ライフサイエンスコーパス: N-terminal domain

1 obular C-terminal domain and an unstructured N-terminal domain.

2 nd Thr231) in the proline-rich region of the N-terminal domain.

3 es: 1 from the palm subdomain and 2 from the N-terminal domain.

4 olar localization, which is dependent on its N-terminal domain.

5 egradation and directly interacts with STAT2 N-terminal domain.

6 in the GSDMD C-terminal domain distal to its N-terminal domain.

7 diated by RAD52 through its highly conserved N-terminal domain.

8 rredoxin (TLF) domain and a widely divergent N-terminal domain.

9 mpanied by carotenoid translocation into the N-terminal domain.

10 promoting eviction of histone H1 through its N-terminal domain.

11 erved oligomerization interface in the mVP40 N-terminal domain.

12 derstood region of the polymerase called the N-terminal domain.

13 repression of Trio GEF activity by the Trio N-terminal domain.

14 tide in the catalytic barrel rather than the N-terminal domain.

15 ly conserved residue located within the PKD1 N-terminal domain.

16 aspases, cleave GSDMB at 88DNVD91 within the N-terminal domain.

17 rms makes extensive contacts with the folded N-terminal domain.

18 which interacts with XPB mainly through its N-terminal domain.

19 c domain remains active independently of the N-terminal domain.

20 binding to a nonoverlapping site on the CD73 N-terminal domain.

21 with a beta-sandwich structure and a diverse N-terminal domain.

22 ket flanked by serine residues between their N-terminal domains.

23 n by these factors is dependent on divergent N-terminal domains.

24 rq1 likely interacts with Pso2 through their N-terminal domains.

25 have established that DnaB is composed of an N-terminal domain, a middle domain, and a C-terminal dom

26 Ligands binding to the N-terminal domain abolish the spontaneous ionic currents

27 A deletion mutant of EZH2, lacking its N-terminal domain, abrogates both TGF-beta-stimulated EZ

28 issociation and separation of C-terminal and N-terminal domains accompanied by carotenoid translocati

29 esistant clinical strains, both LiaX and the N-terminal domain alone are released into the extracellu

30 rODA16 structure revealed a small 80-residue N-terminal domain and a C-terminal 8-bladed beta-propell

31 TET2 has a large N-terminal domain and a catalytic C-terminal region.

32 GDP-bound state, showing the characteristic N-terminal domain and a central G domain that are common

33 DYRKs included an absence of the regulatory N-terminal domain and a unique conformation of the CMGC-

34 Mechanistically, both the Ecm29 N-terminal domain and an intact AIS structure are requir

35 er, electron density was missing for the p59 N-terminal domain and for the linker connecting it to th

36 the presence of an L138P mutation in the VP1 N-terminal domain and identifying 52 additional mutation

37 ctivity is driven by ATP, which binds to the N-terminal domain and induces large conformational chang

38 as a redox-functioning selenocysteine in its N-terminal domain and nine selenium transporter-function

39 skeletal muscle and has a large cytoplasmic N-terminal domain and smaller C-terminal pore-forming do

40 oteins Prp38, Snu23 and Spp381 bind the Prp8 N-terminal domain and stabilize U6 ACAGAGA stem-pre-mRNA

41 nal oligomerization domain, while the folded N-terminal domain and the C-terminal IDR are not require

42 The peptide is clasped between the N-terminal domain and the transmembrane core of the rece

43 formational changes are detected both at the N-terminal domain and within the substrate portal nearly

44 , which reveal the architecture of the GSDMD N-terminal domains and demonstrate distinct and common f

45 that the IMC3 C-terminal domain and the IMC6 N-terminal domain are necessary for binding to ILP1, fur

46 pendent O-GlcNAcylation of SIRT1, within its N-terminal domain, as a crucial determinant of hepatic f

47 CesA's N-terminal domains assemble into a cytosolic stalk that

48 The crystal structure of the N-terminal domain at 1.7 A resolution comprising residue

49 that Rif1 is S-acylated within its conserved N-terminal domain at cysteine residues C466 and C473 by

50 ative N-glycosylation sites within the large N-terminal domain at N65 and N82.

51 inases NEK6 and NEK7 phosphorylated the EML4 N-terminal domain at Ser(144) and Ser(146) in vitro, and

52 asks the RNA polymerase binding site on, the N-terminal domain, autoinhibiting RfaH and restricting i

53 We show that both full-length GSDMB and the N-terminal domain bind to nitrocellulose membranes immob

54 mu1A C-terminal domain, but not the GST-mu1A N-terminal domain, bind to L-selectin tail peptide, and

55 rts of numerous residues associated with the N-terminal domain binding pocket.

56 P7, utilizing a PSTS motif matching the USP7 N-terminal domain-binding A/PxxS consensus, but uniquely

57 The TIMP N-terminal domain binds and inhibits an MMP catalytic do

58 In addition, the GSDMB N-terminal domain binds liposomes containing sulfatide.

59 The cleaved N-terminal domain binds phosphoinositides and cardiolipi

60 During transposition, an array of N-terminal domains binds a single transposon end while t

61 at mature, cleaved, C-terminal AgRP, not the N-terminal domain, binds heparan sulfate.

62 133 C-terminal domain complex and the Nup133 N-terminal domain, both from S. cerevisiae.

63 gammaC0C7 (endogenous [genetically encoded] N'-terminal domains C0 to C7 of cardiac myosin binding p

64 Ligation of rC0C7 (exogenous [recombinant] N'-terminal domains C0 to C7 of cardiac myosin binding p

65 roach for removal and replacement of cMyBP-C N'-terminal domains (C0-C7) in detergent-permeabilized c

66 Binding of cMyBP-C N-terminal domains (C0-C2) to labeled F-actin reduced ro

67 optosis via the pore-forming activity of its N-terminal domain, cleaved by activated caspases associa

68 rough a modular structural architecture: the N-terminal domain comprises a DNA binding/tetramerizatio

69 was delayed specifically in the presence of N-terminal domain containing TDP-43 variants, while C-te

70 of a novel ATPase, Sulfolobus islandicusPilT N-terminal-domain-containing ATPase (SisPINA), encoded b

71 The N-terminal domain contains an apparent eicosanoid bindin

72 lical oligomers which, when aligned with the N-terminal domain crystal structure, suggest an N-termin

73 BB) domain of A55 binds directly to the Cul3 N-terminal domain (Cul3-NTD), forming a 2:2 complex in s

74 A trimer of N-terminal domains define a channel entrance that binds

75 rojects away from the crescent-shaped FIP200 N-terminal domain dimer.

76 e subunits that lack the Rubisco-interacting N-terminal domain displayed a ~2-fold increase in Rca fu

77 er for DNA binding, and two YefM dimers with N-terminal domains dock into the adjacent major grooves

78 Surprisingly, a large interface with the N-terminal domains does not contribute to the stability

79 Overexpression of NRP2 or its N-terminal domain enhances VSV-LUJV infection, and cells

80 ll-length TDP-43, association between folded N-terminal domains enhances the propensity of the intrin

81 revealed that nsP2h adopts a uniquely folded N-terminal domain followed by a superfamily 1 RNA helica

82 nserved protein composed of 5 domains, the 2 N-terminal domains form a stably structured unit cotrans

83 eltaNPylRS/(DeltaNPyl)tRNA pairs (which lack N-terminal domains) form two distinct classes.

84 rst by S1P and then by S2P, liberating their N-terminal domains from membranes and enabling them to a

85 The N-terminal domain had a pentameric nucleoplasmin-fold; m

86 Its N-terminal domain has the same fold as proteins that for

87 tors targeting the ATP-binding pocket of the N-terminal domain have anticancer effects, but most bind

88 N-terminal domain homologs, the helical carotenoid prote

89 ation, not circular or twisted, in which the N-terminal domain I (DI) and the C-terminal domain V (DV

90 that both DDBH1 and DDBH2 interact with the N-terminal domain I of DnaA and studied the DDBH2 intera

91 is event initiates structural changes at the N-terminal domain in 1 mus, which allow the carotenoid t

92 allow the carotenoid to translocate into the N-terminal domain in 10 mus.

93 ing Gle1 function, Gle1 oligomerizes via its N-terminal domain in a phosphorylation-dependent manner.

94 beta1-6A2V, which supports a role of Abeta's N-terminal domain in amyloid fibril formation.

95 these data reveal novel roles for the ANGPT2 N-terminal domain in blood vessel remodeling, tumor grow

96 e present two crystal structures of the MutY N-terminal domain in complex with either undamaged DNA o

97 We solved the structure of the SMU1 N-terminal domain in complex with RED or bound to one of

98 int to a critical importance of the cationic N-terminal domain in mediating antibacterial, antiparasi

99 hasizing an important role for this variable N-terminal domain in regulating actomyosin crossbridge k

100 sue of JBC, Brown and co-workers identify an N-terminal domain in SM that interconverts in a choleste

101 detailed insights into the role of the TET2 N-terminal domain in TET2 regulation.

102 ve surface charge of the hinge region of the N-terminal domain in the GluN1 subunit of the NMDAR is r

103 We used cMyBP-C's regulatory N-terminal domains in defined phosphorylation states for

104 sults underscore the critical roles of SNARE N-terminal domains in mediating interactions with other

105 he clade G6, an ancestral exCNL has lost its N-terminal domains in the course of evolution.

106 ence; the insertion of this sequence in Sdc4 N-terminal domain increases 6-O sulfation of its HS chai

107 analysis of the structural model of the L142 N-terminal domain indicated significant homology with so

108 hen we overexpressed mutants lacking part of N-terminal domains, indicating that the IL1RAPL1 extrace

109 neurotoxic mutants of PrP, and the isolated N-terminal domain induces currents when expressed in the

110 idylinositol (PtdIns) transfer proteins PYK2 N-terminal domain-interacting receptor 2 (Nir2) and Nir3

111 nd to RNA polymerase binding site within the N-terminal domain, into an unbound beta-barrel that inte

112 Its N-terminal domain is the active part of the protein, and

113 to the native wild-type protein, whereas the N-terminal domain is unfolded and comprises an ensemble

114 e ring orients during translocation with the N-terminal domain leading, indicating that the transloca

115 subunit C-terminal domain (CTD) and not the N-terminal domain like other lineage A beta-CoVs to bind

116 has a cleaved N-terminal signal peptide, an N-terminal domain located in the lumen of the rough micr

117 The MCM binding region in the N-terminal domain mapped to the chromatin binding domain

118 Upon heme binding to the N-terminal domain, MFSD7C dissociates from ETC component

119 rnative splicing of a single exon within the N-terminal domain, MKK7gamma encodes a unique PxIxIT mot

120 sion gene construction methodology to screen N-terminal domain mutations discovered in tumors that ar

121 sing N53I substitution, which resides in the N-terminal domain (N-domain).

122 addition to the stabilization of either Rrn7 N-terminal domain near Pol I wall or the tandem winged h

123 mal cholesterol efflux, we found that NPC1's N-terminal domain need not release from the rest of the

124 The structure shows that the NusG N-terminal domain (NGN) binds at the central cleft of RN

125 micellar structures, where the very soluble N-terminal domain (NT) forms the shell.

126 central domain; CD) and CENP-N (through its N-terminal domain; NT).

127 A3G consists of a non-catalytic N-terminal domain (NTD) and a catalytic C-terminal domai

128 A flexible linker connecting the N-terminal domain (NTD) and C-terminal domain (CTD) of A

129 udies to decipher the contributions of Nbr's N-terminal domain (NTD) and exonucleolytic domain (EXO)

130 luorescence to investigate the role of Tau's N-terminal domain (NTD) and proline-rich region (PRR) in

131 A disordered N-terminal domain (NTD) and structured C-terminal domain

132 A tunnel connecting the N-terminal domain (NTD) and the transmembrane sterol-sen

133 TDP-43's N-terminal domain (NTD) is important for these activitie

134 ults of in vitro experiments showed that the N-terminal domain (NTD) is intrinsically disordered and

135 owever, the function of its highly conserved N-terminal domain (NTD) is unknown.

136 g on the conformation of the membrane-distal N-terminal domain (NTD) layer.

137 Tyr(30), Tyr(64), and Tyr(86) in the N-terminal domain (NTD) of beta-catenin.

138 using mutation, showing that for WT p97, the N-terminal domain (NTD) of each subunit can exist in eit

139 MCU-EMRE complexes along an interface at the N-terminal domain (NTD) of human MCU that is a hotspot f

140 The N-terminal domain (NTD) of nsp11 was responsible for STA

141 Here, we report that the N-terminal domain (NTD) of RAD52 devoid of the potential

142 Here we present the crystal structure of the N-terminal domain (NTD) of the A subunit of the Bacillus

143 The N-terminal domain (NTD) of the GluN1 subunit (GluN1-NTD)

144 Mouse hepatitis virus (MHV) uses its N-terminal domain (NTD) of the viral spike (S) protein t

145 Here, we investigate the impact of the PHF1 N-terminal domain (NTD) on the Tudor domain interaction

146 The spidroin N-terminal domain (NTD) plays a pivotal role in this pro

147 BILBO1's N-terminal domain (NTD) plays an essential role in T. br

148 NCR1 has its N-terminal domain (NTD) positioned to deliver a sterol t

149 Here, we show that Cet1's N-terminal domain (NTD) promotes the recruitment of FACT

150 of the MATE subfamily DinF suggest that the N-terminal domain (NTD) supports substrate and ion bindi

151 They also differ substantially at N-terminal domain (NTD) surfaces involved in dimerizatio

152 es and demonstrate that AsfvLIG has a unique N-terminal domain (NTD) that plays critical roles in sub

153 Interactions of the Ded1 N-terminal domain (NTD) with eIF4A, and Ded1-CTD with eI

154 mic conformational equilibrium involving the N-terminal domain (NTD) with implications for the bindin

155 haviour and thereby the role/function of the N-terminal domain (NTD) within chromatin is yet unresolv

156 HSPB6 includes a long disordered N-terminal domain (NTD), a phosphorylation motif around

157 ular chaperones recognize a region of the AR N-terminal domain (NTD), including a FQNLF motif, that i

158 domain (RBD) and those directed against the N-terminal domain (NTD), indicating that both of these r

159 We pinpointed critical N-terminal domain (NTD), NTD-nucleotide-binding domain 1

160 aspase-6 at the hinge between the disordered N-terminal domain (NTD), residues 23-45, and core of the

161 Using the NFAT5 N-terminal domain (NTD), which contains AD1, as a model,

162 slices, we show that the extracellular AMPAR N-terminal domain (NTD), which projects midway into the

163 talytically inactive, strongly ssDNA binding N-terminal domain (NTD).

164 ontrols motions in the distant AMPA receptor N-terminal domain (NTD).

165 n its ligand-independent AF-1 located in its N-terminal domain (NTD).

166 phatidylserine binds to an integral-membrane N-terminal domain (NTD); however, how the NTD activates

167 Previously, we have shown that the sHSP N-terminal domains (NTDs), which have a high degree of i

168 raction to the CARD domains of RIG-I and the N terminal domain of La.

169 the dynamics of selected side chains of the N-terminal domain of Abeta(1-40) fibrils.

170 We also find that the conserved N-terminal domain of AcrIIA13-AcrIIA15 binds to an inver

171 Here we show that the N-terminal domain of AGO2 is enriched with arginine-glyc

172 th the N-terminal GW-domain of GW182 and the N-terminal domain of Ago2, two major components of PB.

173 Original work proposed that the N-terminal domain of AgRP facilitates this interaction.

174 ariability in the dynamics of the disordered N-terminal domain of amyloid-beta fibrils (Abeta), compr

175 lution but can fold and bind in trans to the N-terminal domain of another M1 monomer, thus polymerizi

176 charges of acetylable lysine residues in the N-terminal domain of APE1 are essential for chromatin as

177 sitive charges of the lysine residues in the N-terminal domain of APE1 induces a conformational chang

178 ried out an NMR-based fragment screen on the N-terminal domain of apoE4 and identified a benzyl amidi

179 pecific interactions between residues in the N-terminal domain of ArfA and RF2 help RF2 to adopt a ca

180 Here, we report that the hydrophilic N-terminal domain of Brassica napus DGAT1 (BnaDGAT11-113

181 alpha-helical and develops contacts with the N-terminal domain of CaM more slowly, in about 8 ms.

182 4 lysine residues (K(38)KKK) located in the N-terminal domain of caspase-7 form such an exosite and

183 interacts with a novel binding motif in the N-terminal domain of CaV1 LTCC alpha1 subunits that is n

184 lded central domain of CENP-C and the folded N-terminal domain of CENP-N that becomes rigidified 1,00

185 DNA-mediated condensation involving both the N-terminal domain of cGAS and the site-C cGAS-DNA interf

186 crystal structure of MOR in complex with the N-terminal domain of CI, revealing the structural basis

187 at the C-terminal beta-propeller but not the N-terminal domain of CrODA16 is required for the interac

188 Fn binding by CshA, in which the disordered N-terminal domain of CshA acts to "catch" Fn, via format

189 This suggests that Ca(2+) affinity of the N-terminal domain of cTnC in isolation is insufficient t

190 ractions that begins with the opening of the N-terminal domain of cTnC, followed by cTnC binding the

191 he heterodimer formed by human MCT-1 and the N-terminal domain of DENR at 2.0- angstrom resolution.

192 The N-terminal domain of DENV NS5 has guanylyltransferase an

193 nic repair intermediates and the presence of N-terminal domain of DNA ligase I in a coupled reaction

194 oming nucleotide and a template base and the N-terminal domain of DNA ligase I mediates its interacti

195 Of note, addition of the N-terminal domain of E. coli NfuA to S. aureus Nfu, full

196 th 3D reconstruction revealed that the basic N-terminal domain of EML4 mediated its binding to the ac

197 affinity, and that antibodies targeting the N-terminal domain of ERFE that prevent ERFE-BMP6 interac

198 We found that BMP6 binds the N-terminal domain of ERFE, and a polypeptide derived fro

199 Their study shows that the N-terminal domain of GATA1 is critical to normal red cel

200 o show how a small alpha-helical domain, the N-terminal domain of HemK, folds cotranslationally.

201 sion of intragenic tandem repeats within the N-terminal domain of HPF1 was sufficient to cause pronou

202 t prevents the specific interaction with the N-terminal domain of Hsp90 required for catalysis.

203 We further show that the N-terminal domain of Imh1 is critical for restoring GARP

204 benthamiana that transient expression of the N-terminal domain of JIP60, from which the inhibitor dom

205 ive conserved residues (ELEFN(50-54)) in the N-terminal domain of KSHV gH that are critical for Eph b

206 inding was also mapped within the disordered N-terminal domain of KSHV ORF57, and showed specificity

207 The N-terminal domain of LiaX binds daptomycin and AMPs (suc

208 ison and structural homology modeling of the N-terminal domain of LtpM uncovered a remote similarity

209 argely formed by the interaction between the N-terminal domain of MDM2 and the N-terminal transactiva

210 linking was not prevented by deletion of the N-terminal domain of NPC1, which contains the initial bi

211 LUJV GP binds the N-terminal domain of NRP2, while CD63 stimulates pH-acti

212 Interestingly, the N-terminal domain of nsp11 is responsible for inducing S

213 Carotenoid Proteins [HCPs]), paralogs of the N-terminal domain of OCP, were described.

214 e methyltransferase (MT) domain of L and the N-terminal domain of P (P(NTD)) is missing.

215 In this process, the N-terminal domain of p30 released from GSDMD acts as an

216 -terminus, the antibody response against the N-terminal domain of PfCSP (N-CSP) remains obscure.

217 apical surface of epithelial cells where the N-terminal domain of pIgR, termed secretory component (S

218 We show that the N-terminal domain of proSP-B is a phospholipid-binding a

219 sical techniques, we show that the flexible, N-terminal domain of PrP(C) functions as a powerful toxi

220 The crystal structure of the N-terminal domain of pyoS2 (pyoS2(NTD)) bound to FpvAI (

221 y, we initially present the structure of the N-terminal domain of QseB, the response regulator respon

222 The structural data confirm that the N-terminal domain of RapZ possesses a kinase fold, where

223 a novel bipartite degradation signal in the N-terminal domain of RGS2.

224 eraction between three glutamic acids in the N-terminal domain of RsbR and the membrane-bound mini-pr

225 ing to the SEPT6 and SEPT7 groups and to the N-terminal domain of septins from the SEPT3 group.

226 Although the N-terminal domain of SuiB adopts a typical RRE (RiPP rec

227 binding with TATA-box DNA, and also with the N-terminal domain of TAF1 previously implicated in TATA-

228 rity of the cells recognized epitopes in the N-terminal domain of TG2.

229 ified hemi- and heterozygous variants in the N-terminal domain of the A isoform of FHF2 (FHF2A).

230 separately with CTD and the latter with the N-terminal domain of the C-subunit.

231 tion within the compound-binding site in the N-terminal domain of the CA protein.

232 Phosphorylation of the N-terminal domain of the huntingtin (HTT) protein has em

233 Catalysis of methionine oxidation within the N-terminal domain of the huntingtin protein may potentia

234 fide bond, during the catalytic cycle of the N-terminal domain of the key bacterial oxidoreductase Ds

235 ed states under refolding conditions for the N-terminal domain of the L9 protein (NTL9).

236 e three-dimensional dimeric structure of the N-terminal domain of the MERS-CoV nucleocapsid protein (

237 First, we show that the N-terminal domain of the Nse4 kleisin molecule binds to

238 3 amphipathic alpha-helices clustered in the N-terminal domain of the protein; biochemical analyses d

239 ntains a 197-amino-acid (aa) deletion in the N-terminal domain of the spike (S) protein.

240 ciprocal "tyrosine clasp" formed between the N-terminal domain of TIMP-1 and proximal MMP-3 interface

241 more, the positively charged residues in the N-terminal domain of VDAC1 interact with mtDNA, promotin

242 Modeling of the cytosolic N-terminal domain of Vph1 identified two membrane-orient

243 The cytosolic N-terminal domain of Vph1 is also recruited to membranes

244 ld be partially replaced by RBR fused to the N-terminal domain of XND1.

245 One potential mechanism for the N-terminal domains of cMyBP-C to achieve this is by bind

246 The Nidovirales order-specific N-terminal domains of each nsp13 interact with the N-ter

247 s functional interactions between the C- and N-terminal domains of MukF with the MukB head and neck,

248 hile much is known about the function of the N-terminal domains of OPG, which is responsible for bind

249 intrinsically disordered region (IDR) at the N-terminal domains of OsDGAT1 proteins.

250 Here we solve the crystal structures of the N-terminal domains of PHF1 and MTF2 with bound CpG-conta

251 l analysis suggested that differences in the N-terminal domains of these polymerases are responsible

252 Mutations in the CaV1.3 alpha1 subunit N-terminal domain or in the CaMKII catalytic domain that

253 The p150 subunit of human CAF-1 contains an N-terminal domain (p150N) that is dispensable for histon

254 ts phosphorylation at S54 and S73 within the N-terminal domain (Pdc-ND) followed by association with

255 Signals from the N-terminal domain persist, indicating that this segment

256 Cbp3 consists of two distinct domains: an N-terminal domain present in mitochondrial Cbp3 homologs

257 Anti-ERFE antibodies targeting the N-terminal domain prevented hepcidin suppression in ERFE

258 minal kinase (JNK), phosphorylated the Gle1A N-terminal domain, priming it for phosphorylation by gly

259 Rad51 directly interacts with the Pol alpha N-terminal domain, promoting Pol alpha and delta binding

260 tip of the alpha-hairpin and on neighboring N-terminal domain residues.

261 structured hydrophobic core and a disordered N-terminal domain (residues 1-16).

262 We show that the disordered N-terminal domain (residues approximately 20-100) intera

263 ns of Hsp90 via allosteric modulation of its N-terminal domain, responsible for the chaperone's ATPas

264 chains 6-O sulfation is driven by a specific N-terminal domain sequence; the insertion of this sequen

265 ted that Arg259, which is located within the N-terminal domain, specifically interacts with UDP-GlcUA

266 crack open a DnaB hexamer using an extended N-terminal domain, stabilizing this conformation through

267 hree primary tumor-associated mutants in the N-terminal domain strongly destabilize the coiled-coil s

268 , 8 of the 11 tyrosines are conserved in the N-terminal domain, suggesting that phosphorylation of ty

269 Within RmtC, we defined an N-terminal domain surface, comprising basic residues fro

270 at Inp1 mediates peroxisome retention via an N-terminal domain that binds PI(4,5)P2 and a C-terminal

271 Cdc48 consists of an N-terminal domain that binds UN and two stacked hexameri

272 ons in the receptor-binding domain (RBD) and N-terminal domain that confer resistance to monoclonal a

273 with TNFalpha treatment, generating a GSDMC N-terminal domain that forms pores on the cell membrane

274 dynamical C-terminal domain and a disordered N-terminal domain that forms transient secondary and ter

275 structure of CteB also reveals an accessory N-terminal domain that has high structural similarity to

276 Notably, IL-33 has a distinct N-terminal domain that mediates nuclear localization and

277 se region of the protein, a newly identified N-terminal domain that shares homology with the Guanine

278 erminal domain crystal structure, suggest an N-terminal domain that wraps around the C-terminal domai

279 t "sense" pathogen effectors differ in their N-terminal domains: these are Toll/interleukin-1 recepto

280 The method revealed a novel role for cMyBP-C N'-terminal domains to damp sarcomere-driven contractile

281 tion surface that may work together with the N-terminal domain to allow the formation of large macrom

282 ng ESCRT-III until it encounters the ordered N-terminal domain to destabilize the ESCRT-III lattice.

283 res, whereas its C-terminal domain binds the N-terminal domain to inhibit pyroptosis.

284 oplasmic form of CCN3 interacted with the AR N-terminal domain to sequester AR in the cytoplasm of pr

285 rcoiled DNA substrate first and position the N-terminal domains to bind and cleave the opposite stran

286 ating chloroplast transit peptide (cTP), and N-terminal domains to the ATPase, Rubisco recognition an

287 tudy, we determined the crystal structure of N-terminal domain-truncated p97 in complex with CB-5083.

288 enoid translocation and separation of C- and N-terminal domains upon transition from the basic orange

289 The regulatory role of the N-terminal domain was dissected.

290 nation was localized solely to the protein's N-terminal domain, we find that both domains contribute

291 2 OS cells, the YXY motif and the L-tetherin N-terminal domain were not required for either robust te

292 Both proteins' isolated N-terminal domains were less kinetically stable than the

293 dditionally, like the C-terminal domain, the N-terminal domain when overexpressed partially restores

294 the oligomerization and lipid binding by its N-terminal domain, which assembles membrane pores, where

295 show that ING5 forms homodimers through its N-terminal domain, which folds independently into an elo

296 interactions between the AP2 complex and its N-terminal domain, which in turn recruits endocytic acce

297 a catalytically inactive dioxygenase-related N-terminal domain, which is important for MCM loading, b

298 The RIM-BP N-terminal domain, while dispensable for SV release site

299 Here we show that overexpression of the N-terminal domain with (TDD) or without (TD) the distal

300 hrough the intramolecular association of the N-terminal domain with the FHA domain, thus blocking all