ライフサイエンスコーパス: N-acetylmuramic acid

1 ll peptidoglycan (PG) at the C-6 position on N-acetylmuramic acid.

2 occurrence of N-glycolylmuramic rather than N-acetylmuramic acid.

3 ss-links by cleaving the peptide moiety from N-acetylmuramic acid.

4 group to activate the carboxyl group of UDP-N-acetylmuramic acid.

5 phic for the bacterial cell wall amino sugar N-acetylmuramic acid.

6 sociate with the repeating disaccharide beta-N-acetylmuramic acid, (1-->4)-beta-N-acetylglucosamine o

7 The N-acetylmuramic acid alpha-1-phosphate (MurNAc-alpha1-P)

8 tial septum-specific PGTase in vivo using an N-acetylmuramic acid analogue incorporation assay.

9 Peptidoglycan is made of repeating N-acetylmuramic acid and N-acetylglucosamine disaccharid

10 peating disaccharide unit of beta-1,4-linked N-acetylmuramic acid and N-acetylglucosamine.

11 idoglycan; group B carbohydrate is linked to N-acetylmuramic acid, and capsular polysaccharide is lin

12 Here we show that the 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) is returned to the bios

13 named AmiD, as a possible second 1,6-anhydro-N-acetylmuramic acid (anhMurNAc)-l-alanine amidase in Es

14 h enzyme, the Pseudomonas aeruginosa anhydro-N-acetylmuramic acid (anhNAM) kinase (AnmK).

15 nked disaccharide of N-acetylglucosamine and N-acetylmuramic acid appended with a highly conserved st

16 L1066 and SL1067 were required for growth on N-acetylmuramic acid as a sole carbon source.

17 s formed by linear glycan chains composed of N-acetylmuramic acid-(beta-1,4)-N-acetylglucosamine (Mur

18 ncoding the endospore-specific peptidoglycan-N-acetylmuramic acid deacetylase) serves as a contingenc

19 nts also retain more diaminopimelic acid and N-acetylmuramic acid during germination than wild-type s

20 ease of naked glycans containing 1,6-anhydro N-acetylmuramic acid ends.

21 aride, N-acetylglucosaminyl-beta-1,4-anhydro-N-acetylmuramic acid (GlcNAc-anhMurNAc).

22 The M. smegmatis mutant is devoid of UDP-N-acetylmuramic acid hydroxylase activity and synthesize

23 the gene namH encoding the mycobacterial UDP-N-acetylmuramic acid hydroxylase by computer data base s

24 oped a novel assay for the mycobacterial UDP-N-acetylmuramic acid hydroxylation reaction and demonstr

25 bond between N-acetylglucosamine and anhydro-N-acetylmuramic acid in cell wall degradation products f

26 d by acetylation of the C6 hydroxyl group of N-acetylmuramic acid in the PG glycan backbone.

27 ical C3 enolpyruvyl substrate, to UDP-methyl-N-acetylmuramic acid in the presence of NADPH.

28 e peptidoglycan recycling enzyme 1,6-anhydro-N-acetylmuramic acid kinase (AnmK) from Pseudomonas aeru

29 tion to the structurally related 1,6-anhydro-N-acetylmuramic acid kinase (AnmK), it forms markedly fe

30 The sugar is first phosphorylated by anhydro-N-acetylmuramic acid kinase (AnmK), yielding MurNAc-P, a

31 c determinant of the pneumococcal autolysin (N-acetylmuramic acid-L-alanine amidase).

32 UDP-N-acetylmuramic acid:L-alanine ligase (MurC) catalyzes t

33 rthermore, E. coli also recycles the anhydro-N-acetylmuramic acid moiety by first converting it into

34 r, composed of peptides linked to the sugars N-acetylmuramic acid (MurNAc) and GlcNAc.

35 ves the beta-1,4 glycosidic linkages between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (G

36 l polymer, consisting of a linear, repeating N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (G

37 rolyze the B-1,4-glycosidic bonds connecting N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (G

38 domain peptidoglycan N-deacetylase acting on N-acetylmuramic acid (MurNAc) residues and conferring ly

39 alternating N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc) units, cross-linked via pe

40 ng units of N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc), which are cross-linked by

41 ranscription by binding the PG precursor UDP-N-acetylmuramic acid (MurNAc)-pentapeptide.

42 acetylglucosamine (GlcNAc) B-(1-4)-linked to N-acetylmuramic acid (MurNAc).

43 The muramyl residue is present as N-acetylmuramic acid, N-glycolylmuramic acid, and murami

44 lease of SpA by removing amino sugars [i.e., N-acetylmuramic acid-N-acetylglucosamine (MurNAc-GlcNAc)

45 zes the cleavage of glycosidic bonds between N-acetylmuramic acid (NAM) and N-acetylglucosamine resid

46 of alternating N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) cross-linked by short peptide

47 ating units of N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) with an appended peptide.

48 one repeats of N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM).

49 roscopy analysis of short pulses with either N-acetylmuramic acid or D-alanine metabolic probes showe

50 roup of un-cross-linked peptides attached to N-acetylmuramic acid partially substituting the function

51 d on the detection of the cell precursor UDP-N-acetylmuramic acid pentapeptide intermediate terminati

52 f empedopeptin is undecaprenyl pyrophosphate-N-acetylmuramic acid(pentapeptide)-N-acetylglucosamine (

53 n of the soluble peptidoglycan precursor UDP-N-acetylmuramic acid-pentapeptide (UDP-MurNAc-pentapepti

54 n of the murein precursor, Lipid I, from UDP-N-acetylmuramic acid-pentapeptide and the lipid carrier,

55 ultimate soluble peptidoglycan precursor UDP-N-acetylmuramic acid-pentapeptide in the cytoplasm.

56 MurQ is an N-acetylmuramic acid-phosphate (MurNAc-P) etherase that

57 conversion of the 2,3-dideuterio-UDP-methyl-N-acetylmuramic acid product to 2,3-dideuterio-2-hydroxy

58 res removal of a peptide side chain from the N-acetylmuramic acid residue by a cwlD-encoded muramoyl-

59 ctions of Asn46 and Asp52 with the D-subsite N-acetylmuramic acid residue help to distort that pyrano

60 grees of polymerization and terminating with N-acetylmuramic acid residues at the reducing ends.

61 the deep end of a long binding groove, with N-acetylmuramic acid situated in the middle of the groov

62 and human clinical strains, did not require N-acetylmuramic acid supplementation for growth as pure

63 ate dehydrogenase operon, genes required for N-acetylmuramic acid synthesis, a 14-gene gas vesicle cl

64 r peptide is amide-linked to the carboxyl of N-acetylmuramic acid, thereby tethering the COOH-termina

65 has an enzyme activity that can convert UDP-N-acetylmuramic acid to UDP-N-glycolylmuramic acid.

66 id residues are ligated to uridine diphospho-N-acetylmuramic acid (UDP-MurNAc).

67 enzae MurC in complex with its substrate UDP-N-acetylmuramic acid (UNAM) and Mg(2+) and of a fully as

68 nce of a 40-fold excess of uridine diphospho N-acetylmuramic acid (UNAM) either aerobically or anaero

69 ependent ligation of L-alanine (Ala) and UDP-N-acetylmuramic acid (UNAM) to form UDP-N-acetylmuramyl-

70 exists in a tightly locked complex with UDP-N-acetylmuramic acid (UNAM), the product of the MurB rea

71 Modification of N-acetylmuramic acid with wall teichoic acid, a ribitol-

72 aride units (N-acetylglucosamine-[beta-1, 4]-N-acetylmuramic acid) with different degrees of polymeri