ライフサイエンスコーパス: N-ethyl-N-nitrosourea

1 he spontaneous spectrum or that derived from N-ethyl,N-nitrosourea.

2 mutation in the mouse Nell1 gene, induced by N-ethyl-N-nitrosourea.

3 ns after treatment with the powerful mutagen N-ethyl-N-nitrosourea.

4 y rat that had been treated with the mutagen N-ethyl-N-nitrosourea.

5 type cells was observed after treatment with N-ethyl-N-nitrosourea.

6 le-lethal mouse mutation that was induced by N-ethyl-N-nitrosourea.

7 rmates with a strong DNA-alkylating mutagen, N-ethyl-N-nitrosourea, 55% of transgenic mice developed

8 tically enhanced following administration of N-ethyl-N-nitrosourea, a carcinogen that induces DNA mut

9 Using N-ethyl-N-nitrosourea, a novel recessive mutation named

10 ent, postnatally lethal mutations induced by N-ethyl-N-nitrosourea and mapped near Tyr are alleles of

11 vely resistant to DN, were mutagenized using N-ethyl-N-nitrosourea and screened for mutants that deve

12 outline mouse mutagenesis with the chemical N-ethyl-N-nitrosourea and the strategy used to instantan

13 tissue, treated with the chemical carcinogen N-ethyl-N-nitrosourea, and continuously passaged to yiel

14 Chinese hamster ovary cells were exposed to N-ethyl-N-nitrosourea, and the clearance of the damage f

15 nduced in the germline of C57BL/6J mice with N-ethyl-N-nitrosourea by measuring changes in the perfor

16 REM1 in the development of CDH comes from an N-ethyl-N-nitrosourea -derived mouse strain, eyes2, whic

17 trains postnatally exposed to the carcinogen N-ethyl-N-nitrosourea developed PTMCs, which closely res

18 Point mutations induced by N -ethyl- N -nitrosourea (ENU) provide a unique mutant r

19 In an N-ethyl N-nitrosourea (ENU) mutagenesis strategy, we ide

20 etic response b (pob), was isolated using an N-ethyl N-nitrosourea (ENU)-based screening strategy des

21 N-Ethyl, N-nitrosourea (ENU) was used as a probing agent

22 a genome-wide, phenotype-driven, large-scale N-ethyl-N--nitrosourea (ENU) mutagenesis screen for domi

23 (e1500) was used to determine the utility of N-ethyl-N-nitrosourea (ENU) as a mutagen for genetic res

24 A single dose of N-ethyl-N-nitrosourea (ENU) during late prenatal or earl

25 Treatment with N-ethyl-N-nitrosourea (ENU) efficiently generates single

26 Using a forward genomics approach by N-ethyl-N-nitrosourea (ENU) germline mutagenesis in mice

27 on of mouse mutations with the point mutagen N-ethyl-N-nitrosourea (ENU) is a key strategy for analys

28 Conventional germ-cell mutagenesis with N-ethyl-N-nitrosourea (ENU) is compromised by an inabili

29 mutations generated by the chemical mutagen n-ethyl-n-nitrosourea (ENU) mapped a new mutant locus (5

30 in (spontaneous inflammation) was induced by N-ethyl-N-nitrosourea (ENU) mutagenesis in C57BL/6J mice

31 We conducted a sensitized N-ethyl-N-nitrosourea (ENU) mutagenesis screen for domin

32 y in both humans and mice, we established an N-ethyl-N-nitrosourea (ENU) mutagenesis screen to identi

33 c.T2A start-codon mutation recovered from an N-ethyl-N-nitrosourea (ENU) mutagenesis screen.

34 lister, was identified through a genome-wide N-ethyl-N-nitrosourea (ENU) mutagenesis screen.

35 N-ethyl-N-nitrosourea (ENU) mutagenesis screens in the m

36 utic intervention, we carried out a dominant N-ethyl-N-nitrosourea (ENU) mutagenesis suppressor scree

37 N-ethyl-N-nitrosourea (ENU) mutagenesis was used in the

38 indirect ophthalmoscopy identified a line of N-ethyl-N-nitrosourea (ENU) mutagenized mice demonstrati

39 protocol for the production of mice carrying N-ethyl-N-nitrosourea (ENU) mutations and their screenin

40 ing bone marrow with the chemical carcinogen N-ethyl-N-nitrosourea (ENU) resulted in significantly ac

41 identified by five, independent mutations in N-ethyl-N-nitrosourea (ENU) saturation mutagenesis exper

42 conducted a second-generation (G2) dominant N-ethyl-N-nitrosourea (ENU) screen especially designed t

43 lin resistance has been used to sensitize an N-ethyl-N-nitrosourea (ENU) screen to identify novel mut

44 with dysfunctional IkappaBNS derived from an N-ethyl-N-nitrosourea (ENU) screen, named bumble, to inv

45 We used N-ethyl-N-nitrosourea (ENU) to induce single base substi

46 hemical mutagen of choice for mouse has been N-ethyl-N-nitrosourea (ENU), an alkylating agent that ma

47 a(TM)Mouse mice to benzo[a]pyrene (B[a]P) or N-ethyl-N-nitrosourea (ENU), daily for 28 consecutive da

48 g exposure to sublethal gamma-irradiation or N-ethyl-N-nitrosourea (ENU), MLL-CBP mice developed myel

49 or germline mutations induced by the mutagen N-ethyl-N-nitrosourea (ENU), numerous animals died under

50 treatment of mice with the alkylating agent, N-ethyl-N-nitrosourea (ENU), regardless of the levels of

51 males mutagenized with the germline mutagen N-ethyl-N-nitrosourea (ENU), we identified a recessive m

52 We used N-ethyl-N-nitrosourea (ENU)-exposed Ba/F3-p210(BCR-ABL)

53 , 58% of aflatoxin B1 (AFB1)-induced, 14% of N-ethyl-N-nitrosourea (ENU)-induced and 12% of spontaneo

54 In an N-ethyl-N-nitrosourea (ENU)-induced forward genetic scre

55 ed mice carrying homozygous and heterozygous N-ethyl-N-nitrosourea (ENU)-induced germline mutations f

56 s study, we developed protocols for creating N-ethyl-N-nitrosourea (ENU)-induced germline mutations i

57 We identify an N-ethyl-N-nitrosourea (ENU)-induced I23N mutation in the

58 We describe the effects of seven new N-ethyl-N-nitrosourea (ENU)-induced Kitl(Sl) mutations a

59 Here, we describe an N-ethyl-N-nitrosourea (ENU)-induced missense error in th

60 e report the identification of a hyperactive N-ethyl-N-nitrosourea (ENU)-induced mouse mutant with ab

61 A new N-ethyl-N-nitrosourea (ENU)-induced mouse recessive muta

62 N-ethyl-N-nitrosourea (ENU)-induced mutagenesis provides

63 We report, using N-ethyl-N-nitrosourea (ENU)-induced mutagenesis, the ide

64 In a forward genetic screen of N-ethyl-N-nitrosourea (ENU)-induced mutant mice for aber

65 associated with and stabilized GPR89, and an N-ethyl-N-nitrosourea (ENU)-induced mutation (explorer)

66 A hitherto unidentified N-ethyl-N-nitrosourea (ENU)-induced mutation affects dor

67 We describe a novel N-ethyl-N-nitrosourea (ENU)-induced mutation, early door

68 Catweasel is a novel N-ethyl-N-nitrosourea (ENU)-induced mutation.

69 A screen for N-ethyl-N-nitrosourea (ENU)-induced mutations affecting

70 N-ethyl-N-nitrosourea (ENU)-induced mutations in Adam17

71 Recessive N-ethyl-N-nitrosourea (ENU)-induced mutations recovered

72 ved substrains and used the panel to map two N-ethyl-N-nitrosourea (ENU)-induced mutations responsibl

73 In an ongoing forward genetic screen for N-ethyl-N-nitrosourea (ENU)-induced mutations that incre

74 growth retardation observed in mice carrying N-ethyl-N-nitrosourea (ENU)-induced mutations.

75 ning macrophages isolated from mice carrying N-ethyl-N-nitrosourea (ENU)-induced mutations.

76 man cancers and is mutationally activated in N-ethyl-N-nitrosourea (ENU)-induced rodent tumors of the

77 f magnetic resonance imaging (MRI)-localized N-ethyl-N-nitrosourea (ENU)-induced tumors in rat brains

78 A forward genetic screen with N-ethyl-N-nitrosourea (ENU)-mutagenized mice linked IRF2

79 s throughout Oceania, and A20 I325N, from an N-ethyl-N-nitrosourea (ENU)-mutagenized mouse strain.

80 homozygous disruption of the Runx1 gene with N-ethyl-N-nitrosourea (ENU).

81 el (Sl) locus of mice that were induced with N-ethyl-N-nitrosourea (ENU).

82 (premeiotic) cells with the chemical mutagen N-ethyl-N-nitrosourea (ENU).

83 enesis screen with the chemical supermutagen N-ethyl-N-nitrosourea (ENU).

84 he mouse mutant resource employs the mutagen N-ethyl-N-nitrosourea (ENU).

85 increased by treatment with a single dose of N-ethyl-N-nitrosourea (ENU).

86 6C3F1 Big Blue mice (6 weeks old) exposed to N-ethyl-N-nitrosourea (ENU).

87 types in Mecp2/Y mice after mutagenesis with N-ethyl-N-nitrosourea (ENU).

88 sis screen in C57BL/6 mice using the mutagen N-ethyl-N-nitrosourea (ENU).

89 and longer chain alkylating agents including N-ethyl-N-nitrosourea, ethyl methanesulfonate, N-propyl-

90 Genome-wide allelotyping of early passage N-ethyl-N-nitrosourea-exposed cell populations revealed

91 To this end, we identified two separate N-ethyl-N-nitrosourea-generated mouse lines that harbor

92 induced by the random germ line mutagen ENU (N-ethyl-N-nitrosourea), have disclosed key molecules in

93 Here, we describe a N-ethyl-N-nitrosourea induced recessive mouse mutant, Ms

94 We describe two N-ethyl N-nitrosourea-induced hypomorphic missense allel

95 mouse mutants, we identified ostes, a novel N-ethyl N-nitrosourea-induced mouse mutant with muscle a

96 N-Ethyl-N-nitrosourea-induced (ENU-induced) missense mut

97 n circadian timing in vivo, we exploited the N-ethyl-N-nitrosourea-induced afterhours mutant Fbxl3(Af

98 both the classic head blebs mutant and in an N-ethyl-N-nitrosourea-induced allele.

99 a null allele of the insulin receptor and an N-ethyl-N-nitrosourea-induced alternative splice mutatio

100 The N-Ethyl-N-Nitrosourea-induced germline mutation 3d (Unc3

101 As a consequence of a recessive N-ethyl-N-nitrosourea-induced germline mutation in the P

102 tion mutations in Herc2 in three independent N-ethyl-N-nitrosourea-induced jdf2 mutant alleles, each

103 The perinatal lethal N-ethyl-N-nitrosourea-induced l7Rn6(4234SB) allele conta

104 The N-ethyl-N-nitrosourea-induced lymphomas spread widely, w

105 Here we describe Jinx, an N-ethyl-N-nitrosourea-induced MCMV susceptibility mutati

106 unresponsive phenotype that results from an N-ethyl-N-nitrosourea-induced missense mutation in the T

107 describe the cleft secondary palate 1 (csp1) N-ethyl-N-nitrosourea-induced mouse model of non-syndrom

108 cilia genes, Dnah11 and Mks1, in independent N-ethyl-N-nitrosourea-induced mouse mutant lines with he

109 Here we report an N-ethyl-N-nitrosourea-induced mouse mutation, Opdc, whic

110 in iron-deficiency anemia, as revealed by an N-ethyl-N-nitrosourea-induced mouse phenotype called sub

111 Repro22 is a mutant mouse produced via N-ethyl-N-nitrosourea-induced mutagenesis that shows ste

112 Adult mice from the N-ethyl-N-nitrosourea-induced mutant mouse line nur5 dis

113 Here we describe an N-ethyl-N-nitrosourea-induced mutant mouse, alien (aln),

114 Recently, a new N-ethyl-N-nitrosourea-induced mutant named chuzhoi (chz)

115 Hereditary albuminuric N-ethyl-N-nitrosourea-induced mutants were redesignated

116 henotype-altering mutations from a screen of N-ethyl-N-nitrosourea-induced mutants.

117 have identified 'triple D' (3d), a recessive N-ethyl-N-nitrosourea-induced mutation and phenotype in

118 of inherited immunodeficiency revealed by an N-ethyl-N-nitrosourea-induced mutation called elektra.

119 viral infection was revealed by a recessive N-ethyl-N-nitrosourea-induced mutation called warmflash

120 27(+/-) and p27(-/-) mice displayed a higher N-ethyl-N-nitrosourea-induced mutation frequency in the

121 As a result of an N-ethyl-N-nitrosourea-induced mutation in the last alpha

122 lymphoid lineages in mice, resulting from an N-ethyl-N-nitrosourea-induced mutation in the limb regio

123 Here, we report a novel, N-ethyl-N-nitrosourea-induced mutation that causes a gai

124 The spectrum of N-ethyl-N-nitrosourea-induced mutations also provides ne

125 In a forward genetic screen of mice with N-ethyl-N-nitrosourea-induced mutations for aberrant imm

126 In a forward genetic screen of mice with N-ethyl-N-nitrosourea-induced mutations for defects in a

127 (poly(I:C)) resulting from three independent N-ethyl-N-nitrosourea-induced mutations in host cell fac

128 The immunovariant N-ethyl-N-nitrosourea-induced mutations Pococurante (Poc

129 uce a method for real-time identification of N-ethyl-N-nitrosourea-induced mutations that cause pheno

130 e carried out a genome-wide screen for novel N-ethyl-N-nitrosourea-induced mutations that give rise t

131 Eleven independent, recessive, N-ethyl-N-nitrosourea-induced mutations that map to a ap

132 This process was accelerated by N-ethyl-N-nitrosourea-induced mutations.

133 ubunit of Na(v)1.8 among mice homozygous for N-ethyl-N-nitrosourea-induced mutations.

134 Here we show that an N-ethyl-N-nitrosourea-induced nonsense mutation of Cd36

135 The recessive N-ethyl-N-nitrosourea-induced phenotype toku is characte

136 eport a novel zebrafish gata1 mutant with an N-ethyl-N-nitrosourea-induced point mutation in the C-fi

137 flake (flk), an N-ethyl-N-nitrosourea-induced recessive germ line mutati

138 Within the Munich, Germany, N-ethyl-N-nitrosourea mouse mutagenesis program, we isol

139 Our own N-ethyl-N-nitrosourea mutagenesis effort, which recently

140 Using N-ethyl-N-nitrosourea mutagenesis in mice in combination

141 Using N-ethyl-N-nitrosourea mutagenesis on an alcohol-averse b

142 Combining an unbiased N-ethyl-N-nitrosourea mutagenesis pipeline in mice with

143 Mice from a G3 N-ethyl-N-nitrosourea mutagenesis program were screened

144 s a semidominant mutation identified from an N-ethyl-N-nitrosourea mutagenesis screen in mice.

145 We have utilized N-ethyl-N-nitrosourea mutagenesis to generate pedigrees

146 d out a forward genetic screen in mice using N-ethyl-N-nitrosourea mutagenesis to identify genetic mu

147 Using N-ethyl-N-nitrosourea mutagenesis, we generated and char

148 Through N-ethyl-N-nitrosourea mutagenesis, we have discovered a

149 be the mutant mouse line 20884, generated by N-ethyl-N-nitrosourea mutagenesis, which is characterize

150 These strains were generated by N-ethyl-N-nitrosourea mutagenesis.

151 Forward genetic screens with ENU (N-ethyl-N-nitrosourea) mutagenesis can facilitate gene d

152 overy of another coronin 1A mutant during an N-ethyl-N-nitrosourea-mutagenesis screen for T cell-lymp

153 In a behavioral screen of N-ethyl-N-nitrosourea mutagenized mice we identified a m

154 orn/fetal mice obtained from the breeding of N-ethyl-N-nitrosourea mutagenized mice were formalin-fix

155 e in Pedigree 191 (deficient memory (DM)) of N-ethyl-N-nitrosourea mutagenized mice.

156 invasive high frequency ultrasound to screen N-ethyl-N-nitrosourea mutagenized mouse fetuses for cong

157 A forward genetic screen of N-ethyl-N-nitrosourea mutagenized Xenopus tropicalis has

158 By screening N-ethyl-N-nitrosourea-mutagenized animals for alteration

159 generation germline mutant mice derived from N-ethyl-N-nitrosourea-mutagenized grandsires for intesti

160 Here we identify, from a screen of N-ethyl-N-nitrosourea-mutagenized mice, a mutation causi

161 ntified in a population of G(1) mice born to N-ethyl-N-nitrosourea-mutagenized sires.

162 tion of third generation mice descended from N-ethyl-N-nitrosourea-mutagenized sires.

163 less' (hdl) was detected in third-generation N-ethyl-N-nitrosourea-mutated mice that showed defective

164 Treatment of the DNA template with N-ethyl-N-nitrosourea resulted in a dose-dependent inhib

165 nt of scid/scid mice with gamma radiation or N-ethyl-N-nitrosourea resulted in approximately 86% inci

166 Male zebrafish were mutagenized with N-ethyl N-nitrosourea to induce mutations in spermatogon

167 nome-wide mutagenesis in C57BL/6J mice using N-ethyl-N-nitrosourea to identify mutations causing high

168 by sequencing in first-generation progeny of N-ethyl-N-nitrosourea-treated mice, involving 23 essenti

169 Using N-ethyl-N-nitrosourea, we induced a germline mutation ca