ライフサイエンスコーパス: Mdm2 protein

1 stimulated the expression of the endogenous MDM2 protein.

2 ls but does correlate with reduced levels of mdm2 protein.

3 ability is associated with higher amounts of MDM2 protein.

4 e acids uncovering new interactions with the MDM2 protein.

5 essed leukemic cells with elevated levels of mdm2 protein.

6 nds tightly to the p53-binding pocket on the Mdm2 protein.

7 s controlled is through interaction with the Mdm2 protein.

8 ines is p53 stabilization by an overabundant MDM2 protein.

9 -3sigma results in a significant increase in MDM2 protein.

10 binding region in amino acids 180-298 of the MDM2 protein.

11 n by T34A or AS Survivin resulted in reduced Mdm2 protein.

12 stressors and is primarily regulated by the Mdm2 protein.

13 nuclear translocation and destabilizing the MDM2 protein.

14 berrant post-translational regulation of the Mdm2 protein.

15 ng domain but conserved the remainder of the Mdm2 protein.

16 arbor this mutant possess elevated levels of MDM2 protein.

17 p53-dependent cell cycle arrest involves the Mdm2 protein.

18 s requires the RING domains of both MdmX and Mdm2 proteins.

19 between wild-type and the RING domain mutant MDM2 proteins.

20 hat ZFP871 physically interacts with p53 and MDM2 proteins.

21 ons occur only at selected levels of p53 and MDM2 proteins.

22 TRs) of murine mdm2 affect the expression of MDM2 proteins.

23 normally spliced mdm2 mRNA that encodes both MDM2 proteins.

24 All seven tissues express both MDM2 proteins.

25 tively regulated by the mouse double minute (MDM2) protein.

26 A central node in the p53 pathway is the MDM2 protein, a direct negative regulator of p53.

27 Activation of p53 leads to accumulation of Mdm2 protein, a direct transcriptional target of p53.

28 Moreover, we demonstrate that MDM2 protein accumulates to a much greater extent in pro

29 The p53 negative regulator MDM2 protein also carries a C-terminal RING domain that

30 e-peptides that bind to specific isoforms of MDM2 protein and in this work we subjected the putative

31 continued association of DNA-bound p53 with Mdm2 protein and lack of binding and acetylation by p300

32 cell lines PC3 (p53(null)), curcumin reduced MDM2 protein and mRNA in a dose- and time-dependent mann

33 and time-dependent manner, genistein reduced MDM2 protein and mRNA levels in human cell lines of brea

34 plays the same function as NS in stabilizing MDM2 protein and preventing its ubiquitylation.

35 ed ring system ideally suited to bind to the MDM2 protein and to interrupt its protein-protein intera

36 ufficient for growth inhibition by truncated Mdm2 proteins and could physically interact with either

37 ree highly conserved regions (CRs) shared by MDM2 proteins and MDMX proteins of different species.

38 ted downregulation of murine double minute 2(MDM2) protein, and (b) negative regulation of NF-kappaB

39 ll as the new interactions observed with the MDM2 protein are described herein.

40 us, spleen, and intestine, the levels of the MDM2 proteins are roughly equivalent.

41 lets and p90(MDM2), which is the full-length MDM2 protein, are expressed in approximately equal amoun

42 the yeast two-hybrid assay using full-length MDM2 protein as the bait.

43 ase-defective p300 AT2 mutant stabilized the MDM2 protein as well.

44 oma cell lines that have very high levels of mdm2 proteins as well as elevated levels of a stabilized

45 nterestingly, our results show a decrease of Mdm2 protein associated with p53-responsive elements on

46 In normal cells the MDM2 protein binds to the p53 protein and maintains p53

47 found that the C-terminal RING domain of the MDM2 protein bound to the MYCN mRNA's AREs within the 3'

48 of p300 in cells increased the level of the MDM2 protein but not its mRNA.

49 t the 3'UTR, influences the ratio of the two MDM2 proteins but neither UTR affects MDM2 abundance sig

50 in the level of either p53 or activation of mdm2 protein by p53 was observed in hamster UV61 cells a

51 nger the Mdm2 shuttling is allowed, the more Mdm2 protein colocalizes with p19(ARF) in the nucleolus,

52 Reconstitution of an HSP90-MDM2 protein complex in vitro stimulated the unfolding o

53 We discovered that truncated mdm2 protein constructs without the N-terminal p53 bindi

54 However, the MDM2 protein could be easily detected after treatment of

55 that FKBP12 degrades MDM2 through binding to MDM2 protein, disrupting MDM2/MDM4 interaction and induc

56 suggesting a role of ER in the regulation of Mdm2 protein expression and hence the enhanced GR degrad

57 ediates anti-MM activity by inducing p53 and MDM2 protein expression; inducing the phosphorylation (S

58 The murine double minute 2 (MDM2) protein facilitates G1 to S phase transition by ac

59 Because Mdm2 protein forms a complex with the p53 tumor suppress

60 y, phospho-mimic p53-T21E did dissociate the Mdm2 protein from DNA-bound p53 and recovered p300 bindi

61 The overexpressed MDM2 protein had a short half-life.

62 We also demonstrate that MDM2 protein half-life is extended in some, but not all,

63 The MDM2 protein has been shown to bind to and downmodulate

64 Multiple MDM2 proteins have been detected in tumors and in cell l

65 Oscillations of both p53 and MDM2 proteins have been observed in cells after exposure

66 2 is a significant fraction of the p53-bound MDM2 protein in certain tumor cells, suggesting that it

67 SNP309 G allele and increased the levels of MDM2 protein in estrogen-responsive cells homozygous for

68 orylation and promoted the binding of p53 to Mdm2 protein in hypoxic cells.

69 itially, we noted that the overexpression of MDM2 protein in leukemic bone marrow cells of patients w

70 unction by measuring induction of p21 and/or MDM2 proteins in response to melphalan (L-PAM) in seven

71 tative explanation for the overexpression of mdm2 proteins in this class of human tumors.

72 Normally, MDM2 protein inhibits p53 function in an autoregulatory

73 The mdm2 protein interacts with a number of proteins involve

74 The MDM2 protein is an ubiquitin ligase that plays a critica

75 The Mdm2 protein is frequently overexpressed in human non-se

76 The MDM2 protein is likely to be extensively modified in viv

77 e results further indicate that the elevated MDM2 protein is responsible for wildtype p53 protein acc

78 We show here that the half-life of MDM2 protein is shorter in proliferating than in quiesce

79 MDM2 protein is thought to exhibit tumorigenic activity

80 d expression of NFAT1 results in an elevated MDM2 protein level and reduces p53 activation and functi

81 samples with wild-type p53 between baseline MDM2 protein levels and apoptosis induced by MDM2 inhibi

82 ernative mechanism by which Akt up-regulates MDM2 protein levels and exerts its oncogenic effects on

83 this inhibition coincided with a decrease in MDM2 protein levels and p53.MDM2 complex formation.

84 53 is attributable to the down-regulation of MDM2 protein levels and uncoupling of p53 from its inter

85 es corresponds to a proportional decrease in MDM2 protein levels but an increase in p53-MDM2 binding

86 o by a reduced accumulation of p53, p21, and MDM2 protein levels in co-transfection assays and in res

87 appaB was important to increase steady-state MDM2 protein levels rather than in affecting p53-depende

88 Exercise increased VEGF-A and p-Ser166-Mdm2 protein levels respectively by 157 and 68% in human

89 VEGF-A and p-Ser166-Mdm2 protein levels were measured in human and rodent mu

90 coincident with a downregulation of Bax and Mdm2 protein levels.

91 ted knockdown of G3BP2 caused a reduction in MDM2 protein levels.

92 cent p21-stained PA-SMCs; lung p53, p21, and MDM2 protein levels; and p21, Bax, PUMA, BTG2, and MDM2

93 p53 targets p21 and hdm2 (human homologue of mdm2) protein levels, but dramatically increased p53 lev

94 2 is critical in the p53 pathway because the mdm2 protein marks p53 for proteosome-mediated degradati

95 orylation at serine 15 and downregulation of MDM2 protein may both contribute to stabilization of mut

96 has been suggested that interaction with the Mdm2 protein may target p53 for rapid degradation.

97 r results indicate that the ratio of the two MDM2 proteins may regulate the response of tissues to DN

98 non-apoptotic cells, and may account for the MDM2 proteins of similar mobility seen in tumors and oth

99 inhibited by co-transfection with the human MDM2 protein or a dominant-negative p53 protein and was

100 nternal initiation of translation of a minor MDM2 protein, p76(MDM2), without affecting the efficienc

101 result of our efforts to discover novel p53:MDM2 protein-protein interaction inhibitors useful for t

102 an oligooxopiperazine that inhibits the p53-MDM2 protein-protein interaction.

103 earch of beta-peptide antagonists of the p53-MDM2 protein-protein interaction.

104 The MDM2 protein regulates the functional activity of the p5

105 Overexpression of MDM2 protein (relative to p53 functional lines) was seen

106 ting from loss of p14ARF, and high levels of Mdm2 protein resulting from activated Ras prevent accumu

107 cellular regulator of p53 protein, the human MDM2 protein, resulting in an inhibition of p53 export f

108 Both p53 and Mdm2 proteins showed expected pulses in the wild type, w

109 r Mdm2 that contributes to the regulation of Mdm2 protein stability in cells.

110 ast one of these p53 mutant lines, increased MDM2 protein stability is associated with higher amounts

111 Mdm2 protein stability is regulated by several mechanism

112 ethylation regulated murine double minute 2 (MDM2) protein stability in ALL.

113 n to the IRES region on XIAP mRNA results in MDM2 protein stabilization and enhanced XIAP translation

114 MDMX renders MDM2 protein sufficiently stable to function at its full

115 sphorylation at Ser20 reduces binding of the mdm2 protein, suggesting that a function of the Ser20-ki

116 The MDM2 protein suppresses the ability of p53 to inhibit ce

117 The MDM2 protein targets the p53 tumor suppressor for ubiqui

118 nsactivation by p53 and once synthesized the Mdm2 protein terminates the p53 response.

119 Of the many putative MDM2 proteins that could be examined, the impact of HSP9

120 t not one that inhibits ATP binding, produce MDM2 proteins that have a higher affinity for the BOX-I

121 The MDM2 protein, through its interaction with p53, plays an

122 The impedance changes upon binding of MDM2 protein to the sensor surface was utilized for the

123 ) mutation accumulate p53 as well as p21 and Mdm2 proteins to normal levels after DNA damage.

124 the only two that are designed to stabilize MDM2 protein under basal or induced condition, respectiv

125 a rapid increase in endogenous MDM2 mRNA and MDM2 protein upon induction of MYCN.

126 RF hypermethylation-associated inactivation, MDM2 protein was also seen in the cytosol.

127 The p97 MDM2 protein was not detected by Western blot analysis i

128 transcripts were greatly down-regulated, and MDM2 protein was poorly expressed in GC of Irf8(-/-) mic

129 ding evidence for a conformational change in MDM2 protein when it binds zinc.

130 antly affect the half-life of the endogenous MDM2 protein, whereas p300 enhanced the half-life of MDM

131 3 are unable to induce the expression of the Mdm2 protein which would normally provide a feedback mec

132 t, through inactivation of p14ARF, activates MDM2 protein, which in turn degrades TP53 tumor suppress

133 ent here a 2.0 A resolution structure of the Mdm2 protein with a bound stapled p53 peptide.

134 identified eight inhibitors that blocked the MDM2 protein-XIAP RNA interaction, leading to MDM2 degra