ライフサイエンスコーパス: N-acetylneuraminic acid

1 e, whereas E. coli MG1655 used gluconate and N-acetylneuraminic acid.

2 a coli nanR mutant shows inhibited growth in N-acetylneuraminic acid.

3 ts show growth inhibition in the presence of N-acetylneuraminic acid.

4 ep is likely to be repressor displacement by N-acetylneuraminic acid.

5 pression and recombination are suppressed by N-acetylneuraminic acid.

6 e-stage intermediate in a potential route to N-acetylneuraminic acid.

7 r affinity for N-glycolylneuraminic than for N-acetylneuraminic acid.

8 sphoethanolamine, N-acetylgalactosamine, and N-acetylneuraminic acid.

9 n medium that contained cytidine monophospho-N-acetylneuraminic acid.

10 wn that the rabbit beta-subunit is devoid of N-acetylneuraminic acid.

11 toward increased usage of alpha(2-6)-linked N-acetylneuraminic acid.

12 are organic acids including the sialic acid N-acetylneuraminic acid.

13 nic acid, 5,7-diacetylpseudaminic acid, from N-acetylneuraminic acid.

14 se N from pig and human and sugar coreceptor N-acetylneuraminic acid.

15 n generating N-alkylcarboxamide analogues of N-acetylneuraminic acid.

16 potent compound, 45 (LSP12-3129), inhibited N-acetylneuraminic acid 1 (Neu5Ac) transport in a non-co

17 In contrast, exogenous (13)C-labeled N-acetylneuraminic acid ([(13)C]NeuAc) and N-glycolylneu

18 9-Azido-9-deoxy-2-(e)-3-(a)-difluoro- N-acetylneuraminic acid [2(e)3(a)DFNeu5Ac9N(3)] was iden

19 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid (4-GU-DANA; zanamivir), a sialic

20 substrate, 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (4-MU-NANA), that was dose-depen

21 a2,6-linked N-Acetylneuraminic acid (a2,6-linked NeuAc, E) was found

22 However, N-acetylneuraminic acid abolished adherence to fibronect

23 N-Acetylneuraminic acid abolished adherence, indicating

24 A comparable N-acetylneuraminic acid adamantanylthioglycoside carryin

25 4-aminopyridine, gaboxadol hydrochloride and N-acetylneuraminic acid all rescued at least one aspect

26 d-lactose, d-galactose, N-acetylglucosamine, N-acetylneuraminic acid), 'all-or-none' responses (d-xyl

27 ifically increased levels of alpha2-3-linked N-acetylneuraminic acid (alpha2-3-Neu5Ac or alpha2-3-sia

28 ian influenza viruses preferentially bind to N-acetylneuraminic acid alpha3 (NeuAcalpha3) sugars, whi

29 f the sialic acid analog 2,3-dehydro-2-deoxy-N-acetylneuraminic acid also exhibited increased infecti

30 cartilage, which lack both alpha(2-6)-linked N-acetylneuraminic acid and alpha(1-3)-linked fucose.

31 diates H(+)-coupled symport of acidic sugars N-acetylneuraminic acid and glucuronic acid out of lysos

32 the apparent affinity and transport rate for N-acetylneuraminic acid and glucuronic acid, suggesting

33 ns, there were accumulation of the precursor N-acetylneuraminic acid and increases in sialic acid O a

34 The two major mammalian sialic acids are N-acetylneuraminic acid and N-glycolylneuraminic acid (N

35 Mammals express two major sialic acids, N-acetylneuraminic acid and N-glycolylneuraminic acid (N

36 genes (synX, synC, and synD) involved in CMP-N-acetylneuraminic acid and polysialic acid capsule bios

37 s the formation of a glycosidic bond between N-acetylneuraminic acid and the 6-hydroxyl group of a ga

38 Among the carbohydrate acceptors tested, N-acetylneuraminic acid and the gangliosides G(D3) and G

39 igh thermal stability, bound the sialic acid N-acetylneuraminic acid, and entered murine L cells.

40 to produce chemicals such as 2,3-butanediol, N-acetylneuraminic acid, and n-butanol using S. marcesce

41 At 30 mM, the monosaccharide, N-acetylneuraminic acid, and the trisaccharide mixture,

42 N-acetylglucosamine and N-acetylneuraminic acid appeared to be involved in initi

43 lpha1-3)-linked fucose and (alpha2-6)-linked N-acetylneuraminic acid are also present.

44 these cell lines had less than 1/10 as much N-acetylneuraminic acid as its parent cell line.

45 hydroxyl groups but to acetamido moieties of N-acetylneuraminic acid as well as N-acetylglucosamine r

46 that ArtB binds human glycans, terminated in N-acetylneuraminic acid, as well as glycans terminated i

47 Mutations in the CMP-N-acetylneuraminic acid biosynthesis genes synX and synC

48 atural anionic structures not only including N-acetylneuraminic acid but also N-glycolylneuraminic ac

49 ive sialidase inhibitor, 2,3-dehydro-2-deoxy-N-acetylneuraminic acid but not its negative control.

50 GalNAc-4-ST2 (CHST9) or with alpha2,6-linked N-acetylneuraminic acid by alpha2,6-sialyltransferase 1

51 ound (6'-sialyllactose) or free sialic acid (N-acetylneuraminic acid) by oral, continuous administrat

52 s sensitive to normal human serum unless CMP-N-acetylneuraminic acid (CMP-NANA) is present.

53 ic acid [NANA]) from cytidine 5'-monophospho-N-acetylneuraminic acid (CMP-NANA) mainly to the termina

54 strain was grown with 5'-cytidinemonophospho-N-acetylneuraminic acid (CMP-NANA) to increase LPS sialy

55 erogroups) sources of 5'-cytidinemonophospho-N-acetylneuraminic acid (CMP-NANA).

56 ) using host-derived cytidine-5'-monophospho-N-acetylneuraminic acid (CMP-Neu5Ac or CMP-sialic acid).

57 the precursor molecule cytidine monophospho-N-acetylneuraminic acid (CMP-Neu5Ac) are considered a li

58 mutation of the gene encoding the enzyme CMP-N-acetylneuraminic acid (CMP-Neu5Ac) hydroxylase (CMAH).

59 a matrix in the presence and absence of CMP-N-acetylneuraminic acid (CMP-Neu5Ac).

60 lcNAc 2-epimerase) by cytidine monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac).

61 th of disease isolates of H. somnus with CMP-N-acetylneuraminic acid (CMP-NeuAc) or NeuAc added to th

62 activating enzyme, cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuAc) synthetase.

63 fer sialic acid from cytidine 5'-monophospho-N-acetylneuraminic acid (CMP-NeuAc) to an acceptor molec

64 cumented microheterogeneity dependent on the N-acetylneuraminic acid content, which has functional co

65 e identification and characterization of the N-acetylneuraminic acid cytidylsynthetase gene (neuA).

66 An N-acetylneuraminic acid cytidylyltransferase (EC 2.7.7.4

67 volution from the Escherichia coli D-Neu5Ac (N-acetylneuraminic acid, D-sialic acid) aldolase.

68 -modified analogues of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) and tested them against t

69 transition state analog 2,3-dehydro-2-deoxy-N-acetylneuraminic acid (DANA) is 3.5 +/- 0.8 muM (n = 5

70 for NEU inhibitors is 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) where C9 modifications ca

71 s zanamivir (ZANA) and 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA).

72 and their corresponding 2,3-dehydro-2-deoxy-N-acetylneuraminic acid derivatives is described.

73 as were normalized to the internal standard, N-acetylneuraminic acid derivatized with ANDSA.

74 ow that YjhS (NanS) is a probable 9-O-acetyl N-acetylneuraminic acid esterase required for E. coli to

75 chemical (NaIO4), mono- or oligosaccharides (N-acetylneuraminic acid, galactose, and 6'-sialyllactose

76 onization: gluconate > N-acetylglucosamine > N-acetylneuraminic acid = glucuronate > mannose > fucose

77 Both alpha(2-6)- and alpha(2-3)-linked N-acetylneuraminic acid have been found in the capping o

78 s in the side chain, as in the 8-position of N-acetylneuraminic acid, have little impact on the confo

79 most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia

80 ues of wild-type mice or in mice lacking CMP-N-acetylneuraminic acid hydroxylase (CMAH) enzyme, which

81 eletion in the cytidine-5'-monophospho-(CMP)-N-acetylneuraminic acid hydroxylase (CMAH) gene responsi

82 se (GGTA1) KO, GGTA1/ cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) KO, and GGTA1

83 CMP-N-acetylneuraminic acid hydroxylase (CMAH) loss occurred

84 ans have a unique mutation of the enzyme CMP-N-acetylneuraminic acid hydroxylase (CMAH), causing loss

85 The genes for cytidine monophospho-N-acetylneuraminic acid hydroxylase (NeuAc-H) and beta-1

86 ibody when grafted in cytidine monophosphate-N-acetylneuraminic acid hydroxylase KO mice and exhibite

87 idney from GGTA1, CMAH (cytidine monophospho-N-acetylneuraminic acid hydroxylase), and b4GNT2/b4GALNT

88 to a common ion of m/z 290, a derivative of N-acetylneuraminic acid; (ii) phospholipids exert a prof

89 synthesis of a legionaminic acid donor from N-acetylneuraminic acid in 15 steps and 17% overall yiel

90 gh formation of a 4-keto-2-deoxy-2,3-dehydro-N-acetylneuraminic acid intermediate and NAD(+) regenera

91 y generating Neu5Gc is the conversion of CMP-N-acetylneuraminic acid into CMP-Neu5Gc, which is cataly

92 CMP-N-acetylneuraminic acid is a critical metabolite in the

93 A covalent complex with 3-fluoro-beta-N-acetylneuraminic acid is also presented, suggesting a

94 N-Acetylneuraminic acid is the most abundant sialic acid

95 osal sialoglycans, 2) liberated sialic acid (N-acetylneuraminic acid) is transported into the bacteri

96 d by an increase in in vitro and in vivo CMP-N-acetylneuraminic acid levels when expressed in a heter

97 acquired specificity for the human receptor, N-acetylneuraminic acid linked to galactose of cellular

98 ifferent positions within the active site of N-acetylneuraminic acid lyase (NAL), and the resulting c

99 N-Acetylneuraminic acid lyase (NAL, E.C. number 4.1.3.3)

100 uctures: the structures of wild-type E. coli N-acetylneuraminic acid lyase in the presence and in the

101 he substrate specificity of Escherichia coli N-acetylneuraminic acid lyase was previously switched fr

102 A theoretical model of N-acetylneuraminic acid metabolism (i.e., in particular

103 orogenic reagent 2'-O-(4-methylumbelliferyl)-N-acetylneuraminic acid (MUN).

104 1 (FA-1), 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (MUNANA) at 100 microM was used

105 using the 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (MUNANA) substrate.

106 r absence of opsonins was inhibited (90%) by N-acetylneuraminic acid (NAcNeu).

107 Moreover, the content of N-Acetylneuraminic acid (NANA) and EGF are established a

108 novel molecule identified in this study, and N-acetylneuraminic acid (NANA) were each significantly (

109 ically recognizing glucuronic acid (GlcA) or N-acetylneuraminic acid (NANA) were prepared.

110 id (GlcA), a substructure of hyaluronan, and N-acetylneuraminic acid (NANA), the most common member o

111 sma metabolite profiling, we identified free N-acetylneuraminic acid (NANA), the predominant sialic a

112 isms (gonococci [GC]) transfers sialic acid (N-acetylneuraminic acid [NANA]) from cytidine 5'-monopho

113 W CPS oligosaccharides containing 7-O-acetyl-N-acetylneuraminic acid (Neu5,7Ac(2)) and/or 9-O-acetyl-

114 onstrated that IDV binds both 9-O-acetylated N-acetylneuraminic acid (Neu5,9Ac(2)) and 9-O-acetylated

115 that IDV binds exclusively to 9-O-acetylated N-acetylneuraminic acid (Neu5,9Ac(2)) and non-human 9-O-

116 NeuA de-O-acetylation of free 9-O-acetyl-N-acetylneuraminic acid (Neu5,9Ac(2)) was enhanced by CT

117 raminic acid (Neu5,7Ac(2)) and/or 9-O-acetyl-N-acetylneuraminic acid (Neu5,9Ac(2)).

118 N -Acetylneuraminic acid (Neu5Ac) is a negatively charge

119 We have demonstrated that N-acetylneuraminic acid (Neu5Ac or sialic acid) uptake i

120 N-acetylneuraminic acid (Neu5Ac or sialic acid), at the

121 lective ring-opening of the key intermediate N-acetylneuraminic acid (Neu5Ac) 2,3-beta-epoxide with a

122 uB-negative mutant of E. coli and results in N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-gl

123 s (H) oligosaccharide receptors that contain N-acetylneuraminic acid (Neu5Ac) and cleaves (N) Neu5Ac

124 ty of sialyl chlorides and bromides based on N-acetylneuraminic acid (Neu5Ac) and its deaminated anal

125 The sialic acid (Sia) N-acetylneuraminic acid (Neu5Ac) and its hydroxylated de

126 e common sialic acids of mammalian cells are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuramini

127 , and, in vertebrates, the major species are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuramini

128 e predominantly occupied by the sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuramini

129 stronger than the derivatives of more common N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuramini

130 es, express two major kinds of sialic acids, N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuramini

131 The synthesis of 4-O-alkyl analogues of N-acetylneuraminic acid (Neu5Ac) and the scope of the re

132 The human ligand has N-acetylneuraminic acid (Neu5Ac) as the sialic acid, and

133 Gc, which differs from the human sialic acid N-acetylneuraminic acid (Neu5Ac) by 1 oxygen atom.

134 es because humans exclusively synthesize the N-acetylneuraminic acid (Neu5Ac) form of sialic acid, wh

135 t Ruminococcus gnavus scavenges host-derived N-acetylneuraminic acid (Neu5Ac) from mucins by converti

136 t catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (Neu5Ac) from pyruvate and N-ace

137 o pseudogenization of cytidine monophosphate-N-acetylneuraminic acid (Neu5Ac) hydroxylase (CMAH), whi

138 levels of both sialylation and the precursor N-acetylneuraminic acid (Neu5Ac) in a number of insect c

139 e have identified a gene for the addition of N-acetylneuraminic acid (Neu5Ac) in an alpha-2,3-linkage

140 raminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuramin

141 Although N-acetylneuraminic acid (Neu5Ac) is the main form of sia

142 on of N-glycolylneuraminic acid (Neu5Gc) and N-acetylneuraminic acid (Neu5Ac) on glycoproteins.

143 rythrocyte binding has been shown to involve N-acetylneuraminic acid (Neu5Ac) on the surface of human

144 lly bind to glycan receptors terminated with N-acetylneuraminic acid (Neu5Ac) or N-glycolylneuraminic

145 d to the neuraminidase-catalyzed cleavage of N-acetylneuraminic acid (Neu5Ac) residues from a series

146 PltB, which has binding specificity for the N-acetylneuraminic acid (Neu5Ac) sialoglycans (6,13) pro

147 ack of CMAH, which in other mammals converts N-acetylneuraminic acid (Neu5Ac) to N-glycolylneuraminic

148 a mutation in the enzyme CMAH that converts N-acetylneuraminic acid (Neu5Ac) to Neu5Gc.

149 estigated the contribution of 9-O-acetylated N-acetylneuraminic acid (Neu5Ac) to survival and drug re

150 Sialic acid (N-acetylneuraminic acid (Neu5Ac)) is commonly found in t

151 ly-sialic acids containing alpha2-8-linked 5-N-acetylneuraminic acid (Neu5Ac), 5-N-glycolylneuraminic

152 ar metabolic pathways, including sialic acid N-acetylneuraminic acid (Neu5Ac), and downregulation of

153 elect bacteria biosynthesize the sialic acid N-acetylneuraminic acid (Neu5Ac), and the ability to pro

154 oselectively modify the mucus sialic acid, 5-N-acetylneuraminic acid (Neu5Ac), at the 9-OH group to g

155 GHs recognize the terminal monosaccharides (N-acetylneuraminic acid (Neu5Ac), galactose, mannose, an

156 zing either glucose or sialic acids, such as N-acetylneuraminic acid (Neu5Ac), which are the end prod

157 on of several 3,4-unsaturated derivatives of N-acetylneuraminic acid (Neu5Ac), which have been recent

158 5Gc) with those seen in mice expressing only N-acetylneuraminic acid (Neu5Ac).

159 y, human IAVs preferentially bind to the Sia N-acetylneuraminic acid (Neu5Ac).

160 acetamido, C8-azido, or C8-amino derivatized N-acetylneuraminic acid (Neu5Ac).

161 preferentially expressed in human tissues is N-acetylneuraminic acid (Neu5Ac).

162 nd cleaves (N) oligosaccharides that contain N-acetylneuraminic acid (Neu5Ac).

163 and increase in expression of the precursor N-acetylneuraminic acid (Neu5Ac); increased expression o

164 ave a terminal alpha 2-3-linked sialic acid [N-acetylneuraminic acid (Neu5Ac)], which interferes with

165 KDN (2), a potential oncofetal antigen, and N-acetylneuraminic acid (Neu5Ac, 1), the most naturally

166 dem mass spectrometry method to characterize N-acetylneuraminic acid (Neu5Ac, Sa) linkage in N-linked

167 tly expressed by various hosts, for example, N-acetylneuraminic acid (Neu5Ac; prominent in humans) or

168 t desialylated N-oligosaccharides (DeNO) and N-acetylneuraminic acids (Neu5Ac) could be monitored by

169 Sialic acid (N-acetylneuraminic acid [Neu5Ac]) is a bioavailable carb

170 hydroxylated form of the common sialic acid N-acetylneuraminic acid, Neu5Ac), it is a major componen

171 rst product of NanC is 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (Neu5Ac2en) that can be slowly h

172 as been a target for 2-deoxy-2,3-didehydro-d-N-acetylneuraminic acid (Neu5Ac2en)-based inhibitor deve

173 ry reaction product is 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (Neu5Ac2en, also known as DANA),

174 nsferase (ST6Gal-I) to enzymatically add 13C-N-acetylneuraminic acid (NeuAc or sialic acid) to glycop

175 ibit differences in glycopeptides containing N-acetylneuraminic acid (NeuAc) and N-acetylhexosamine (

176 ably express two major forms of sialic acid, N-acetylneuraminic acid (NeuAc) and N-glycolylneuraminic

177 minal sugar on these glycans is often either N-acetylneuraminic acid (NeuAc) or N-glycolylneuraminic

178 with terminal sialic acids, which are either N-acetylneuraminic acid (NeuAc) or N-glycolylneuraminic

179 es, were shown to be effective receptors for N-acetylneuraminic acid (NeuAc), the most common occurri

180 whereas the less polar GM3 species contained N-acetylneuraminic acid (NeuAc).

181 tion and increased urinary excretion of free N-acetylneuraminic acid (NeuAc, sialic acid).

182 strains contain high levels of sialic acid (N-acetylneuraminic acid, NeuAc) in their LOS.

183 myeloma proteins with enzymatically removed N-acetylneuraminic acid (NeuNAc) and galactose (Gal); re

184 (neuC1), part of the biosynthetic pathway of N-acetylneuraminic acid (NeuNAc), have identical phenoty

185 in NANS, the gene encoding the synthase for N-acetylneuraminic acid (NeuNAc; sialic acid), in nine i

186 N-acetylneuraminic acid oligomers and colominic acid wer

187 lidase activity by cleaving off the terminal N-acetylneuraminic acid on alpha-2,3 or alpha-2,6 sialic

188 lutinin surface glycoprotein to sialic acid (N-acetylneuraminic acid) on the surface of the host cell

189 m resistance in the absence of exogenous CMP-N-acetylneuraminic acid or detectable sialylation.

190 nd only lectins that are specific for either N-acetylneuraminic acid or N-acetylgalactosamine, sugges

191 In vitro, such an UPEC induced N-acetylneuraminic acid release from human spermatozoa w

192 of 19 test glycosphingolipids, an alpha 2,3-N-acetylneuraminic acid residue on the terminal galactos

193 ition state bears considerable charge on the N-acetylneuraminic acid residue, and this and other feat

194 Chemical modifications of N-acetylneuraminic acid residues (on GD1a) abrogated MAG

195 lex type N-glycans with and without terminal N-acetylneuraminic acid residues connected via the alpha

196 epididymitis in mice, a substantial loss of N-acetylneuraminic acid residues was detected in epididy

197 alone or in complex with 2-deoxy-2,3-dehydro-N-acetylneuraminic acid revealed substantial conformatio

198 N-Acetylneuraminic acid (sialic acid) can be incorporate

199 sed when a chemically defined medium lacking N-acetylneuraminic acid (sialic acid) was used.

200 While avian and human IAVs tend to bind to N-acetylneuraminic acid (sialic acid), equine H7 viruses

201 d to study the conformational changes in the N-acetylneuraminic acid-specific SBP VcSiaP.

202 Two of the top candidates identified, CMP N-acetylneuraminic acid synthetase (Cmas) and solute car

203 The enzyme cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS) biosynthesizes

204 019 with mutations in the genes encoding CMP-N-acetylneuraminic acid synthetase (siaB), one of the th

205 M(r) 26,598 with significant homology to CMP-N-acetylneuraminic acid synthetase enzymes involved in s

206 selective advantage of the excess of the Sia N-acetylneuraminic acid (the precursor of N-glycolylneur

207 richia coli are coregulated by environmental N-acetylneuraminic acid, the most prevalent sialic acid

208 in a release of 2.8 mM galactose and 4.3 mM N-acetylneuraminic acid; these sugar concentrations were

209 cleophile in the oxidative deamination of an N-acetylneuraminic acid thioglycoside leading to the for

210 pyruvate with N-acetylmannosamine, yielding N-acetylneuraminic acid, to the aldol condensation gener

211 understood, the transporter responsible for N-acetylneuraminic acid uptake in H. influenzae has yet

212 2 (tauro-GM2) in which the carboxyl group of N-acetylneuraminic acid was amidated by taurine.

213 Glucose, galactose, and N-acetylneuraminic acid were covalently coupled to 3-mor

214 Two sialylated glycans bearing N-acetylneuraminic acid were detected, the first direct

215 t ganglioside ligand for MAG was GM3 bearing N-acetylneuraminic acid, whereas GM3 bearing N-glycolyln

216 Nuclear dreCmas1 favored N-acetylneuraminic acid, whereas the cytosolic dreCmas2

217 - and alpha2-6-linked sialosides, as well as N-acetylneuraminic acid, which is captured in the crysta

218 ae in the presence of 5'-cytidinemonophospho-N-acetylneuraminic acid, which sialylates lipooligosacch

219 agglutinin specifically binds alpha-anomeric N-acetylneuraminic acid with a K(d) of 1.2 mM.

220 retention times significantly; replacing the N-acetylneuraminic acid with the N-glycolyl variant lead