ライフサイエンスコーパス: Met-enkephalin

1 or prodynorphin) with enkephalin (or Phe-Arg-Met-enkephalin).

2 ith morphine, but not opioid peptides (i.e., Met-enkephalin).

3 nosine, serotonin, or methionine enkephalin (met-enkephalin).

4 t-enk-Arg-Phe cleavage preferred (Met-enk is met-enkephalin).

5 ed amounts of nicotine-induced secretion of (Met)enkephalin.

6 the BD simulations for the global motions of met-enkephalin.

7 biological importance, the neurotransmitter met-enkephalin.

8 ay was demonstrated by its cosecretion with [Met]enkephalin.

9 In all neurons tested, methionine (Met)-enkephalin (0.003-30 microm) inhibited the peak amp

10 cordings with patch electrodes, bath-applied met-enkephalin, a nonselective opioid receptor agonist,

11 Thus, amnestic effects of [Leu]- or [Met]enkephalin administration are brain-region specific.

12 y formation produced by [Leu]enkephalin and [Met]enkephalin administration in 2 regions of the 2-day-

13 with localized amnestic effects produced by [Met]enkephalin administration.

14 Previous studies show that Met-enkephalin, an endogenous opioid, down-regulates che

15 ry vesicle cathepsin L in the production of [Met]enkephalin, an endogenous peptide neurotransmitter.

16 The met-enkephalin analog D-Ala2-methionine enkephalinamide

17 nalization, and also enhanced the effects of Met-enkephalin and alpha-neoendorphin, but not endomorph

18 Met-Enkephalin and beta-Endorphin were not affected by d

19 PepE hydrolyzed internal peptide bonds in Met-enkephalin and bradykinin; however, hydrolysis of al

20 ecursor should contain the sequences of both Met-enkephalin and Leu-enkephalin as seen for mammalian

21 The previous detection of Met-enkephalin and Leu-enkephalin in the CNS of the Aust

22 Basal dialysate levels of Met-enkephalin and Leu-enkephalin were 60 +/- 30 and 70

23 Computational studies for met-enkephalin and melittin, employing sequential and pa

24 Accordingly, immunofluorescence for met-enkephalin and neuropeptide tyrosine in these animal

25 Met-enkephalin and substance-P levels declined approxima

26 Here, we report that Leu- and Met-enkephalin and their des-tyrosyl derivatives potentl

27 ssing the D1 subtype were immunopositive for met-enkephalin and vesicular glutamate transporter VGLUT

28 dopin 1 with chromaffin granule components, [Met]enkephalin and a cysteine protease known as "prohorm

29 esses endogenous opioids (beta-endorphin and Met-enkephalin) and uroguanylin in apical compartments c

30 torphin II, [d-Pen(2), d-pen(5)]-enkephalin, met-enkephalin, and SNC-80 ((+)-4-[(alphaR)-alpha-((2S,5

31 ntagonists to attenuate the loss of striatal met-enkephalin are consistent with an excitotoxic lesion

32 for serotonin, dopamine-beta-hydroxylase and met-enkephalin are observed in the area and aid in the d

33 imilar to that of DAMGO, alpha-neoendorphin, Met-enkephalin-Arg-Phe, and the putatively endogenous pe

34 Met-enkephalin, as well as morphine, inhibited IL-8-indu

35 Met-enkephalin, but not the mu-selective (DAMGO) and del

36 alized with the secretory vesicle component (Met)enkephalin by confocal immunonfluorescence microscop

37 human SK-N-MC cells results in reduction of (Met)enkephalin by more than 80%, illustrating the promin

38 y 60 min after the last injection to measure met-enkephalin by radioimmunoassay.

39 Production of [Met]enkephalin by cathepsin L occurred by proteolytic pr

40 Training decreased [Met]enkephalin concentration in the LPO but not in the I

41 ) in dorsal horn homogenates and presynaptic met-enkephalin-containing boutons.

42 of the previously studied glycine oligomers; met-enkephalin contains the interesting motions of pheny

43 Met-enkephalin decreased the binding of 125I-Tyr-MIF-1 t

44 dependent secretion of KPI/APP with PTP and (Met)enkephalin demonstrated the colocalization of these

45 Regional activity of endogenous [Met]enkephalin during memory formation is consistent wit

46 Met-enkephalin (ENK) suppressed spontaneous and NMDA-ind

47 bition by gamma-aminobutyric acid (GABA) and met-enkephalin (ENK).

48 onal SK-N-MC cells results in production of (Met)enkephalin from proenkephalin.

49 neuropeptides (neuropeptide Y, substance P, met-enkephalin, galanin, dynorphin A and somatostatin) w

50 either the potency nor the efficacy of D-Ala-Met-enkephalin-Gly-ol (DAMGO) were changed; however, the

51 aining), and within given brain nuclei (more met-enkephalin immunoreactive cells).

52 mouse brains with a decrease in the level of Met-Enkephalin immunoreactivity (ir-Met-Enk) and an accu

53 ss (110 kDa), were colocalized with PTP and (Met)enkephalin in secretory vesicles of adrenal medulla

54 SNL led to increased immunoreactivity for met-enkephalin in dorsal horn homogenates, which was dos

55 Mass spectroscopy confirmed Leu- and Met-enkephalin in skin.

56 ociated with changes in the concentration of met-enkephalin in the brain.

57 Furthermore, labeling for the opioid met-enkephalin in the medial preoptic nucleus (POM) corr

58 owed the colocalization of cathepsin L with [Met]enkephalin in secretory vesicles of neuroendocrine c

59 The endogenous opioid met-enkephalin induced monocyte chemotaxis in a pertussi

60 Our data showed that preincubation with Met-enkephalin inhibited both MIP-1 alpha-mediated chemo

61 a(2), N-Me-Phe(4), Gly-ol(5)]-enkephalin and met-enkephalin inhibited both ST-stimulated EPSCs and th

62 Neuropeptides dynorphin and met-enkephalin inhibited dopamine neurons, whereas oxyto

63 These results demonstrate that met-enkephalin inhibition of cholinergic secretion is me

64 O to determine the role of the G proteins in met-enkephalin inhibition of cholinergic stimulation of

65 The SCN did not contain cell bodies with met-enkephalin-IR and substance P-IR, but did contain fi

66 The dynamics of met-enkephalin is considerably more complicated than tha

67 Met-enkephalin is one of the smallest opiate peptides.

68 dy, which recognized Leu-, Met-, and Phe-Arg-Met-enkephalin, labeled the dorsolateral funiculus and n

69 enkephalin, which did not recognize Leu- and Met-enkephalin, labeled the same puncta.

70 MS2 scans enabled simultaneous monitoring of Met-enkephalin, Leu-enkephalin, and unknown peptides.

71 The method was used to determine met-enkephalin, leu-enkephalin, dynorphin A(1-8), and be

72 rtex and midbrain region and the decrease in met-enkephalin level in the medulla region observed in m

73 by reversing some of the changes induced in met-enkephalin levels in brain by morphine in morphine t

74 ether, midazolam antagonized the increase in met-enkephalin levels in cortex and midbrain region and

75 Met-enkephalin levels in neuronal projections from the e

76 ant animals showed a significant increase in met-enkephalin levels in the cortex (137%) and midbrain

77 ted animals showed a significant decrease in met-enkephalin levels in the pituitary (63%), cortex (39

78 idbrain (89%), and a significant decrease in met-enkephalin levels in the pituitary (74%), cerebellum

79 of midazolam, morphine, and both together on met-enkephalin levels in the rat.

80 drenals (43%), and a significant increase in met-enkephalin levels in the striatum (54%) and pons (51

81 Y 274614 ameliorated the decline in striatal met-enkephalin levels observed in mice after 8 weeks of

82 Hippocampal met-enkephalin levels were reduced to 50% only at 12 wee

83 Finally, in cathepsin L gene knockout mice, [Met]enkephalin levels in brain were reduced significantl

84 YAP3p generated Met-enkephalin-Lys-Lys from amidorphin showing that clea

85 amphetamine (METH) significantly altered the met-enkephalin (M-Enk) systems associated with some, but

86 In contrast, [Met]enkephalin may be amnestic when administered in the

87 Cs (eIPSCs) was unaffected by perfusion with met-enkephalin (ME) or by mu-, delta-, or kappa-opioid r

88 [Met]Enkephalin (ME), [D-Ser2,Leu5,Thr6]-enkephalin, etor

89 Numerous met-enkephalin (mENK) and dynorphin-immunoreactive bouto

90 Met-enkephalin (mENK), an endogenous opioid, and exogeno

91 vasopressin (AVP), angiotensin II (AII) and met-enkephalin (mENK), and receive input from galanin (G

92 ut was combined with local microinjection of met-enkephalin (Met-ENK) and naltrexone (NLTX) to determ

93 presumed synthesis/enhanced accumulation) of met-enkephalin (Met-Enk) in dorsal and ventral striatum

94 nvestigate the effects of the opioid peptide Met-enkephalin (met-enk) on the release of substance P-l

95 proOpiomelanocortin (POMC), or PVN levels of Met-Enkephalin or beta-Endorphin.

96 de of evoked IPSCs was not altered either by Met-enkephalin or by any of the opioid receptor-selectiv

97 ochemistry for either methionine enkephalin (met-enkephalin) or leucine enkephalin (leu-enkephalin),

98 eine protease cathepsin L for producing the (Met)enkephalin peptide neurotransmitter from proenkephal

99 flux induced by chemokines was unaffected by met-enkephalin pretreatment.

100 lation of enkephalin precursor Penk mRNA and met-enkephalin protein in sensory neurons.

101 subtype regulates MOR function by modulating met-enkephalin release.

102 lted in highly increased cellular levels of (Met)enkephalin, resulting from the conversion of PE to e

103 There are five copies of the Met-enkephalin sequence flanked by sets of paired basic

104 Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) and Met-enkephalin share a saturable transport system (pepti

105 Our initial study on met-enkephalin strongly suggests that even fairly long t

106 ressing immunoreactivity for calbindin D28k, met-enkephalin, substance P, tyrosine hydroxylase, and p

107 ussis toxin-sensitive G proteins that couple met-enkephalin to the inhibition of cholinergically stim

108 nal nerve ligation is accompanied by D1R and met-enkephalin upregulation, acquired D1LR-mediated anti

109 sensory cells that coexpress beta-endorphin, Met-enkephalin, uroguanylin, and Trpm5 exist in mouse du

110 tch those of mammals (i.e., distributions of met-enkephalin, vasotocin, galanin, calcitonin gene-rela

111 ranslational processing of preproenkephalin, met-enkephalin was more abundant than leu-enkephalin bot

112 lin, and the main olfactory bulb, where only met-enkephalin was observed.

113 All effects of met-enkephalin were mimicked by a mu receptor agonist, b

114 ntrations of endogenous [Leu]enkephalin and [Met]enkephalin were determined for 5 brain regions, and

115 An antibody against Phe-Arg-Met-enkephalin, which did not recognize Leu- and Met-enk

116 These results indicate increased levels of (Met)enkephalin within secretory vesicles of the regulate

117 sites and two C-terminally extended forms of Met-enkephalin: YGGFMRSL and YGGFMGY.