ライフサイエンスコーパス: Mpl ligand

1 ose expression is upregulated in response to Mpl ligand.

2 nding activity is significantly increased by Mpl ligand.

3 ter activity and eliminates the induction by Mpl ligand.

4 chromatin reorganization, are upregulated by Mpl ligand.

5 glycosylation analogs of rHuEPO, leptin, and Mpl ligand.

6 ets, even after prolonged stimulation with c-Mpl ligand.

7 nd megakaryocytes, which bind and catabolize Mpl ligand.

8 -, maturation-, and ploidy-promoting factor, Mpl ligand.

9 domitosis, similar to changes seen following Mpl ligand administration to normal mice.

10 The Mpl ligands also may be effective in reducing the thromb

11 The cloning of the gene for the endogenous c-mpl ligand, also known as thrombopoietin, was first repo

12 classes (rHuEPO is an N-linked glycoprotein, Mpl ligand an O-linked glycoprotein, and leptin contains

13 g/d produced similar blood concentrations of Mpl-ligand and platelets as 10 times the dose of rHu-MGD

14 reased in vivo activities of thrombopoietin (Mpl ligand) and leptin following carbohydrate addition t

15 The Mpl ligands are a family of closely related hematopoieti

16 Recombinant mpl ligands based on this gene have been extensively eva

17 rol levels in both models, suggesting that c-mpl ligand can directly or indirectly support the mainte

18 Recombinant mpl ligands can substantially reduce the severity and du

19 actor (PEG-rHuMGDF), a truncated polypeptide Mpl-ligand derivitized with poly-(ethylene glycol), indu

20 Although Mpl ligand did not affect the short half-lives of the P2

21 feration- and ploidy-promoting factor, the c-Mpl ligand, display increased activities of the ubiquiti

22 Mpl ligand enhanced levels of P2Y(1) mRNAs in Y10/L8057

23 with kit ligand, flk2/flt3 ligand, GM-CSF, c-mpl ligand, erythropoietin, and IL-15.

24 The effects of thrombopoietin (TPO; c-mpl ligand), FLT3/FLK-2 ligand (FL), and interleukin-6 (

25 34(+) marrow cells); and (4) serum levels of Mpl ligand from 926 +/- 364 pg/mL (endogenous TPO) to pr

26 latelets produced in response to recombinant mpl ligand function appropriately and should not pose an

27 ponse to a single injection of recombinant c-mpl ligand has not been performed.

28 Thrombopoietin (TPO; mpl ligand) has been shown to have dramatic thrombocytop

29 Thrombopoietin (TPO, c-mpl ligand) has emerged as a major hematopoietic cytokin

30 the primary regulator of thrombopoiesis, the Mpl ligand, has led to an explosion of information conce

31 hysiologic regulator of platelet production, Mpl ligand, has recently been cloned and characterized.

32 s of long-term in vivo expression of human c-mpl ligand in a mouse model were examined.

33 The eventual role of Mpl ligand in clinical practice will be determined by th

34 ent of P2Y(1) receptor expression induced by Mpl ligand in megakaryocytes may be an integral feature

35 cycle, it also points to the unique role of Mpl ligand in priming megakaryocytes towards platelet fr

36 el of cyclin D3 protein are increased by the Mpl ligand in the Y10/L8057 megakaryocytic cell line, as

37 This correlates with the finding that Mpl ligand increases GPIIb mRNA in megakaryocytes but no

38 ses cyclin D3 gene expression and suppresses Mpl ligand induction.

39 Injection of Mpl ligand into mice up-regulated P2Y(1) receptor mRNAs

40 The Mpl ligand is a hematopoietic cytokine which exerts its

41 In vivo studies have confirmed that c-mpl ligand is a lineage-dominant cytokine and is the pri

42 bopoietic efficacy of recombinant forms of c-mpl ligand is being actively investigated in preclinical

43 Mpl ligand is the hematopoietic growth factor responsibl

44 Moreover, when recombinant mpl ligand is used in combination with r-metHuG-CSF, bot

45 The clinical utility of recombinant Mpl ligands is currently under intense investigation.

46 Thrombopoietin (TPO), the c-Mpl ligand, is the primary physiologic regulator of mega

47 the effects of a recombinant truncated human Mpl ligand, megakaryocyte growth and development factor

48 The MpL ligand (ML) is a potent stimulus for thrombocytopoie

49 A single dose of Mpl ligand (Mpl-L) given immediately after lethal DNA-da

50 merous studies investigating the action of c-mpl ligand, no reports have defined the in vivo changes

51 s, we cultured mouse fetal livers with the c-Mpl ligand, obtained highly enriched megakaryocyte popul

52 To define the regulatory role of Mpl ligand on platelet production and function we measur

53 complementary and synergistic effect with c-Mpl ligands on thrombopoiesis.

54 ts of recombinant human thrombopoietin (TPO; mpl ligand) on the proliferation of human primitive hema

55 MGDF), a molecule related to thrombopoietin (mpl ligand or TPO) in minimizing the thrombocytopenia as

56 Mpl ligand, thrombopoietin, two recombinant Mpl ligands, recombinant thrombopoietin and pegylated me

57 of TPO in 1994, 2 recombinant forms of the c-Mpl ligand--recombinant human thrombopoietin (rhTPO) and

58 ing chemotherapy in animal models or humans, Mpl ligands reduce the duration and sometimes the degree

59 Thrombopoietin (TPO) is the physiologic Mpl-ligand regulating platelet production.

60 It is possible that NAPs contribute to Mpl ligand's induced effects on hematopoietic cells.

61 xpressing transgenic line maintained human c-mpl ligand serum levels of 3 ng/mL.

62 ving an effect on the megakaryocyte lineage, Mpl ligand supports the growth of stem cells, multipoten

63 topenia was shorter in patients treated with Mpl ligand than in those receiving placebo.

64 In animals deficient in Mpl ligand, the number of megakaryocytes and platelets d

65 lls have previously been shown to respond to Mpl ligand, the pivotal regulator of megakaryocytopoiesi

66 The recently cloned c-mpl ligand, thrombopoietin (Tpo), has been extensively c

67 The endogenous Mpl ligand, thrombopoietin, is produced in the liver and

68 In addition to the endogenous Mpl ligand, thrombopoietin, two recombinant Mpl ligands,

69 Our data point to the potential of Mpl ligand to activate at once several Sp1-dependent gen

70 Mpl ligand treatment results in increased levels of Sp1