ライフサイエンスコーパス: Mullerian duct

1 bud, mesonephric tubules, Wolffian duct, and Mullerian duct.

2 equently the non-cell-autonomous loss of the Mullerian duct.

3 , represses the expression of Hoxa-10 in the Mullerian duct.

4 pothesized to occur at its target organ, the Mullerian duct.

5 receptor for beta-catenin activation in the Mullerian duct.

6 lffian duct does not contribute cells to the Mullerian duct.

7 atenin specifically in the mesenchyme of the Mullerian duct.

8 d for the development and maintenance of the Mullerian duct.

9 anephric tubules and caudal extension of the Mullerian duct.

10 in beta-catenin expression in the embryonic Mullerian duct.

11 Lhx1 is expressed in both the Wolffian and Mullerian ducts.

12 ype I receptor for Amh-induced regression of Mullerian ducts.

13 e the specialized epithelia derived from the mullerian ducts.

14 sufficient MIS was produced to eliminate the MUllerian ducts.

15 allows sexually dimorphic development of the Mullerian ducts.

16 s epithelium of the urogenital sinus or from mullerian ducts.

17 t is still responsible for regression of the Mullerian ducts.

18 development) by the former and the uterus by Mullerian ducts.

19 es that are embryologically derived from the Mullerian ducts.

20 two pairs of genital ducts, the Wolffian and Mullerian ducts.

21 o arise from the coelomic epithelium and the Mullerian ducts.

22 ervix and upper vagina, are derived from the Mullerian ducts, a pair of epithelial tubes that form wi

23 ian duct showed that epithelial cells of the Mullerian duct actively migrate along the anterior-poste

24 Mullerian duct adenocarcinomas, in particular epithelial

25 ession in males causes the regression of the Mullerian ducts, an essential process in male sexual dif

26 enital anomaly of urogenital tract involving Mullerian ducts and mesonephric ducts.

27 ien, Wolffian (mesonephric) ducts instead of Mullerian ducts and sinovaginal bulbs, give rise to the

28 On embryonic day 15.5, mutant Mullerian ducts and Wolffian ducts have elongated but th

29 male reproductive tracts are developed from Mullerian ducts and Wolffian ducts, respectively, involv

30 , including the ureteric bud, Wolffian duct, Mullerian duct, and developing tubules in the mesonephro

31 While estimates of the frequency of mullerian duct anomalies vary widely owing to different

32 Robert's uterus is a very rare mullerian duct anomaly which is characterised by septate

33 iation of uterine tissues from the embryonic Mullerian duct are critical for normal fertility.

34 chanisms that regulate the elongation of the Mullerian duct are currently unclear.

35 sis reveals that the cells of the developing Mullerian duct are mesoepithelial when deposited, and su

36 ule Wnt-7a fail to undergo regression of the Mullerian duct as a result of the absence of the recepto

37 ts of limb patterning defects accompanied by Mullerian duct-associated sterility in both sexes.

38 There is increasing evidence that Mullerian duct cancers may exfoliate cells.

39 MRKH) syndrome is a congenital defect of the Mullerian ducts characterized by uterovaginal agenesis a

40 We show that all Mullerian duct components derive from the coelomic epith

41 ess, white belly spotting, and hypoplasia of Mullerian duct derivatives.

42 of the oviduct and uterus, both of which are Mullerian duct derivatives.

43 phologic features that resemble those of the mullerian duct-derived epithelia of the reproductive tra

44 inclusion cysts in normal ovaries and in the mullerian duct-derived epithelium of normal fallopian tu

45 en exhibit morphologic features of embryonic Mullerian duct-derived tissue lineages and colonize peri

46 In females, Mullerian ducts develop into the oviduct, uterus, cervix

47 ound that HOX genes, which normally regulate mullerian duct differentiation, are not expressed in nor

48 y and could possibly function redundantly in Mullerian duct differentiation.

49 ssion is altered by DES, leading to abnormal Mullerian duct differentiation.

50 (MIS) functions to promote regression of the Mullerian duct during male development.

51 epubertal testes, promotes involution of the mullerian ducts during normal male sexual differentiatio

52 Programmed cell death of the Mullerian duct eliminates the primitive female reproduct

53 In vertebrates, the Mullerian duct elongates along the Wolffian duct, a meso

54 Mullerian duct epithelium led to a block in Mullerian duct elongation and uterine hypoplasia charact

55 However, the precise mechanism of Mullerian duct elongation remains to be elucidated.

56 usly to maintain ductal progenitor cells for Mullerian duct elongation.

57 deciding vaginal epithelial cell fate in the Mullerian duct epithelial cells (MDECs) via direct bindi

58 f the tip of the duct; however, migration of Mullerian duct epithelial cells proximal to the tip rema

59 ranscription factor that is essential in the Mullerian duct epithelial progenitor cells for female re

60 genesis in mesenchymal cells adjacent to the Mullerian duct epithelium and in Sertoli and granulosa c

61 3K/AKT signaling pathway is activated in the Mullerian duct epithelium and is required for elongation

62 Cervicovaginal mesenchyme induced p63 in Mullerian duct epithelium and subsequent squamous differ

63 that Lim1 is required cell autonomously for Mullerian duct epithelium formation.

64 Loss of Lhx1 in the Mullerian duct epithelium led to a block in Mullerian du

65 Thus, p63 is an identity switch for Mullerian duct epithelium to be cervicovaginal versus ut

66 termine the role of Lhx1 specifically in the Mullerian duct epithelium, we performed a Mullerian duct

67 , thereby altering the developmental fate of Mullerian duct epithelium.

68 senchyme that culminates in apoptosis of the Mullerian duct epithelium.

69 Female Mullerian ducts exposed to MIS also exhibited prominent

70 The Mullerian ducts form in a rostral to caudal manner, guid

71 erstanding of the mechanisms contributing to Mullerian duct formation and to the general process of e

72 Recently, several genes required for initial Mullerian duct formation have been identified.

73 a mesonephric structure that is required for Mullerian duct formation.

74 define cellular and molecular mechanisms for Mullerian duct formation.

75 ed to provide information of the dynamics of Mullerian duct formation.

76 As the Mullerian duct forms, its growing tip is intimately asso

77 (didelphic) uterus, representing defects of Mullerian duct fusion.

78 1830, the origin of the cells making up the Mullerian duct has remained controversial.

79 beta family member, causes regression of the Mullerian duct in male embryos.

80 -beta superfamily, induces regression of the Mullerian duct in male embryos.

81 amic morphological changes in the elongating Mullerian duct in rat urogenital ridges in organ culture

82 In addition to causing regression of the Mullerian duct in the male embryo, Mullerian Inhibiting

83 response modifiers, causes regression of the Mullerian ducts in developing male embryos.

84 iological modifier that causes regression of Mullerian ducts in male embryos, is effective as a singl

85 e (AMH) is responsible for regression of the Mullerian ducts in males during embryonic development.

86 ibiting Substance (MIS) causes regression of Mullerian ducts in the mammalian embryo.

87 ian epithelial tumors arise from remnants of mullerian ducts in the vicinity of the ovary therefore m

88 enerally not maintained and extension of the Mullerian duct inhibited.

89 Wnt4 is required for Mullerian duct initiation, whereas Wnt7a is required for

90 ed in the formation and morphogenesis of the Mullerian duct into various parts of the female reproduc

91 r, Wnt-4-mutant females are masculinized-the Mullerian duct is absent while the Wolffian duct continu

92 Lim1 expression in the Mullerian duct is dynamic, corresponding to its formatio

93 The Mullerian duct is known to form by invagination of the c

94 MIS type II receptor in the Mullerian duct is temporally and spatially regulated dur

95 own as Alk3) in the mesenchymal cells of the Mullerian ducts leads to retention of oviducts and uteri

96 gonads to testicular differentiation, causes Mullerian duct (MD) regression.

97 1 (serine threonine kinase 11), in the fetal Mullerian duct mesenchyme (MDM), the caudal remnant of w

98 und that Fzd1 is one receptor present in the Mullerian duct mesenchyme and could be the putative rece

99 conditional deletion of beta-catenin in the Mullerian duct mesenchyme before postnatal differentiati

100 that male-specific Wnt4 expression in mouse Mullerian duct mesenchyme depends upon AMH signaling, im

101 At birth, loss of beta-catenin in the Mullerian duct mesenchyme disrupted the normal coiling o

102 d not affect AMH signaling activation in the Mullerian duct mesenchyme, but did block Mullerian duct

103 ignificantly elevated in male but not female Mullerian duct mesenchyme.

104 bstance (MIS) causes regression of the fetal Mullerian duct on binding a heteromeric complex of types

105 substance (MIS), initiates regression of the Mullerian duct or female reproductive tract anlagen; thi

106 s which involve defects of the limbs and the Mullerian ducts or its derivatives.

107 the uterine cervix is derived from the same Mullerian duct precursor as the epithelium of the ovary,

108 hat precursor cells at the caudal tip of the Mullerian duct proliferate to deposit a cord of cells al

109 We were intrigued that both the limb and the Mullerian duct px phenotypes are similar to those caused

110 Mullerian duct regression can also be inhibited or accel

111 that beta-catenin mediates AMH signaling for Mullerian duct regression during male sexual differentia

112 Smad proteins that are required in vivo for Mullerian duct regression have not yet been identified.

113 Here, we show that apoptosis occurs during Mullerian duct regression in male embryos beginning at E

114 erian-inhibiting substance, which stimulates Mullerian duct regression in males.

115 he coelomic epithelium to the mesenchyme and Mullerian duct regression in organ culture.

116 We chose to examine Mullerian duct regression in the developing reproductive

117 During male gonadal development Mullerian duct regression is mediated by the actions of

118 In addition to its role in causing Mullerian duct regression, Mullerian inhibiting substanc

119 molecular and cellular mechanisms leading to Mullerian duct regression, the present findings provide

120 experiments resulted in partial blockage of Mullerian duct regression.

121 the WNT pathway as a downstream mediator of Mullerian duct regression.

122 the Mullerian duct mesenchyme, but did block Mullerian duct regression.

123 ption, germ cell depletion and inhibition of Mullerian duct regression.

124 ributed to a window of MIS responsiveness in Mullerian duct regression.

125 e mesenchyme, suggesting sequential roles in Mullerian duct regression.

126 e to function as a paracrine death factor in Mullerian duct regression.

127 tivation of MMP2 promoted ligand-independent Mullerian duct regression.

128 Mechanical division of the developing Mullerian duct showed that epithelial cells of the Mulle

129 By using the Mullerian duct-specific anti-Mullerian hormone receptor

130 he Mullerian duct epithelium, we performed a Mullerian duct-specific knockout study using Wnt7a-Cre m

131 also be a contributing factor in persistent Mullerian duct syndrome, a form of male pseudohermaphrod

132 ngenital total lipodystrophy, and persistent mullerian duct syndrome.

133 xpressed by mesenchymal cells underlying the Mullerian duct that are thought to mediate regression of

134 expression, the epithelium of the developing Mullerian duct that gives rise to the oviduct, uterus an

135 nic) and metanephric (adult) kidneys and the Mullerian duct, the anlage of much of the female reprodu

136 e elongation and maintenance of the adjacent Mullerian duct, the anlage of the female reproductive tr

137 e fetal testes and induces regression of the Mullerian ducts, the primordia of the female reproductiv

138 tance (Mis)), which causes regression of the Mullerian ducts, the primordia of the oviducts, uterus a

139 required in both sexes for formation of the Mullerian duct, then Wnt-4 in the developing ovary appea

140 anscript levels, perhaps for influencing non-Mullerian duct tissues.

141 udies indicate that caudal elongation of the Mullerian duct towards the urogenital sinus occurs in pa

142 ate into the mesenchyme surrounding the male Mullerian duct under the influence of MIS.

143 ive from a pair of tubular structures called Mullerian ducts, which are composed of three elements: a