ライフサイエンスコーパス: N-acetylglucosaminyltransferase

1 n-synthesizing enzyme GCNT3 (core 2 beta-1,6 N-acetylglucosaminyltransferase).

2 hamster ovary cells expressing core2 beta1,6-N-acetylglucosaminyltransferase.

3 which is synthesized by I-branching beta1, 6-N-acetylglucosaminyltransferase.

4 es, which are synthesized by core 2 beta-1,6-N-acetylglucosaminyltransferase.

5 cal fringe is also a fucose-specific beta1,3-N-acetylglucosaminyltransferase.

6 drolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases.

7 ein, a proposed substrate of Fringe beta-1,3-N-acetylglucosaminyltransferases.

8 eficient for the glycosyltransferase beta1,3-N-acetylglucosaminyltransferase 1 (beta3GnT1), a key enz

9 Core 2 N-acetylglucosaminyltransferase 1 (C2GnT1) is a key enzy

10 rnatively, protein O-linked mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGNT1) catalyzes th

11 disease, mice deficient in O-mannose beta1,2-N-acetylglucosaminyltransferase 1 (POMGnT1).

12 isease, mice deficient in O-mannose beta31,2-N-acetylglucosaminyltransferase 1 (POMGnT1).

13 ng fukutin, protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase 1 and the fukutin-relate

14 -DG was increased by co-expression of core 2 N-acetylglucosaminyltransferase 1 with Large.

15 oss of an enzyme (protein O-mannose beta-1,2-N-acetylglucosaminyltransferase 1) that modifies O-manno

16 uding protein O-mannosyltransferase 1, beta3-N-acetylglucosaminyltransferase 1, and like-acetylglucos

17 eased by co-expression of protein:O-mannosyl N-acetylglucosaminyltransferase 1.

18 iated with the decreased expression of beta3-N-acetylglucosaminyltransferase-1 (beta3GnT1).

19 igands elaborated by LSST and core 2 beta1,6-N-acetylglucosaminyltransferase-1 (Core2GlcNAcT) have be

20 -185 targets UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT1) a

21 Protein O-linked mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) catalyzes th

22 Core 2 N-acetylglucosaminyltransferase 2/M (C2GnT-M) synthesize

23 Core2 beta1,6-N-acetylglucosaminyltransferase-2 (C2GnT-2) was markedly

24 osyltransferase (C1GalT1) and core 2 beta1,6-N-acetylglucosaminyltransferase-2 or mucus type (C2GnT-M

25 es, beta1,4-galactosyltransferase-I, beta1,3-N-acetylglucosaminyltransferase-2, hCGn6ST, and keratan

26 In this study, we first show that beta1,3-N-acetylglucosaminyltransferase-3 (beta3GlcNAcT-3) is al

27 d in C2GnT-2 knock-out mice but not in core2 N-acetylglucosaminyltransferase-3 (C2GnT-3) nulls.

28 3 and LNCaP prostate cancer cells with beta3-N-acetylglucosaminyltransferase-6 (core3 synthase) requi

29 LEM domain nuclear lamina component by beta-N-acetylglucosaminyltransferase, a nutrient sensor that

30 an in vitro glycosylation assay to evaluate N-acetylglucosaminyltransferase activity after bacterial

31 d residues that are known to be critical for N-acetylglucosaminyltransferase activity of yeast chitin

32 e proteins possess a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that initiates

33 The mutant had normal levels of N-acetylglucosaminyltransferase activity, and the partia

34 The former mutant lacks the Golgi N-acetylglucosaminyltransferase activity, whereas the la

35 We conclude that beta-N-acetylglucosaminyltransferase, an essential enzyme, co

36 ar poly-N-acetyllactosamines, while beta1, 3-N-acetylglucosaminyltransferase and beta4Gal-TI efficien

37 rent cellular proteins catalyzed by O-linked N-acetylglucosaminyltransferase and O-linked N-acetylglu

38 presence of the enzymes for addition (O-beta-N-acetylglucosaminyltransferase) and removal (O-beta-N-a

39 The Fringe family of beta1,3-N-acetylglucosaminyltransferases are regulators of this

40 s-Golgi poly-LacNAc extension enzyme beta1,3-N-acetylglucosaminyltransferase (B3GNT).

41 e gene encoding the K. lactis Golgi membrane N-acetylglucosaminyltransferase by complementation of th

42 o the alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (MGAT4C) gene on 12q21

43 esized with the Golgi enzyme core 2 beta-1,6-N-acetylglucosaminyltransferase (C2 GlcNAcT).

44 gulation of the expression of core-2 beta1,6-N-acetylglucosaminyltransferase (C2GnT) 1, a key enzyme

45 nsferase VII (Fuc-T VII) and core 2 beta-1,6-N-acetylglucosaminyltransferase (C2GnT) are critical for

46 ansgenic mice overexpressing core 2 beta-1,6-N-acetylglucosaminyltransferase (C2GnT) in T cells, and

47 de is synthesized only when core 2 beta-1, 6-N-acetylglucosaminyltransferase (C2GnT) is present, and

48 ) BW5147 T cells lacking the core 2 beta-1,6-N-acetylglucosaminyltransferase (C2GnT) were resistant t

49 3-fucosyltransferase-VII, and core 2 beta1,6 N-acetylglucosaminyltransferase (C2GnT).

50 cause they do not express the core 2 beta1 6-N-acetylglucosaminyltransferase (C2GnT).

51 nds for galectin-1 created by core 2 beta1,6-N-acetylglucosaminyltransferase (C2GnT-I).

52 Core 2 beta-1,6-N-acetylglucosaminyltransferase, C2GnT, is a key enzyme

53 s, we engineered mice lacking core 3 beta1,3-N-acetylglucosaminyltransferase (C3GnT), an enzyme predi

54 and Nod2 agonists upregulated core 3 beta1,3-N-acetylglucosaminyltransferase (C3GnT; an important enz

55 arcinoma AGS cells transfected with alpha1,4-N-acetylglucosaminyltransferase cDNA.

56 ctions mediated by UDP-GlcNAc:GlcNAc-P-P-Dol N-acetylglucosaminyltransferase (chitobiosyl-P-P-lipid s

57 first demonstrate that I-branching beta1, 6-N-acetylglucosaminyltransferase cloned from human PA-1 e

58 one of the protein subunits of the alpha1-6-N acetylglucosaminyltransferase complex, which catalyses

59 The four known mucin beta1,6-N-acetylglucosaminyltransferases contain nine conserved

60 The core 2 beta-1, 6-N-acetylglucosaminyltransferase (core 2 GnT) creates a b

61 ar cloning of a HEV-expressed core1-beta 1,3-N-acetylglucosaminyltransferase (Core1-beta 3GlcNAcT) en

62 of glycoproteins by leukocyte core2 beta1,6-N-acetylglucosaminyltransferase (Core2GlcNAcT-I).

63 produced glycosyltransferases including key N-acetylglucosaminyltransferases (e.g., GnTI, GnTII, and

64 The Golgi N-acetylglucosaminyltransferases encoded by Mgat1, Mgat2

65 nly non-conserved residue within the beta1,6-N-acetylglucosaminyltransferase family, Cys235, is also

66 ongation of O-fucose on Notch by the beta1,3-N-acetylglucosaminyltransferase Fringe modulates the abi

67 Upon expression of the beta3-N-acetylglucosaminyltransferase Fringe with Notch, we ob

68 galactosyltransferase or beta1-2- or beta1-6-N-acetylglucosaminyltransferase genes have been found in

69 ynthesized in the presence of core 2 beta1,6-N-acetylglucosaminyltransferase, GlcAT-P, and HNK-1ST.

70 ries glycolipids is catalyzed by the beta1,3 N-acetylglucosaminyltransferase GlcNAc(beta1,3)Gal(beta1

71 s, GlcNAc transfer is mediated by a distinct N-acetylglucosaminyltransferase (GlcNAc-T) activity.

72 of the glycosylating enzyme core 2 beta 1,6-N-acetylglucosaminyltransferase (GlcNAc-T) through prote

73 ty of the regulatory enzyme lactosylceramide N-acetylglucosaminyltransferase (GlcNAc-Tr) with age in

74 lglucosamine (GlcNAc), which is generated by N-acetylglucosaminyltransferase (GnT)-IV, is a good subs

75 A paralog of GnT-Vb, N-acetylglucosaminyltransferase (GnT-V), is expressed in

76 Our previous studies on a beta1,6-N-acetylglucosaminyltransferase, GnT-IX (GnT-Vb), a homo

77 nits of the multisubunit enzyme complex, GPI-N-acetylglucosaminyltransferase (GPI-GnT), involved in t

78 (siaA), and the undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase homolog (wecA) produced

79 significantly lower levels of core 2 beta1,6 N-acetylglucosaminyltransferase I (C2GlcNAcT-I), but no

80 Core 2 beta1,6-N-acetylglucosaminyltransferase I (C2GnT-I) plays a pivo

81 those of transcripts encoding core 2 beta1,6-N-acetylglucosaminyltransferase I (Core2GlcNAcT-I).

82 The Mgat1 gene encodes N-acetylglucosaminyltransferase I (Glc-NAc-TI; EC 2.4.1.

83 etylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GlcNAc-TI, EC 2.4.1.1

84 sulted in a marked and specific reduction in N-acetylglucosaminyltransferase I (GlcNAcT-I) activity a

85 ression of erythropoietin (EPO) in a HEK293S N-acetylglucosaminyltransferase I (GnT I)(-/-) cell line

86 N-acetylglucosaminyltransferase I (GNT-I) contributes to

87 ed glycosylation caused by a mutation in the N-acetylglucosaminyltransferase I (GnT1) gene.

88 embryonic kidney 293 (HEK293S) cells lacking N-acetylglucosaminyltransferase I (GnTI(-)), and was rec

89 It was shown to lack N-acetylglucosaminyltransferase I (GnTI) activity, and c

90 ive alpha-1,2-mannosidase and human beta-1,2-N-acetylglucosaminyltransferase I (GnTI) in the secretor

91 ment to the NH2-terminal retention signal of N-acetylglucosaminyltransferase I (NAGT I).

92 , we identified a highly divergent T. brucei N-acetylglucosaminyltransferase I (TbGnTI) among a set o

93 sident UDP-GlcNAc:alpha3-D-mannoside beta1-2-N-acetylglucosaminyltransferase I activity (TbGnTI).

94 the O-glycan branching enzyme core 2 beta1,6-N-acetylglucosaminyltransferase I and its independent re

95 in and siRNA-mediated knockdown of the Golgi N-acetylglucosaminyltransferase I gene (MGAT1) induce pa

96 inhibition of glycosylation in the Golgi by N-acetylglucosaminyltransferase I gene inactivation nor

97 his organism, no homologues of the canonical N-acetylglucosaminyltransferase I or II genes can be fou

98 pha-mannosidase I, Nicotiana tabacum beta1,2-N-acetylglucosaminyltransferase I, Arabidopsis Golgi alp

99 y the lowest levels, partial deficiencies in N-acetylglucosaminyltransferase I, II, and V (i.e. Mgat1

100 ialyltransferase, galactosyltransferase, and N-acetylglucosaminyltransferase I, was dramatically disr

101 , the protease was efficiently secreted from N-acetylglucosaminyltransferase I-deficient Lec1 Chinese

102 rate baculovirus, transduce HEK293S GnTI(-) (N-acetylglucosaminyltransferase I-negative) cells in sus

103 ly expressed alpha-2,6-sialyltransferase and N-acetylglucosaminyltransferase-I (NAGT-I), both C-termi

104 -selectin ligands derived from core2 beta1,6-N-acetylglucosaminyltransferase-I null mice.

105 ghly homologous to the I branching beta-1, 6-N-acetylglucosaminyltransferase (IGnT).

106 ce paucimannosidic N-glycans or elongated by N-acetylglucosaminyltransferase II (GNT-II) to produce c

107 sferase family, encodes an equally divergent N-acetylglucosaminyltransferase II (TbGnTII) activity.

108 insect cell lines lacked adequate endogenous N-acetylglucosaminyltransferase II activity for biantenn

109 ding UDP-GlcNAc:alpha-6-d-mannoside beta-1,2-N-acetylglucosaminyltransferase II enzyme exhibit defici

110 of mammalian glycosyltransferases, including N-acetylglucosaminyltransferase II.

111 Mice lacking N-acetylglucosaminyltransferase III (GlcNAc-TIII) exhibi

112 N-acetylglucosaminyltransferase III (GlcNAc-TIII) is enc

113 N-Acetylglucosaminyltransferase III (GlcNAc-TIII), the p

114 gene transfection of U373 MG cells with the N-acetylglucosaminyltransferase III (GnT-III).

115 ed gene expression of the responsible enzyme N-acetylglucosaminyltransferase III (GnT-III).

116 t polylactosamine elongation by knockdown of N-acetylglucosaminyltransferase III or V had no effect o

117 Addition of O-GlcNAc by O-beta-N-acetylglucosaminyltransferase increased InsP(3)R-3 sin

118 nechocystis sp. strain PCC6803, which encode N-acetylglucosaminyltransferases involved in peptidoglyc

119 tion, suggesting developmental regulation of N-acetylglucosaminyltransferases IV and V and alpha6-fuc

120 thermore, the mRNA and protein expression of N-acetylglucosaminyltransferase IVa (GnT-IVa), which was

121 of this capsular polysaccharide involves in N-acetylglucosaminyltransferase (KfiA) and d-glucuronylt

122 The N-acetylglucosaminyltransferase known as GnT-Vb or -IX i

123 g), which encodes an O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase known to modify epiderma

124 e 2 branching enzyme, termed core 2 beta-1,6-N-acetylglucosaminyltransferase-leukocyte type (C2GnT-L)

125 Bovine core 2 beta1,6-N-acetylglucosaminyltransferase-M (bC2GnT-M) catalyzes t

126 is (hexosamine pathway) and in turn to Golgi N-acetylglucosaminyltransferases Mgat1, -2, -4, and -5.

127 ion of beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (MGAT3) (P < 0.001) and

128 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (Mgat4) with UDP-GlcNAc.

129 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (Mgat5) in the Golgi mem

130 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (Mgat5).

131 Fringe O-fucose-beta1,3-N-acetylglucosaminyltransferases modulate Notch signalin

132 ogue of the cellular core 2 protein beta-1,6-N-acetylglucosaminyltransferase-mucin type (C2GnT-M), wh

133 ncreased mRNA for nucleocytoplasmic O-linked N-acetylglucosaminyltransferase (ncOGT).

134 c mutation in the gene encoding the alpha1-6-N-acetylglucosaminyltransferase necessary for the format

135 ligosaccharides on the physiology of plants, N-ACETYLGLUCOSAMINYLTRANSFERASE (NodC) of Azorhizobium c

136 r GnT1IP-L inhibits other N-glycan branching N-acetylglucosaminyltransferases of the medial Golgi.

137 O-Linked N-acetylglucosaminyltransferase (OGT) catalyzes the tran

138 her, the mRNA for nucleocytoplasmic O-linked N-acetylglucosaminyltransferase (OGT) increases 3.4-fold

139 tter did not have a soluble inhibitor of the N-acetylglucosaminyltransferase or a hexosaminidase that

140 n ligand-synthesizing enzymes core-2 beta1,6-N-acetylglucosaminyltransferase or fucosyltransferases I

141 ion is evident in protein O-mannose beta-1,2-N-acetylglucosaminyltransferase (POMGnT1) knockout mouse

142 -Man glycans, the protein O-mannose beta-1,2-N-acetylglucosaminyltransferase, POMGnT1.

143 have identified an enzyme, polypeptide alpha-N-acetylglucosaminyltransferase (pp alpha-GlcNAc-T2), th

144 mZP3 and huZP3 affect the ability of core 2 N-acetylglucosaminyltransferase(s) to extend the core 1

145 pressed in cultured cells inhibit MGAT1, the N-acetylglucosaminyltransferase that initiates the synth

146 We demonstrate that MGAT4A, an N-acetylglucosaminyltransferase that installs the beta-1

147 -fucosyltransferase-1) and Fringe, a beta1,3-N-acetylglucosaminyltransferase that modifies O-fucose i

148 Fringe is a fucose-specific beta1,3-N-acetylglucosaminyltransferase that modifies O-fucose m

149 inge proteins are O-fucose-specific beta-1,3 N-acetylglucosaminyltransferases that glycosylate the ex

150 nd Radical Fringe (LFNG, MFNG, and RFNG) are N-acetylglucosaminyltransferases that modify Notch recep

151 Fringe proteins are beta3-N-acetylglucosaminyltransferases that modulate Notch act

152 Fringe proteins are beta1,3-N-acetylglucosaminyltransferases that modulate signaling

153 ent in milk and the recently cloned beta-1,3-N-acetylglucosaminyltransferase, the formation of poly-N

154 xture of beta4Gal-TI and i-extension beta1,3-N-acetylglucosaminyltransferase, the major product was t

155 beta-1,6-N-Acetylglucosaminyltransferase V (EC 2.4.1.155) catalyz

156 activity and mRNA transcript levels encoding N-acetylglucosaminyltransferase V (GlcNAc-T V).

157 Changes in the levels of N-acetylglucosaminyltransferase V (GnT-V) can alter the

158 N-Acetylglucosaminyltransferase V (GnT-V) is an enzyme i

159 The expression of N-acetylglucosaminyltransferase V (GnT-V) mRNA, which is

160 small interfering RNA-directed knockdown of N-acetylglucosaminyltransferase V (GnT-V), a glycosyltra

161 human clinical samples, we demonstrated that N-acetylglucosaminyltransferase V (GnT-V)-mediated glyco

162 beta(1,6)-linked GlcNAc, synthesized by the N-acetylglucosaminyltransferase V (GnT-V).

163 glycans caused by increased transcription of N-acetylglucosaminyltransferase V (GnT-V).

164 harides caused by increased transcription of N-acetylglucosaminyltransferase V (GnT-V).

165 s, including branched N-glycans generated by N-acetylglucosaminyltransferase V (Mgat5) activity, form

166 N-Acetylglucosaminyltransferase V (MGAT5) mediates beta1

167 ed that beta1,6GlcNAc-branched complex-type (N-acetylglucosaminyltransferase V (Mgat5)) N-glycans on

168 cetylglucosamine:alpha-6-D-mannoside beta1,6-N-acetylglucosaminyltransferase V (MGAT5)-modified N-gly

169 Lec4 and Lec13 cells, which are defective in N-acetylglucosaminyltransferase V and GDP-fucose synthes

170 h aberrant N-glycosylation caused by altered N-acetylglucosaminyltransferase V(GnT-V, GnT-Va, and Mga

171 experiments indicated that HG-CD147 contains N-acetylglucosaminyltransferase V-catalyzed, beta1,6-bra

172 A glycosyltransferase that branches O-Man, N-acetylglucosaminyltransferase Vb (GnT-Vb), is highly e

173 hether Fringe, an O-fucose specific beta 1,3-N-acetylglucosaminyltransferase, was capable of modifyin

174 reover, beta4Gal-TIV, together with beta-1,3-N-acetylglucosaminyltransferase, was capable of synthesi

175 e identified one glycosyltransferase, core 2 N-acetylglucosaminyltransferase, which is down-regulated

176 TDC2) is a protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase whose product could be e

177 Here we report this enzyme is not a beta-1,3-N-acetylglucosaminyltransferase with catalytic activity