ライフサイエンスコーパス: N termini

1 when tagged at the C termini but not at the N termini.

2 is first to aggregate, followed by the C and N termini.

3 s two potential binding domains at the C and N termini.

4 rchitecture facilitated by their cytoplasmic N termini.

5 d identities ranging from 58 to 72% in their N termini.

6 by a mechanism that depends on their similar N termini.

7 the control of targeting sequences in their N termini.

8 her than to differences in the M1 versus M23 N termini.

9 in the alpha(4), beta(2), and delta subunit N termini.

10 g an antiparallel four-helix bundle at their N termini.

11 g intermolecular bond formation between gp93 N termini.

12 e methylated at conserved positions in their N termini.

13 tones H2A and H4, which have SGGKG and SGRGK N termini.

14 the same face of the complex, near the RAG1 N termini.

15 such preference was found between the C and N termini.

16 rved Pro-Glu and Pro-Pro-Glu motifs in their N termini.

17 gly depends on the substitution at the C and N termini.

18 for substrates with intrinsically disordered N termini.

19 forms a tight dimer through swapping of the N termini.

20 ng (Abeta(1-40)) but can have variable C and N termini.

21 flexible and charged segments of the peptide N termini.

22 nkyrin repeat (AR) domain at their cytosolic N termini.

23 des, and chemoproteomic analysis of cellular N termini.

24 flecting functional regulation through their N termini.

25 ass spectrometry spectra matching to protein N termini.

26 forms, KCC2a and KCC2b, that differ in their N-termini.

27 in osteoclasts are caused by their distinct N-termini.

28 sites, one each on the intracellular C- and N-termini.

29 two distinct imaging reporters at the C- and N-termini.

30 Ks contain three tandem HR1 domains at their N-termini.

31 comes from the interaction of VP4C and VP4B N-termini.

32 in vitro and in vivo through their conserved N-termini.

33 is of two dipeptides derived from the C- and N-termini.

34 to its edge interact primarily through their N-termini.

35 at allow characterization of both the C- and N-termini.

36 ogen of Thr (6) for peptides with acetylated N-termini.

37 orms, E2f3a and E2f3b, which differ in their N-termini.

38 omote the formation of an alpha-helix in the N-termini.

39 between peptide segments attached via their N-termini.

40 twin-arginine signal-like sequences at their N-termini.

41 Mg(2+)-free structures of KRAS with flexible N-termini.

42 iate the effect of modulating the C- and the N-termini.

43 Orb2 has two isoforms that differ in their N-termini.

44 ction between the AR carboxyl (C) and amino (N) termini.

45 Most N termini (77%) were internal neo-N termini (105 were novel potential alternative translat

46 decreased usage of alternative promoters and N-termini, 5'-end variations and mutually-exclusive exon

47 Most N termini (77%) were internal neo-N termini (105 were no

48 ey exhibit different charge density at their N termini (a proposed myosin-binding interface).

49 rise to two protein isoforms with different N termini: AKR1B15.1 is a 316-amino acid protein with 91

50 The adhesion GPCR N termini also contain GPCR proteolytic site motifs that

51 The N termini also promote nuclear localization of CLKs, but

52 M2 domains are centrally located relative to N termini and M1 domains, respectively.

53 chanism for ENaC activation regulated by the N termini and sheds light on a potential general mechani

54 at distinct polycysteine sequences in their N termini and that the polycysteine sequence along with

55 n be subdivided based on their short or long N termini and the presence of the 13-amino acid C-termin

56 e of peptides, including those with expanded N termini and unfitting anchor residues.

57 exing in trans through their membrane-distal N termini and zippering toward their membrane-embedded C

58 terminome of S. cerevisiae, identifying 2190 N-termini and 1562 C-termini.

59 s), a general approach for profiling protein N-termini and identifying protein cleavage sites during

60 "heavy" labeled acetyl groups to block both N-termini and lysine residues of tryptic peptides.

61 CHD5-PHD(1-2) simultaneously engages two H3 N-termini and results in a 4-11-fold increase in affinit

62 rs that were quantitatively labeled at their N-termini and retained their binding characteristics.

63 ent and site-selective way to modify protein N-termini and the unnatural amino acid p-aminophenylalan

64 N',N'',N'''-tetraacetic acid (DOTA) to their N termini, and used optical and positron emission tomogr

65 cluding light, enzymatic processing of their N-termini, and binding of proteins, peptides, or small m

66 tion, producing isoforms with long and short N-termini, and that the distal half of the N-terminus co

67 contain similarly overlooked motifs in their N-termini, and that their C-termini share a previously u

68 However, externalization of VP1 N termini appears to be unaffected by packaged genome le

69 Canonical histone N termini are hotspots of conserved posttranslational mo

70 Their N termini are important for the heterodimer's translocon

71 Hence, STIM N termini are powerful coupling modifiers, functioning i

72 Notably, Ub E2 N termini are serine/threonine rich in many other Ub E2s

73 Effector N termini are thought to contain the signal, but they la

74 Protein amino (N) termini are prone to modifications and are major dete

75 meric GK forms, the conformations of the two N-termini are asymmetric, and the asymmetry is different

76 ive survey showed that in each Bak dimer the N-termini are fully solvent-exposed and mobile, the core

77 The evolutionarily conserved C- and N-termini are involved in these functions independently.

78 Protein N-termini are selectively converted to reactive thiol gr

79 Moreover, 85% of the N-termini are splayed, and the splayed N-terminus can ca

80 h has a cis-configuration between the C- and N-termini around the cyclopentane core.

81 he Mdv1 CC lies parallel to the bilayer with N termini at opposite ends bound to Fis1 and C-terminal

82 The helices are closely associated at their N termini, bend between the 2F5 and 4E10 epitopes, and g

83 Because unprocessed N termini block Patched receptor binding sites in the cl

84 The GATA-1 and GATA-2 N-termini both confer stabilization to their respective

85 TF are isoforms that are identical in their N termini but unique in their C termini due to a -1 ribo

86 minal glycine degrons are depleted at native N-termini but strongly enriched at caspase cleavage site

87 We discovered that it was not the N termini, but the loop2 regions connecting TM2 and TM3

88 urther enzymatic modification of various neo-N termini by arginylation that generates potentially neo

89 disulfide bonds and then join through their N termini by further disulfide bonding.

90 monomers of different chains binding its own N termini by self-association to the active site, but a

91 The LC of a mAb product was truncated at its N termini by two amino acid residues at approximately 3-

92 y reduced with the proteolysis at the C- and N- termini by recombinant pig MMP-20 (rpMMP20) and recom

93 ht protein isoforms (Fgf8a-h) with different N-termini by alternative splicing.

94 which self-activate after cleavage of their N-termini by mainly serine proteases.

95 studies have demonstrated that adhesion GPCR N termini can bind to multiple ligands, which may differ

96 ge cavity along the fibril axis and that the N-termini can assist in the stabilization of the fibril

97 r initial ligation strategy targeted a C --> N termini condensation between glycopeptide 3 and peptid

98 Adhesion GPCRs possess large N termini containing various functional domains.

99 They depend on their fatty-acylated N-termini, containing N-myristate and either a polybasic

100 quencing definitively revealed peptides with N termini corresponding to full-length, (des-Leu)-trunca

101 There is also increasing evidence that N-termini could act as important protein stability deter

102 protein where the intersection of two helix N-termini creates a region with a strong, localized posi

103 Quantitative mapping of N-termini demonstrated perturbation of protease action d

104 iced to generate two proteins with different N termini, designated as MeCP2-e1 and MeCP2-e2.

105 d lack information about the receptor distal N-termini, despite the importance of the latter in signa

106 tion of the transmembrane helices near their N termini, dimerization of the juxtamembrane segments, a

107 sins, and alpha-defensin variants with novel N termini due to alternative processing were identified

108 s that are homologous to GPA1, whereas their N-termini each contain a cysteine-rich region and a puta

109 nel rapidly inactivates when one of its four N-termini enters and occludes the channel pore.

110 y anchored to Golgi membranes, whereas their N termini extend into the cytoplasm to initiate vesicle

111 Removal of the N-termini extensively increased the right-handed conform

112 Unlike in the known rhodopsins, in HeRs the N termini face the cytoplasm.

113 Pairing is mediated by the septin N-termini face, and may occur symmetrically or staggered

114 inner mitochondrial membrane with the C and N termini facing the intermembrane space.

115 ons and are characterized by extremely large N termini featuring various adhesion domains capable of

116 revealed that portions of both Hec1 and Nuf2 N termini fold into calponin homology (CH) domains, whic

117 ions that first lead to the extrusion of VP1 N termini, followed by genome exposure.

118 zyme to selectively biotinylate free protein N termini for positive enrichment of corresponding N-ter

119 ontrast, in Abeta11-40/42 conformations, the N-termini formed more contacts and were less accessible

120 the expression of proteins encoding distinct N termini from a single gene.

121 n (MBP)-NDM-1 fusion proteins with different N-termini (full-length, Delta6, Delta21, and Delta36).

122 Substitution of the N termini had no effect.

123 EL1 isoforms (A, B, C, and D) have identical N termini harboring the Rab-like GTPase domains but cont

124 sive characterization of chloroplast protein N termini in Arabidopsis (Arabidopsis thaliana) using te

125 highlighted a critical role for their unique N termini in defining PP1alpha and PP1beta functions in

126 From ab initio folding simulations of the N termini in the presence and absence of phosphatidylino

127 The N-termini in these three structures display a novel conf

128 EED, also interact with histone H3 via their N termini, indicating that the interaction of ESC with h

129 slocon association, with Pam18's and Pam16's N termini interacting in the intermembrane space and the

130 ned covalently attached to the resin via the N-termini ("inverted" peptides).

131 K dimer, the conformational asymmetry of the N-termini is retained.

132 Glu-, Met-Asp-, and Met-Asn-starting protein N termini, is presumed to Nt-acetylate 15% of all yeast

133 silica surfaces by ion pairing of protonated N-termini, Lys side chains, and Arg side chains with neg

134 As with CK, the GK N-termini mediate the dimer interface.

135 the identification and enrichment of protein N-termini not accessible in GluC- or trypsin-digested sa

136 e relationship between the nature of protein N-termini, Nt-processing events and proteolysis in plant

137 ulting in two viral proteins, V and P, whose N termini of 164 amino acid residues are identical.

138 tated the five Cys residues in the identical N termini of 6K and TF, the four additional Cys residues

139 NatA co-translationally acetylates the N termini of a wide variety of nascent polypeptides.

140 We find that expression of the N termini of all four WNKs results in modest to strong a

141 hose with active-site Cys thiols residing at N termini of alpha-helices or within catalytic loops wer

142 e particle (CP) is blocked by the convergent N termini of alpha-subunits.

143 kin-17A (IL17A) was genetically fused to the N termini of an anti-IL22 antibody, through either the l

144 NRBF2 interacts primarily with the N termini of ATG14 and BECN1.

145 es to show that AtVAP27-1 interacts with the N termini of AtSEIPIN2 and AtSEIPIN3 and likely supports

146 esis elaborated PIP(2) interactions with the N termini of beta- (K(d) ~5.2 mum) and gamma-ENaC (K(d)

147 rase) proteins revealed that the cytoplasmic N termini of both DAT and synaptogyrin-3 are sufficient

148 We found that the N termini of both GSK-3 isoforms were dispensable, where

149 d sequons except for the site closest to the N termini of both proteins.

150 Here, we report that the N termini of both the transmembrane (including S0) and c

151 The N termini of bound peptides most probably bind first in

152 The N termini of CC chemokines are shown to be involved in r

153 -Leu)-truncated, and (des-Leu-Arg)-truncated N termini of Crps 1-4 and 6.

154 etes with homotypic interactions between the N termini of different HttEx1Qn molecules that trigger t

155 ween HMG2L1 and myocardin were mapped to the N termini of each of the proteins.

156 Differences between the N termini of Ets1 and Ets2, rather than differences in t

157 usively show that sequence divergence at the N termini of FGFs is the primary regulator of the recept

158 combinant FWPVs expressing EGFP fused to the N termini of FWPV structural proteins Fpv140, Fpv168, Fp

159 onserved motifs-motifs I, II, and III-in the N termini of geminivirus Rep proteins are essential for

160 e at the interface between the extracellular N termini of GluN1 and GluN2B subunits, supporting the v

161 Thus, the N termini of H3/H4 tetramers are required for efficient

162 NatD, was previously shown to acetylate the N termini of histones H2A and H4, which have SGGKG and S

163 The N termini of insect and vertebrate Pumilio and Fem-3 bin

164 Consequently, N termini of mature chloroplast proteins cannot be accur

165 cting protein (KChIP) family bind the distal N termini of members of the Shal subfamily of voltage-ga

166 iously uncharacterized structures within the N termini of MKK4/5.

167 The N termini of MTBP and Sld7 share an essential origin fir

168 We find that B9D1, AHI1, and the N termini of NPHP4 and NPHP5 interact with the transmemb

169 of a network of E1B-55K dimers bound to the N termini of p53 tetramers.

170 is a protein domain frequently found at the N termini of proteins encoded by mammalian tandem zinc f

171 UBE2W ubiquitinates N termini of proteins rather than internal lysine residu

172 g a strategy specifically designed to enrich N termini of proteins, we demonstrate that many human pr

173 urea solution can cause carbamylation at the N termini of proteins/peptides and at the side chain ami

174 arrangement of DNA and protein subunits, the N termini of RAG1 and RAG2 are positioned at opposing en

175 Both glutamine and glutamate at the N termini of recombinant monoclonal antibodies can cycli

176 RimL, which acetylate, correspondingly, the N termini of ribosomal proteins S18, S5, and L12.

177 The N termini of several needle proteins were truncated and

178 Importantly, our studies highlight that the N termini of SLN and PLB influence their respective uniq

179 In this study, we demonstrated that the N termini of some needle proteins, particularly the N te

180 The N termini of some RGS4-family proteins provide receptor

181 The N termini of STC1 and TPS26 are predicted to encode plas

182 ase RNA molecules (pRNA) positioned near the N termini of subunits of the dodecameric head-tail conne

183 dues Tyr(240) and Tyr(274) binding the C and N termini of the B and C helices of IFN-beta, respective

184 cluding two highly flexible regions) and the N termini of the beta-chain, confirm these models with k

185 in blocks the catalytic pocket, close to the N termini of the beta5 proteasome subunit, more efficien

186 ee icosahedrally related His residues in the N termini of the C subunit at the quasi-6-fold axes.

187 The N termini of the capsid proteins VP1 and VP2 of adeno-as

188 matching of the anionic RNA and the cationic N termini of the CP).

189 center-to-center distance (54 A) between two N termini of the dimer, and a large flexible ligand-bind

190 from degrading and allows two structure-free N termini of the dimerized ORF57 to work coordinately fo

191 less ordered 3' arm reaches toward the C and N termini of the enzyme, which are binding sites for T4

192 e capsid shell via 5 asymmetrically arranged N termini of the inner capsid shell protein VP3A around

193 to five-layered beta-sheets with alternating N termini of the monomers perpendicular to the fibril ax

194 brane into the peripheral stalk and that the N termini of the other supernumerary subunits are on the

195 in preferred contexts that could extend the N termini of the predicted polypeptides.

196 nusual HTH-DNA interaction mode in which the N termini of the recognition helices insert into a singl

197 h, encompassing the two wing regions and the N termini of the recognition helices, mediates DNA bindi

198 ariety of experimental approaches placed the N termini of the ssSPTs in the cytosol, their C termini

199 The data show that the N termini of the subunits form an alpha-helical coiled-c

200 g site within the beta annulus formed by the N termini of the three C subunits at the icosahedral 3-f

201 In ligand-free dimers, by holding apart the N termini of the transmembrane helices, the extracellula

202 aratus, and has a preference for acetylating N termini of the transmembrane proteins.

203 The N termini of the WNKs also have the capacity to interact

204 domains, and recently it was shown that the N termini of these proteins form a tubulin-binding modul

205 fine the specificity of the highly conserved N termini of three short, non-muscle TMs (alpha, gamma,

206 dynamic and transiently displays the buried N termini of viral protein 1 (VP1) and VP4.

207 metry axis and included those connecting the N termini of VP1 and VP4 with other regions, in particul

208 39 to 55 of VP1, was utilized to locate the N termini of VP1 in native (160S) particles in this "bre

209 Furthermore, there is evidence that the N termini of VP4 are interacting with each other upon ex

210 encher (Dabcyl) pair was added to the C- and N-termini of a support-bound peptide.

211 In this study we establish that N-termini of amino acid transporters can also determine

212 Our findings suggest a possible role for the N-termini of ASPP proteins in binding to other proteins

213 The N-termini of bacterial lipoproteins are acylated with a

214 The C- and N-termini of BamA fold into trans-membrane beta-barrel a

215 s (including complex peptide thio acids with N-termini of complex peptides) has thus been realized.

216 atC), which co-translationally acetylate the N-termini of eukaryotic proteins.

217 that DHX34 induces extensive changes in the N-termini of every RUVBL2 subunit in the complex, stabil

218 ings will provide evidence for targeting the N-termini of FSGS ACTN4 mutants to downregulate their ac

219 variant residue pairs within the DNA binding N-termini of helices alpha2 and alpha3; and gamma/delta'

220 We have studied the role of the N-termini of histones H3/H4 in the regulation of the con

221 The N-termini of major UNC-13/Munc13 isoforms contain a non-

222 ient protein, and revealed that the flexible N-termini of mTXNPx form a well-resolved central belt th

223 LLxxEx (MADA motif) that is conserved at the N-termini of NRC family proteins and ~20% of coiled-coil

224 ates that Capu-NT is a dimer, similar to the N-termini of other formins.

225 ed that, despite their high variability, the N-termini of P/V might all be homologous; however, using

226 ation attaches a fixed charge group onto the N-termini of peptides, and the enzymatic digestion after

227 f a wide variety of functional groups at the N-termini of poly-beta-peptide chains.

228 quential removal of dipeptides from the free N-termini of proteins and peptides.

229 pass alternative 5'-untranslated regions and N-termini of proteins evolve under strong nucleotide-lev

230 N-CLAP peptides, which are derived from the N-termini of proteins, including the N-termini of the ne

231 d induced conformational change bringing the N-termini of RAR and RXR closer together.

232 N-termini of several proteases were downregulated in prt

233 have previously demonstrated that the C- and N-termini of SK2 channels interact with the actin-bindin

234 syntaxin induced a close association of the N-termini of SN1 and SN2.

235 aminopeptidase DPP9 removes dipeptides from N-termini of substrates having a proline or alanine in s

236 figurations/orientation, especially when the N-termini of Sx1A-Sb2 are left to interact freely.

237 scent dyes or other functional groups to the N-termini of synthetic peptides prior to cleavage and de

238 The N-termini of the CPs form a contiguous network that inte

239 DPP4 cleaved within the N-termini of the CSFs granulocyte-macrophage (GM)-CSF, G

240 bin cleaves fibrinopeptides A and B from the N-termini of the fibrinogen Aalpha and Bbeta chains.

241 terial enzyme, OpeRATOR, and released at the N-termini of the Gal((13)C(6))-Tn-occupied Ser/Thr resid

242 xylosone modifies various amines (e.g., the N-termini of the heavy and light chains and susceptible

243 displayed different susceptibilities of the N-termini of the light chain, heavy chain, or both.

244 rom the N-termini of proteins, including the N-termini of the newly formed polypeptide products of pr

245 ide chains emerging from a 5-fold hub to the N-termini of their corresponding principal domains, clus

246 The N-termini of two gA peptides were linked to various mole

247 The N-termini of two proteins, Mpc54p and Spo21p, were orien

248 Finally, intertwining of the N-termini of two-fold symmetry-related VP4A capsid prote

249 e was required for interactions with histone N termini or for yFACT-mediated nucleosome reorganizatio

250 in the identification of 1672 unique protein N-termini or proteolytic cleavage sites from 690 unique

251 e SGK1 mRNA produces isoforms with different N-termini owing to alternative translation initiation.

252 se that hkNBCe1 (and other SLC4) cytoplasmic N termini play roles in controlling HCO(3)(-) permeation

253 pies of VP2, arranged with their hydrophobic N termini pointing away from the virion surface.

254 er, both proteins appear to target chemokine N termini, presumably because these domains are key to r

255 t reveals how conformational changes in CCL3 N termini profoundly alter its surface properties and di

256 d structure of intermediate oligomers in the N-termini relative to well-developed fibrils provides a

257 H3 and H4 that were either acetylated or the N-termini removed, it was also determined that the N-ter

258 GPCRs have revealed that truncations of the N termini result in constitutively active receptors, sug

259 Further truncation of the N-termini resulted in a pFNRII protein which failed to b

260 The positively charged N-termini serve as a primary point of interaction.

261 observe over enrichment of SSRs near protein N-termini significantly beyond expectation based on stru

262 o, NatB was seen to preferentially acetylate N termini starting with the initiator Met followed by ac

263 proteins with buried or sterically hindered N termini, such as virus-like particles (VLPs) composed

264 menon, its location, and features of protein N termini suggested the involvement of ribosome-associat

265 PCDH21 and PCDH24 contain similarly charged N termini, suggesting that a subset of cadherins share a

266 demethylase (AcCYP51)] formed a dimer via an N-termini swap, whereas drug-bound AcCYP51 was monomeric

267 AcCYP51 dimerized head-to-head via N-termini swapping, resulting in formation of a nonplana

268 hich are 4 and 13 amino acids shorter in the N termini than canonical PGC-1alpha and NT-PGC-1alpha, r

269 gomers had more flexible and solvent-exposed N-termini than Abeta1-40 oligomers.

270 nificantly more flexible and solvent-exposed N-termini than Abeta1-40/42 conformations.

271 The CLKs have disordered N termini that bind tightly to RS domains, enhancing SR

272 V)1.2 channels containing e1b or e1c-encoded N termini that contribute to Ca(V)1.2 surface expression

273 All three glycoproteins have identical N termini that include the receptor-binding region (RBR)

274 by an unusual transmembrane domain at their N termini that modulates Kv4 channel gating and traffick

275 STIM proteins contain an EF-hand in their N-termini that faces the lumen side of the ER allowing t

276 3, exCNLs have substantially elongated their N-termini through tandem duplications of exon segments.

277 tion, mapping, and quantification of protein N-termini to comprehensively characterize cleaved podocy

278 his nucleus toward both termini and from the N-termini to the C-termini of several beta-strands is be

279 ation which converts basic amine sites (Lys, N-termini) to less basic amides for enhanced analysis in

280 REs can assemble in multiple stages from the N-termini toward the C-termini.

281 igh HSC/HSP70 binding scores and hydrophobic N-termini, two characteristics that were previously obse

282 orporation of a Ca(2+) cation, attaching the N termini under the icosahedral fivefold symmetry axis,

283 ttranslational modifications on human CENP-A N termini using high-resolution MS: trimethylation of Gl

284 We now compared the N-termini using sensitive sequence similarity search pro

285 ted into peptides with sterically accessible N-termini using specially adapted conditions of solid-ph

286 peptides with a removable Fmoc or acetylated N-termini via their C-termini to produce active peptide

287 eins accumulated with two or three different N termini; we evaluated the significance of these differ

288 cated at D431 and L39, and the resulting new N termini were N-myristoylated and N-acetylated, respect

289 sed from the acid-labile resin, their C- and N-termini were intramolecularly coupled in solution to a

290 ended with glycosidic groups at its multiple N-termini were investigated for binding to the Pseudomon

291 , and, after proteolysis of externalized VP2 N termini, were unable to protect the VP1 domain, which

292 PDE11A1, which contain progressively shorter N-termini, were more sensitive than PDE11A4 to inhibitio

293 rotein conformation surrounding their buried N termini where a beta-strand distortion results in a so

294 estingly, these substrates included Met-Gln- N-termini, which are thus now classified as in vivo NatB

295 We tag Sb2 protein at C- and N termini with a pair of fluorophores, which allows us t

296 bound peptides, selectively labeled at their N-termini with a positive charge-bearing group, are subj

297 gy for the selective modification of protein N-termini with mass boosters.

298 estigated, through derivatization of peptide N-termini with various reagents containing one or more c

299 y identical proteins differing only at their N termini, with P58 extending MP upstream by 102 amino a

300 37 degrees C continue to sequester their VP1 N termini within the intact capsid, suggesting that thes