

256 or ultrasensitive and selective detection of Mb, based on Y-shape structure of dual-aptamer (DApt)-co

257 idation more readily than oxidative forms of Mb that retain their protoporphyrin moiety.

258 rs of magnitude larger than the prefactor of Mb and Hb ( approximately 10(9) s(-1)).

259 A 3:1 ratio of Mb:Hb promoted lipid oxidation similarly compared to add

260 similarly compared to adding a 1:1 ratio of Mb:Hb to washed muscle.

261 cted by direct electrocatalytic reduction of Mb by square wave voltammetry (SWV) or differential puls

262 ct of endurance training on O2 saturation of Mb (SmbO2) and PmbO2 kinetics during muscle contraction.

263 tured myoblasts; in contrast, suppression of Mb expression induces a decrease in complex IV activity

264 ated in myoblasts transiently overexpressing Mb; complex IV activity was solely activated in Mb-overe

265 that: (i) the lipid binding affinity for oxy-Mb increases as the chain length increases (i.e. C12:0 t

266 This suggests that oxy-Mb may play an important role in fuel delivery in Mb-ric

267 h fatty acids and acylcarnitines bind to oxy-Mb in 1:1 stoichiometry.

268 er, our results support a model in which oxy-Mb is a novel regulator of long-chain acylcarnitine and

269 both fatty acids and acylcarnitines with oxy-Mb using molecular dynamic simulations and isothermal ti

270 il to achieve a stable conformation with oxy-Mb.

271 ither fatty acids or acylcarnitines with oxy-Mb.

272 LCR22D, resulting in a 3 million base pair (Mb) deletion.

273 k the symmetry" of a Mb homodimer by pairing Mb constructs with complementary highly positive and hig

274 proliferative fitness ( approximately 3% per Mb), slowed tumor growth, and reduced metastatic progres

275 xposure, cisplatin induces 0.8 mutations per Mb, equivalent to the median mutational burden in common

276 64)Cu-NODAGA-PSMA-IgG and (64)Cu-NODAGA-PSMA-Mb retained the ability to bind cell surface PSMA, and b

277 64)Cu-NODAGA-PSMA-IgG and (64)Cu-NODAGA-PSMA-Mb was observed by CLI as early as 3 h after injection,

278 them, but the precise role of the remaining Mb, MbIV, and the reason for its preservation in vertebr

279 cificity of polymeric antibodies to template Mb, with an imprinting factor determined as a ratio Imax

280 Here, we demonstrate that Mb facilitates mitochondrial respiratory capacity in ske

281 iomyocytes), and raises the possibility that Mb also serves as an acylcarnitine-binding protein.

282 espiratory chain complex IV, suggesting that Mb could be a factor that regulates mitochondrial respir

283 To date, four of the Mb motifs (MbI, MbII, MbIIIa and MbIIIb) have had a mole

284 Therefore, Mb enhances the enzymatic activity of complex IV to amel

285 een Mo17, B73, and mexicana, including three Mb-size structural rearrangements.

286 of target, the DApt leave the CS and bind to Mb, leading to disassembly of Y-shape structure and foll

287 ed aptasensor showed high selectivity toward Mb with a limit of detection (LOD) as low as 27 pM.

288 ion was suppressed by Mb-siRNA transfection (Mb vector transfected vs. Mb vector, control siRNA trans

289 hanced lipid oxidation compared to wild-type Mb exposed to HNE.

290 5 orders of magnitude relative to wild-type Mb values.

291 the identification of the myoglobin variant Mb(L29S,H64V,V68F), which is capable of mediating asymme

292 or, control siRNA transfected vs. Mb vector, Mb siRNA transfected: 0.15 vs. 0.15 vs. 0.06).

293 e myotubes than that in mock cells (Mock vs. Mb-Flag::GFP: state 4, 1.00 +/- 0.09 vs. 1.77 +/- 0.34;

294 iRNA transfection (Mb vector transfected vs. Mb vector, control siRNA transfected vs. Mb vector, Mb s

295 vs. Mb vector, control siRNA transfected vs. Mb vector, Mb siRNA transfected: 0.15 vs. 0.15 vs. 0.06)

296 HNE became covalently bound to sperm whale Mb at up to five sites based on ESI-MS analysis.

297 The potential mechanisms by which Mb binding of alpha,beta-unsaturated aldehydes affect Mb

298 vity was decreased in the myoblasts in which Mb expression was suppressed by Mb-siRNA transfection (M

299 d in Mb-free diluted human serum spiked with Mb as well as in plasma samples of patients with acute m

300 ntrast to the cryoreduced oxy-wild-type (WT) Mb, which is unable to deliver a proton and shows a sign