ライフサイエンスコーパス: N termini

1 is first to aggregate, followed by the C and N termini.

2 s two potential binding domains at the C and N termini.

3 rchitecture facilitated by their cytoplasmic N termini.

4 d identities ranging from 58 to 72% in their N termini.

5 by a mechanism that depends on their similar N termini.

6 the control of targeting sequences in their N termini.

7 her than to differences in the M1 versus M23 N termini.

8 in the alpha(4), beta(2), and delta subunit N termini.

9 g an antiparallel four-helix bundle at their N termini.

10 g intermolecular bond formation between gp93 N termini.

11 e methylated at conserved positions in their N termini.

12 gly depends on the substitution at the C and N termini.

13 tones H2A and H4, which have SGGKG and SGRGK N termini.

14 the same face of the complex, near the RAG1 N termini.

15 for substrates with intrinsically disordered N termini.

16 such preference was found between the C and N termini.

17 tion signals that are often located at their N termini.

18 forms a tight dimer through swapping of the N termini.

19 ng (Abeta(1-40)) but can have variable C and N termini.

20 flexible and charged segments of the peptide N termini.

21 nkyrin repeat (AR) domain at their cytosolic N termini.

22 flecting functional regulation through their N termini.

23 ass spectrometry spectra matching to protein N termini.

24 when tagged at the C termini but not at the N termini.

25 iate the effect of modulating the C- and the N-termini.

26 two distinct imaging reporters at the C- and N-termini.

27 Ks contain three tandem HR1 domains at their N-termini.

28 in vitro and in vivo through their conserved N-termini.

29 Orb2 has two isoforms that differ in their N-termini.

30 is of two dipeptides derived from the C- and N-termini.

31 to its edge interact primarily through their N-termini.

32 at allow characterization of both the C- and N-termini.

33 ogen of Thr (6) for peptides with acetylated N-termini.

34 orms, E2f3a and E2f3b, which differ in their N-termini.

35 omote the formation of an alpha-helix in the N-termini.

36 between peptide segments attached via their N-termini.

37 twin-arginine signal-like sequences at their N-termini.

38 P-43, which bind to rafts via their acylated N-termini.

39 ly identified, being primarily acetylated at N-termini.

40 tacting the centromeric DNA and unstructured N-termini.

41 e cell membrane and co-localization with its N-termini.

42 forms, KCC2a and KCC2b, that differ in their N-termini.

43 in osteoclasts are caused by their distinct N-termini.

44 sites, one each on the intracellular C- and N-termini.

45 ction between the AR carboxyl (C) and amino (N) termini.

46 Most N termini (77%) were internal neo-N termini (105 were novel potential alternative translat

47 decreased usage of alternative promoters and N-termini, 5'-end variations and mutually-exclusive exon

48 Most N termini (77%) were internal neo-N termini (105 were no

49 ey exhibit different charge density at their N termini (a proposed myosin-binding interface).

50 rise to two protein isoforms with different N termini: AKR1B15.1 is a 316-amino acid protein with 91

51 The adhesion GPCR N termini also contain GPCR proteolytic site motifs that

52 M2 domains are centrally located relative to N termini and M1 domains, respectively.

53 chanism for ENaC activation regulated by the N termini and sheds light on a potential general mechani

54 at distinct polycysteine sequences in their N termini and that the polycysteine sequence along with

55 n be subdivided based on their short or long N termini and the presence of the 13-amino acid C-termin

56 e of peptides, including those with expanded N termini and unfitting anchor residues.

57 exing in trans through their membrane-distal N termini and zippering toward their membrane-embedded C

58 s), a general approach for profiling protein N-termini and identifying protein cleavage sites during

59 "heavy" labeled acetyl groups to block both N-termini and lysine residues of tryptic peptides.

60 CHD5-PHD(1-2) simultaneously engages two H3 N-termini and results in a 4-11-fold increase in affinit

61 entical except for their unique, cytoplasmic N termini, and they readily co-assemble in heterologous

62 N',N'',N'''-tetraacetic acid (DOTA) to their N termini, and used optical and positron emission tomogr

63 cluding light, enzymatic processing of their N-termini, and binding of proteins, peptides, or small m

64 tion, producing isoforms with long and short N-termini, and that the distal half of the N-terminus co

65 contain similarly overlooked motifs in their N-termini, and that their C-termini share a previously u

66 However, externalization of VP1 N termini appears to be unaffected by packaged genome le

67 Canonical histone N termini are hotspots of conserved posttranslational mo

68 Their N termini are important for the heterodimer's translocon

69 fter treatment with DTT, suggesting that the N termini are linked by interchain disulfide bonds and a

70 Hence, STIM N termini are powerful coupling modifiers, functioning i

71 Notably, Ub E2 N termini are serine/threonine rich in many other Ub E2s

72 Effector N termini are thought to contain the signal, but they la

73 Protein amino (N) termini are prone to modifications and are major dete

74 meric GK forms, the conformations of the two N-termini are asymmetric, and the asymmetry is different

75 r Prohead II and immature EI-III states, the N-termini are found to make transient interactions with

76 ive survey showed that in each Bak dimer the N-termini are fully solvent-exposed and mobile, the core

77 The evolutionarily conserved C- and N-termini are involved in these functions independently.

78 Protein N-termini are selectively converted to reactive thiol gr

79 Moreover, 85% of the N-termini are splayed, and the splayed N-terminus can ca

80 idues in IL-8 (H18 and F21) and the receptor N-termini as the major structural determinants regulatin

81 he Mdv1 CC lies parallel to the bilayer with N termini at opposite ends bound to Fis1 and C-terminal

82 The helices are closely associated at their N termini, bend between the 2F5 and 4E10 epitopes, and g

83 Because unprocessed N termini block Patched receptor binding sites in the cl

84 The GATA-1 and GATA-2 N-termini both confer stabilization to their respective

85 TF are isoforms that are identical in their N termini but unique in their C termini due to a -1 ribo

86 We discovered that it was not the N termini, but the loop2 regions connecting TM2 and TM3

87 disulfide bonds and then join through their N termini by further disulfide bonding.

88 plying that modification of histone H3 or H4 N termini by Gcn5p, Esa1p, Rpd3p, and Set1p, but not by

89 monomers of different chains binding its own N termini by self-association to the active site, but a

90 The LC of a mAb product was truncated at its N termini by two amino acid residues at approximately 3-

91 y reduced with the proteolysis at the C- and N- termini by recombinant pig MMP-20 (rpMMP20) and recom

92 ht protein isoforms (Fgf8a-h) with different N-termini by alternative splicing.

93 which self-activate after cleavage of their N-termini by mainly serine proteases.

94 studies have demonstrated that adhesion GPCR N termini can bind to multiple ligands, which may differ

95 ge cavity along the fibril axis and that the N-termini can assist in the stabilization of the fibril

96 r initial ligation strategy targeted a C --> N termini condensation between glycopeptide 3 and peptid

97 Adhesion GPCRs possess large N termini containing various functional domains.

98 They depend on their fatty-acylated N-termini, containing N-myristate and either a polybasic

99 quencing definitively revealed peptides with N termini corresponding to full-length, (des-Leu)-trunca

100 There is also increasing evidence that N-termini could act as important protein stability deter

101 protein where the intersection of two helix N-termini creates a region with a strong, localized posi

102 Quantitative mapping of N-termini demonstrated perturbation of protease action d

103 iced to generate two proteins with different N termini, designated as MeCP2-e1 and MeCP2-e2.

104 tion of the transmembrane helices near their N termini, dimerization of the juxtamembrane segments, a

105 nge upon depolarization, indicating that the N termini do not rearrange relative to each other, but t

106 sins, and alpha-defensin variants with novel N termini due to alternative processing were identified

107 s that are homologous to GPA1, whereas their N-termini each contain a cysteine-rich region and a puta

108 Removal of the N-termini extensively increased the right-handed conform

109 inner mitochondrial membrane with the C and N termini facing the intermembrane space.

110 ons and are characterized by extremely large N termini featuring various adhesion domains capable of

111 revealed that portions of both Hec1 and Nuf2 N termini fold into calponin homology (CH) domains, whic

112 ions that first lead to the extrusion of VP1 N termini, followed by genome exposure.

113 zyme to selectively biotinylate free protein N termini for positive enrichment of corresponding N-ter

114 One model proposes that the extreme N-termini form a cluster of amphipathic helices that ser

115 ontrast, in Abeta11-40/42 conformations, the N-termini formed more contacts and were less accessible

116 the expression of proteins encoding distinct N termini from a single gene.

117 n (MBP)-NDM-1 fusion proteins with different N-termini (full-length, Delta6, Delta21, and Delta36).

118 Substitution of the N termini had no effect.

119 stones in which key lysine residues in their N-termini had been mutated to arginine.

120 EL1 isoforms (A, B, C, and D) have identical N termini harboring the Rab-like GTPase domains but cont

121 sive characterization of chloroplast protein N termini in Arabidopsis (Arabidopsis thaliana) using te

122 highlighted a critical role for their unique N termini in defining PP1alpha and PP1beta functions in

123 From ab initio folding simulations of the N termini in the presence and absence of phosphatidylino

124 r capsid surface, while at least a subset of N-termini in EI-III becomes more flexible with time.

125 The N-termini in these three structures display a novel conf

126 ndent enzyme, deacetylates histone H3 and H4 N termini, in particular histone H4 K16, enabling more S

127 EED, also interact with histone H3 via their N termini, indicating that the interaction of ESC with h

128 slocon association, with Pam18's and Pam16's N termini interacting in the intermembrane space and the

129 ned covalently attached to the resin via the N-termini ("inverted" peptides).

130 K dimer, the conformational asymmetry of the N-termini is retained.

131 Glu-, Met-Asp-, and Met-Asn-starting protein N termini, is presumed to Nt-acetylate 15% of all yeast

132 silica surfaces by ion pairing of protonated N-termini, Lys side chains, and Arg side chains with neg

133 As with CK, the GK N-termini mediate the dimer interface.

134 e relationship between the nature of protein N-termini, Nt-processing events and proteolysis in plant

135 ulting in two viral proteins, V and P, whose N termini of 164 amino acid residues are identical.

136 tated the five Cys residues in the identical N termini of 6K and TF, the four additional Cys residues

137 NatA co-translationally acetylates the N termini of a wide variety of nascent polypeptides.

138 We find that expression of the N termini of all four WNKs results in modest to strong a

139 hose with active-site Cys thiols residing at N termini of alpha-helices or within catalytic loops wer

140 e particle (CP) is blocked by the convergent N termini of alpha-subunits.

141 kin-17A (IL17A) was genetically fused to the N termini of an anti-IL22 antibody, through either the l

142 NRBF2 interacts primarily with the N termini of ATG14 and BECN1.

143 rase) proteins revealed that the cytoplasmic N termini of both DAT and synaptogyrin-3 are sufficient

144 We found that the N termini of both GSK-3 isoforms were dispensable, where

145 Here, we report that the N termini of both the transmembrane (including S0) and c

146 The N termini of CC chemokines are shown to be involved in r

147 -Leu)-truncated, and (des-Leu-Arg)-truncated N termini of Crps 1-4 and 6.

148 etes with homotypic interactions between the N termini of different HttEx1Qn molecules that trigger t

149 ween HMG2L1 and myocardin were mapped to the N termini of each of the proteins.

150 Differences between the N termini of Ets1 and Ets2, rather than differences in t

151 usively show that sequence divergence at the N termini of FGFs is the primary regulator of the recept

152 combinant FWPVs expressing EGFP fused to the N termini of FWPV structural proteins Fpv140, Fpv168, Fp

153 Surprisingly, the isolated N termini of G14alpha and G16alpha expressed as peptides

154 onserved motifs-motifs I, II, and III-in the N termini of geminivirus Rep proteins are essential for

155 e at the interface between the extracellular N termini of GluN1 and GluN2B subunits, supporting the v

156 er, the resulting polypeptide defined by the N termini of GN and GC is predicted to be larger (58 kDa

157 -1 and a SKI-1-like protease to generate the N termini of GN and GC, respectively.

158 evidence indicating an essential role of the N termini of GPCRs in the export from distinct intracell

159 Thus, the N termini of H3/H4 tetramers are required for efficient

160 NatD, was previously shown to acetylate the N termini of histones H2A and H4, which have SGGKG and S

161 Therefore, we conclude that the N termini of human hACV and hACVI are necessary for inte

162 The N termini of insect and vertebrate Pumilio and Fem-3 bin

163 We found that Galpha(q) interacted with N termini of Kir3.1, Kir3.2, and Kir3.4.

164 Consequently, N termini of mature chloroplast proteins cannot be accur

165 cting protein (KChIP) family bind the distal N termini of members of the Shal subfamily of voltage-ga

166 iously uncharacterized structures within the N termini of MKK4/5.

167 We find that B9D1, AHI1, and the N termini of NPHP4 and NPHP5 interact with the transmemb

168 of a network of E1B-55K dimers bound to the N termini of p53 tetramers.

169 is a protein domain frequently found at the N termini of proteins encoded by mammalian tandem zinc f

170 UBE2W ubiquitinates N termini of proteins rather than internal lysine residu

171 g a strategy specifically designed to enrich N termini of proteins, we demonstrate that many human pr

172 urea solution can cause carbamylation at the N termini of proteins/peptides and at the side chain ami

173 arrangement of DNA and protein subunits, the N termini of RAG1 and RAG2 are positioned at opposing en

174 Both glutamine and glutamate at the N termini of recombinant monoclonal antibodies can cycli

175 RimL, which acetylate, correspondingly, the N termini of ribosomal proteins S18, S5, and L12.

176 The N termini of several needle proteins were truncated and

177 Importantly, our studies highlight that the N termini of SLN and PLB influence their respective uniq

178 In this study, we demonstrated that the N termini of some needle proteins, particularly the N te

179 The N termini of some RGS4-family proteins provide receptor

180 The N termini of STC1 and TPS26 are predicted to encode plas

181 ase RNA molecules (pRNA) positioned near the N termini of subunits of the dodecameric head-tail conne

182 dues Tyr(240) and Tyr(274) binding the C and N termini of the B and C helices of IFN-beta, respective

183 in blocks the catalytic pocket, close to the N termini of the beta5 proteasome subunit, more efficien

184 ee icosahedrally related His residues in the N termini of the C subunit at the quasi-6-fold axes.

185 The N termini of the capsid proteins VP1 and VP2 of adeno-as

186 matching of the anionic RNA and the cationic N termini of the CP).

187 , the ends of the genes corresponding to the N termini of the cyan or yellow fluorescent proteins wer

188 center-to-center distance (54 A) between two N termini of the dimer, and a large flexible ligand-bind

189 from degrading and allows two structure-free N termini of the dimerized ORF57 to work coordinately fo

190 less ordered 3' arm reaches toward the C and N termini of the enzyme, which are binding sites for T4

191 was detected only in constructs in which the N termini of the mature envelope proteins were missing.

192 to five-layered beta-sheets with alternating N termini of the monomers perpendicular to the fibril ax

193 brane into the peripheral stalk and that the N termini of the other supernumerary subunits are on the

194 in preferred contexts that could extend the N termini of the predicted polypeptides.

195 These results demonstrate that the different N termini of the predominant endogenous forms of PSD-95

196 nusual HTH-DNA interaction mode in which the N termini of the recognition helices insert into a singl

197 h, encompassing the two wing regions and the N termini of the recognition helices, mediates DNA bindi

198 ILYPR, respectively), located near the C and N termini of the respective proteins.

199 ariety of experimental approaches placed the N termini of the ssSPTs in the cytosol, their C termini

200 The data show that the N termini of the subunits form an alpha-helical coiled-c

201 g site within the beta annulus formed by the N termini of the three C subunits at the icosahedral 3-f

202 In ligand-free dimers, by holding apart the N termini of the transmembrane helices, the extracellula

203 aratus, and has a preference for acetylating N termini of the transmembrane proteins.

204 The N termini of the WNKs also have the capacity to interact

205 The N termini of these ATPases consist of six metal binding

206 domains, and recently it was shown that the N termini of these proteins form a tubulin-binding modul

207 fine the specificity of the highly conserved N termini of three short, non-muscle TMs (alpha, gamma,

208 dynamic and transiently displays the buried N termini of viral protein 1 (VP1) and VP4.

209 metry axis and included those connecting the N termini of VP1 and VP4 with other regions, in particul

210 39 to 55 of VP1, was utilized to locate the N termini of VP1 in native (160S) particles in this "bre

211 Furthermore, there is evidence that the N termini of VP4 are interacting with each other upon ex

212 encher (Dabcyl) pair was added to the C- and N-termini of a support-bound peptide.

213 In this study we establish that N-termini of amino acid transporters can also determine

214 Our findings suggest a possible role for the N-termini of ASPP proteins in binding to other proteins

215 The N-termini of bacterial lipoproteins are acylated with a

216 The C- and N-termini of BamA fold into trans-membrane beta-barrel a

217 central E region preferentially through its N-termini of Bbeta chains and that removal of fibrinopep

218 s (including complex peptide thio acids with N-termini of complex peptides) has thus been realized.

219 methylation of lysines and arginines in the N-termini of H3, H3.3, and H4.

220 We have studied the role of the N-termini of histones H3/H4 in the regulation of the con

221 The N-termini of major UNC-13/Munc13 isoforms contain a non-

222 Although the interaction between the N-termini of mdm2 and p53 blocks the transactivation act

223 ates that Capu-NT is a dimer, similar to the N-termini of other formins.

224 ed that, despite their high variability, the N-termini of P/V might all be homologous; however, using

225 main oligomerization contacts are within the N-termini of PDE isozymes.

226 ation attaches a fixed charge group onto the N-termini of peptides, and the enzymatic digestion after

227 f a wide variety of functional groups at the N-termini of poly-beta-peptide chains.

228 To address the role of the N-termini of pro-apoptotic ASPP proteins, we solved the

229 quential removal of dipeptides from the free N-termini of proteins and peptides.

230 pass alternative 5'-untranslated regions and N-termini of proteins evolve under strong nucleotide-lev

231 N-CLAP peptides, which are derived from the N-termini of proteins, including the N-termini of the ne

232 N-termini of several proteases were downregulated in prt

233 have previously demonstrated that the C- and N-termini of SK2 channels interact with the actin-bindin

234 syntaxin induced a close association of the N-termini of SN1 and SN2.

235 aminopeptidase DPP9 removes dipeptides from N-termini of substrates having a proline or alanine in s

236 figurations/orientation, especially when the N-termini of Sx1A-Sb2 are left to interact freely.

237 scent dyes or other functional groups to the N-termini of synthetic peptides prior to cleavage and de

238 at (BIR) domains, which bind directly to the N-termini of target proteins including those of caspases

239 The N-termini of the CPs form a contiguous network that inte

240 DPP4 cleaved within the N-termini of the CSFs granulocyte-macrophage (GM)-CSF, G

241 near-infrared fluorochromes attached to the N-termini of the dendritic arms was quenched.

242 bin cleaves fibrinopeptides A and B from the N-termini of the fibrinogen Aalpha and Bbeta chains.

243 xylosone modifies various amines (e.g., the N-termini of the heavy and light chains and susceptible

244 displayed different susceptibilities of the N-termini of the light chain, heavy chain, or both.

245 rom the N-termini of proteins, including the N-termini of the newly formed polypeptide products of pr

246 h results in identification of two different N-termini of the protein.

247 ide chains emerging from a 5-fold hub to the N-termini of their corresponding principal domains, clus

248 The N-termini of two gA peptides were linked to various mole

249 The N-termini of two proteins, Mpc54p and Spo21p, were orien

250 e was required for interactions with histone N termini or for yFACT-mediated nucleosome reorganizatio

251 in the identification of 1672 unique protein N-termini or proteolytic cleavage sites from 690 unique

252 e SGK1 mRNA produces isoforms with different N-termini owing to alternative translation initiation.

253 se that hkNBCe1 (and other SLC4) cytoplasmic N termini play roles in controlling HCO(3)(-) permeation

254 er, both proteins appear to target chemokine N termini, presumably because these domains are key to r

255 t reveals how conformational changes in CCL3 N termini profoundly alter its surface properties and di

256 the hypothesis that interactions of nascent N termini promote heteromeric assembly of 1a and 1b subu

257 A series of C-terminal TTR fragments with N-termini ranging from amino acids 46 to 55 were identif

258 d structure of intermediate oligomers in the N-termini relative to well-developed fibrils provides a

259 H3 and H4 that were either acetylated or the N-termini removed, it was also determined that the N-ter

260 GPCRs have revealed that truncations of the N termini result in constitutively active receptors, sug

261 Further truncation of the N-termini resulted in a pFNRII protein which failed to b

262 ntity of the beta-arrestins throughout their N termini, sequence variability is present at a small nu

263 The positively charged N-termini serve as a primary point of interaction.

264 observe over enrichment of SSRs near protein N-termini significantly beyond expectation based on stru

265 menon, its location, and features of protein N termini suggested the involvement of ribosome-associat

266 PCDH21 and PCDH24 contain similarly charged N termini, suggesting that a subset of cadherins share a

267 hich are 4 and 13 amino acids shorter in the N termini than canonical PGC-1alpha and NT-PGC-1alpha, r

268 gomers had more flexible and solvent-exposed N-termini than Abeta1-40 oligomers.

269 nificantly more flexible and solvent-exposed N-termini than Abeta1-40/42 conformations.

270 Both structures reveal extended N termini that approach the active site of the neighbori

271 rtite domain structure in proximity to their N termini that consists of a RING finger domain, followe

272 V)1.2 channels containing e1b or e1c-encoded N termini that contribute to Ca(V)1.2 surface expression

273 All three glycoproteins have identical N termini that include the receptor-binding region (RBR)

274 by an unusual transmembrane domain at their N termini that modulates Kv4 channel gating and traffick

275 STIM proteins contain an EF-hand in their N-termini that faces the lumen side of the ER allowing t

276 tion, mapping, and quantification of protein N-termini to comprehensively characterize cleaved podocy

277 his nucleus toward both termini and from the N-termini to the C-termini of several beta-strands is be

278 ation which converts basic amine sites (Lys, N-termini) to less basic amides for enhanced analysis in

279 REs can assemble in multiple stages from the N-termini toward the C-termini.

280 igh HSC/HSP70 binding scores and hydrophobic N-termini, two characteristics that were previously obse

281 ttranslational modifications on human CENP-A N termini using high-resolution MS: trimethylation of Gl

282 We now compared the N-termini using sensitive sequence similarity search pro

283 hydrolyzes cAMP and cGMP; the amino-termini (N-termini) vary in length and amino acid sequence.

284 peptides with a removable Fmoc or acetylated N-termini via their C-termini to produce active peptide

285 The entire modification status of intact N termini was obtained and indicated correlations betwee

286 eins accumulated with two or three different N termini; we evaluated the significance of these differ

287 The unique Vp1 N termini were found to be exposed on the surfaces of th

288 cated at D431 and L39, and the resulting new N termini were N-myristoylated and N-acetylated, respect

289 sed from the acid-labile resin, their C- and N-termini were intramolecularly coupled in solution to a

290 ended with glycosidic groups at its multiple N-termini were investigated for binding to the Pseudomon

291 oluble forms of ACV and ACVI, which lack the N termini, were not enhanced by Gbetagamma subunits.

292 , and, after proteolysis of externalized VP2 N termini, were unable to protect the VP1 domain, which

293 PDE11A1, which contain progressively shorter N-termini, were more sensitive than PDE11A4 to inhibitio

294 rotein conformation surrounding their buried N termini where a beta-strand distortion results in a so

295 estingly, these substrates included Met-Gln- N-termini, which are thus now classified as in vivo NatB

296 We tag Sb2 protein at C- and N termini with a pair of fluorophores, which allows us t

297 bound peptides, selectively labeled at their N-termini with a positive charge-bearing group, are subj

298 estigated, through derivatization of peptide N-termini with various reagents containing one or more c

299 y identical proteins differing only at their N termini, with P58 extending MP upstream by 102 amino a

300 37 degrees C continue to sequester their VP1 N termini within the intact capsid, suggesting that thes