ライフサイエンスコーパス: N-ethyl-N-nitrosourea

1 he spontaneous spectrum or that derived from N-ethyl,N-nitrosourea.

2 ns after treatment with the powerful mutagen N-ethyl-N-nitrosourea.

3 y rat that had been treated with the mutagen N-ethyl-N-nitrosourea.

4 type cells was observed after treatment with N-ethyl-N-nitrosourea.

5 le-lethal mouse mutation that was induced by N-ethyl-N-nitrosourea.

6 mutation in the mouse Nell1 gene, induced by N-ethyl-N-nitrosourea.

7 rmates with a strong DNA-alkylating mutagen, N-ethyl-N-nitrosourea, 55% of transgenic mice developed

8 tically enhanced following administration of N-ethyl-N-nitrosourea, a carcinogen that induces DNA mut

9 Using N-ethyl-N-nitrosourea, a novel recessive mutation named

10 ent, postnatally lethal mutations induced by N-ethyl-N-nitrosourea and mapped near Tyr are alleles of

11 vely resistant to DN, were mutagenized using N-ethyl-N-nitrosourea and screened for mutants that deve

12 tissue, treated with the chemical carcinogen N-ethyl-N-nitrosourea, and continuously passaged to yiel

13 Chinese hamster ovary cells were exposed to N-ethyl-N-nitrosourea, and the clearance of the damage f

14 REM1 in the development of CDH comes from an N-ethyl-N-nitrosourea -derived mouse strain, eyes2, whic

15 Point mutations induced by N -ethyl- N -nitrosourea (ENU) provide a unique mutant r

16 In an N-ethyl N-nitrosourea (ENU) mutagenesis strategy, we ide

17 etic response b (pob), was isolated using an N-ethyl N-nitrosourea (ENU)-based screening strategy des

18 N-Ethyl, N-nitrosourea (ENU) was used as a probing agent

19 a genome-wide, phenotype-driven, large-scale N-ethyl-N--nitrosourea (ENU) mutagenesis screen for domi

20 (e1500) was used to determine the utility of N-ethyl-N-nitrosourea (ENU) as a mutagen for genetic res

21 A single dose of N-ethyl-N-nitrosourea (ENU) during late prenatal or earl

22 Treatment with N-ethyl-N-nitrosourea (ENU) efficiently generates single

23 Using a forward genomics approach by N-ethyl-N-nitrosourea (ENU) germline mutagenesis in mice

24 on of mouse mutations with the point mutagen N-ethyl-N-nitrosourea (ENU) is a key strategy for analys

25 Conventional germ-cell mutagenesis with N-ethyl-N-nitrosourea (ENU) is compromised by an inabili

26 mutations generated by the chemical mutagen n-ethyl-n-nitrosourea (ENU) mapped a new mutant locus (5

27 in (spontaneous inflammation) was induced by N-ethyl-N-nitrosourea (ENU) mutagenesis in C57BL/6J mice

28 We conducted a sensitized N-ethyl-N-nitrosourea (ENU) mutagenesis screen for domin

29 y in both humans and mice, we established an N-ethyl-N-nitrosourea (ENU) mutagenesis screen to identi

30 c.T2A start-codon mutation recovered from an N-ethyl-N-nitrosourea (ENU) mutagenesis screen.

31 lister, was identified through a genome-wide N-ethyl-N-nitrosourea (ENU) mutagenesis screen.

32 N-ethyl-N-nitrosourea (ENU) mutagenesis screens in the m

33 utic intervention, we carried out a dominant N-ethyl-N-nitrosourea (ENU) mutagenesis suppressor scree

34 N-ethyl-N-nitrosourea (ENU) mutagenesis was used in the

35 indirect ophthalmoscopy identified a line of N-ethyl-N-nitrosourea (ENU) mutagenized mice demonstrati

36 protocol for the production of mice carrying N-ethyl-N-nitrosourea (ENU) mutations and their screenin

37 ing bone marrow with the chemical carcinogen N-ethyl-N-nitrosourea (ENU) resulted in significantly ac

38 identified by five, independent mutations in N-ethyl-N-nitrosourea (ENU) saturation mutagenesis exper

39 conducted a second-generation (G2) dominant N-ethyl-N-nitrosourea (ENU) screen especially designed t

40 lin resistance has been used to sensitize an N-ethyl-N-nitrosourea (ENU) screen to identify novel mut

41 with dysfunctional IkappaBNS derived from an N-ethyl-N-nitrosourea (ENU) screen, named bumble, to inv

42 hemical mutagen of choice for mouse has been N-ethyl-N-nitrosourea (ENU), an alkylating agent that ma

43 a(TM)Mouse mice to benzo[a]pyrene (B[a]P) or N-ethyl-N-nitrosourea (ENU), daily for 28 consecutive da

44 g exposure to sublethal gamma-irradiation or N-ethyl-N-nitrosourea (ENU), MLL-CBP mice developed myel

45 or germline mutations induced by the mutagen N-ethyl-N-nitrosourea (ENU), numerous animals died under

46 treatment of mice with the alkylating agent, N-ethyl-N-nitrosourea (ENU), regardless of the levels of

47 males mutagenized with the germline mutagen N-ethyl-N-nitrosourea (ENU), we identified a recessive m

48 We used N-ethyl-N-nitrosourea (ENU)-exposed Ba/F3-p210(BCR-ABL)

49 , 58% of aflatoxin B1 (AFB1)-induced, 14% of N-ethyl-N-nitrosourea (ENU)-induced and 12% of spontaneo

50 In an N-ethyl-N-nitrosourea (ENU)-induced forward genetic scre

51 s study, we developed protocols for creating N-ethyl-N-nitrosourea (ENU)-induced germline mutations i

52 We identify an N-ethyl-N-nitrosourea (ENU)-induced I23N mutation in the

53 We describe the effects of seven new N-ethyl-N-nitrosourea (ENU)-induced Kitl(Sl) mutations a

54 Here, we describe an N-ethyl-N-nitrosourea (ENU)-induced missense error in th

55 e report the identification of a hyperactive N-ethyl-N-nitrosourea (ENU)-induced mouse mutant with ab

56 A new N-ethyl-N-nitrosourea (ENU)-induced mouse recessive muta

57 N-ethyl-N-nitrosourea (ENU)-induced mutagenesis provides

58 We report, using N-ethyl-N-nitrosourea (ENU)-induced mutagenesis, the ide

59 A hitherto unidentified N-ethyl-N-nitrosourea (ENU)-induced mutation affects dor

60 We describe a novel N-ethyl-N-nitrosourea (ENU)-induced mutation, early door

61 Catweasel is a novel N-ethyl-N-nitrosourea (ENU)-induced mutation.

62 A screen for N-ethyl-N-nitrosourea (ENU)-induced mutations affecting

63 N-ethyl-N-nitrosourea (ENU)-induced mutations in Adam17

64 Recessive N-ethyl-N-nitrosourea (ENU)-induced mutations recovered

65 ved substrains and used the panel to map two N-ethyl-N-nitrosourea (ENU)-induced mutations responsibl

66 growth retardation observed in mice carrying N-ethyl-N-nitrosourea (ENU)-induced mutations.

67 ning macrophages isolated from mice carrying N-ethyl-N-nitrosourea (ENU)-induced mutations.

68 man cancers and is mutationally activated in N-ethyl-N-nitrosourea (ENU)-induced rodent tumors of the

69 f magnetic resonance imaging (MRI)-localized N-ethyl-N-nitrosourea (ENU)-induced tumors in rat brains

70 homozygous disruption of the Runx1 gene with N-ethyl-N-nitrosourea (ENU).

71 el (Sl) locus of mice that were induced with N-ethyl-N-nitrosourea (ENU).

72 (premeiotic) cells with the chemical mutagen N-ethyl-N-nitrosourea (ENU).

73 enesis screen with the chemical supermutagen N-ethyl-N-nitrosourea (ENU).

74 he mouse mutant resource employs the mutagen N-ethyl-N-nitrosourea (ENU).

75 increased by treatment with a single dose of N-ethyl-N-nitrosourea (ENU).

76 6C3F1 Big Blue mice (6 weeks old) exposed to N-ethyl-N-nitrosourea (ENU).

77 sis screen in C57BL/6 mice using the mutagen N-ethyl-N-nitrosourea (ENU).

78 and longer chain alkylating agents including N-ethyl-N-nitrosourea, ethyl methanesulfonate, N-propyl-

79 Genome-wide allelotyping of early passage N-ethyl-N-nitrosourea-exposed cell populations revealed

80 To this end, we identified two separate N-ethyl-N-nitrosourea-generated mouse lines that harbor

81 induced by the random germ line mutagen ENU (N-ethyl-N-nitrosourea), have disclosed key molecules in

82 Here, we describe a N-ethyl-N-nitrosourea induced recessive mouse mutant, Ms

83 We describe two N-ethyl N-nitrosourea-induced hypomorphic missense allel

84 mouse mutants, we identified ostes, a novel N-ethyl N-nitrosourea-induced mouse mutant with muscle a

85 N-Ethyl-N-nitrosourea-induced (ENU-induced) missense mut

86 n circadian timing in vivo, we exploited the N-ethyl-N-nitrosourea-induced afterhours mutant Fbxl3(Af

87 both the classic head blebs mutant and in an N-ethyl-N-nitrosourea-induced allele.

88 a null allele of the insulin receptor and an N-ethyl-N-nitrosourea-induced alternative splice mutatio

89 The N-Ethyl-N-Nitrosourea-induced germline mutation 3d (Unc3

90 As a consequence of a recessive N-ethyl-N-nitrosourea-induced germline mutation in the P

91 tion mutations in Herc2 in three independent N-ethyl-N-nitrosourea-induced jdf2 mutant alleles, each

92 The perinatal lethal N-ethyl-N-nitrosourea-induced l7Rn6(4234SB) allele conta

93 The N-ethyl-N-nitrosourea-induced lymphomas spread widely, w

94 Here we describe Jinx, an N-ethyl-N-nitrosourea-induced MCMV susceptibility mutati

95 unresponsive phenotype that results from an N-ethyl-N-nitrosourea-induced missense mutation in the T

96 describe the cleft secondary palate 1 (csp1) N-ethyl-N-nitrosourea-induced mouse model of non-syndrom

97 cilia genes, Dnah11 and Mks1, in independent N-ethyl-N-nitrosourea-induced mouse mutant lines with he

98 Here we report an N-ethyl-N-nitrosourea-induced mouse mutation, Opdc, whic

99 in iron-deficiency anemia, as revealed by an N-ethyl-N-nitrosourea-induced mouse phenotype called sub

100 Repro22 is a mutant mouse produced via N-ethyl-N-nitrosourea-induced mutagenesis that shows ste

101 Adult mice from the N-ethyl-N-nitrosourea-induced mutant mouse line nur5 dis

102 Here we describe an N-ethyl-N-nitrosourea-induced mutant mouse, alien (aln),

103 Recently, a new N-ethyl-N-nitrosourea-induced mutant named chuzhoi (chz)

104 Hereditary albuminuric N-ethyl-N-nitrosourea-induced mutants were redesignated

105 henotype-altering mutations from a screen of N-ethyl-N-nitrosourea-induced mutants.

106 have identified 'triple D' (3d), a recessive N-ethyl-N-nitrosourea-induced mutation and phenotype in

107 of inherited immunodeficiency revealed by an N-ethyl-N-nitrosourea-induced mutation called elektra.

108 viral infection was revealed by a recessive N-ethyl-N-nitrosourea-induced mutation called warmflash

109 27(+/-) and p27(-/-) mice displayed a higher N-ethyl-N-nitrosourea-induced mutation frequency in the

110 As a result of an N-ethyl-N-nitrosourea-induced mutation in the last alpha

111 Here, we report a novel, N-ethyl-N-nitrosourea-induced mutation that causes a gai

112 The spectrum of N-ethyl-N-nitrosourea-induced mutations also provides ne

113 (poly(I:C)) resulting from three independent N-ethyl-N-nitrosourea-induced mutations in host cell fac

114 The immunovariant N-ethyl-N-nitrosourea-induced mutations Pococurante (Poc

115 uce a method for real-time identification of N-ethyl-N-nitrosourea-induced mutations that cause pheno

116 e carried out a genome-wide screen for novel N-ethyl-N-nitrosourea-induced mutations that give rise t

117 Eleven independent, recessive, N-ethyl-N-nitrosourea-induced mutations that map to a ap

118 This process was accelerated by N-ethyl-N-nitrosourea-induced mutations.

119 ubunit of Na(v)1.8 among mice homozygous for N-ethyl-N-nitrosourea-induced mutations.

120 Here we show that an N-ethyl-N-nitrosourea-induced nonsense mutation of Cd36

121 The recessive N-ethyl-N-nitrosourea-induced phenotype toku is characte

122 eport a novel zebrafish gata1 mutant with an N-ethyl-N-nitrosourea-induced point mutation in the C-fi

123 flake (flk), an N-ethyl-N-nitrosourea-induced recessive germ line mutati

124 Within the Munich, Germany, N-ethyl-N-nitrosourea mouse mutagenesis program, we isol

125 Our own N-ethyl-N-nitrosourea mutagenesis effort, which recently

126 Using N-ethyl-N-nitrosourea mutagenesis on an alcohol-averse b

127 Mice from a G3 N-ethyl-N-nitrosourea mutagenesis program were screened

128 s a semidominant mutation identified from an N-ethyl-N-nitrosourea mutagenesis screen in mice.

129 We have utilized N-ethyl-N-nitrosourea mutagenesis to generate pedigrees

130 d out a forward genetic screen in mice using N-ethyl-N-nitrosourea mutagenesis to identify genetic mu

131 Using N-ethyl-N-nitrosourea mutagenesis, we generated and char

132 be the mutant mouse line 20884, generated by N-ethyl-N-nitrosourea mutagenesis, which is characterize

133 These strains were generated by N-ethyl-N-nitrosourea mutagenesis.

134 Forward genetic screens with ENU (N-ethyl-N-nitrosourea) mutagenesis can facilitate gene d

135 overy of another coronin 1A mutant during an N-ethyl-N-nitrosourea-mutagenesis screen for T cell-lymp

136 orn/fetal mice obtained from the breeding of N-ethyl-N-nitrosourea mutagenized mice were formalin-fix

137 e in Pedigree 191 (deficient memory (DM)) of N-ethyl-N-nitrosourea mutagenized mice.

138 invasive high frequency ultrasound to screen N-ethyl-N-nitrosourea mutagenized mouse fetuses for cong

139 A forward genetic screen of N-ethyl-N-nitrosourea mutagenized Xenopus tropicalis has

140 By screening N-ethyl-N-nitrosourea-mutagenized animals for alteration

141 generation germline mutant mice derived from N-ethyl-N-nitrosourea-mutagenized grandsires for intesti

142 Here we identify, from a screen of N-ethyl-N-nitrosourea-mutagenized mice, a mutation causi

143 tion of third generation mice descended from N-ethyl-N-nitrosourea-mutagenized sires.

144 ntified in a population of G(1) mice born to N-ethyl-N-nitrosourea-mutagenized sires.

145 less' (hdl) was detected in third-generation N-ethyl-N-nitrosourea-mutated mice that showed defective

146 Treatment of the DNA template with N-ethyl-N-nitrosourea resulted in a dose-dependent inhib

147 nt of scid/scid mice with gamma radiation or N-ethyl-N-nitrosourea resulted in approximately 86% inci

148 Male zebrafish were mutagenized with N-ethyl N-nitrosourea to induce mutations in spermatogon

149 nome-wide mutagenesis in C57BL/6J mice using N-ethyl-N-nitrosourea to identify mutations causing high

150 by sequencing in first-generation progeny of N-ethyl-N-nitrosourea-treated mice, involving 23 essenti

151 Using N-ethyl-N-nitrosourea, we induced a germline mutation ca