ライフサイエンスコーパス: Monod

1 Monod kinetics for utilization of acetate were relativel

2 Monod kinetics with competitive inhibition are used to d

3 Monod, Wyman, and Changeux (MWC) explained allostery in

4 A Monod-Wyman-Changeux co-agonist mechanism with two equiv

5 is described by either of two models: (1) a Monod-Wyman-Changeux-based model (MWC) where salt bridge

6 heteromultimeric channels were well fit by a Monod, Wyman, and Changeux model with a concerted allost

7 Here I show that, for a Monod-Wyman-Changeux model with independent sensors, the

8 This is based on the development of a Monod-equation based, differential equation model, which

9 We have devised a model based on a Monod-Wyman-Changeux cooperative mechanism with volume c

10 Our results rule out a Monod-Wyman-Changeux allosteric mechanism with a central

11 It is now 50 years since Jacob and Monod first proposed a model for gene regulation, which

12 The papers from the Jacob and Monod groups that presented the operon model and repress

13 The operon model, proposed by Jacob and Monod, provides a cogent depiction for how gene expressi

14 n is based on dual-substrate utilization and Monod growth kinetics.

15 r effect (1904) to the birth of allostery by Monod and Jacob (1961).

16 lanation of enzymatic adaptation proposed by Monod and shared by scientists for more than half a cent

17 Microbial Evolution, beginning with work by Monod.

18 By extending the classic Monod model of resource-limited population growth to all

19 The 50th anniversary of the classic Monod-Wyman-Changeux (MWC) model provides an opportunity

20 se, that are well described by the classical Monod, Wyman and Changeux (MWC) model.

21 The classical Monod-Wyman-Changeux model for homogeneous allosteric pr

22 egulation is well described by the classical Monod-Wyman-Changeux model of allostery.

23 on has often been described by the concerted Monod-Wyman-Changeux and sequential Koshland-Nemethy-Fil

24 A dual Monod model of dehalorespiration provided a good fit to

25 ing these complex interactions into the dual Monod model.

26 ysis of mutant activity using an established Monod-Wyman-Changeux (MWC) allosteric model indicates th

27 PURPOSE OF REVIEW: Formal Monod-Wyman-Changeux allosteric mechanisms have proven v

28 plained consistently within this generalized Monod-Wyman-Changeux model.

29 s and their metabolism and microbial growth (Monod kinetics with decay) and tested it with three aero

30 nsible for the rapid acceptance of the Jacob-Monod model and inhibited suggestions for alternative me

31 pher Democritus and later adopted by Jacques Monod is "everything existing in the universe is the fru

32 st, Hungary, I was fortunate to meet Jacques Monod at the Pasteur Institute, and this became a turnin

33 scinating, for I met and worked with Jacques Monod and Francois Jacob, a collaboration that culminate

34 ribing such transitions is the multistimulus Monod-Wyman-Changeux model, in which each stimulus inter

35 The MWC (Monod-Wyman-Changeux) allosteric model postulates concer

36 at maximum current density revealed a Nernst-Monod response with a half saturation potential (EKA) of

37 multiple layers of active cells, and Nernst-Monod behavior support extracellular electron transfer (

38 to extend the two-state allosteric model of Monod, Wyman, and Changeux (MWC) to include geminate lig

39 emoglobin: the quaternary two-state model of Monod, Wyman, and Changeux; the tertiary two-state model

40 ls of binding cooperativity, such as that of Monod, Wyman, and Changeux, in the limit of an infinite

41 fruit of chance and necessity." While I read Monod's book Chance and Necessity as an undergraduate st

42 We show that the model recovers Monod's law for the growth of microbes and two other emp

43 Methanocaldococcus jannaschii showed similar Monod growth kinetics when grown in a bioreactor at vary

44 f oxygenation properties under the two-state Monod-Wyman-Changeux allosteric model revealed that the

45 ubunits activate in a single concerted step (Monod-Wyman-Changeux model) or in four independent steps

46 one-dimension model includes dual-substrate Monod kinetics for a steady-state biofilm with five soli

47 nce analysis (FBA) into a multiple-substrate Monod model to perform the dynamic flux balance analysis

48 The Monod-Wyman-Changeux (MWC) model was conceived in 1965 t

49 The Monod-Wyman-Changeux (MWC) model was initially proposed

50 l and two-dimensional lattice models and the Monod-Wyman-Changeux model of isolated strongly-coupled

51 e (e.g., galactose), a paradigm known as the Monod model.

52 or of detailed multisite systems such as the Monod-Wyman-Changeux allosteric model or rule-based mode

53 or concerted transitions as specified by the Monod-Wyman-Changeux model.

54 etically beyond what can be explained by the Monod-Wyman-Changeux/Perutz model.

55 te statistical mechanical description of the Monod-Wyman-Changeaux allosteric model for both single a

56 The acknowledged success of the Monod-Wyman-Changeux (MWC) allosteric model stems from i

57 al., which is the simplest extension of the Monod-Wyman-Changeux model to include pre-equilibria of

58 ons can be interpreted in the context of the Monod-Wyman-Changeux model.

59 ing to the inactive (T) state complex of the Monod-Wyman-Changeux two-state model.

60 T/R quaternary structural transition of the Monod-Wyman-Changeux/Perutz model.

61 Recent experiments show that the Monod, Wyman and Changeux formalism for allosteric prote

62 i.e., approximately 400 mini-FBAs), then the Monod model provided time-dependent inflow/outflow fluxe

63 ity-velocity qualitatively is similar to the Monod equation, while providing additional information o

64 Contradictions to the Monod-Wyman-Changeaux/Perutz allosteric model arise sinc

65 We fit the data sets to the Monod-Wyman-Changeux model to extract microscopic parame

66 steric ligand and can be explained using the Monod-Wyman-Changeux two-state model of allostery.

67 simulations are largely consistent with the Monod-Wyman-Changeux model for allosteric activation but

68 f receptor coupling, but consistent with the Monod-Wyman-Changeux model of receptor coupling, suggest

69 ll culture behavior which may not conform to Monod kinetics.

70 ten-Henri (MMH) and Gene-Regulation (GRN) to Monod-Wyman-Changeaux (MWC), user defined reactions and

71 rate data fit reasonably well to a trimeric Monod-Wyman-Changeux model, suggesting a two-state confo

72 We used Monod kinetic models to describe substrate utilization a