ライフサイエンスコーパス: N-acetylmannosamine

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1 ype 9V wcjE mediates 6-O-acetylation of beta-N-acetylmannosamine.

2 cetylglucosamine, N-acetylgalactosamine, and N-acetylmannosamine.

3 hydrolysis of sialic acid into pyruvate and N-acetylmannosamine.

4 ride repeating unit containing mannoheptose, N-acetylmannosamine, 3-acetamido-3,6-dideoxyglucose, 2-a

5 In vitro the human enzyme uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate

6 gions, and the Neu5Ac catabolic intermediate N-acetylmannosamine-6-phosphate (ManNAc-6P) relieves Nan

7 The essential N-acetylmannosamine-6-phosphate 2-epimerase (NanE) belon

8 including an epimerase (NanE) that converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6

9 als have evaluated the use of sialic acid or N-acetylmannosamine (a precursor of sialic acid) in pati

10 also contained -CH(2) O-acetylation of beta-N-acetylmannosamine, a modification that disappeared fol

11 In this work, four different C-3 modified N-acetylmannosamine analogs were tested as potential inh

12 Exogenously supplied N-acetylmannosamine analogues were not converted to LOS-

13 ynthetic pathway by converting UDP-GlcNAc to N-acetylmannosamine are described in this report.

14 ified EPS is identified as a beta-1,4-linked N-acetylmannosamine chain decorated with terminal alpha-

15 ajority of strains contain homologs of wcgC (N-acetylmannosamine dehydrogenase), wcfF (putative dehyd

16 DP-N-acetylglucosamine 2-epimerase and a UDP-N-acetylmannosamine dehydrogenase, respectively.

17 des, including glucose, glucuronic acid, and N-acetylmannosamine, do not express this activity.

18 e MMP0706 protein used NAD(+) to oxidize UDP-N-acetylmannosamine, forming UDP-N-acetylmannosaminurona

19 (i) the incorporation of labeled leucine and N-acetylmannosamine into immunoprecipitable clusterin in

20 ManDiaz, which is a diazo derivative of N-acetylmannosamine, is found to endure cellular metabol

21 present the crystal structures of the human N-acetylmannosamine kinase (MNK) domain of UDP-N-acetylg

22 omain of UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase in complexes with ManNAc at 1

23 nctional UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase that transforms UDP-N-acetylg

24 Binding kinetics of the inhibitor and human N-acetylmannosamine kinase were evaluated using surface

25 ies, UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase, in sialic acid biosynthetic

26 Using UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase-deficient cells, we confirm t

27 iosynthesis, N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase.

28 osynthetic pathway with exogenously supplied N-acetylmannosamine (ManNAc) analogs has many potential

29 The high affinity ligand N-acetylmannosamine (ManNAc) binds in the S1 site, predo

30 gh the metabolic transformation of unnatural N-acetylmannosamine (ManNAc) derivatives.

31 phosphate synthase (SAS) in combination with N-acetylmannosamine (ManNAc) feeding has been shown to o

32 e that transforms UDP-N-acetylglucosamine to N-acetylmannosamine (ManNAc) followed by its phosphoryla

33 oducts were readily advanced to a variety of N-acetylmannosamine (ManNAc) frameworks, using an intram

34 N-Acetylmannosamine (ManNAc) is the first committed inte

35 ne diphospho-N-acetylglucosamine 2-epimerase/N-acetylmannosamine (ManNAc) kinase (GNE/MNK), result in

36 Administration of the sialic acid precursor N-acetylmannosamine (ManNAc) led to improved sialylation

37 onstoichiometrically acetylated at O3 of the N-acetylmannosamine (ManNAc) residue.

38 btilis is catalyzed by TagA, which transfers N-acetylmannosamine (ManNAc) to the C4 hydroxyl of a mem

39 step in this process, the production of free N-acetylmannosamine (ManNAc), has not been defined.

40 yl sugar monomers, based on fucose (Fuc) and N-acetylmannosamine (ManNAc), were incorporated into fuc

41 Starting from N-acetylmannosamine, mannose or their chemically or enzy

42 ity to synthesize the sialic acid precursor, N-acetylmannosamine (neuC), indicated that NeuO does not

43 3 phenotype was rescued by exogenously added N-acetylmannosamine or mannosamine but not by the same c

44 a sialyl transferase (cstII) and a putative N-acetylmannosamine synthetase (neuC1), part of the bios

45 -GlcNAc) precursor that is epimerized to UDP-N-acetylmannosamine (UDP-ManNAc) and then oxidized to UD

46 UDP-N-acetyl glucosamine (UDP-GlcNAc) to UDP-N-acetylmannosamine (UDP-ManNAc).

47 The HPLC profile of alkali-treated N-acetylmannosamine was identical to that of the product

48 om the natural condensation of pyruvate with N-acetylmannosamine, yielding N-acetylneuraminic acid, t

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