ライフサイエンスコーパス: N-acetylneuraminic acid

1 pression and recombination are suppressed by N-acetylneuraminic acid.

2 e-stage intermediate in a potential route to N-acetylneuraminic acid.

3 r affinity for N-glycolylneuraminic than for N-acetylneuraminic acid.

4 sphoethanolamine, N-acetylgalactosamine, and N-acetylneuraminic acid.

5 n medium that contained cytidine monophospho-N-acetylneuraminic acid.

6 wn that the rabbit beta-subunit is devoid of N-acetylneuraminic acid.

7 nic acid, 5,7-diacetylpseudaminic acid, from N-acetylneuraminic acid.

8 se N from pig and human and sugar coreceptor N-acetylneuraminic acid.

9 are organic acids including the sialic acid N-acetylneuraminic acid.

10 n generating N-alkylcarboxamide analogues of N-acetylneuraminic acid.

11 e, whereas E. coli MG1655 used gluconate and N-acetylneuraminic acid.

12 a coli nanR mutant shows inhibited growth in N-acetylneuraminic acid.

13 ts show growth inhibition in the presence of N-acetylneuraminic acid.

14 ep is likely to be repressor displacement by N-acetylneuraminic acid.

15 In contrast, exogenous (13)C-labeled N-acetylneuraminic acid ([(13)C]NeuAc) and N-glycolylneu

16 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid (4-GU-DANA; zanamivir), a sialic

17 substrate, 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (4-MU-NANA), that was dose-depen

18 However, N-acetylneuraminic acid abolished adherence to fibronect

19 N-Acetylneuraminic acid abolished adherence, indicating

20 A comparable N-acetylneuraminic acid adamantanylthioglycoside carryin

21 4-aminopyridine, gaboxadol hydrochloride and N-acetylneuraminic acid all rescued at least one aspect

22 d-lactose, d-galactose, N-acetylglucosamine, N-acetylneuraminic acid), 'all-or-none' responses (d-xyl

23 ian influenza viruses preferentially bind to N-acetylneuraminic acid alpha3 (NeuAcalpha3) sugars, whi

24 f the sialic acid analog 2,3-dehydro-2-deoxy-N-acetylneuraminic acid also exhibited increased infecti

25 cartilage, which lack both alpha(2-6)-linked N-acetylneuraminic acid and alpha(1-3)-linked fucose.

26 diates H(+)-coupled symport of acidic sugars N-acetylneuraminic acid and glucuronic acid out of lysos

27 the apparent affinity and transport rate for N-acetylneuraminic acid and glucuronic acid, suggesting

28 ns, there were accumulation of the precursor N-acetylneuraminic acid and increases in sialic acid O a

29 The two major mammalian sialic acids are N-acetylneuraminic acid and N-glycolylneuraminic acid (N

30 Mammals express two major sialic acids, N-acetylneuraminic acid and N-glycolylneuraminic acid (N

31 genes (synX, synC, and synD) involved in CMP-N-acetylneuraminic acid and polysialic acid capsule bios

32 s the formation of a glycosidic bond between N-acetylneuraminic acid and the 6-hydroxyl group of a ga

33 Among the carbohydrate acceptors tested, N-acetylneuraminic acid and the gangliosides G(D3) and G

34 At 30 mM, the monosaccharide, N-acetylneuraminic acid, and the trisaccharide mixture,

35 N-acetylglucosamine and N-acetylneuraminic acid appeared to be involved in initi

36 lpha1-3)-linked fucose and (alpha2-6)-linked N-acetylneuraminic acid are also present.

37 these cell lines had less than 1/10 as much N-acetylneuraminic acid as its parent cell line.

38 that ArtB binds human glycans, terminated in N-acetylneuraminic acid, as well as glycans terminated i

39 Mutations in the CMP-N-acetylneuraminic acid biosynthesis genes synX and synC

40 ive sialidase inhibitor, 2,3-dehydro-2-deoxy-N-acetylneuraminic acid but not its negative control.

41 GalNAc-4-ST2 (CHST9) or with alpha2,6-linked N-acetylneuraminic acid by alpha2,6-sialyltransferase 1

42 ound (6'-sialyllactose) or free sialic acid (N-acetylneuraminic acid) by oral, continuous administrat

43 s sensitive to normal human serum unless CMP-N-acetylneuraminic acid (CMP-NANA) is present.

44 ic acid [NANA]) from cytidine 5'-monophospho-N-acetylneuraminic acid (CMP-NANA) mainly to the termina

45 strain was grown with 5'-cytidinemonophospho-N-acetylneuraminic acid (CMP-NANA) to increase LPS sialy

46 erogroups) sources of 5'-cytidinemonophospho-N-acetylneuraminic acid (CMP-NANA).

47 the precursor molecule cytidine monophospho-N-acetylneuraminic acid (CMP-Neu5Ac) are considered a li

48 mutation of the gene encoding the enzyme CMP-N-acetylneuraminic acid (CMP-Neu5Ac) hydroxylase (CMAH).

49 lcNAc 2-epimerase) by cytidine monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac).

50 a matrix in the presence and absence of CMP-N-acetylneuraminic acid (CMP-Neu5Ac).

51 th of disease isolates of H. somnus with CMP-N-acetylneuraminic acid (CMP-NeuAc) or NeuAc added to th

52 activating enzyme, cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuAc) synthetase.

53 fer sialic acid from cytidine 5'-monophospho-N-acetylneuraminic acid (CMP-NeuAc) to an acceptor molec

54 cumented microheterogeneity dependent on the N-acetylneuraminic acid content, which has functional co

55 e identification and characterization of the N-acetylneuraminic acid cytidylsynthetase gene (neuA).

56 An N-acetylneuraminic acid cytidylyltransferase (EC 2.7.7.4

57 volution from the Escherichia coli D-Neu5Ac (N-acetylneuraminic acid, D-sialic acid) aldolase.

58 -modified analogues of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) and tested them against t

59 s zanamivir (ZANA) and 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA).

60 and their corresponding 2,3-dehydro-2-deoxy-N-acetylneuraminic acid derivatives is described.

61 as were normalized to the internal standard, N-acetylneuraminic acid derivatized with ANDSA.

62 ow that YjhS (NanS) is a probable 9-O-acetyl N-acetylneuraminic acid esterase required for E. coli to

63 chemical (NaIO4), mono- or oligosaccharides (N-acetylneuraminic acid, galactose, and 6'-sialyllactose

64 onization: gluconate > N-acetylglucosamine > N-acetylneuraminic acid = glucuronate > mannose > fucose

65 Both alpha(2-6)- and alpha(2-3)-linked N-acetylneuraminic acid have been found in the capping o

66 most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia

67 se (GGTA1) KO, GGTA1/ cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) KO, and GGTA1

68 CMP-N-acetylneuraminic acid hydroxylase (CMAH) loss occurred

69 ans have a unique mutation of the enzyme CMP-N-acetylneuraminic acid hydroxylase (CMAH), causing loss

70 The genes for cytidine monophospho-N-acetylneuraminic acid hydroxylase (NeuAc-H) and beta-1

71 ibody when grafted in cytidine monophosphate-N-acetylneuraminic acid hydroxylase KO mice and exhibite

72 to a common ion of m/z 290, a derivative of N-acetylneuraminic acid; (ii) phospholipids exert a prof

73 synthesis of a legionaminic acid donor from N-acetylneuraminic acid in 15 steps and 17% overall yiel

74 y generating Neu5Gc is the conversion of CMP-N-acetylneuraminic acid into CMP-Neu5Gc, which is cataly

75 CMP-N-acetylneuraminic acid is a critical metabolite in the

76 A covalent complex with 3-fluoro-beta-N-acetylneuraminic acid is also presented, suggesting a

77 osal sialoglycans, 2) liberated sialic acid (N-acetylneuraminic acid) is transported into the bacteri

78 d by an increase in in vitro and in vivo CMP-N-acetylneuraminic acid levels when expressed in a heter

79 acquired specificity for the human receptor, N-acetylneuraminic acid linked to galactose of cellular

80 ifferent positions within the active site of N-acetylneuraminic acid lyase (NAL), and the resulting c

81 N-Acetylneuraminic acid lyase (NAL, E.C. number 4.1.3.3)

82 uctures: the structures of wild-type E. coli N-acetylneuraminic acid lyase in the presence and in the

83 he substrate specificity of Escherichia coli N-acetylneuraminic acid lyase was previously switched fr

84 A theoretical model of N-acetylneuraminic acid metabolism (i.e., in particular

85 orogenic reagent 2'-O-(4-methylumbelliferyl)-N-acetylneuraminic acid (MUN).

86 1 (FA-1), 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (MUNANA) at 100 microM was used

87 using the 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (MUNANA) substrate.

88 r absence of opsonins was inhibited (90%) by N-acetylneuraminic acid (NAcNeu).

89 Moreover, the content of N-Acetylneuraminic acid (NANA) and EGF are established a

90 novel molecule identified in this study, and N-acetylneuraminic acid (NANA) were each significantly (

91 ically recognizing glucuronic acid (GlcA) or N-acetylneuraminic acid (NANA) were prepared.

92 id (GlcA), a substructure of hyaluronan, and N-acetylneuraminic acid (NANA), the most common member o

93 isms (gonococci [GC]) transfers sialic acid (N-acetylneuraminic acid [NANA]) from cytidine 5'-monopho

94 NeuA de-O-acetylation of free 9-O-acetyl-N-acetylneuraminic acid (Neu5,9Ac(2)) was enhanced by CT

95 We have demonstrated that N-acetylneuraminic acid (Neu5Ac or sialic acid) uptake i

96 N-acetylneuraminic acid (Neu5Ac or sialic acid), at the

97 lective ring-opening of the key intermediate N-acetylneuraminic acid (Neu5Ac) 2,3-beta-epoxide with a

98 uB-negative mutant of E. coli and results in N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-gl

99 s (H) oligosaccharide receptors that contain N-acetylneuraminic acid (Neu5Ac) and cleaves (N) Neu5Ac

100 The sialic acid (Sia) N-acetylneuraminic acid (Neu5Ac) and its hydroxylated de

101 e common sialic acids of mammalian cells are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuramini

102 , and, in vertebrates, the major species are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuramini

103 e predominantly occupied by the sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuramini

104 stronger than the derivatives of more common N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuramini

105 es, express two major kinds of sialic acids, N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuramini

106 The human ligand has N-acetylneuraminic acid (Neu5Ac) as the sialic acid, and

107 Gc, which differs from the human sialic acid N-acetylneuraminic acid (Neu5Ac) by 1 oxygen atom.

108 t catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (Neu5Ac) from pyruvate and N-ace

109 levels of both sialylation and the precursor N-acetylneuraminic acid (Neu5Ac) in a number of insect c

110 e have identified a gene for the addition of N-acetylneuraminic acid (Neu5Ac) in an alpha-2,3-linkage

111 raminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuramin

112 on of N-glycolylneuraminic acid (Neu5Gc) and N-acetylneuraminic acid (Neu5Ac) on glycoproteins.

113 rythrocyte binding has been shown to involve N-acetylneuraminic acid (Neu5Ac) on the surface of human

114 PltB, which has binding specificity for the N-acetylneuraminic acid (Neu5Ac) sialoglycans (6,13) pro

115 ack of CMAH, which in other mammals converts N-acetylneuraminic acid (Neu5Ac) to N-glycolylneuraminic

116 a mutation in the enzyme CMAH that converts N-acetylneuraminic acid (Neu5Ac) to Neu5Gc.

117 estigated the contribution of 9-O-acetylated N-acetylneuraminic acid (Neu5Ac) to survival and drug re

118 ly-sialic acids containing alpha2-8-linked 5-N-acetylneuraminic acid (Neu5Ac), 5-N-glycolylneuraminic

119 ar metabolic pathways, including sialic acid N-acetylneuraminic acid (Neu5Ac), and downregulation of

120 GHs recognize the terminal monosaccharides (N-acetylneuraminic acid (Neu5Ac), galactose, mannose, an

121 zing either glucose or sialic acids, such as N-acetylneuraminic acid (Neu5Ac), which are the end prod

122 preferentially expressed in human tissues is N-acetylneuraminic acid (Neu5Ac).

123 nd cleaves (N) oligosaccharides that contain N-acetylneuraminic acid (Neu5Ac).

124 and increase in expression of the precursor N-acetylneuraminic acid (Neu5Ac); increased expression o

125 ave a terminal alpha 2-3-linked sialic acid [N-acetylneuraminic acid (Neu5Ac)], which interferes with

126 KDN (2), a potential oncofetal antigen, and N-acetylneuraminic acid (Neu5Ac, 1), the most naturally

127 Sialic acid (N-acetylneuraminic acid [Neu5Ac]) is a bioavailable carb

128 hydroxylated form of the common sialic acid N-acetylneuraminic acid, Neu5Ac), it is a major componen

129 rst product of NanC is 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (Neu5Ac2en) that can be slowly h

130 as been a target for 2-deoxy-2,3-didehydro-d-N-acetylneuraminic acid (Neu5Ac2en)-based inhibitor deve

131 ry reaction product is 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (Neu5Ac2en, also known as DANA),

132 nsferase (ST6Gal-I) to enzymatically add 13C-N-acetylneuraminic acid (NeuAc or sialic acid) to glycop

133 ibit differences in glycopeptides containing N-acetylneuraminic acid (NeuAc) and N-acetylhexosamine (

134 es, were shown to be effective receptors for N-acetylneuraminic acid (NeuAc), the most common occurri

135 whereas the less polar GM3 species contained N-acetylneuraminic acid (NeuAc).

136 tion and increased urinary excretion of free N-acetylneuraminic acid (NeuAc, sialic acid).

137 strains contain high levels of sialic acid (N-acetylneuraminic acid, NeuAc) in their LOS.

138 myeloma proteins with enzymatically removed N-acetylneuraminic acid (NeuNAc) and galactose (Gal); re

139 (neuC1), part of the biosynthetic pathway of N-acetylneuraminic acid (NeuNAc), have identical phenoty

140 in NANS, the gene encoding the synthase for N-acetylneuraminic acid (NeuNAc; sialic acid), in nine i

141 N-acetylneuraminic acid oligomers and colominic acid wer

142 lidase activity by cleaving off the terminal N-acetylneuraminic acid on alpha-2,3 or alpha-2,6 sialic

143 lutinin surface glycoprotein to sialic acid (N-acetylneuraminic acid) on the surface of the host cell

144 m resistance in the absence of exogenous CMP-N-acetylneuraminic acid or detectable sialylation.

145 nd only lectins that are specific for either N-acetylneuraminic acid or N-acetylgalactosamine, sugges

146 In vitro, such an UPEC induced N-acetylneuraminic acid release from human spermatozoa w

147 of 19 test glycosphingolipids, an alpha 2,3-N-acetylneuraminic acid residue on the terminal galactos

148 ition state bears considerable charge on the N-acetylneuraminic acid residue, and this and other feat

149 Chemical modifications of N-acetylneuraminic acid residues (on GD1a) abrogated MAG

150 lex type N-glycans with and without terminal N-acetylneuraminic acid residues connected via the alpha

151 epididymitis in mice, a substantial loss of N-acetylneuraminic acid residues was detected in epididy

152 alone or in complex with 2-deoxy-2,3-dehydro-N-acetylneuraminic acid revealed substantial conformatio

153 N-Acetylneuraminic acid (sialic acid) can be incorporate

154 sed when a chemically defined medium lacking N-acetylneuraminic acid (sialic acid) was used.

155 d to study the conformational changes in the N-acetylneuraminic acid-specific SBP VcSiaP.

156 019 with mutations in the genes encoding CMP-N-acetylneuraminic acid synthetase (siaB), one of the th

157 M(r) 26,598 with significant homology to CMP-N-acetylneuraminic acid synthetase enzymes involved in s

158 selective advantage of the excess of the Sia N-acetylneuraminic acid (the precursor of N-glycolylneur

159 richia coli are coregulated by environmental N-acetylneuraminic acid, the most prevalent sialic acid

160 in a release of 2.8 mM galactose and 4.3 mM N-acetylneuraminic acid; these sugar concentrations were

161 cleophile in the oxidative deamination of an N-acetylneuraminic acid thioglycoside leading to the for

162 pyruvate with N-acetylmannosamine, yielding N-acetylneuraminic acid, to the aldol condensation gener

163 understood, the transporter responsible for N-acetylneuraminic acid uptake in H. influenzae has yet

164 2 (tauro-GM2) in which the carboxyl group of N-acetylneuraminic acid was amidated by taurine.

165 Glucose, galactose, and N-acetylneuraminic acid were covalently coupled to 3-mor

166 Two sialylated glycans bearing N-acetylneuraminic acid were detected, the first direct

167 t ganglioside ligand for MAG was GM3 bearing N-acetylneuraminic acid, whereas GM3 bearing N-glycolyln

168 Nuclear dreCmas1 favored N-acetylneuraminic acid, whereas the cytosolic dreCmas2

169 - and alpha2-6-linked sialosides, as well as N-acetylneuraminic acid, which is captured in the crysta

170 ae in the presence of 5'-cytidinemonophospho-N-acetylneuraminic acid, which sialylates lipooligosacch

171 agglutinin specifically binds alpha-anomeric N-acetylneuraminic acid with a K(d) of 1.2 mM.

172 retention times significantly; replacing the N-acetylneuraminic acid with the N-glycolyl variant lead