ライフサイエンスコーパス: N-linked oligosaccharide

1 e most commonly found glycosidic linkages in N-linked oligosaccharides.

2 attach the essential glucose residues on the N-linked oligosaccharides.

3 in significant alterations in the profile of N-linked oligosaccharides.

4 asialoglycopeptides containing triantennary N-linked oligosaccharides.

5 s that the alternative proreceptor contained N-linked oligosaccharides.

6 ion and increases the beta(1,6) branching of N-linked oligosaccharides.

7 on in the classical biosynthetic pathway for N-linked oligosaccharides.

8 verified by profiling and sequencing of the N-linked oligosaccharides.

9 ate glycoproteins that have monoglucosylated N-linked oligosaccharides.

10 -linkage to the alpha(1,6)-linked mannose of N-linked oligosaccharides.

11 ,6-linkage to the asparagine-bound GlcNAc of N-linked oligosaccharides.

12 e human transferrin receptor (TfR) has three N-linked oligosaccharides.

13 at adds sialic acid residues to glycoprotein N-linked oligosaccharides.

14 ts of hCG-beta subunit that lack both of the N-linked oligosaccharides.

15 Ser, which we call phosphoglycosylation, and N-linked oligosaccharides.

16 glycoprotein with more extensively processed N-linked oligosaccharides.

17 n of alpha2-6-linked sialic acid residues on N-linked oligosaccharides.

18 diates transfer of GalNAc to each of its two N-linked oligosaccharides.

19 ) to obtain structural information for large N-linked oligosaccharides.

20 cross-ring cleavages were observed only for N-linked oligosaccharides.

21 esonance mass spectrometry was observed with N-linked oligosaccharides.

22 g and the proportion of Kv1.1 with processed N-linked oligosaccharides.

23 positive electrode contained more sialylated N-linked oligosaccharides.

24 ymes containing mannose 6-phosphate on their N-linked oligosaccharides.

25 numula and Dhume, originally used to analyze N-linked oligosaccharides.

26 ster ovary cells and contained complex type, N-linked oligosaccharides.

27 m defects in the synthesis and processing of N-linked oligosaccharides.

28 ASOR, that contain tri- and tetra-antennary N-linked oligosaccharides.

29 f both the peptide recognition motif and the N-linked oligosaccharide acceptors to transfer GalNAc in

30 ne kidney cells, indicating that no specific N-linked oligosaccharide acts as a determinant for apica

31 glycoproteins possess an invariant site for N-linked oligosaccharide addition at position 86 of the

32 ontains only a single consensus sequence for N-linked oligosaccharide addition within its extracellul

33 293 cells with tunicamycin, an inhibitor of N-linked oligosaccharide addition, was found to prevent

34 osaccharide moiety, sialyl Lewisx (sLex), as N-linked oligosaccharide adducts.

35 dic liquid chromatography (LC) of methylated N-linked oligosaccharide alditols resolved some closely

36 Decorin can be efficiently secreted with N-linked oligosaccharides alone or with a single chondro

37 The expressed protein devoid of N-linked oligosaccharides also formed trimers, but was s

38 onstrate a novel functional role for a gp120 N-linked oligosaccharide and a high degree of adaptabili

39 ligand for BAEBL (VSTK) being, in part, the N-linked oligosaccharide and suggest that single-point m

40 with a single chondroitin sulfate chain and N-linked oligosaccharides and a core protein glycoform s

41 th glycoproteins containing monoglucosylated N-linked oligosaccharides and are proposed to traffic pr

42 -, alpha1,2-, and alpha1,3-linked mannose to N-linked oligosaccharides and by a Kex2p-initiated prote

43 nts, including appropriate substitution with N-linked oligosaccharides and factors involved in glycos

44 combinant TM14 protein was glycosylated with N-linked oligosaccharides and interacted with heparin, f

45 ectric point, is partly a consequence of the N-linked oligosaccharides and not the polypeptide chain

46 ns lie glycosylation sites, with up to three N-linked oligosaccharides and probably three chondroitin

47 t to an approximately 28-kDa form that lacks N-linked oligosaccharides and the N-terminal signal pept

48 The structure of the four N-linked oligosaccharides and the type of substitution a

49 s used to characterize the structures of the N-linked oligosaccharides and to map their locations.

50 the C-terminus by events that do not involve N-linked oligosaccharides and which are consistent with

51 N-glycanase treatment removed N-linked oligosaccharides and yielded products of 41 kDa

52 All the glycoforms were substituted with two N-linked oligosaccharides, and the disaccharide composit

53 N-linked oligosaccharides appear to be important for the

54 The mannose branch points of N-linked oligosaccharides are apparently more susceptibl

55 stant to endo H treatment; thus, some of its N-linked oligosaccharides are of the complex/hybrid type

56 Unfortunately, N-linked oligosaccharides are relatively large compounds

57 a key mannosyl donor for the biosynthesis of N-linked oligosaccharides as well as for O-linked oligos

58 ative gD conformation but independent of its N-linked oligosaccharides, as expected from previous str

59 hree subunits of the 300-kDa species contain N-linked oligosaccharides, as indicated by increased mig

60 a GalNAc for galactose substitution on some N-linked oligosaccharides, as well as a high degree of f

61 Here we sequence the N-linked oligosaccharides associated with a reporter pro

62 Plasminogen 1 contains an N-linked oligosaccharide at Asn-289 and an O-linked olig

63 increase in the size and sialylation of the N-linked oligosaccharide at Asn-70.

64 Many plant proteins are modified with N-linked oligosaccharides at asparagine-X-serine/threoni

65 e of CGalT without affecting the trimming of N-linked oligosaccharides at CGalT.

66 ytoplasmic region of the receptor as well as N-linked oligosaccharides at positions 31, 57, and 87 ar

67 ional modification, a sialylated diantennary N-linked oligosaccharide attached to the asparagine resi

68 Structures of the N-linked oligosaccharide attached to the heavy chain of

69 show that biotinylated channel proteins with N-linked oligosaccharides attached at positions 140 and

70 A decorin core protein mutant devoid of N-linked oligosaccharide attachment sites will not be se

71 Three of the four potential N-linked oligosaccharide binding sites (Asn(125), Asn(14

72 less, the CCR5(Y14N) component that lacks an N-linked oligosaccharide binds the chemokine MIP-lbeta w

73 inant hHARE contains approximately 25 kDa of N-linked oligosaccharides, binds HA in a ligand blot ass

74 dies reveal cell-type-specific variations in N-linked oligosaccharide biosynthesis and an essential r

75 gC2(426t) contains N-linked oligosaccharides, but no O-linked oligosacchari

76 Removal of this N-linked oligosaccharide by mutagenesis enabled hamster

77 Mannose phosphorylation of N-linked oligosaccharides by UDP-GlcNAc:lysosomal enzyme

78 t was shown that the inherent flexibility of N-linked oligosaccharides can account for the specificit

79 ontrol mechanisms sensitive to an absence of N-linked oligosaccharides can be abrogated by interactio

80 he first enzyme in the processing pathway of N-linked oligosaccharide), cause the rare congenital dis

81 is the highly elevated beta1,6 branching of N-linked oligosaccharides caused by increased transcript

82 ites and the biantennary, mannose-containing N-linked oligosaccharide chain are involved in this inte

83 anching pattern of extracellular asparagine (N)-linked oligosaccharide chains (N-glycans), results in

84 a 221 amino acid glycoprotein possessing two N-linked oligosaccharide chains (8% glycosylated by weig

85 of the receptor and have the same number of N-linked oligosaccharide chains but differ in the extent

86 suggest that cell surface glycoproteins with N-linked oligosaccharide chains contribute to the entry

87 lucosamine (GlcNAc) residues of the branched N-linked oligosaccharide chains of glycoproteins.

88 Recent evidence shows that trimming of their N-linked oligosaccharide chains plays a key role in targ

89 syndrome (CDGS) patients fail to add entire N-linked oligosaccharide chains to some serum glycoprote

90 ially synthesized with multiple high mannose N-linked oligosaccharide chains, and some, but not all,

91 inal domain binds to the mannose moieties of N-linked oligosaccharide chains, and we further show tha

92 protein, a sialoglycoprotein containing two N-linked oligosaccharide chains, from its normal form (P

93 f Russell's viper venom (RVV-X) contains six N-linked oligosaccharide chains: four in the heavy chain

94 ctions, hamster ASCT1 contains an additional N-linked oligosaccharide clustered close to the others i

95 This work describes a novel N-linked oligosaccharide containing a repeating SQ-Hex u

96 ificity for E-selectin binding to a panel of N-linked oligosaccharides containing a clustered array o

97 osphatidylcholine to hybrid and complex type N-linked oligosaccharides containing mannose residues di

98 analysis of HvALP revealed the existence of N-linked oligosaccharides containing terminal N-acetylga

99 For example, the N-linked oligosaccharides containing the [GlcNAc beta(1,

100 Analysis of N-linked oligosaccharide content by mass matching paradi

101 ition of the alpha-1-6 linked Man residue in N-linked oligosaccharide core structures.

102 osidase F (PNGase F) in order to release the N-linked oligosaccharides, derivatized, and analyzed by

103 The release of sub-picomole levels of N-linked oligosaccharides directly from 1-5 micrograms o

104 function, we released and characterized the N-linked oligosaccharide distribution in these three gly

105 of the fragments identified sialic acids and N-linked oligosaccharides exclusively on the 45-kDa [125

106 The HRP epitope is an N-linked oligosaccharide expressed on a subset of neuron

107 have characterised all of the major neutral N-linked oligosaccharides expressed in adult rat using a

108 ions in the V4 loop that eliminated the same N-linked oligosaccharide from position N403.

109 The N-linked oligosaccharide from soy bean agglutinin (Man9)

110 Moreover, removal of the N-linked oligosaccharide from the wild-type glycophorin

111 Furthermore, elimination of the two N-linked oligosaccharides from extracellular loop 2 of m

112 n as peptide: N-glycanases (PNGases) release N-linked oligosaccharides from glycopeptides and/or glyc

113 Removal of N-linked oligosaccharides from hEGP with PNGaseF did not

114 In addition, elimination of the two N-linked oligosaccharides from mASCT2 by mutagenesis, as

115 Peptide N-glycanase removes N-linked oligosaccharides from misfolded glycoproteins a

116 Deletion of the N-linked oligosaccharides from SP-A by mutagenesis of th

117 Treatment of cells with PNGase F, to remove N-linked oligosaccharides from the cell surface, did not

118 a simple and sensitive method for analyzing N-linked oligosaccharides from the individual isoelectri

119 Labeling of released asparagine-linked (N-linked) oligosaccharides from glycoproteins is commonl

120 Removal of asparagine-linked (N-linked) oligosaccharides from gp55, by extensive diges

121 of mannose residues from asparagine-linked (N-linked) oligosaccharides, generation of ubiquitinated

122 Glucosylated oligomannose N-linked oligosaccharides (Glc(x)Man9GlcNAc2 where x = 1

123 Core fucosylation of N-linked oligosaccharides (GlcNAcbeta1, 4(Fucalpha1,6)Gl

124 A gD variant lacking all signals for N-linked oligosaccharides had an affinity for HveAt simi

125 1) that is unable to synthesize complex-type N-linked oligosaccharides had an increased susceptibilit

126 h terminal fucose, the sialyl T-antigen, and N-linked oligosaccharides identified as potentially impo

127 In addition, mutation of the single N-linked oligosaccharide in punctin-1 led to decreased l

128 binations of amino acid sequence changes and N-linked oligosaccharides in a critical carboxyl-termina

129 Because the only two N-linked oligosaccharides in mASCT1 occur in the carboxy

130 en together, these studies define a role for N-linked oligosaccharides in supporting the stability an

131 or one beta-linked GalNAc residue), whereas N-linked oligosaccharides in the Fc region contained typ

132 pyruvate functional groups being attached to N-linked oligosaccharides in yeast and appears only to b

133 lation of delta F508 protein bearing complex N-linked oligosaccharides, indicative of their transit t

134 the terminal alpha2,3-linked sialic acid on N-linked oligosaccharides inhibited binding; (b) the fir

135 Altered expression of cell surface N-linked oligosaccharides is associatedwith the oncogeni

136 Mannose in N-linked oligosaccharides is assumed to be derived prima

137 The structural diversity of glycoprotein N-linked oligosaccharides is determined by the expressio

138 used to differentiate glycoprotein-released N-linked oligosaccharide isomers directly from aliquots

139 hey interact with substrate monoglucosylated N-linked oligosaccharides, it has been proposed that the

140 t that SLex biantennary and triantennary are N-linked oligosaccharide ligands for E-selectin and impl

141 The single consensus N-linked oligosaccharide linkage site in SakSTAR (at Asn

142 Analysis revealed three N-linked oligosaccharides located on Asn251 and Asn554 o

143 single glycosaminoglycan chain and the three N-linked oligosaccharides located on the same side of th

144 hetic six-mannose fragment of a high mannose N-linked oligosaccharide, Manalpha1-2Manalpha1-3[Manalph

145 sion to hyaluronate, suggesting that complex N-linked oligosaccharides may not be required for and ma

146 A novel system for characterizing complex N-linked oligosaccharide mixtures that uses a combinatio

147 These processing alterations were non-N-linked oligosaccharide modifications that could not be

148 rminal sialic acids on glycoproteins bearing N-linked oligosaccharides, most notably on alpha3beta1 i

149 e biosynthesis of complex asparagine-linked (N-linked) oligosaccharides (N-glycans).

150 rocess that requires neither the addition of N-linked oligosaccharides nor modification in the Golgi

151 re consistent with the proposal that neither N-linked oligosaccharides nor sialic acid is an essentia

152 Since the addition of N-linked oligosaccharides occurs only after the glycosyl

153 The N-linked oligosaccharide of Gerbich-negative glycophorin

154 at functions in the late Golgi to modify the N-linked oligosaccharides of glycoproteins.

155 nique beta-linked mannose sugar found in all N-linked oligosaccharides of glycoproteins.

156 Structural studies on the N-linked oligosaccharides of Haemonchus contortus, an ec

157 ere we report the structural features of the N-linked oligosaccharides of the beta-subunit from rabbi

158 to mannose 6-phosphate residues found on the N-linked oligosaccharides of their ligands.

159 Analysis of the N-linked oligosaccharides of these proteins demonstrates

160 The heterogeneous N-linked oligosaccharides of TNFR-IgG contain sialic aci

161 N-linked oligosaccharides often act as ligands for recep

162 was a glycoprotein containing ca. 60 kDa of N-linked oligosaccharides on a peptide backbone of 65 kD

163 that protein-specific transfer of GalNAc to N-linked oligosaccharides on glycoprotein substrates is

164 er ), which mediates sulfate addition to the N-linked oligosaccharides on LH and other pituitary glyc

165 -4-ST1 also efficiently transfers sulfate to N-linked oligosaccharides on native LH and other glycopr

166 h calreticulin, suggesting a requirement for N-linked oligosaccharides on newly synthesized proteins

167 -linked N-acetylgalactosamine (O-GalNAc), or N-linked oligosaccharides on ovalbumin and immunoglobuli

168 izes sialic acid linked alpha2,6 to terminal N-linked oligosaccharides on selected cell surface glyco

169 ver, dimer formation is not dependent on the N-linked oligosaccharides on the domain.

170 Both betaGTs transfer GalNAc to N-linked oligosaccharides on the luteinizing hormone alp

171 in proteins are mediated at least in part by N-linked oligosaccharides on the proteoglycan, N-deglyco

172 is study was to investigate the roles of the N-linked oligosaccharides on the secreted form of mouse

173 Is glycosylation with either N-linked oligosaccharides or glycosaminoglycan required

174 th glycoproteins that carry monoglucosylated N-linked oligosaccharides, others have reported that it

175 n/acquisition and processing/modification of N-linked oligosaccharides play a role in the functional

176 Our results indicate that N-linked oligosaccharides play an important role in cori

177 to study the influence of the late steps in N-linked oligosaccharide processing on glycoprotein func

178 Inhibitors of N-linked oligosaccharide processing or of O-glycosylatio

179 a-D-mannosidase, an enzyme involved in early N-linked oligosaccharide processing, has been isolated f

180 The large N-linked oligosaccharides released by endo-beta-N-acetyl

181 of sialic acid loss during 2-AB labeling of N-linked oligosaccharides released from bovine fetuin, p

182 surface receptor containing sialic acid and N-linked oligosaccharide residues, whereas the 125-kD ba

183 linked oligosaccharide substitution (2 and 3 N-linked oligosaccharides, respectively).

184 N-Glycanase treatment to remove N-linked oligosaccharides shifted the subunit molecular

185 sized glycoproteins required trimming of the N-linked oligosaccharide side chain.

186 us system typically lack complex biantennary N-linked oligosaccharide side chains containing penultim

187 d to both human IgA1 and IgA2, primarily via N-linked oligosaccharide side chains.

188 indicate that eight to nine of the predicted N-linked oligosaccharide sites on gC1(457t) are occupied

189 calculated from its composition including 14 N-linked oligosaccharide sites, and confirmed that sCR1

190 cterized by a deficiency in glycosylation of N-linked oligosaccharides, still bound rotavirus.

191 inant glycoproteins with complex biantennary N-linked oligosaccharides structurally identical to thos

192 We report that N-linked oligosaccharide structures can be present on an

193 Results showed that the major N-linked oligosaccharide structures in the Fv region hav

194 N-linked oligosaccharide structures synthesized by cells

195 ately 53 kDa) that differed in the extent of N-linked oligosaccharide substitution (2 and 3 N-linked

196 firmed that they have the same defect in the N-linked oligosaccharide synthesis pathway.

197 NE2G216 has been linked to the structures of N-linked oligosaccharides synthesized by arthropod cells

198 the molecular layer of the cerebellum bears N-linked oligosaccharides terminating with beta1,4-linke

199 N-Linked oligosaccharides terminating with the sequence

200 glutamine produced a transporter lacking its N-linked oligosaccharide that exhibited a 2.5-fold incre

201 hormone and carbonic anhydrase-VI (CA6) bear N-linked oligosaccharides that are modified with beta1,4

202 ynthesized in the kidney and the brain bears N-linked oligosaccharides that are modified with termina

203 ose 6-phosphate recognition markers on their N-linked oligosaccharides that are recognized by two dis

204 efore require an expression host that yields N-linked oligosaccharides that are structurally and func

205 In contrast to mASCT1, which contains two N-linked oligosaccharides that partially restrict viral

206 cells to determine the roles of a conserved N-linked oligosaccharide, the collagen helix, and interc

207 Asn-108 and Asn-133 carried oligomannosidic N-linked oligosaccharides, the six other glycosylation s

208 from the limited processing undergone by its N-linked oligosaccharides; this stood in contrast to lys

209 ication of a specific cluster of asparagine (N)-linked oligosaccharides to a fully glucose-trimmed, m

210 unicamycin, a drug that prevents addition of N-linked oligosaccharides to nascent polypeptide chains.

211 ave a role in the conversion of high mannose N-linked oligosaccharides to polylactosamine and/or kera

212 te processing which limits the processing of N-linked oligosaccharides to structures that are structu

213 P-xylose to the beta-linked mannose of plant N-linked oligosaccharides was purified about 51,000-fold

214 The seventh LRR and an N-linked oligosaccharide were between the two C-terminal

215 The location and structural features of the N-linked oligosaccharides were determined using matrix-a

216 opolysaccharide, radioiodinated tyrosinamide N-linked oligosaccharides were dosed i.v. and analyzed f

217 At least 20 different N-linked oligosaccharides were fractionated by high-pH a

218 A number of other N-linked oligosaccharides were poor acceptors, especiall

219 N-linked oligosaccharides were released and profiled fro

220 The N-linked oligosaccharides were released by treatment wit

221 vered by a glycan shield of approximately 90 N-linked oligosaccharides, which comprises roughly half

222 raction yielded small quantities of a single N-linked oligosaccharide with the structure Man alpha1-6

223 lycosylation pathway in P. pastoris to yield N-linked oligosaccharides with hybrid structures that ar

224 lation mutants to produce class I HC bearing N-linked oligosaccharides with the specific structure Gl

225 wide range of fucosylated glycans, including N-linked oligosaccharides with unusual complex core modi