ライフサイエンスコーパス: N-terminal

1 nced green fluorescent protein (EGFP) at the N-terminal.

2 0-2 that truncated 71 amino-acid residues in N-terminal.

3 Addition of an N-terminal 1-adamantanecarbonyl pharmacophore significan

4 egrees C) suggested early involvement of the N-terminal (1-11) and central (12-19) fragments in inter

5 H)2s and m01s because of the presence of the N-terminal 3(10)-helix and beta-turn type III.

6 The N-terminal 640 residues (NTD) of FIP200 interact with th

7 t animals by priming with the most prevalent N-terminal 8 residues of the HIV-1 fusion peptide (FP8),

8 veals a dimerization domain inserted into an N-terminal ABC ATPase fold and a C-terminal Toprim domai

9 N-terminal acetylation (NTA) is one of the most widespre

10 the modus operandi for NAA80-mediated actin N-terminal acetylation, a modification with a major impa

11 NatB is one of three major N-terminal acetyltransferase (NAT) complexes (NatA-NatC)

12 stable interactor and regulator of the actin N-terminal acetyltransferase NAA80, and establish the mo

13 , we describe the role of an uncharacterized N-terminal acetyltransferase, NAA50, in the regulation o

14 is carried out by a family of enzymes called N-terminal acetyltransferases (NATs).

15 instead uses TORC1-activated Art1 to detect N-terminal acidic sorting motifs within the same AATs, w

16 In the proposed model, the N-terminal actin-binding site of leiomodin can act as a

17 importance of stereochemistry, the effect of N-terminal acylation, and homologation between the two e

18 The lumen of the CdiB pore is occluded by an N-terminal alpha-helix and the conserved extracellular l

19 ta-sheet adjacent to the N130 GlcNAc and the N-terminal alpha-helix near the peptide-binding site whi

20 n alternative reaction pathway leading to an N-terminal amidine rendering the side chain thiol availa

21 thyltransferases (NTMTs) methylate the alpha-N-terminal amines of proteins starting with the canonica

22 ly suppresses membrane interactions with the N-terminal and central alphaS regions.

23 TAT3 and bind with nanomolar affinity to the N-terminal and coiled-coil domains.

24 within exons 1 and 9 produces four different N-terminal and three different C-terminal products (type

25 within the flexible, structurally unresolved N-terminal APN region using direct binding fluorescence

26 Hsp90 has an N-terminal ATPase domain (N), a middle domain (M) that i

27 OLD family nucleases contain an N-terminal ATPase domain and a C-terminal Toprim domain.

28 d well-established biomarkers of post-MI HF: N-terminal B-type natriuretic peptide and troponin T, an

29 -rich stretch causes a backbone twist in the N-terminal beta strand, stabilizing the monomeric form.

30 While an N-terminal CAL1 fragment wraps around CENP-A/H4 through

31 Only the N-terminal cassette of BRR2 is an active ATPase and can

32 effects on the RNA-unwinding activity of the N-terminal cassette, with one configuration enhancing an

33 fluence RNA-stimulated ATP hydrolysis by the N-terminal cassette.

34 The N-terminal coiled-coil CC1 domain is required for microt

35 SMTNL2 binds to coronin-1B through its N-terminal coiled-coil region and negates its function t

36 Here, a fusion protein containing an N-terminal cutinase and a C-terminal SnapTag domain reac

37 oupled to form [4Fe-4S](2+) clusters on both N-terminal CX(13)CX(2)CX(5)C and C-terminal CPXC motifs

38 ze the reaction of oxygen with the conserved N-terminal cysteine of ERF-VIIs to form cysteine sulfini

39 erial lipoproteins share a variably acylated N-terminal cysteine residue.

40 ble condensation between CBT derivatives and N-terminal cysteine residues has been established as a b

41 ngs of C-type lectin-like domains, where the N-terminal cysteine-rich and fibronectin domains reside

42 We report a novel conjugation of N-terminal cysteines (NCys) that proceeds with fast kine

43 njugation of 2-cyanobenzothiazole (CBT) with N-terminal cysteines (NCys) typically gives a luciferin

44 er the control of an evolutionarily extended N-terminal cytoplasmic tail.

45 increases NLRP1 activation in the context of N-terminal destabilization, but decreases NLRP1 activati

46 INF2 is regulated by interaction between its N-terminal diaphanous inhibitory domain (DID) and its C-

47 We also show that the N-terminal disease-related surface contributes to the el

48 h allosterically affects the conformation of N-terminal DNA-binding domain.

49 sing N53I substitution, which resides in the N-terminal domain (N-domain).

50 domain (RBD) and those directed against the N-terminal domain (NTD), indicating that both of these r

51 Mechanistically, both the Ecm29 N-terminal domain and an intact AIS structure are requir

52 nal oligomerization domain, while the folded N-terminal domain and the C-terminal IDR are not require

53 ative N-glycosylation sites within the large N-terminal domain at N65 and N82.

54 was delayed specifically in the presence of N-terminal domain containing TDP-43 variants, while C-te

55 lical oligomers which, when aligned with the N-terminal domain crystal structure, suggest an N-termin

56 The N-terminal domain had a pentameric nucleoplasmin-fold; m

57 Its N-terminal domain has the same fold as proteins that for

58 ation, not circular or twisted, in which the N-terminal domain I (DI) and the C-terminal domain V (DV

59 ing Gle1 function, Gle1 oligomerizes via its N-terminal domain in a phosphorylation-dependent manner.

60 these data reveal novel roles for the ANGPT2 N-terminal domain in blood vessel remodeling, tumor grow

61 int to a critical importance of the cationic N-terminal domain in mediating antibacterial, antiparasi

62 detailed insights into the role of the TET2 N-terminal domain in TET2 regulation.

63 ve surface charge of the hinge region of the N-terminal domain in the GluN1 subunit of the NMDAR is r

64 alpha-helical and develops contacts with the N-terminal domain of CaM more slowly, in about 8 ms.

65 oming nucleotide and a template base and the N-terminal domain of DNA ligase I mediates its interacti

66 affinity, and that antibodies targeting the N-terminal domain of ERFE that prevent ERFE-BMP6 interac

67 o show how a small alpha-helical domain, the N-terminal domain of HemK, folds cotranslationally.

68 benthamiana that transient expression of the N-terminal domain of JIP60, from which the inhibitor dom

69 ive conserved residues (ELEFN(50-54)) in the N-terminal domain of KSHV gH that are critical for Eph b

70 -terminus, the antibody response against the N-terminal domain of PfCSP (N-CSP) remains obscure.

71 ified hemi- and heterozygous variants in the N-terminal domain of the A isoform of FHF2 (FHF2A).

72 Phosphorylation of the N-terminal domain of the huntingtin (HTT) protein has em

73 fide bond, during the catalytic cycle of the N-terminal domain of the key bacterial oxidoreductase Ds

74 e three-dimensional dimeric structure of the N-terminal domain of the MERS-CoV nucleocapsid protein (

75 tip of the alpha-hairpin and on neighboring N-terminal domain residues.

76 erminal domain crystal structure, suggest an N-terminal domain that wraps around the C-terminal domai

77 The regulatory role of the N-terminal domain was dissected.

78 Here we show that overexpression of the N-terminal domain with (TDD) or without (TD) the distal

79 optosis via the pore-forming activity of its N-terminal domain, cleaved by activated caspases associa

80 ted that Arg259, which is located within the N-terminal domain, specifically interacts with UDP-GlcUA

81 interactions between the AP2 complex and its N-terminal domain, which in turn recruits endocytic acce

82 The RIM-BP N-terminal domain, while dispensable for SV release site

83 P7, utilizing a PSTS motif matching the USP7 N-terminal domain-binding A/PxxS consensus, but uniquely

84 in the GSDMD C-terminal domain distal to its N-terminal domain.

85 promoting eviction of histone H1 through its N-terminal domain.

86 obular C-terminal domain and an unstructured N-terminal domain.

87 which interacts with XPB mainly through its N-terminal domain.

88 c domain remains active independently of the N-terminal domain.

89 gammaC0C7 (endogenous [genetically encoded] N'-terminal domains C0 to C7 of cardiac myosin binding p

90 Ligation of rC0C7 (exogenous [recombinant] N'-terminal domains C0 to C7 of cardiac myosin binding p

91 CesA's N-terminal domains assemble into a cytosolic stalk that

92 hile much is known about the function of the N-terminal domains of OPG, which is responsible for bind

93 rcoiled DNA substrate first and position the N-terminal domains to bind and cleave the opposite stran

94 ket flanked by serine residues between their N-terminal domains.

95 The N-terminal ectodomain of BTNL2 has a significantly reduc

96 The N-terminal ectodomain of BTNL2, which was able to inhibi

97 y and functionally modular, consisting of an N-terminal effector domain (NTD) and a C-terminal regula

98 We substituted the N-terminal eight residues of FP (FP8, residues 512 to 51

99 f human endemic coronaviruses, compared with N-terminal epitopes.

100 of each FimA subunit is complemented by the N-terminal extension (Nte) of the next subunit.

101 t engagement of the intrinsically disordered N-terminal extension of ClpS by ClpA is both necessary a

102 The N-terminal extension of one regulatory light chain inter

103 While the SEC14 domain and its CRAL-TRIO-N-terminal extension serve general membrane attachment o

104 the C terminus but additionally features an N-terminal extension with low-complexity regions.

105 w that a soluble fragment generated from the N-terminal extracellular domain of PC-1 functions as an

106 f GK-15, molecular docking of GK-15 into the N-terminal extracellular ligand-binding domain of the um

107 s, synthetic binding proteins, that bind the N-terminal four-helix bundle (4HB) "killer" domain and n

108 In solution, the N-terminal fragment of ALIX-PRD is dynamically disordere

109 ther demonstrate that acutely introducing an N-terminal fragment of FMRP into BCs normalizes GABA rel

110 Here we quantify plasma concentrations of an N-terminal fragment of tau (NT1) in a large, well-charac

111 Cleavage allows the N-terminal fragment to function independently and helps

112 tic dissection experiments revealed that the N-terminal G domain of GBP2 mediates these anti-MNV effe

113 Vp which cleaves cMyBP-C to create a soluble N'-terminal gammaC0C7 (endogenous [genetically encoded]

114 Fe(II) complex located in the oxygen-sensing N-terminal globin domain.

115 d process involving its internal 150-residue N-terminal globular domain (N-domain).

116 es, including the endoplasmic reticulum, via N-terminal glycine myristoylation.

117 Unexpectedly, we find that human N-terminal glycine myristoyltransferases (NMT) 1 and 2 c

118 ve protein biogenesis, and that alpha(1D)-AR N-terminal glycosylation is required for complete transl

119 e found that distal regions of each leg bind N-terminal Habc domains of the ER SNAREs Sec20 (a Qb-SNA

120 of the LegK7-MOB1A complex revealed that the N-terminal half of LegK7 is structurally similar to euka

121 Considering that the N-terminal half of TIMP-1 is sufficient for TIMP-1's MMP

122 e largest among human herpesviruses-uses its N-terminal half to bridge hexon MCP subunits and possess

123 We found that the BET N-terminal halves bearing the bromodomains convey marked

124 the gamma-secretase complex that contain an N-terminal helical peptide region that engages a substra

125 dynamic binding and release of its two most N-terminal helices from the catalytic core.

126 imers tailored for antigen fusion, featuring N-terminal helices positioned to match the C termini of

127 We show here that the strongly amphipathic N-terminal helix of CPn0678 mediates binding to phosphol

128 own function that is predicted to contain an N-terminal helix-turn-helix (HTH) domain.

129 An N-terminal hepta-peptide sequence of yeast prion protein

130 assays utilize GPCRs genetically fused to an N-terminal HiBiT peptide (1.3 kDa), which produces brigh

131 ins relevant to SOS1 activity, including the N-terminal histone fold, as well as the C-terminal REM (

132 HIPR-1 harboring the human HIP1 ANTH (AP180 N-terminal homology) domain rescued Orsay infection in C

133 t efficiently phosphorylates full-length and N-terminal HTT fragments in vitro (at S13/S16), in cells

134 This N-terminal HTT leads to similar HD-like phenotypes and a

135 (HD), proteolytic processing generates toxic N-terminal huntingtin (HTT) fragments that preferentiall

136 tspots were identified within the A-band and N-terminal I-band that closely correlated with regions o

137 intrinsically disordered regions (IDRs), the N-terminal IDR and central-linker IDR, as well as the fo

138 To enhance NKp30 binding, the solitary N-terminal IgV domain of B7-H6 (DeltaB7-H6) was affinity

139 Interestingly, whereas the N-terminal inserts do not contribute to any morphologica

140 sequestered full-length TDP43 via preserved N-terminal interactions.

141 xpressed from two promoters and produces two N-terminal isoforms, TAp63 and DeltaNp63.

142 gy analysis indicated that ICP22 contains an N-terminal J domain and a C-terminal substrate binding d

143 or NEMO in the activation of oncogenic c-Jun N-terminal kinase (JNK) signaling, induced by the latent

144 nt integrin alpha3beta1 signaling, via c-Jun-N-terminal kinase (JNK), inhibited expression of the gem

145 d by the stress- and immune-responsive c-Jun N-terminal kinase (JNK).

146 expression of TNFalpha and activation of JUN N-terminal kinase (JNK).

147 extracellular signal-regulated kinase, c-Jun N-terminal kinase 1/2, and p38).

148 llular signal-regulated kinase 1/2 and c-Jun N-terminal kinase activation, which contributed to CXL14

149 epilepsy brain samples, including the c-Jun N-terminal kinase and the protein kinase R-like endoplas

150 aimed at blocking protein kinase C and c-Jun N-terminal kinase had no effect on desensitization in ti

151 We found that JNK2, but not JNK1 (c-Jun N-terminal kinase isoform 1), increased SERCA2 uptake an

152 e VSMCs and by palmitate in a p38- and c-Jun N-terminal kinase-dependent manner.

153 ion of the signalling pathways (STAT3, c-jun n-terminal kinases (JNK), EKR1/2, nuclear factor-kappa B

154 These NleDs disable specifically Jun N-terminal kinases (JNKs) and p38s that are required for

155 The cleavage releases the cargo with the N-terminal linker amino acid from the peptide prior to t

156 ed to access lipovelutibol B and a series of N-terminal lipid analogues of the natural products.

157 to a different number of active sites, C and N terminal locations and arrangement, therefore, individ

158 ncated mature frataxin (79-207) in which the N-terminal lysine residue has been lost.

159 cient and unprecedented myristoylation of an N-terminal lysine side chain, providing evidence that NM

160 in, providing evidence that NMT acts both as N-terminal-lysine and glycine myristoyltransferase.

161 leaflet of the plasma membrane through their N-terminal matrix (MA) domain.

162 Protein N-terminal methyltransferases (NTMTs) methylate the alph

163 Unlike KIFC1, KIFC2 and KIFC3 lack the N-terminal microtubule binding domain and only have one

164 nventional Ncd-type kinesin-14 that uses its N-terminal microtubule-binding tail to achieve minus-end

165 c6 is composed of three independent domains: N-terminal, middle and C-terminal (HsOrc6-N, HsOrc6-M an

166 ntly more potent than the S diastereomer and N-terminal modification generally lowers TLR2 activity.

167 n dimerization, while cluster binding to the N-terminal motif does not affect the quaternary structur

168 that the [4Fe-4S](2+) cluster formed at the N-terminal motif of NUBP1 is tightly bound, while the [4

169 istoylation of G9 was unaffected by the near-N-terminal mutations.

170 structural modeling have suggested that the N-terminal myristoylation signal and the C-terminal FXXF

171 confocal, and EM analyses, we show that the N-terminal N-BAR domain of ASAP1 directly binds to F-act

172 to the outer kinetochore through its HFD and N-terminal Ndc80-binding motif, respectively.

173 e also observe ADP-Mg(2+) bound in the nsp12 N-terminal nidovirus RdRp-associated nucleotidyltransfer

174 g reveals a crystalline intermediate wherein N-terminal nucleation domains exhibit motional dynamics

175 Further characterization revealed the N-terminal nucleoplasmin domain to interact with H2A/H2B

176 This study identifies the role of the N-terminal oligomerization domain of angiopoietin-2 in v

177 roteins for degradation by recognizing their N-terminal or internal degrons.

178 en identified to differentially regulate the N-terminal p63 isoforms, it is unclear how the C-termina

179 ccommodates a polyproline stretch within the N-terminal PDZD11 region.

180 is highest during start codon initiation and N-terminal peptide elongation, regulating ribosome occup

181 , indicating that this previously unresolved N-terminal peptide is responsible for a ball-and-chain i

182 CheY binds to the N-terminal peptide of the FliM motor protein (FliM(N)).

183 fibrosis biomarkers (PIIINP [procollagen III N-terminal peptide], CITP [C-telopeptide for type I coll

184 by an intramolecular interaction between its N-terminal pleckstrin homology (PH) domain and kinase do

185 Furthermore, amisyn contains an N-terminal pleckstrin homology domain that mediates its

186 ecifically, we show that substitution of the N-terminal plug His-221 disrupts both signaling and tran

187 Pol2 is a fusion of two B-family Pols; the N-terminal Pol module is catalytic and the C-terminal Po

188 Here, we show that analogues with an N-terminal polyethylene glycol (PEG) extension as well a

189 D) is caused by an expansion mutation of the N-terminal polyglutamine of huntingtin (mHTT).

190 etween mixing and freezing, we find that the N-terminal portion of M13 converts from a conformational

191 ing (ChIP-seq) was used to assess a range of N-terminal posttranscriptional modifications (marks) to

192 Many mitochondrial proteins contain N-terminal presequences that direct them to the organell

193 ins are synthesized as precursors that carry N-terminal presequences.

194 rculating IL6 (interleukin-6) and NT-proBNP (N terminal pro B-type natriuretic peptide) levels were e

195 tricular ejection fraction (LVEF) >=55%, and N-terminal pro-B-type natriuretic peptide (NT-proBNP) >=

196 gh-sensitivity cardiac troponin I (hs-cTnI), N-terminal pro-B-type natriuretic peptide (NT-proBNP), a

197 onnaire overall summary score (KCCQ-OSS) and N-terminal pro-B-type natriuretic peptide (NT-proBNP).

198 = -0.52 vs. r = -0.24; Meng test p = 0.03), N-terminal pro-B-type natriuretic peptide (r = 0.56 vs.

199 tum >11 mm) and elevated cardiac biomarkers (N-terminal pro-B-type natriuretic peptide [>40 pg/mL] or

200 Preoperative N-terminal pro-B-type natriuretic peptide and cardiovasc

201 N-terminal pro-B-type natriuretic peptide declined signi

202 ors including age, diabetes, renal function, N-terminal pro-b-type natriuretic peptide serum concentr

203 y cardiac troponin-T) <6 ng/L and NT-proBNP (N-terminal pro-B-type natriuretic peptide) <100 pg/mL),

204 NT-proBNP (N-terminal pro-B-type natriuretic peptide) was not affec

205 n <=40% and a modest elevation of NT-proBNP (N-terminal pro-B-type natriuretic peptide) were eligible

206 Longitudinal changes in NT-proBNP (N-terminal pro-B-type natriuretic peptide), cardiac reve

207 to extracellular matrix turnover), ST-2, and N-terminal pro-B-type natriuretic peptide.

208 ositively correlated with the cardiac marker N-terminal pro-B-type natriuretic peptide.

209 fluid loss (P=0.001), decrease in NT-proBNP (N-terminal pro-B-type natriuretic peptide; P=0.002), and

210 9%) were female; mean EF was 56%; and median N-terminal pro-brain natriuretic peptide level was 1403

211 c resonance neurography (MRN) with hsTNT and N-terminal pro-brain natriuretic peptide serum levels in

212 e aminotransferases, and neoepitope-specific N-terminal pro-peptide of type III collagen (Pro-C3) tha

213 3.8x10(-)(5); 3 with higher risk: NT-proBNP [N-terminal proB-type natriuretic peptide], TSP2 [thrombo

214 N-terminal prohormone of brain natriuretic peptide >8500

215 relationship between GMD and the NT-proBNP (N-terminal prohormone of brain natriuretic peptide)-a bi

216 hybrid peptide-thiourea catalyst features a N-terminal proline moiety for aldehyde activation and a

217 ST2 by 4% (95% CI: 1% to 7%; p = 0.002), and N-terminal propeptide of collagen III by 3% (95% CI: 0%

218 in immune responses by activating the c-Jun N-terminal protein kinase (JNK) and NF-kappaB pathways;

219 Immunodepletion of C- but not N-terminal proteoforms nor intact lacritin, from normal

220 d dry eye tears is rescuable with C- but not N-terminal proteoforms.

221 for ACLP secretion and identified a specific N-terminal proteolytic ACLP fragment.

222 Because the N-terminal RDs are conserved in mammalian Pumilio orthol

223 nd to sites within the enigmatic, disordered N-terminal region (NTR) of HspB1.

224 Effects on alpha6beta4 involve BARP's N-terminal region and IRE1alpha's splicing of XBP1 mRNA.

225 king of the [4Fe-4S] cluster by the flexible N-terminal region and the associated inhibition of the a

226 rin homology (PH) domains interacts with the N-terminal region comprising ARL8- and kinesin-1-binding

227 ed missense mutations in the RING domain and N-terminal region compromise its activity, and therefore

228 with a C-terminal RING domain and disordered N-terminal region containing SUMO Interactions Motifs (S

229 Although the N-terminal region normally localizes to podocyte foot pr

230 stigated metal ions bind specifically to the N-terminal region of Abeta, forming a dynamic, partially

231 ombine the CsgG nanopore with the 35-residue N-terminal region of its extracellular interaction partn

232 However, how the N-terminal region of PDZD11 interacts with the N-termina

233 Here we show that, although the N-terminal region of RNF4 bears no secondary structure,

234 The sequence-variable N-terminal region of the M protein defines the M type an

235 over that the major ATRX RBR lies within the N-terminal region of the protein, distinct from its PHD

236 Using the disordered N-terminal region of the Sic1 protein as a test case, we

237 localization signal within an unstructured, N-terminal region that is rich in serine and threonine r

238 Ahnak, through its N-terminal region, scaffolds the L-type pore-forming alp

239 enetrating cation-dependent mechanism in its N-terminal region.

240 gnition of acetylated lysine residues in the N-terminal regions of histones.

241 s, however, additionally have low-complexity N-terminal regions of unknown function.

242 uncated catalytic domain of TDP1 lacking the N-terminal regulatory domain (Delta1-147), suggesting an

243 gradation of target mRNAs, mediated by three N-terminal Repression Domains (RDs), which are unique to

244 O-glycopeptides with a modified N-terminal residue, such as those generated by OpeRATOR,

245 plex with full-length CsgF shows that the 33 N-terminal residues of CsgF bind inside the beta-barrel

246 suggesting the fibril twist is modulated by N-terminal residues outside the amyloid core.

247 Progressive deletion of N-terminal residues revealed an unexpected contribution

248 plex, the protein target failed to refold 74 N-terminal residues, suggesting a fundamentally differen

249 vuconazole-bound AcCYP51 failed to refold 74 N-terminal residues.

250 M28 formed complexes with TRIM27 through its N-terminal RING-B boxes-Coiled-Coil domain.

251 We hypothesized that these N-terminal SC residues modulate ProT binding and activat

252 for competitively defining the affinities of N-terminal SC(1-246) variants preselected by modeling.

253 o show that structural rearrangements in the N-terminal segment (NTS) can stabilize this Pfr-like sta

254 Before binding, the N-terminal segment 1 of ArkA is pre-structured and adopt

255 CTD and the His-Cys-His (HCH) motif from the N-terminal segment of the neighboring subunit.

256 DGAT1 forms a homodimer through N-terminal segments and a hydrophobic interface, with pu

257 The N-to-N terminal self-interaction is modulated by ssDNA.

258 luence of additional modification within the N-terminal sequence has been explored.

259 ltiple protein isoforms that differ in their N-terminal sequence.

260 ution of a class of NLRs, CNLs with extended N-terminal sequences previously named Solanaceae Domain.

261 Tat system is mediated by the presence of an N-terminal signal sequence containing a highly conserved

262 pseudobactin BN7/8 transport system, and the N-terminal signaling domain (NTSD) of PupB, an outer-mem

263 Slp-4 binds vesicular Rab proteins via an N-terminal Slp homology domain, interacts with plasma me

264 The N-terminal SNAG domain and C-terminal ZF domains of Gfi1

265 teins in a proline-rich region between their N-terminal Src homology and Bcr homology domains disrupt

266 omain at the C-terminus and a highly charged N-terminal stretch, which has been reported to bind to h

267 eta-fold, followed by a secretin/TonB, short N-terminal subdomain at the C terminus of the CCSSD, a p

268 Finally, we investigate the effect of C- and N-terminal tagging of the luminal ATPase torsinA on its

269 ividing cells and binds directly to both the N-terminal tail and the histone fold domain of non-nucle

270 riants H2AZ and macroH2A1/2 at the divergent N-terminal tail lysine residue.

271 Collectively, our results reveal that the N-terminal tail of GiKIN14a is a de facto dual regulator

272 ion might be dictated by a conserved kleisin N-terminal tail that guides the DNA through the kleisin

273 ng of the core histone H2A C-terminal and H3 N-terminal tails in the chromatosomes.

274 terminal region of PDZD11 interacts with the N-terminal tandem WW domains of PLEKHA7 and how this int

275 We show that the N-terminal targeting sequence (N) of CsgA binds specific

276 d interactions with the telomerase essential N-terminal (TEN) domain and roles in telomerase activity

277 N-terminal TMIE deletions affect the response of the mec

278 Here we identify that bulky residues located N-terminal to the DFG motif (DFG-1) represent an opportu

279 e specifically, we show that acidic residues N-terminal to the substrate pTyr in EGFR and HER2 mediat

280 d that a conserved transesterification unit (N-terminal toroid structure) for cutting and rejoining o

281 These are located on the USP7 N-terminal TRAF-like (TRAF) domain and the first and sec

282 es ICCB-19 and Apt-1 bind to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), whic

283 nism by which the intrinsically unstructured N-terminal translocation domain (IUTD) of the endonuclea

284 Many effectors harbor N-terminal transmembrane domains (TMDs) implicated in ef

285 l T6SS-1 activity requires Rhs that contains N-terminal transmembrane helices, the PAAR domain, and a

286 L-Phe binding and mutation of the conserved N-terminal Trp8 to Ala both promote an inward-facing sta

287 N-terminal truncation of 1 resulted in a tetrapeptide (A

288 pting the Src-binding motif of Kv1.5 through N-terminal truncation or mutagenesis abolished the mecha

289 xtracellularly applied proteinase K (PK), an N-terminal truncation up to amino acid residue 209 alter

290 Previously, we identified an N-terminal truncation variant of ASPP2 (t-ASPP2) as a dr

291 ven truncating variants, all residing in the N-terminal two thirds of the protein.

292 We demonstrate that an engineered N-terminal ubiquitin modification changes the aggregatio

293 As multidomain enzymes, they contain an N-terminal ubiquitin-association domain, a central Src h

294 st a possible disassembly mechanism by which N-terminal ubiquitination and the proteasome may togethe

295 Dnmt3a2, an active isoform that lacks the N-terminal uncharacterized region of Dnmt3a1 including a

296 nal cassette modulates the activities of the N-terminal unit remain elusive.

297 role of new domains in Uaf30 that include an N-terminal winged helix domain and a disordered tetherin

298 a expression identified an effector, with an N terminal Y/FxC motif, that induced a strong hypersensi

299 e among innate immune sensors because of its N-terminal Zalpha1 and Zalpha2 domains, which bind to nu

300 ivirus PRRSV, which has multiple domains: an N-terminal zinc-binding domain (ZBD), a 1B domain, and h