ライフサイエンスコーパス: Michael

1 Michael addition has been achieved with a variety of ami

2 Michael addition is a premier synthetic method for carbo

3 Michael addition of phosphorus nucleophiles to the unsym

4 Michael addition of thiourea to enones with subsequent i

5 Michael Gross reports.

6 Michael Gross reports.

7 Michael Gross rounds up some unusual suspects.

8 Michael Parker and Dominic Kwiatkowski discuss important

9 Michael's Hospital (Toronto, Canada) between 1994 and 20

10 ly observed electrophilic reactivities of 44 Michael acceptors and their calculated methyl anion affi

11 In addition, a Michael addition to dimethoxy cyclohexadienones was stud

12 We demonstrated that zinc ion and a Michael acceptor-based peptidomimetic inhibitor synergis

13 mplex with dual inhibitors, a zinc ion and a Michael acceptor.

14 p of calpain's catalytic Cys115 residue by a Michael 1,4-addition reaction.

15 onding tert-butyl ester 3 was initiated by a Michael reaction to introduce the cyclohexyl ring.

16 ysis reveals that the reaction proceeds by a Michael/Michael/cyclopropanation/epimerization cascade i

17 dised EC reacts with lysine through either a Michael type addition or a "Strecker like" reaction and

18 Only Bar-Me forms a Michael addition adduct with glutathione (GSH) and inhib

19 via isobenzofuranone ring opening of 2 in a Michael-type reaction.

20 er key reactions in the synthesis involved a Michael addition of dimethyl malonate on cyclohexadienon

21 proceeds via a cascade reaction involving a Michael addition-6pi-electrocyclic ring opening-proton t

22 ing group was added at the alpha-carbon of a Michael acceptor.

23 s by intramolecular nucleophilic attack on a Michael acceptor with an allylic leaving group.

24 applied to detect cyanide (CN(-)) based on a Michael-type nucleophilic addition reaction and intramol

25 This inhibition was due to a Michael addition of the penultimate selenocysteine resid

26 electrogenerated quinone diimine undergoes a Michael-type addition reaction with arylsulfinic acids t

27 yzed retro-aldol cleavage of 2-VIC unmasks a Michael substrate, 2-vinylglyoxylate, which then forms a

28 Second, using a Michael reaction whose kinetics depends on the redox sta

29 ne-3,7-dione scaffolds was synthesized via a Michael addition and reductive cyclization strategy.

30 bond to cysteine-316 in alpha-tubulin via a Michael addition reaction.

31 dehyde using DABCO at room temperature via a Michael addition, 5-exo-dig carboannulation, and oxidati

32 ucture of HCoV-NL63 M(pro) in complex with a Michael acceptor inhibitor N3.

33 ctivity, including both C- and O-alkylation, Michael addition via C-5 to an acetylenic ester, tetrach

34 tics, are viable reaction partners, allowing Michael-type reactivity to be expanded beyond alpha,beta

35 Although Michael acceptors display a potent and broad spectrum of

36 starting from alpha-bromoamido alcohols and Michael acceptors under mild conditions is presented.

37 vations on catalytic aqueous Diels-Alder and Michael reactions in heterogeneous fashion employing a d

38 cts with aS via formation of Schiff-base and Michael-addition adducts with Lys residues, in addition

39 n a Perspective article, Sigrid Carlsson and Michael Kattan discuss Gnanapragasam and colleagues' acc

40 Semenkovich, MD, the Irene E. and Michael M.

41 r Award, Swim across America Foundation, and Michael J Rainen Family Foundation.

42 hiobarbiturate with diarylcarbenium ions and Michael acceptors have been determined in dimethyl sulfo

43 reaction tolerates a variety of nitriles and Michael acceptors with different steric features and acc

44 onors Ralf Bartenschlager, Charles Rice, and Michael Sofia, pioneers in the development of curative a

45 warded to Jeffrey Hall, Michael Rosbash, and Michael Young for elucidating molecular mechanisms of th

46 ces the reactivity between a given thiol and Michael acceptor.

47 ,2-dihydropyridines with alkyl triflates and Michael acceptors was developed to introduce quaternary

48 zed by Carol Mason (Columbia University) and Michael Crair (Yale University).

49 and amides have been shown to be appropriate Michael donors in this type of reaction.

50 ters and nitro olefins have been employed as Michael acceptors, while moderate nitrogen nucleophiles

51 ir susceptibility to other reactions such as Michael additions and the difficulty of controlling the

52 Allene carboxylates, scarcely used as Michael acceptors, serve as acceptors in the annulation

53 Catalytic and asymmetric Michael reactions constitute very powerful tools for the

54 natural amino acids and catalyze asymmetric Michael additions of ketones to nitroalkenes.

55 eochemical outcome of a catalyzed asymmetric Michael addition.

56 A mild protocol for the asymmetric Michael addition of dimethyl malonate to various alpha,b

57 t cinchona thioureas catalyze the asymmetric Michael addition of nitroalkanes to enones.

58 nt, one-pot domino process through a 1,6-aza-Michael addition-triggered sequence and an original Mits

59 e reactions including Michael additions, aza-Michael additions, and direct Aldol reactions.

60 example of an asymmetric aminocatalyzed aza-Michael addition of 1H-indazole derivatives to alpha,bet

61 heterocyclic systems is initiated by an aza-Michael reaction followed by intramolecular cyclization.

62 The key steps are an aza-Michael reaction from an alpha,beta-unsaturated diazoket

63 leading to quinazolinone derivatives and aza-Michael adducts under mild reaction conditions.

64 assembled rapidly via Baylis-Hillman and aza-Michael reactions.

65 reoselective (dr >/=96:4) acid-catalyzed aza-Michael reaction to give trans-2,5-disubstituted pyrroli

66 nd formation through palladium-catalyzed aza-Michael reaction.

67 amework, providing access to the desired aza-Michael products.

68 Study of the intramolecular aza-Michael addition reaction from an aminofluorovinylsulfon

69 aziridines followed by an intramolecular aza-Michael reaction in a domino fashion.

70 hed via a TBSOTf-mediated intramolecular aza-Michael reaction, and the relative stereochemistry of th

71 on, which relies on an omega-TA-mediated aza-Michael reaction.

72 he reaction involves a tandem pathway of aza-Michael addition, SN2, and a unique redox-neutral proces

73 l reaction followed by a tandem Robinson-aza-Michael double cyclization catalyzed by PS-BEMP, and (ii

74 e the mechanism, which favors a stepwise aza-Michael/spirocyclization sequence over the alternate het

75 Products are formed by the aza-Michael addition followed by intramolecular acyl substit

76 tional study and kinetic analysis of the aza-Michael addition of primary and secondary amines to acry

77 The aza-Michael addition of the in situ formed enamine, generate

78 at for primary and secondary amines, the aza-Michael addition to ethyl acrylate occurs preferentially

79 ty and exquisite site-selectivity of the aza-Michael ligation described herein allows the constructio

80 and the relative stereochemistry of the aza-Michael product (30) was confirmed by X-ray crystallogra

81 The aza-Michael reaction was first observed when the starting en

82 ACUA pairs that genetically encode three aza-Michael acceptor amino acids, N(epsilon)-acryloyl-(S)-ly

83 (ii) installation of the amino group via aza-Michael addition/elimination, and crucially (iii) facile

84 s starting from the versatile chromone-based Michael acceptors platform are reported herein.

85 Although adducts formed by Michael addition are thought to be largely irreversible,

86 r nucleophiles such as cysteine thiolates by Michael addition.

87 rphenyls were synthesized in good yields, by Michael addition of a conjugate base of core-substituted

88 a-amino ester)s (HPAEs) via a new "A2+B3+C2" Michael addition approach demonstrating 2 to 126-fold hi

89 ved ligand provided in the presence of CaCl2 Michael adducts in moderate to high enantioselectivities

90 This strategy, which involves a cascade Michael addition-Dieckmann cyclization-elimination seque

91 scribe herein a catalyst/ligand free cascade Michael-type addition/intramolecular cyclization/carbohy

92 the stereoselectivity of an enzyme-catalysed Michael-type addition during the biosynthesis of lanthip

93 The first example of a catalytic Michael addition reaction of non-activated aliphatic nit

94 amine the two key processes of the catalytic Michael reaction between propanal and beta-nitrostyrene

95 ehyde, diastereoselective Cu(OTf)2-catalyzed Michael reaction/tandem aldol cyclizations, and one-pot

96 urea was used to trigger the base-catalyzed Michael addition of a water-soluble trithiol to a polyet

97 N-heterocyclic carbene catalyzed Michael additions have been revisited with 1,3-dialkyl-

98 tive ligands for asymmetric copper-catalyzed Michael addition.

99 operative hydrogen bonding/enamine-catalyzed Michael addition as the key step.

100 An intramolecular FeCl3-catalyzed Michael addition reaction of styrene, a poor nucleophile

101 r the enantioselective isothiourea-catalyzed Michael addition of nitroalkanes to alpha,beta-unsaturat

102 In this issue of Developmental Cell, Michael and colleagues (2016) show that the actin bindin

103 versary of the birth of the physical chemist Michael Polanyi, as well as the 40th of his death.

104 ganobase-catalyzed and highly chemoselective Michael-Michael-acetalization cascade is presented for t

105 ify the electrophilic reactivities of common Michael acceptors, we measured the kinetics of the react

106 l Diels-Alder cycloaddition or a competitive Michael addition/reduction to access aspidosperma-type a

107 e of homopropargyl malonates 3 a consecutive Michael-type addition/cyclopentannulation/6-exo cyclizat

108 n A has been developed employing consecutive Michael additions of a 4-hydroxypyrone to a sorbicillino

109 uding an intramolecular chelation-controlled Michael spirocyclization of an N-Cbz-lactam titanium eno

110 on (SI-GTP), and extension to N-coordinating Michael-type monomers (2-vinylpridine (2VP), 2-isopropen

111 n of a range of reactants into corresponding Michael adducts in a couple of hours with exquisite sele

112 the first step, leading to the corresponding Michael adduct.

113 A cascade Friedel-Crafts/Michael annulation reaction between acryloyl chloride an

114 compounds possess a piperidinyl crotonamide Michael acceptor and a 3-chloro-4-fluoroaniline, indicat

115 aromatic amines, onto sluggish (cumbersome) Michael acceptors without any promoter or workup.

116 yzed enantioselective and diastereoselective Michael reactions of cyclic ketoesters and enones to ins

117 ive recoverable organocatalysts in different Michael additions, in neat conditions at room temperatur

118 al theory (DFT), investigating the different Michael-addition approaches of the sulfur ylide, the tra

119 talyzed and highly diastereoselective direct Michael addition-isomerization sequence is presented for

120 t on the catalytic polymerization of diverse Michael-type monomers with high precision by using simpl

121 des with 1,4-dithiane-2,5-diol, and a domino Michael/alpha-alkylation reaction of the derived chiral

122 en synthesized via a copper-catalyzed domino Michael/oxidative cross-coupling reaction between adenin

123 ters or beta-diketones undergo facile domino Michael-Michael reaction with nitro-olefins to afford th

124 nt and application of the arene-fused domino Michael/Mannich route to the tetrahydrocarbazole (ABE) c

125 ta-diketones via a K-enolate mediated domino Michael-Michael reaction sequence with moderate to good

126 mine) and the electrophilic component (i.e., Michael acceptor).

127 Using a refined beta-elimination/Michael addition with tandem mass tags (TMT)-labeling pr

128 acycline (1) has been developed by employing Michael-Dieckmann cyclization between enone 3 and a full

129 and the use of alpha'-oxy enones as enabling Michael acceptors with ambivalent H-bond acceptor/donor

130 a diastereoselective intramolecular enamine/Michael cascade reaction that forms two rings and two st

131 nes via two alternative enantiocomplementary Michael-type reactions: enamine-mediated addition of ace

132 Enantioselective Michael addition of tertiary alpha-nitroesters to beta-u

133 Enantioselective Michael addition-cyclization reactions using different a

134 Enantioselective Michael additions of 4-hydroxycoumarin to beta-nitrostyr

135 aries, we report the direct enantioselective Michael addition of carboxylic acids.

136 on with the organocatalytic enantioselective Michael-acetalization-Henry reaction of 2-hydroxynitrost

137 Amide coupling and thiol-ene Michael addition were found to be ineffective for the sy

138 d peptoids were prepared using the thiol-ene Michael-type reaction.

139 organic synthesis such as acetals, enolates, Michael acceptors, acylating reagents, and activated aro

140 t time, to catalytically polymerize extended Michael systems, like 4-vinylpyridine.

141 to be a similar if not superior catalyst for Michael additions compared with typical Lewis acids.

142 n effective hydrogen-bond-donor catalyst for Michael reactions of a series of water-insoluble nitro-o

143 empirical electrophilicity parameters E for Michael acceptors 1 and 2.

144 uble cyclopropanation of this functionalized Michael-acceptor will be useful guidelines for the synth

145 ates in multiple pathways, including further Michael addition, proton abstraction, and catalyst deact

146 so typical that many have proper names (e.g. Michael addition, Amadori rearrangement, and Pictet-Spen

147 versatile CO2-extrusion platform to generate Michael donors without the requirement for organometalli

148 Andras Varro, Heike Wulff, Eleonora Grandi, Michael Sanguinetti, Donald Bers, Jeanne Nerbonne and Ni

149 Physiology has been awarded to Jeffrey Hall, Michael Rosbash, and Michael Young for elucidating molec

150 base-induced tandem beta-elimination/hetero-Michael addition rearrangement of (E)-N-benzoylethylpyri

151 lear that a good understanding of the hetero-Michael addition reaction and the relative reactivities

152 in metathesis, Heck coupling, hydroarylation Michael addition and tandem coupling.

153 However, the hypothetical Michael adducts in this mechanism have only been detecte

154 mation of the substrate into the impermanent Michael adduct.

155 a systematic assessment of its reactivity in Michael, radical, and cycloaddition reactions.

156 mechanistically diverse reactions including Michael additions, aza-Michael additions, and direct Ald

157 for the transformation, involving an initial Michael-type addition of the imine to the nitro-alkene f

158 In a cascade event, initial Michael addition of NaNO2 to the MBH acetate furnishes t

159 An intermolecular Michael addition reaction and an intramolecular condensa

160 pivotal step includes a novel intermolecular Michael-type addition of an indole ester dianion to a pi

161 tions as pivotal steps: 1) an intramolecular Michael addition of a benzyloxycarbonyl-protected lactam

162 into tricyclic compounds via intramolecular Michael addition.

163 substrates are exocyclic methylene lactamyl Michael acceptors.

164 ethodologies including aldol-lactonisations, Michael-lactonisations/lactamisations and [2,3]-rearrang

165 ynine, employing a proline-catalyzed Mannich-Michael reaction sequence as the key transformation.

166 systems are also applicable in the Mukaiyama-Michael reactions and tandem Michael-Michael reactions.

167 The fluoride-promoted vinylogous Mukaiyama-Michael reaction of 2-[(trimethylsilyl)oxy]furan with di

168 2-hydroxyacetophenones is disclosed, namely Michael-hemiacetalization reaction of 2-hydroxyacetophen

169 This new Michael acceptor on reactions with different nucleophile

170 A diverse array of Michael acceptors is amenable to this new conjugate addi

171 cientific and philosophical contributions of Michael Polanyi, is based on the presentation given by D

172 eaction mixtures confirmed the formations of Michael adduct and Schiff base of HMF with amino acids.

173 84 named Faradaurate-279 (F-279) in honor of Michael Faraday's (1857) pioneering work on nanoparticle

174 which readily combines with a wide range of Michael acceptors to produce beta-alkyl aldehydes in a h

175 d to calculate the rates of the reactions of Michael acceptors 1 and 2 with any nucleophile of known

176 ce the electrophilicity and reversibility of Michael acceptors.

177 Because of the large structural variety of Michael acceptors considered for these correlations, whi

178 report a new dynamic polymerization based on Michael addition-elimination reaction of structurally di

179 Humanities was the title of the symposium on Michael Polanyi that took place at the Technische Univer

180 tereochemical outcome of the organocatalytic Michael reactions between benzylic aldehydes and nitrost

181 lementary strategies: (i) an organocatalyzed Michael reaction followed by a tandem Robinson-aza-Micha

182 verse-electron-demand hetero-Diels-Alder/oxa-Michael reaction catalyzed by modularly designed organoc

183 to benzoquinone, which is followed by an oxa-Michael ring-closure.

184 sis of chiral chroman derivatives via an oxa-Michael-Michael cascade reaction has been developed usin

185 The enantioselective oxa-Michael reaction of alkoxyboronate strategy was demonstr

186 tion of a phenol and a hemiacetalization/oxa-Michael cascade to form the tricyclic ring system.

187 lective allylations, a hemiacetalization/oxa-Michael sequence, and a 1,3-syn reduction.

188 cedented enantioselective intramolecular oxa-Michael reaction of enols has been described.

189 ue, biomimetic asymmetric intramolecular oxa-Michael reaction/hydrogenation sequence that allows dias

190 to a cascade of reactions, namely oxidation, Michael addition, reduction, acetylation, and cycloconde

191 The method is based on an oxidative Michael addition of suitable indoles on the double bond

192 Hf(OTf)4 was used to convert the double oxy-Michael product 28 into C1-C19 building block 10.

193 An intramolecular oxy-Michael reaction under basic conditions was used to cons

194 xposition on CH2 CH-SO2 -F, the most perfect Michael acceptor ever found.98 To this history we add se

195 clic phosphine (NHP) and allenes via phospha-Michael/intramolecular nucleophilic substitution reactio

196 In the photograph: Michael Polanyi at the Fritz Haber Institute in 1968.

197 Health Research, Trust Family, Loker Pinard, Michael Brigham, and Gerald DeWulf.

198 iene dicarboxylate (OND) reagents are potent Michael acceptors, the adducts of which undergo fragment

199 11-keto group in CF3DODA-Me, which prevents Michael addition by the conjugated en-one in the A-ring.

200 as a traceless activation group for radical Michael additions has been accomplished via visible ligh

201 ications: First, a fast exothermic reaction (Michael addition) was monitored with backscattering fibe

202 this series, and it proved to be a reactive Michael acceptor, irreversibly trapping thiol nucleophil

203 -1,4-dienecarbonitrile) is a highly reactive Michael acceptor leading to reversible adducts with nucl

204 nomers were prepared via the highly reliable Michael addition of ethenesulfonyl fluoride and amines/a

205 heir catalytic performance in representative Michael addition reactions was used in an effort to comp

206 The Canadian Institutes of Health Research, Michael Smith Foundation for Health Research, and BC Cen

207 c product is formed subsequently via a retro Michael elimination of a hindered ether followed by addi

208 elimination of the maleimide through a retro-Michael reaction, which results in loss of drug-linker f

209 s favored by glutathione, indicating a retro-Michael reaction, which unveils new implications of cyPG

210 Reversible Michael acceptors have been reported in which an additio

211 A reversible Michael addition reaction between thiol nucleophiles and

212 Although reversible Michael acceptors have been reported, the structural req

213 e crystallographic observation of reversible Michael addition with a potent cyanoenone drug candidate

214 and anti-inflammatory effects via reversible Michael addition to thiol-containing proteins in key sig

215 r, Cu(I)-catalyzed azide-alkyne) or the same Michael-type reaction as for cyclization.

216 ptors and a single thiol or between a single Michael acceptor and two thiols using three different ca

217 e recorded among infertile women seen at St. Michael's Hospital in Bristol, United Kingdom, during th

218 n subject of this paper, features a one-step Michael addition of t-butyl 2-((diphenylmethylene)amino)

219 oncerted Diels-Alder reaction and a stepwise Michael addition, for the formation of corresponding pro

220 ing of the 3-aroylbenzofurans and subsequent Michael addition of the resulting 1,3-dicarbonyl interme

221 Sulfa-Michael additions to alpha,beta-unsaturated N-acylated o

222 in a simple and reliable way through a sulfa-Michael reaction that proceeds with high yield and chemo

223 alpha,beta-unsaturated ester, affords sulfa-Michael adducts in excellent yields (up to >99%) and ena

224 A highly enantioselective cascade sulfa-Michael/Julia-Kocienski olefination reaction between 2-m

225 ne or cinchona alkaloid-urea catalyzed sulfa-Michael addition reactions, also applies to the catalyti

226 e of the procedure, some NHC-catalyzed sulfa-Michael/aldol organocascades were also investigated.

227 (aryl)-S coupling, thioester cleavage, sulfa-Michael addition, aldol reaction, and elimination reacti

228 tial domino reactions, namely a domino sulfa-Michael/aldol condensation of alpha,beta-unsaturated ald

229 The highly enantioselective sulfa-Michael addition of alkyl thiols to unactivated alpha-su

230 The mechanism of the enantioselective sulfa-Michael addition reaction catalyzed by a cinchona alkalo

231 The products of the organocatalytic sulfa-Michael addition to alpha,beta-unsaturated alpha-amino a

232 were investigated to control a keto sulfone Michael addition to construct the C7-C12 linkage.

233 n the Mukaiyama-Michael reactions and tandem Michael-Michael reactions.

234 furans is developed via DBU-mediated tandem Michael addition/5-exo-dig-cycloisomerization of enynes

235 rocyclization of peptides bearing N-terminal Michael acceptors has been developed.

236 The Michael acceptor reactivity of the scaffold may have a r

237 The Michael acceptors inhibited both rhodesain and falcipain

238 The Michael addition of free amino acids to acrylamide was f

239 The Michael addition of phosphorus nucleophiles is postulate

240 The Michael adducts subsequently undergo base-promoted diast

241 Bis-cinchona catalyst 3b activates the Michael addition reaction between malononitrile derivati

242 f Neurological Disorders and Stroke, and the Michael J Fox Foundation.

243 with an alpha,beta-unsaturated ketone as the Michael acceptor and does not occur when an alpha,beta-u

244 step, the nucleophilic attack of 3-5 at the Michael acceptors with formation of acyclic intermediate

245 ic surgery with hardware implantation at the Michael E.

246 -derived bifunctional organocatalyst for the Michael addition step.

247 lenonyl group served as an activator for the Michael addition, a leaving group and a latent oxidant i

248 II) salts as highly active catalysts for the Michael reactions of traditionally unreactive beta,beta'

249 n stereoselectivity and reaction rate in the Michael addition was observed.

250 when an alpha,beta-unsaturated ester is the Michael acceptor.

251 ng electron-withdrawing group as part of the Michael acceptor, a high energy concerted SN2' reaction

252 to interrogate the rate-limiting step of the Michael addition of glycinate imines to benzyl acrylate

253 n ONIOM(QM/MM) study on the mechanism of the Michael addition to triple bonds catalyzed by chiral dii

254 The remarkable diastereoselectivity of the Michael addition was specifically demonstrated with diff

255 nic transition state and intermediate of the Michael addition, but less intuitively, it destabilizes

256 states determine the face selectivity of the Michael-type cyclization.

257 of a COOEt-stabilized sulfur ylide onto the Michael acceptor.

258 e tertiary amine that is able to promote the Michael reaction between enolizable carbonyl compounds a

259 For thiol addition to be reversible, the Michael acceptor must also contain a suitable substituen

260 te of Neurological Disorders and Stroke, the Michael J Fox Foundation, Mayo Foundation, the Roger de

261 We found that the Michael acceptor bis(2-hydoxybenzylidene)acetone (HBB2),

262 orm for anchoring chemical functions via the Michael addition reaction; and (iii) PDOPA was used as a

263 in contrast to expectation from HSAB theory, Michael-acceptor ketones, aldehydes and esters may form

264 ns to determine why thiol additions to these Michael acceptors are reversible.

265 conveniently synthesized via selective thia-Michael addition of a commercially available methacrylat

266 stries are thiol-disulfide exchange and thio-Michael addition, sharing the thiol as the common buildi

267 reversibly switched from predominantly thio-Michael chemistry to predominantly disulfide chemistry,

268 These reagents undergo rapid thiol Michael-addition under biocompatible conditions in stoic

269 Thiol-Michael "click" reactions are essential synthetic tools

270 These approaches employ thiol-ene and thiol-Michael reactions to form homopolymers of a single nucle

271 Despite increasing efforts to apply thiol-Michael chemistry in a controlled fashion, the selectivi

272 undamental study of the selectivity of thiol-Michael reactions through a series of 270 ternary reacti

273 ivity of base- or nucleophile-promoted thiol-Michael reactions in complex mixtures of multiple thiols

274 insights into the design of selective thiol-Michael reactions that can be used for the synthesis and

275 -pot quaternary, and sequential senary thiol-Michael reactions were designed and their selectivities

276 ing the intrinsic reversibility of the thiol-Michael reaction to be tuned in a predictable manner.

277 nctionalized acrylates synthesized via thiol-Michael addition, which are then polymerized using two-p

278 n of benzoyl-substituted indolizines through Michael addition followed by C-N bond formation, which a

279 ic addition of electron-rich heteroarenes to Michael acceptors, very few methods exploit transition m

280 on of photogenerated alpha-amino radicals to Michael acceptors.

281 Additions of cysteine thiols to Michael acceptors underpin the mechanism of action of se

282 N2' substitution, intramolecular 6-endo-trig Michael addition and double elimination.

283 nce for the formally disfavoured 5-endo-trig Michael reaction over the formally favoured 5-exo-trig D

284 Compounds bearing two Michael-type acceptors proved to be the most active.

285 explored using ternary reactions between two Michael acceptors and a single thiol or between a single

286 tron rich and electron poor enones underwent Michael addition of nitrophosphonates to afford the quat

287 ta'-ketoesters that results in unprecedented Michael adducts containing vicinal all-carbon quaternary

288 tions using different alpha,beta-unsaturated Michael acceptors have been performed to form dihydropyr

289 Various Michael-type compounds were designed and synthesized, an

290 ed covalent immobilisation of tryptamine via Michael type-reaction.

291 An asymmetric doubly vinylogous Michael addition (DVMA) of alpha,beta-unsaturated gamma-

292 An unprecedented DVMA/vinylogous Michael addition/isomerization cascade reaction affords

293 The enantioselective vinylogous Michael/aldol cascade is an underdeveloped approach to c

294 ylation/[1,2]-Brook rearrangement/vinylogous Michael cascade of silyl glyoximide, vinylmagnesium brom

295 succinimides was realized via the vinylogous Michael addition of 3-substituted cyclohexenones to N-(2

296 symmetric 3-alkylidene groups via vinylogous Michael-type addition to nitroolefins was realized.

297 anched C-H alkylation of benzimidazoles with Michael acceptors.

298 lways forms the initial reaction of GSH with Michael-acceptor carbonyls.

299 dichloroacetates with nitroarenes react with Michael acceptors to give esters of cyclopropane carboxy

300 ative reactivities of biological thiols with Michael acceptors under physiological conditions is need