ライフサイエンスコーパス: Michael addition

1 into tricyclic compounds via intramolecular Michael addition.

2 eochemical outcome of a catalyzed asymmetric Michael addition.

3 of these catalysts for enantioselective aza-Michael addition.

4 on step via a Diels-Alder cycloaddition or a Michael addition.

5 a substituted hydroquinone by reductive 1,4-Michael addition.

6 and covalently bind PPARgamma at Cys-285 via Michael addition.

7 A by redox cycling and/or depurination via a Michael addition.

8 ably due to the less steric hindrance in the Michael addition.

9 the three His residues in Abeta proteins by Michael addition.

10 s, the N-nitroso aldol reaction, followed by Michael addition.

11 ed to glutathione conjugates (LNO(2)-SG) via Michael addition.

12 vity, due to intramolecular catalysis of the Michael addition.

13 etion or direct chemical interaction through Michael addition.

14 17 derivative 25 is described using internal Michael addition.

15 ivity due to intramolecular catalysis of the Michael addition.

16 tive ligands for asymmetric copper-catalyzed Michael addition.

17 r nucleophiles such as cysteine thiolates by Michael addition.

18 facilitates enantioselective, intramolecular Michael additions.

19 resented, utilizing a tandem oxime formation/Michael addition/[3 + 2] cycloaddition as the key step.

20 dehyde using DABCO at room temperature via a Michael addition, 5-exo-dig carboannulation, and oxidati

21 furans is developed via DBU-mediated tandem Michael addition/5-exo-dig-cycloisomerization of enynes

22 proceeds via a cascade reaction involving a Michael addition-6pi-electrocyclic ring opening-proton t

23 lenonyl group served as an activator for the Michael addition, a leaving group and a latent oxidant i

24 of five fragments through a stereoselective Michael addition, a three-component nitro-Mannich lactam

25 terium-exchange experiments suggest that the Michael addition adduct formed between DABCO and methyl

26 Only Bar-Me forms a Michael addition adduct with glutathione (GSH) and inhib

27 Mass spectrometry identified Michael addition adducts of 4-HNE on Cys(130), Cys(174),

28 cts with aS via formation of Schiff-base and Michael-addition adducts with Lys residues, in addition

29 y a stepwise (4 + 2) cycloaddition involving Michael addition, aldol cyclization, and lactonization.

30 (aryl)-S coupling, thioester cleavage, sulfa-Michael addition, aldol reaction, and elimination reacti

31 igands relying on an organocatalytic one-pot Michael addition-aldol reaction with cheap 2-cyclohexeno

32 so typical that many have proper names (e.g. Michael addition, Amadori rearrangement, and Pictet-Spen

33 N2' substitution, intramolecular 6-endo-trig Michael addition and double elimination.

34 rocyclic core, followed by an intramolecular Michael addition and oxidative radical cyclization to ac

35 ne-3,7-dione scaffolds was synthesized via a Michael addition and reductive cyclization strategy.

36 ers of laurenditerpenol involving sequential Michael addition and remote homoallylic hydroxyl group-d

37 This protocol involves Michael addition and subsequent carbonylation.

38 in metathesis, Heck coupling, hydroarylation Michael addition and tandem coupling.

39 sion is provided for both the intramolecular Michael addition and the sulfone rearrangement.

40 vity, due to intramolecular catalysis of the Michael addition and/or an inductive effect of the proto

41 ir susceptibility to other reactions such as Michael additions and the difficulty of controlling the

42 itu silyl ether cleavage, acetal hydrolysis, Michael addition, and caged ketal formation.

43 eacted with GSH to form GS-hydroquinones via Michael addition, and four GS-HQRs from yeast and bacter

44 benzoquinones reacting with reduced GSH via Michael addition, and GS-HQRs convert the conjugates to

45 o different reagents to yield cycloaddition, Michael addition, and other reactions at double bonds.

46 ed CBS reduction, Achmatowicz rearrangement, Michael addition, and reductive amination as key steps.

47 e reactions including Michael additions, aza-Michael additions, and direct Aldol reactions.

48 a-amino ester)s (HPAEs) via a new "A2+B3+C2" Michael addition approach demonstrating 2 to 126-fold hi

49 al theory (DFT), investigating the different Michael-addition approaches of the sulfur ylide, the tra

50 Although adducts formed by Michael addition are thought to be largely irreversible,

51 operative hydrogen bonding/enamine-catalyzed Michael addition as the key step.

52 synthesized using intra- and intermolecular Michael additions as the key reactions, followed by the

53 e first domino reaction, two consecutive aza-Michael additions assemble the six-membered ring heteroc

54 mechanistically diverse reactions including Michael additions, aza-Michael additions, and direct Ald

55 njunction with alkaline beta-elimination and Michael addition (BEMA) reactions for the specific detec

56 The usage of a diastereoselective oxy-Michael addition/benzylidene acetal formation coupled wi

57 nic transition state and intermediate of the Michael addition, but less intuitively, it destabilizes

58 11-keto group in CF3DODA-Me, which prevents Michael addition by the conjugated en-one in the A-ring.

59 ton has been synthesized by enantioselective Michael addition catalyzed by PYBOX-DIPH-Zn(OTf)(2) comp

60 An asymmetric Michael addition, CBS reduction, and proline-catalyzed c

61 odified through beta elimination followed by Michael addition chemistry to install a photolabile grou

62 with naphthalenethiol using well established Michael Addition chemistry.

63 to be a similar if not superior catalyst for Michael additions compared with typical Lewis acids.

64 Enantioselective Michael addition-cyclization reactions using different a

65 l Knoevenagel condensation/enamine formation/Michael addition/cyclization sequence is highlighted by

66 The process relies on a tandem double Michael addition-Dieckmann condensation reaction, which

67 This strategy, which involves a cascade Michael addition-Dieckmann cyclization-elimination seque

68 ates that there is a rate enhancement of the Michael addition due to the urea groups on the surface o

69 que carrier system is fabricated using a new Michael addition during (water-in-oil) emulsion (MADE) m

70 An asymmetric doubly vinylogous Michael addition (DVMA) of alpha,beta-unsaturated gamma-

71 report a new dynamic polymerization based on Michael addition-elimination reaction of structurally di

72 (ii) installation of the amino group via aza-Michael addition/elimination, and crucially (iii) facile

73 process involves a secondary amine catalyzed Michael addition followed by a N-heterocyclic carbene ca

74 on hydrolysis in one pot, an intramolecular Michael addition followed by a retro-Michael-type elimin

75 The cascade proceeds via amine-mediated Michael addition followed by an N-heterocyclic carbene-p

76 n of benzoyl-substituted indolizines through Michael addition followed by C-N bond formation, which a

77 Products are formed by the aza-Michael addition followed by intramolecular acyl substit

78 f 1,3-syn-diols via an intramolecular hetero-Michael addition followed by reductive deprotection of t

79 Intramolecular Michael addition follows to give either N-aminoisoindolo

80 oncerted Diels-Alder reaction and a stepwise Michael addition, for the formation of corresponding pro

81 A tandem phenol oxidation-Michael addition furnishing oxo- and -aza-heterocycles h

82 Michael addition has been achieved with a variety of ami

83 as a traceless activation group for radical Michael additions has been accomplished via visible ligh

84 ing and arylating nucleophilic substrates by Michael addition, has been extensively studied as a mode

85 N-heterocyclic carbene catalyzed Michael additions have been revisited with 1,3-dialkyl-

86 dergo Bronsted acid catalyzed intramolecular Michael addition in one-pot to produce oxo- and -aza-het

87 ive recoverable organocatalysts in different Michael additions, in neat conditions at room temperatur

88 socyanide zwitterionic intermediates through Michael addition/intramolecular cyclization and double [

89 lytic [3 + 3] annulation strategy based on a Michael addition/intramolecular Julia-Kocienski olefinat

90 Michael addition is a premier synthetic method for carbo

91 n organocatalyzed, intramolecular heteroatom Michael addition is described.

92 t of stereoselectivity as that seen when the Michael addition is performed at very low temperatures.

93 rmore, an important feature of 1 is that its Michael addition is reversible.

94 talyzed and highly diastereoselective direct Michael addition-isomerization sequence is presented for

95 An unprecedented DVMA/vinylogous Michael addition/isomerization cascade reaction affords

96 C12 stereocenter during the ultimate one-pot Michael addition/ketalization cascade to form the CDE-ri

97 This process proceeds by intermolecular Michael addition/lactamization, thiophenol elimination,

98 otes the catalytic asymmetric intramolecular Michael addition-lactonization of a variety of enone aci

99 mote the catalytic asymmetric intermolecular Michael addition-lactonization of arylacetic acids and a

100 ween enzyme and isomerized 5-FU we propose a Michael addition mechanism for pseudouridine formation t

101 es revealed that aromatization competes with Michael addition mechanism in the presence of 5-amino-2-

102 effect on inactivators that inactivate by a Michael addition mechanism than by an enamine mechanism.

103 lizing the aci-carboxylate intermediate in a Michael addition mechanism.

104 hosphonate (PAA-BP) was synthesized by using Michael addition methodology.

105 on-mediated beta-elimination followed by the Michael addition of 1,2-ethanedithiol (EDT).

106 -1,2-diamine]Br(2) was shown to catalyze the Michael addition of 1,3-dicarbonyl compounds to nitroalk

107 example of an asymmetric aminocatalyzed aza-Michael addition of 1H-indazole derivatives to alpha,bet

108 succinimides was realized via the vinylogous Michael addition of 3-substituted cyclohexenones to N-(2

109 tions as pivotal steps: 1) an intramolecular Michael addition of a benzyloxycarbonyl-protected lactam

110 limination of the phosphorylated group, (ii) Michael addition of a bifunctional group, and then (iii)

111 Michael addition of a chiral hydroxylamine, derived from

112 conveniently synthesized via selective thia-Michael addition of a commercially available methacrylat

113 rphenyls were synthesized in good yields, by Michael addition of a conjugate base of core-substituted

114 readily prepared by phase-transfer-catalyzed Michael addition of a glycine Schiff base to a variety o

115 ence include organocatalytic, intramolecular Michael addition of a keto sulfone and a tandem 1,3-sulf

116 It is found that the Michael addition of a range of enolizable carbonyl compo

117 urea was used to trigger the base-catalyzed Michael addition of a water-soluble trithiol to a polyet

118 Enantioselective organocatalytic Michael addition of aldehydes to nitroethylene catalyzed

119 novel strategy for the catalytic asymmetric Michael addition of aldehydes to nitroolefins on water h

120 The highly enantioselective sulfa-Michael addition of alkyl thiols to unactivated alpha-su

121 In water, the rate of Michael addition of amines and thiols to dehydroalanine

122 utomerization into the PLP ring, followed by Michael addition of an active site lysine residue at the

123 ecedented transformation is shown to involve Michael addition of an acylperoxy radical and fragmentat

124 The key step involves organocatalytic Michael addition of an aldehyde to 1-nitrocyclohexene.

125 otelluration process is described in which a Michael addition of an alkyl or aryl tellurolate anion o

126 igh yield and exquisite stereoselectivity by Michael addition of an enantioenriched hydroazulenone en

127 The protocol consists of the Michael addition of an unsaturated alkoxide to beta-nitr

128 Stereoselective sulfa-Michael addition of appropriately protected thiocarbohyd

129 A new practical method for the asymmetric Michael addition of arylboronic acids to alpha,beta-unsa

130 Complexes 4 and 9 were found to catalyze the Michael addition of benzyl cyanide derivatives to alpha,

131 aries, we report the direct enantioselective Michael addition of carboxylic acids.

132 plished in seven subsequent steps, including Michael addition of cis-1-propenylcuprate at C4 and intr

133 The Michael addition of deoxyguanosine to HNE yields four di

134 Michael addition of di-tert-butyl methylenemalonate to t

135 er key reactions in the synthesis involved a Michael addition of dimethyl malonate on cyclohexadienon

136 asily accessed via a highly enantioselective Michael addition of dimethyl malonate to a nitrostyrene,

137 A mild protocol for the asymmetric Michael addition of dimethyl malonate to various alpha,b

138 e microgels is achieved via the nucleophilic Michael addition of dithiolated PEG macro-cross-linkers

139 nomers were prepared via the highly reliable Michael addition of ethenesulfonyl fluoride and amines/a

140 The Michael addition of free amino acids to acrylamide was f

141 Michael addition of glutathione and other sulfur nucleop

142 Michael addition of glutathione to the double bond of an

143 to interrogate the rate-limiting step of the Michael addition of glycinate imines to benzyl acrylate

144 ess likely involves initial enzyme-catalyzed Michael addition of GSH to the COMC derivative to give a

145 a glutathiylated conjugated quinone and (ii) Michael addition of GSH to the quinone, a 2-electron red

146 were successfully applied to the asymmetric Michael addition of ketones to alkylidene malonates, off

147 The asymmetric Michael addition of ketones to allylidene malonates was

148 , which implies a sequential organocatalyzed Michael addition of ketones to enals, followed by cataly

149 Michael addition of MVK to the naphthalene complex (1) f

150 Michael addition of N-diphenylmethyleneglycine tert-buty

151 In a cascade event, initial Michael addition of NaNO2 to the MBH acetate furnishes t

152 An efficient and highly enantioselective Michael addition of nitroalkanes to 3-ylidene oxindoles

153 r the enantioselective isothiourea-catalyzed Michael addition of nitroalkanes to alpha,beta-unsaturat

154 t cinchona thioureas catalyze the asymmetric Michael addition of nitroalkanes to enones.

155 ynthesized, and evaluated for the asymmetric Michael addition of nitroalkanes to nitroalkenes.

156 butanol in turn is prepared in two steps via Michael addition of nitromethane to acrylate followed by

157 tron rich and electron poor enones underwent Michael addition of nitrophosphonates to afford the quat

158 The Michael addition of phosphorus nucleophiles is postulate

159 Michael addition of phosphorus nucleophiles to the unsym

160 tional study and kinetic analysis of the aza-Michael addition of primary and secondary amines to acry

161 A totally stereocontrolled C-Michael addition of serine-equivalent C-nucleophiles to

162 The method is based on an oxidative Michael addition of suitable indoles on the double bond

163 ComA catalyzed the stereospecific Michael addition of sulfite to phosphoenolpyruvate over

164 hat ComA, which catalyzes the stereospecific Michael addition of sulfite to phosphoenolpyruvate to fo

165 n subject of this paper, features a one-step Michael addition of t-butyl 2-((diphenylmethylene)amino)

166 Enantioselective Michael addition of tertiary alpha-nitroesters to beta-u

167 -directed and irreversible, resulting from a Michael addition of the active-site Cys Sgamma onto the

168 been prepared by a new method that involves Michael addition of the appropriate 1-nitroalkene with 2

169 Evidence suggests that Michael addition of the benzylic anion derived from a gi

170 Michael addition of the deprotonated aminonitriles to th

171 Michael addition of the deprotonated tosylamides to the

172 Michael addition of the dianion of N-Boc-anilines in the

173 The aza-Michael addition of the in situ formed enamine, generate

174 This inhibition was due to a Michael addition of the penultimate selenocysteine resid

175 ing of the 3-aroylbenzofurans and subsequent Michael addition of the resulting 1,3-dicarbonyl interme

176 which arise from the sequential 1,6- and 1,4-Michael addition of thiol nucleophiles.

177 Michael addition of thiourea to enones with subsequent i

178 chael donors, intermediates arising from the Michael addition of unsaturated beta-ketoesters to alpha

179 o EA-tuned peptides via beta-elimination and Michael addition of various thiol compounds.

180 A (BFA) analogues were prepared through the Michael addition of various thiols.

181 for elimination of homocysteine, followed by Michael addition of water to the resulting intermediate

182 k at C-3 of 3-chloropropiolate to initiate a Michael addition of water.

183 hydroxy mesylates 23 and 34, intramolecular Michael additions of 29 and 37, and a one-pot, HF-induce

184 Enantioselective Michael additions of 4-hydroxycoumarin to beta-nitrostyr

185 n A has been developed employing consecutive Michael additions of a 4-hydroxypyrone to a sorbicillino

186 on of acetylenic dienophiles with subsequent Michael additions of aromatic ketones to install a chrom

187 ghly enantioselective and diastereoselective Michael additions of enolsilanes to unsaturated imide de

188 natural amino acids and catalyze asymmetric Michael additions of ketones to nitroalkenes.

189 The other pathway involves conjugate (Michael) addition of the enol ether to the nitrovinylqui

190 d transformations proceed via intramolecular Michael addition or activation of the enone moiety pathw

191 ly long-lived that they can damage DNA via a Michael addition or by redox cycling.

192 This model indicated that the major Michael addition pathway could only occur if the vinyl g

193 An intramolecular Michael addition pathway for 41 has been demonstrated by

194 igned to prevent bond rotation and block the Michael addition pathway.

195 ve stability and operate via a complementary Michael addition-pathway upon enzymatic oxidation of the

196 vel diastereoselective, intramolecular amide Michael addition process.

197 ectrospray tandem mass spectrometry as a 1,4 Michael addition product 5-oxo-7-glutathionyl-8,11,14-ei

198 enium-supplemented cells correlated with the Michael addition product of 15d-PGJ2 with Cys-179 of IKK

199 N(2)-propanodeoxyguanosine (PdG) adducts are Michael addition products from reactions of deoxyguanosi

200 with up to six HNE molecules incorporated as Michael addition products.

201 ates in multiple pathways, including further Michael addition, proton abstraction, and catalyst deact

202 An intermolecular Michael addition reaction and an intramolecular condensa

203 lear that a good understanding of the hetero-Michael addition reaction and the relative reactivities

204 Bis-cinchona catalyst 3b activates the Michael addition reaction between malononitrile derivati

205 A reversible Michael addition reaction between thiol nucleophiles and

206 The mechanism of the enantioselective sulfa-Michael addition reaction catalyzed by a cinchona alkalo

207 Study of the intramolecular aza-Michael addition reaction from an aminofluorovinylsulfon

208 The beta-elimination/Michael addition reaction has been employed for the modi

209 loro ketone can be efficiently combined to a Michael addition reaction in a new two-step domino react

210 he PPARgamma ligand binding domain through a Michael addition reaction involving a protein cysteine r

211 center has been developed via a tandem thio-Michael addition reaction of an in situ generated alpha,

212 An efficient Michael addition reaction of differently substituted eno

213 ration of 1 was confirmed by thiol-selective Michael addition reaction of immunoprecipitated CD43-myc

214 The first example of a catalytic Michael addition reaction of non-activated aliphatic nit

215 An intramolecular FeCl3-catalyzed Michael addition reaction of styrene, a poor nucleophile

216 (2-succinyl)cysteine (2SC) is formed by a Michael addition reaction of the Krebs cycle intermediat

217 film not only electrostatically but also by Michael addition reaction to cysteine, lysine, or argini

218 enolate that will undergo an intramolecular Michael addition reaction to form two new stereogenic ce

219 generated p-quinone imine participates in a Michael addition reaction with 2-SH-benzazoles leading t

220 id (LNO2) rapidly react with GSH and Cys via Michael addition reaction.

221 s modification sites by the beta-elimination/Michael addition reaction.

222 bond to cysteine-316 in alpha-tubulin via a Michael addition reaction.

223 orm for anchoring chemical functions via the Michael addition reaction; and (iii) PDOPA was used as a

224 es containing a cis-enone are susceptible to Michael addition reactions and are potent inhibitors of

225 ontrolling the stereochemical outcome of the Michael addition reactions between nucleophilic glycine

226 ed diastereoselectivity in the corresponding Michael addition reactions between the Ni(II) complex of

227 (12)H(12)](2-) are excellent participants in Michael addition reactions in the presence of a strong a

228 e (PABP)] 2 via alkyl halide alkylations and Michael addition reactions was systematically studied as

229 heir catalytic performance in representative Michael addition reactions was used in an effort to comp

230 The corresponding Michael addition reactions were found to proceed at room

231 beta to the nitro group, thus competent for Michael addition reactions with cysteine and histidine.

232 Such reactive aldehydes are subject to Michael addition reactions with the side chains of lysin

233 icyclic structures studied rapidly underwent Michael addition reactions with the test nucleophile glu

234 nation of Se-alkylselenocysteine followed by Michael addition reactions with various thiol nucleophil

235 unsaturated aldehydes) with lysine residues (Michael addition reactions) and also by interactions wit

236 ne or cinchona alkaloid-urea catalyzed sulfa-Michael addition reactions, also applies to the catalyti

237 ciency and expanding the generality of these Michael addition reactions.

238 base-induced tandem beta-elimination/hetero-Michael addition rearrangement of (E)-N-benzoylethylpyri

239 to a cascade of reactions, namely oxidation, Michael addition, reduction, acetylation, and cycloconde

240 l Diels-Alder cycloaddition or a competitive Michael addition/reduction to access aspidosperma-type a

241 ynthesis involves a Knoevenagel condensation/Michael addition sequence, followed by the formation of

242 stries are thiol-disulfide exchange and thio-Michael addition, sharing the thiol as the common buildi

243 he reaction involves a tandem pathway of aza-Michael addition, SN2, and a unique redox-neutral proces

244 e N or S heteronucleophile to give the first Michael addition step affording regioselective substitut

245 the products and the stereochemistry of the Michael addition step were unequivocally established by

246 to increase the efficiency and yield of the Michael addition step.

247 -derived bifunctional organocatalyst for the Michael addition step.

248 ng to that in 1 and 5, and an intramolecular Michael addition that leads to the tetracyclic corynanth

249 hrough use of an organocatalyzed, heteroatom Michael addition to access a common intermediate.

250 sequential activation initiated by a hetero-Michael addition to alpha,beta-unsaturated aldehydes aff

251 The products of the organocatalytic sulfa-Michael addition to alpha,beta-unsaturated alpha-amino a

252 e converted to the desired pseudopeptides by Michael addition to alpha-methyleneglutarate esters.

253 thermodynamically controlled intramolecular Michael addition to close the F-ring pyran.

254 were investigated to control a keto sulfone Michael addition to construct the C7-C12 linkage.

255 The synthesis utilizes Michael addition to create a branch point at the end of

256 In addition, a Michael addition to dimethoxy cyclohexadienones was stud

257 at for primary and secondary amines, the aza-Michael addition to ethyl acrylate occurs preferentially

258 exchange from 27a to 30a, the intramolecular Michael addition to generate the enolate 31a, and conver

259 lic reactivity of KETE-PEs is shown by their Michael addition to glutathione and cysteine.

260 number of key steps, including an asymmetric Michael addition to install the C4'-C3'-C7' stereotriad,

261 e showed the highest selectivity for the aza-Michael addition to substituted alkyl acrylates.

262 ctive umpolung synthons for enantioselective Michael addition to substituted enones.

263 ivative in that the reaction is initiated by Michael addition to the beta-carbon atom of the alpha,be

264 the peptide substrate toward intramolecular Michael addition to the dehydroalanine and dehydrobutyri

265 n by 1 involving amine oxidation followed by Michael addition to the propargylic imine.

266 t strongly disfavors a mechanism involving a Michael addition to the pyrimidine ring.

267 t that the reaction sequence is initiated by Michael addition to the side chain enone.

268 and anti-inflammatory effects via reversible Michael addition to thiol-containing proteins in key sig

269 n ONIOM(QM/MM) study on the mechanism of the Michael addition to triple bonds catalyzed by chiral dii

270 Sulfa-Michael additions to alpha,beta-unsaturated N-acylated o

271 experiments establish the relative rates of Michael additions to be in the following order: Et>i-Pr>

272 nt, one-pot domino process through a 1,6-aza-Michael addition-triggered sequence and an original Mits

273 pid peptide and protein conjugates formed by Michael addition-type conjugation reactions of alpha,bet

274 ction with a diastereoselective nitro olefin Michael addition under bifunctional organocatalysis and

275 These reagents undergo rapid thiol Michael-addition under biocompatible conditions in stoic

276 ctivity, including both C- and O-alkylation, Michael addition via C-5 to an acetylenic ester, tetrach

277 beta-position through a putative reversible Michael addition was observed.

278 n stereoselectivity and reaction rate in the Michael addition was observed.

279 The remarkable diastereoselectivity of the Michael addition was specifically demonstrated with diff

280 ications: First, a fast exothermic reaction (Michael addition) was monitored with backscattering fibe

281 Amide coupling and thiol-ene Michael addition were found to be ineffective for the sy

282 ber of efficient carba-, sulfa-, and phospha-Michael additions were achieved very conveniently, witho

283 nctionalized acrylates synthesized via thiol-Michael addition, which are then polymerized using two-p

284 e products undergo reversible intramolecular Michael addition, which protects the monoalkenylated pro

285 in the synthetic sequence are an asymmetric Michael addition, which yields 5c, and a stereoselective

286 t binding of HNE to Mb at both pH values via Michael addition, while Western blot analysis indicated

287 e crystallographic observation of reversible Michael addition with a potent cyanoenone drug candidate

288 de; the resulting hemithioacetal undergoes a Michael addition with an adjacent unsaturated acrylate e

289 Quinolacetic acid reacts readily by Michael addition with cellular thiols to form a two-elec

290 or 196 Da from this peptide, and subsequent Michael addition with cysteamine increased masses by the

291 egradation and beta-elimination, followed by Michael addition with dithiothreitol (BEMAD).

292 beta-Elimination followed by Michael addition with dithiothreitol facilitates the stu

293 lopment of mild beta-elimination followed by Michael addition with dithiothreitol has significantly i

294 would be predicted that they readily undergo Michael addition with glutathione and adduct covalently

295 tography/mass spectrometry that they undergo Michael addition with GSH.

296 , the trapping of the enolate resulting from Michael addition with prochiral electrophiles, such as a

297 Using a refined beta-elimination/Michael addition with tandem mass tags (TMT)-labeling pr

298 then undergo a rapid and chemoselective 1,4-Michael addition with the pKa-perturbed Lys-15 epsilon-a

299 It is known to undergo Michael additions with biological sulfur nucleophiles.

300 to be a superior glycine derivative for the Michael additions with various (R)- or (S)-N-(E-enoyl)-4