ライフサイエンスコーパス: N-terminal

1 o acid L-allo-End, while the other is at the N-terminal.

2 hat the evolutionarily conserved human CDC73 N-terminal 111 residues form a globularly folded domain

3 e both required for the association with the N-terminal 147 residues of IFT46.

4 We find that the addition of the N-terminal 17-residue sequence ([Formula: see text]) fac

5 lity and activity of agave Rca mapped to the N-terminal 244 residues.

6 ll as a 'recruitment' strategy attaching the N-terminal 45 residues of FOG1 to dCas9 to recruit the e

7 We find that the N-terminal ABD1 blocks actin filament barbed-end elongat

8 ly provided several sequence determinants of N-terminal acetylation for proteins lacking (i)Met, some

9 N-terminal acetylation is one of the most common protein

10 As the occurrence of N-terminal acetylation strongly depends on the context o

11 s to understand the sequence determinants of N-terminal acetylation were conducted initially by simpl

12 med NT-AcPredictor, accurately predicted the N-terminal acetylation, with an overall performance comp

13 was recently identified as an unconventional N-terminal acetyltransferase (NAT) because it localizes

14 side phosphotransferase(2'')-Ia possesses an N-terminal acetyltransferase domain and a C-terminal pho

15 It has an N-terminal acidic (A-) domain that extends into the cyto

16 t Lysine 1016 and Phenylalanine1037 with the N-terminal acidic domain of the telomere shelterin prote

17 the presence of Ng13-49 by showing that the N-terminal acidic region of Ng peptide pries open the be

18 indicated that the L142 protein contains an N-terminal acyltransferase domain and a predicted C-term

19 to the mitochondrial outer membrane via its N-terminal alpha helix domain and hosts a redox-active [

20 N-methylation of the N-terminal amine further limited its interactions with p

21 To address this problem, we modified the N-terminal amine of leptin with Pluronic P85 (LepNP85) a

22 , respectively, which differ solely in their N-terminal amino acid sequences.

23 ding site residue Y745 and, essentially, the N-terminal amino acids 1-800.

24 active region(s) of Ov-GRN-1, four truncated N-terminal analogues were synthesized and characterized

25 e made as precursors with positively charged N-terminal anchors, whose cleavage via the prepilin pept

26 ptor Toll-like receptor 4 (TLR4) through its N terminal and modulates STAT3 and TBK1 signaling, trigg

27 The N-terminal and C-terminal domains of CA (NTD and CTD, re

28 Effects of N-terminal and C-terminal STIM1 antibodies on TRPC1-base

29 Here we report that the N-terminal ankyrin repeats of TRPA1 directly bind to the

30 Tau13, another N-terminal antibody, was not sensitive to pathological N

31 ind the 0-layer of the SNARE complex and its N-terminal apolar loop.

32 e RxLR effectors, defined by their conserved N-terminal Arg-Xaa-Leu-Arg (RxLR) motif.

33 e intracellular Hsp90 is attributed to their N-terminal ATPase-driven chaperone function.

34 vity troponin T, creatine kinase, myoglobin, N-terminal B-type natriuretic peptide, C-reactive protei

35 ns and the long isoforms containing a unique N-terminal beta-catenin-interacting domain.

36 recombinant alpha-syn protein containing an N-terminal bicysteine tag (C2-alpha-syn).

37 putative scaffold interactions involving the N-terminal BRCT domains 1 to 4 of Brc1 have remained obs

38 Finally, we observed that the N-terminal, but not the C-terminal, moiety of MF6p/HDMs

39 hile 12 binds an RNA-binding site inside the N-terminal cassette.

40 BoNTs are dichain toxins, comprising an N-terminal catalytic domain (LC) disulfide bond linked t

41 The N-terminal chain is unstructured and leads the permeatio

42 Ser(41) as a mechanism that prevents beta1AR N-terminal cleavage.

43 al footprint extends 13 nucleotides into the N-terminal coding region and, when a mRNA structure over

44 antibody, was not sensitive to pathological N-terminal conformations.

45 e sequence of the phosphorylated CTD via its N-terminal CTD-interacting domain.

46 adotropes express a TET1 isoform lacking the N-terminal CXXC-domain, which represses Lhb gene express

47 In viruses with the N-terminal Cys residues mutated, TF is much less efficie

48 rom a phospholipid to the amine group of the N-terminal cysteine residue of the apolipoprotein.

49 cated that, when V1 is released from Vo, the N-terminal cytoplasmic domain of subunit a (aNT) changes

50 onformational change unveils a region of the N-terminal cytosolic tail targeted by the Art1 alpha-arr

51 ic bi-lobal architecture, with the catalytic N-terminal DHH domain linked to the substrate binding C-

52 The structure shows that the NusG N-terminal domain (NGN) binds at the central cleft of RN

53 micellar structures, where the very soluble N-terminal domain (NT) forms the shell.

54 A flexible linker connecting the N-terminal domain (NTD) and C-terminal domain (CTD) of A

55 Here, we investigate the impact of the PHF1 N-terminal domain (NTD) on the Tudor domain interaction

56 Here, we show that Cet1's N-terminal domain (NTD) promotes the recruitment of FACT

57 mic conformational equilibrium involving the N-terminal domain (NTD) with implications for the bindin

58 The p150 subunit of human CAF-1 contains an N-terminal domain (p150N) that is dispensable for histon

59 We show that the disordered N-terminal domain (residues approximately 20-100) intera

60 Ligands binding to the N-terminal domain abolish the spontaneous ionic currents

61 rODA16 structure revealed a small 80-residue N-terminal domain and a C-terminal 8-bladed beta-propell

62 GDP-bound state, showing the characteristic N-terminal domain and a central G domain that are common

63 er, electron density was missing for the p59 N-terminal domain and for the linker connecting it to th

64 the presence of an L138P mutation in the VP1 N-terminal domain and identifying 52 additional mutation

65 skeletal muscle and has a large cytoplasmic N-terminal domain and smaller C-terminal pore-forming do

66 The peptide is clasped between the N-terminal domain and the transmembrane core of the rece

67 formational changes are detected both at the N-terminal domain and within the substrate portal nearly

68 We show that both full-length GSDMB and the N-terminal domain bind to nitrocellulose membranes immob

69 In addition, the GSDMB N-terminal domain binds liposomes containing sulfatide.

70 Overexpression of NRP2 or its N-terminal domain enhances VSV-LUJV infection, and cells

71 N-terminal domain homologs, the helical carotenoid prote

72 beta1-6A2V, which supports a role of Abeta's N-terminal domain in amyloid fibril formation.

73 analysis of the structural model of the L142 N-terminal domain indicated significant homology with so

74 neurotoxic mutants of PrP, and the isolated N-terminal domain induces currents when expressed in the

75 Its N-terminal domain is the active part of the protein, and

76 to the native wild-type protein, whereas the N-terminal domain is unfolded and comprises an ensemble

77 sion gene construction methodology to screen N-terminal domain mutations discovered in tumors that ar

78 sitive charges of the lysine residues in the N-terminal domain of APE1 induces a conformational chang

79 Here, we report that the hydrophilic N-terminal domain of Brassica napus DGAT1 (BnaDGAT11-113

80 interacts with a novel binding motif in the N-terminal domain of CaV1 LTCC alpha1 subunits that is n

81 at the C-terminal beta-propeller but not the N-terminal domain of CrODA16 is required for the interac

82 This suggests that Ca(2+) affinity of the N-terminal domain of cTnC in isolation is insufficient t

83 ractions that begins with the opening of the N-terminal domain of cTnC, followed by cTnC binding the

84 t prevents the specific interaction with the N-terminal domain of Hsp90 required for catalysis.

85 linking was not prevented by deletion of the N-terminal domain of NPC1, which contains the initial bi

86 LUJV GP binds the N-terminal domain of NRP2, while CD63 stimulates pH-acti

87 In this process, the N-terminal domain of p30 released from GSDMD acts as an

88 sical techniques, we show that the flexible, N-terminal domain of PrP(C) functions as a powerful toxi

89 The crystal structure of the N-terminal domain of pyoS2 (pyoS2(NTD)) bound to FpvAI (

90 The structural data confirm that the N-terminal domain of RapZ possesses a kinase fold, where

91 binding with TATA-box DNA, and also with the N-terminal domain of TAF1 previously implicated in TATA-

92 separately with CTD and the latter with the N-terminal domain of the C-subunit.

93 ntains a 197-amino-acid (aa) deletion in the N-terminal domain of the spike (S) protein.

94 Cdc48 consists of an N-terminal domain that binds UN and two stacked hexameri

95 oplasmic form of CCN3 interacted with the AR N-terminal domain to sequester AR in the cytoplasm of pr

96 have established that DnaB is composed of an N-terminal domain, a middle domain, and a C-terminal dom

97 a catalytically inactive dioxygenase-related N-terminal domain, which is important for MCM loading, b

98 erved oligomerization interface in the mVP40 N-terminal domain.

99 derstood region of the polymerase called the N-terminal domain.

100 repression of Trio GEF activity by the Trio N-terminal domain.

101 ll-length TDP-43, association between folded N-terminal domains enhances the propensity of the intrin

102 Here we solve the crystal structures of the N-terminal domains of PHF1 and MTF2 with bound CpG-conta

103 ating chloroplast transit peptide (cTP), and N-terminal domains to the ATPase, Rubisco recognition an

104 ion of a nitroxide spin label, placed at the N-terminal end of the first beta-strand of Het-s fibrils

105 xAC database, confirms that mutations in the N-terminal end of the kinase domain are more disruptive

106 ls where it truncates core histones at their N-terminal ends.

107 ansion in the PABPN1 gene that results in an N-terminal expanded polyalanine tract in polyA-binding p

108 Bacteria encoding L27 with this N-terminal extension also encode a sequence-specific cys

109 ha is soluble, either phosphorylation of its N-terminal extension or DNA binding promotes the formati

110 D contains an approximately 170-residue-long N-terminal extension that structurally mimics a dimer-di

111 f actomyosin, through the interaction of its N-terminal extension with actin and its C-terminal lobe

112 EF loop of VP2, the GH loop of VP3, and the N-terminal extensions of VP1 and VP2, which, in retrospe

113 y with the crystal structure of the isolated N-terminal extracellular domain of the GLP-1R in complex

114 tion of Cys14 to Ala, which destabilized the N-terminal Fe4 S4 cluster in vitro, caused mild growth d

115 We show that an N-terminal fragment comprising the catalytic domain can

116 the Q193-G194 pair, resulting in a truncated N-terminal fragment disrupted for inducing cell pyroptos

117 it undergoes auto-processing to release its N-terminal fragment from the ER, which enters the nucleu

118 R6/2 mice contain an N-terminal fragment of human huntingtin with an expanded

119 hermocellum ATCC 27405, with both SAM and an N-terminal fragment of its peptidyl-substrate at 2.04 A

120 idues) are natural agonists of PTHR1, and an N-terminal fragment of PTH, PTH(1-34), is used clinicall

121 Here, we present the crystal structure of an N-terminal fragment of Saccharomyces cerevisiae Hsp104 w

122 ved for a mixture of Abeta1-28WT and a short N-terminal fragment, Abeta1-6A2V, which supports a role

123 sential for the biological functions of Myrf N-terminal fragment, and that the region adjacent to the

124 s studies have shown that the aggregation of N-terminal fragments (encoded by HTT exon 1) underlies t

125 Vasoinhibins are N-terminal fragments of prolactin that prevent BRB break

126 diates the homo-trimeric DNA binding of Myrf N-terminal fragments.

127 ons either as a stand-alone protein or as an N-terminal fusion to the respective RS enzyme.

128 Together, our study suggests that the N-terminal gelsolin fragment enhances TRAIL-induced loss

129 ing properties of 40 CBMs, in fusion with an N-terminal GFP domain, revealed that type A CBMs possess

130 O2 binding to the Fe(II) heme complex of its N-terminal globin domain strongly stimulates autophospho

131 droitin sulfate A, indicating binding to the N-terminal globular domain or type I repeats of hTSP-1.

132 on, and the translocation and delivery of an N-terminal glucosyltransferase domain that inactivates h

133 The N-terminal Gly-rich fragment of rSp0032 and the C-termin

134 Via a native N-terminal glycine and an added GGGGSLPETGG peptide at C

135 , we determined the crystal structure of the N-terminal half of a conserved tegument protein, UL37, f

136 The N-terminal half of adenovirus e1a assembles multimeric c

137 stead shows limited sequence identity in its N-terminal half with fungal DSDs.

138 The N-terminal head domain contains both the F3 integrin-act

139 losteric site between the C-terminal and the N-terminal helicase cassettes, while 12 binds an RNA-bin

140 es result from the C112R substitution in the N-terminal helix bundle and likely relate to a reduced a

141 known p53-binding pocket in mdm2 whereas the N-terminal helix serves as an affinity enhancer.

142 Nearly all functional PTMs are found on the N-terminal histone domains (tails) of approximately 50 r

143 Using the endocytic protein epsin1 N-terminal homology domain (ENTH), previously thought to

144 In contrast, the N-terminal hydrophobic core showed extremely slow solven

145 at IL-23R bound to IL-23 exclusively via its N-terminal immunoglobulin domain.

146 Here we report the crystal structure of the N-terminal IMS domain of Toc75 from Arabidopsis thaliana

147 ously characterized serines within the Kv3.4 N-terminal inactivation domain eliminated the effects of

148 resonance spectroscopy demonstrated that the N-terminal inhibitory domain (NID) is intrinsically diso

149 Tau isoforms without the N-terminal inserts were sorted efficiently into the axon

150 to have a beta-barrel fold consisting of an N-terminal intermembrane space (IMS) domain and a C-term

151 that UBE3B interacts with calmodulin via its N-terminal isoleucine-glutamine (IQ) motif.

152 vere TBI elicits neuroinflammation and c-Jun-N-terminal kinase (JNK) activation, which is associated

153 We show that ATZ induces activation of c-Jun N-terminal kinase (JNK) and c-Jun and that genetic ablat

154 Moreover, c-Jun N-terminal kinase (JNK) has been implicated in regulatio

155 lular signal-regulated kinase (MEK), and Jun N-terminal kinase (JNK) inhibited induction of IL-17C pr

156 c-Jun N-terminal kinase (JNK) is a member of the mitogen-activ

157 cellular signal-regulated kinase (ERK)/C-Jun N-terminal kinase (JNK) mitogen-activated protein kinase

158 Because islet amyloid increases c-Jun N-terminal kinase (JNK) pathway activation, we investiga

159 ited to the opioid receptor complex by c-Jun N-terminal kinase (JNK) phosphorylation.

160 is possibly mediated by suppression of c-Jun N-terminal kinase (JNK) phosphorylation.

161 c-Jun N-terminal kinase (JNK) plays a vital role in malignant

162 rus-induced activation of proapoptotic c-Jun N-terminal kinase (JNK) signaling.

163 ) act downstream of Draper to activate c-Jun N-terminal kinase (JNK) signalling in glia, resulting in

164 lator of both IkappaB kinase (IKK) and c-Jun N-terminal kinase (JNK), and an important mediator of au

165 ing the rapid activation of NF-kappaB, c-Jun N-terminal kinase (JNK), extracellular signal-regulated

166 stigate the role of one such MAPK, the c-Jun N-terminal kinase (JNK), in VZV lytic infection and reac

167 , which leads to activation in turn of c-Jun N-terminal kinase (JNK), the Axl receptor tyrosine kinas

168 eased phosphorylation of Akt, p38, and c-Jun N-terminal kinase 1 that was also beta2-integrin depende

169 The concept of covalent inhibition of c-Jun N-terminal kinase 3 (JNK3) was successfully transferred

170 s 3 and 7, which resulted from reduced c-Jun N-terminal kinase activation and initiator caspase 8 cle

171 essor function for KIND1, and identify c-Jun N-terminal kinase and NF-kappaB as potential therapeutic

172 Jun N-terminal kinase inhibition decreased SP-induced miR-31

173 Conversely, the c-Jun N-terminal kinase inhibitor SP600125 and the peroxisome

174 apoptosis and recently a specific JNK (c-Jun N-terminal kinase)-dependent S574 phosphorylated form (p

175 his effect was attributed to increased c-Jun N-terminal kinase, thereby inhibiting peroxisome prolife

176 ative allosteric control over binding of the N-terminal lectin domain to mannosylated ligands on host

177 ion 1261 is the most critical residue of the N-terminal linker for inhibiting binding of the VWF A1 d

178 n Asp(1261) and the rest of A1 that lock the N-terminal linker in place such that it reduces binding

179 directly destabilize the complex through the N-terminal linker.

180 minal lobe of CaM but not the weakly binding N-terminal lobe.

181 The N-terminal LOK kinase domain can then access a site 40 r

182 s that influence the ability of the flexible N-terminal loop for adopting its active conformation, th

183 dent on both the presence of a 22-amino-acid N-terminal 'loop' region and its catalytic activity.

184 tion of K29-linked ubiquitin chains with two N-terminal loops of Ufd2p.

185 d reactivity against recombinantly expressed N-terminal LRP2 fragments on Western blots and immunopre

186 humans, CCR4 can interact with CAF1 via its N-terminal LRR domain.

187 beta contains a specific NLS sequence in the N-terminal lyase domain that promotes transport of the p

188 ed with epigenetic alterations in histone H3 N-terminal lysine 4 trimethylation (H3K4me3) over the Cr

189 brevin-associated proteins (VAPs) contain an N-terminal major sperm protein domain (MSPd) that is ass

190 Truncations, N-terminal methionine excision, signal peptide removal,

191 N-terminal mHtt accumulates in the nuclei and forms aggr

192 It has an N-terminal mitochondrial targeting peptide that is prote

193 protein and the peptide corresponding to the N-terminal moiety of MF6p/FhHDM-1 interact in vitro with

194 ctivation domain (C-TAD), but not HIF-1alpha-N-terminal-(N)-TAD or HIF-2alpha-TAD.

195 Disruption of the N-terminal NMB0419 signal peptide, predicted to export t

196 The molecular basis of how the N-terminal non-catalytic CD1 regulates the catalytic act

197 protein-protein interactions mediated by the N-terminal non-kinase fusion partner, such as QKI.

198 Unlike IL-1beta, IL-1alpha carries an N-terminal nuclear localisation sequence (NLS) and is tr

199 onistic activities of both a peptide-encoded N-terminal nuclear localization signal and C-terminal nu

200 NA isoforms were full length, containing the N-terminal nuclear localization signal.

201 tion between two well-structured domains: an N-terminal nucleotide-binding domain (NBD) and a C-termi

202 This study identifies beta1AR N-terminal O-glycosylation at Ser(37)/Ser(41) as a mecha

203 ognition by the CD8(+) T cell clone required N-terminal O-linked mannosylation of MPT32 by a mannosyl

204 ich amphipathic peptide sequence attached to N-terminal of bZIP53 leucine zipper.

205 The N-terminal of MyRF, which contains a proline-rich region

206 furin-dependent proteolytic cleavage of the N-terminal part of FcgRIIA, shifting neutrophils away fr

207 ein groups exhibited significantly increased N-terminal peptide abundance in prt6 seedlings, includin

208 Furthermore, expression of the Stx4 N-terminal peptide decreased invadopodium formation and

209 in vitro Of note, cells expressing the Stx4 N-terminal peptide exhibited impaired trafficking of mem

210 The in situ maturation of UQCRFS1 produces N-terminal polypeptides, which remain bound to holocompl

211 ng of the antiviral drug, amantadine, at the N-terminal pore at low pH did not convert all histidines

212 MD simulations suggested that the remaining N-terminal portion in the non-functional Orai1 N-truncat

213 ased on TREM2 and TYROBP fusion to the C- or N-terminal portion of the Renilla luciferase gene.

214 c ribosomes as a preprotein with a cleavable N-terminal presequence that is the mitochondrial targeti

215 yocyte hypertrophy, cardiomyocyte death, and N-terminal pro B-type natriuretic peptide release; all a

216 hypertrophy by ECG, coronary artery calcium, N-terminal pro B-type natriuretic peptide, high-sensitiv

217 N-Terminal pro-B type natriuretic peptide levels were be

218 lines recommend use of natriuretic peptides (N-terminal pro-B type natriuretic peptide) and rest/exer

219 Increased N-terminal pro-B-type natriuretic peptide (NT-proBNP) co

220 Serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) is

221 f high-dose spironolactone and usual care on N-terminal pro-B-type natriuretic peptide (NT-proBNP) le

222 ere change in 6-minute walk distance, plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) le

223 Failure score (48 versus 40), higher median N-terminal pro-B-type natriuretic peptide concentration

224 N-terminal pro-B-type natriuretic peptide levels decreas

225 of congestion, worse quality of life, higher N-terminal pro-B-type natriuretic peptide levels, and a

226 32 mL [517-768 mL]; P<0.0001), despite lower N-terminal pro-B-type natriuretic peptide levels.

227 have higher circulating levels of NT-proBNP (N-terminal pro-B-type natriuretic peptide) than HF patie

228 ion class III/IV, RVESRI, and log NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) were retained

229 gmentation index, (4) circulating NT-proBNP (N-terminal pro-B-type natriuretic peptide), TNF-alpha, I

230 mained independent after adjustment for age, N-terminal pro-B-type natriuretic peptide, ejection frac

231 N-terminal pro-brain natriuretic peptide (NT-proBNP) and

232 ular EF, peak aerobic exercise capacity, and N-terminal pro-brain natriuretic peptide (P>0.30 for all

233 stolic function was robustly associated with N-terminal pro-brain natriuretic peptide and incident HF

234 E/e', and left atrial size) with concomitant N-terminal pro-brain natriuretic peptide and subsequent

235 even outperform traditional markers, such as N-terminal probrain natriuretic peptide.

236 After processing in the Golgi to cleave the N-terminal prodomain from the C-terminal growth factor (

237 value of cardiac markers (troponins I and T, N-terminal prohormone of brain natriuretic peptide [NT-p

238 ne bridges with Cys-158 of the very flexible N-terminal propeptide being covalently linked to Cys-319

239 N-terminal propeptide of type I procollagen (PINP) and C

240 itogen-activated protein kinases p38 and Jun N-terminal protein kinase (JNK).

241 s-the bacterial chemotaxis protein CheY, the N-terminal receiver domain of the nitrogen regulation pr

242 Although the extended transmembrane Orai N-terminal region (Orai1 amino acids 73-91; Orai3 amino

243 ed form higher-order oligomers through their N-terminal region and that the same AT-rich site is reco

244 i activation required not only the conserved N-terminal region but also permissive communication of t

245 allographic structure of the Arabidopsis TPL N-terminal region comprising the LisH and CTLH (C-termin

246 t a structural description of the Fn binding N-terminal region of CshA, derived from a combination of

247 e non-synonymous substitution (A120G) in the N-terminal region of eIF2Bbeta was responsible for the T

248 munoprecipitated the recombinantly expressed N-terminal region of LRP2.

249 TFAM tethers the N-terminal region of mtRNAP to recruit the polymerase to

250 shallow pocket adjacent to the groove in the N-terminal region of NHR trimer as a new drug target, an

251 1 cleaved eight amino acid residues from the N-terminal region of Prx1 inside the matrix, without int

252 Interestingly, the N-terminal region of SS4 alone or when fused to GS confe

253 ted versions of SS4 and a fusion between the N-terminal region of SS4 and GS in the Arabidopsis ss4 m

254 r caused by a polyglutamine expansion in the N-terminal region of the huntingtin protein (N17).

255 o, mediated by the coiled-coil domain at the N-terminal region of the protein.

256 An unstructured N-terminal region of Tim10 is necessary and sufficient t

257 cent segment (positions 61-67) in the FLIL33 N-terminal region.

258 tremely transient helices are present in the N-terminal region.

259 rom the presence of an acidic residue at its N-terminal region.

260 ly spliced isoforms, differing only in their N-terminal regions (NTRs).

261 Here, we show that the regulatory N-terminal residues and the EH domain keep the EHD2 dime

262 tion of full-length Drs2p, whereas the 1-104 N-terminal residues have an additional but more modest s

263 mino acid p-azido-l-phenylalanine (azF) into N-terminal residues of a full-length functional human GL

264 ds two copies of M18BP1 through M18BP1's 140 N-terminal residues.

265 The PilZ domain, consisting of an N-terminal "RxxxR" motif and a beta-barrel domain, repre

266 The N-terminal segment of MBD1-3 was found to interact with

267 of the permeation of the lethal factor (LF) N-terminal segment through the anthrax channel.

268 Manipulation of the N-terminal sequence affected the amount of Polbeta in th

269 conducted initially by simply examining the N-terminal sequences of many acetylated and unacetylated

270 Interestingly, GRIP1 is phosphorylated at an N-terminal serine cluster by cyclin-dependent kinase-9 (

271 Deletion of the N-terminal signal peptide of IL-12 can effect such a cha

272 This localization did not depend on the N-terminal signal peptide that mediates APOL1 secretion

273 tem, a protein-of-interest is tagged with an N-terminal split RNAP (RNAPN), and multiple potential bi

274 tein is a fusion of two distinct modules: an N-terminal sugar phosphate isomerase-like domain associa

275 e regions of the Het-s fibril comprising the N-terminal tail and a loop connecting beta-strands 4 and

276 osome remodeling enzymes need the histone H4 N-terminal tail to mobilize nucleosomes.

277 orylation of several Ser/Thr residues in the N-terminal tail.

278 A critical target of Aurora B is the N-terminal "tail" domain of Hec1, which is a component o

279 ramatically decreased the acetylation of the N-terminal tails of cytosolic histones.

280 almitoylation on two Cys residues within the N-terminal targeting domain.

281 d tau uptake in an epitope-dependent manner: N-terminal (Tau13) and middomain (6C5 and HT7) antibodie

282 C-terminal trans-prenyltransferase (PT) and N-terminal terpene synthase (TPS) domains.

283 e ASK1 kinase domain in conjunction with its N-terminal thioredoxin-binding domain, along with a cent

284 ) with high affinity through a palmitoylated N-terminal "thumb" and a disulfide-stabilized C-terminal

285 ure consisting of a classic chemokine domain N-terminal to a second unique domain, resulting from the

286 ngation was the dominant activity during the N-terminal to C-terminal metamorphosis of FPPase to CPPa

287 f Tiam1, such as the region encompassing the N-terminal to C-terminal pleckstrin homology domains (PH

288 heir stereotypical multidomain structure: an N-terminal Toll-interleukin receptor (TIR) or coiled-coi

289 essive function on CDF1, as mutations of the N-terminal TPL binding domain largely impair the ability

290 racts with TAK1, predominantly via PPARalpha N-terminal transactivation domain (AF-1) thereby masking

291 The soluble SREBP N-terminal transcription factor domain is then released

292 ainst resistant bacteria, contain disordered N-terminal translocation domains (T-domains) that are es

293 heral SUR1s each anchored to a Kir6.2 by its N-terminal transmembrane domain (TMD0).

294 'pole' and four helical 'ribs' spanning the N-terminal TRPM homology regions (MHRs), thus holding fo

295 1 and Orai3 isoforms, Orai3 tolerates larger N-terminal truncations than Orai1 in retaining store-ope

296 rotubule polymerase activity is driven by an N-terminal tumor overexpressed gene (TOG) domain array,

297 Further analyses revealed that the N-terminal unfolded region of cargo proteins is critical

298 comprises three large structural units: the N-terminal unit, the Circular Cradle, and the Head.

299 mmune evasion protein, E3, which contains an N-terminal Z-nucleic acid binding (Zalpha) domain that i

300 ned for its conserved methylated DNA binding N-terminal ZF region; however, a specific role for the C