ライフサイエンスコーパス: N-terminal fragment

1 mammalian-derived expanded huntingtin exon-1 N-terminal fragment.

2 bound to GPIHBP1 avidly, independent of the N-terminal fragment.

3 ies of the amyloid-like aggregates of an htt N-terminal fragment.

4 for the coiled-coil Jun, is attached to the N-terminal fragment.

5 I, and restores motogenic activity to the FN N-terminal fragment.

6 mation to facilitate macrocyclization of the N-terminal fragment.

7 ize a large conformational change within the N-terminal fragment.

8 the htt(NT) domains of polyQ-containing htt N-terminal fragments.

9 he oligomer-mediated amyloid assembly of htt N-terminal fragments.

10 ach was used to stabilize the C-terminal and N-terminal fragments.

11 into two distinct forms: the C-terminal and N-terminal fragments.

12 defines the DNA binding specificity of Myrf N-terminal fragments.

13 ractions between amelogenin and ameloblastin N-terminal fragments.

14 diates the homo-trimeric DNA binding of Myrf N-terminal fragments.

15 rane binding by prothrombin, mediated by its N-terminal fragment 1 (F1) domain, plays an essential ro

16 hrombin and severs covalent linkage with the N-terminal fragment 1.2 (F12) region.

17 apatite (HA) formation and growth, while its N-terminal fragment (37K) promotes HA formation.

18 es an initial cleavage that releases a large N-terminal fragment (A1-F92) as well as multiple smaller

19 ved for a mixture of Abeta1-28WT and a short N-terminal fragment, Abeta1-6A2V, which supports a role

20 ormally, but no monomers or oligomers of the N-terminal fragments accumulated in the medium; medium f

21 The N-terminal fragment also rescued LTP inhibited by elevat

22 Cmu directly phosphorylated rVR1 or a longer N-terminal fragment (amino acids 1-118) of rVR1 but not

23 for the polypeptide backbone of a tetrameric N-terminal fragment (amino acids 1-181) of the Aplysia K

24 ucture of the complex between the mesothelin N-terminal fragment and Fab of MORAb-009 at 2.6 A resolu

25 collagen-like stalk, as the presence of C1q N-terminal fragment and low m.w. heparin but not the C-t

26 encoding compact beta variants of Htt exon 1 N-terminal fragment and tested their ability to aggregat

27 s with destabilized interactions between the N-terminal fragment and the channel domain.

28 e CUE domain, interact strongly with an RPM1 N-terminal fragment and weakly with a similar domain fro

29 overning the biogenesis and function of Myrf N-terminal fragments and its physiological significance.

30 Two N-terminal fragments and one C-terminal fragment of E. c

31 t promotes the nuclear accumulation of small N-terminal fragments and reduces the interaction of N-te

32 peptides are simplified due to the enhanced N-terminal fragments and suppressed internal fragments.

33 a-cleavage of APP generates a large secreted N-terminal fragment, and a smaller cellular C-terminal f

34 This domain is separable from the N-terminal fragment, and its activity is identical to th

35 sential for the biological functions of Myrf N-terminal fragment, and that the region adjacent to the

36 Smaller soluble N-terminal fragments appear to accumulate over time, pea

37 Although several p65 N-terminal fragments are generated by either protease cl

38 Consequently, Myrf N-terminal fragments are released from the ER only as ho

39 full-length mhtt and a small amount of mhtt N-terminal fragments are sufficient to elicit the diseas

40 nd limited proteolysis studies identified an N-terminal fragment as a candidate for one of the domain

41 Here, we report that Myrf N-terminal fragments assemble into stable homo-trimers b

42 e ABC-stroke score includes age, biomarkers (N-terminal fragment B-type natriuretic peptide and high-

43 Levels of N-terminal fragment B-type natriuretic peptide, high-sen

44 e, biomarkers [high-sensitivity troponin and N-terminal fragment B-type natriuretic peptide], and cli

45 xtensibility and shifting the phosphorylated N-terminal fragments back to the extended state, as if u

46 The N-terminal fragment bearing the bZIP DNA binding domain

47 We found that 1a and 1b N-terminal fragments bind in a direct and dose-dependent

48 /cytoplasmic C-terminal fragment but not the N-terminal fragment binding partner CD55.

49 udy the structural and functional effects of N-terminal fragments binding to thin filaments.

50 plexed with Dss1 binds DNA slowly, while the N-terminal fragment binds quickly.

51 11_0521, but not truncated forms lacking the N terminal fragment, block its interaction with ICAM-1.

52 the cleavage does not dissociate the C- and N-terminal fragments, but it generates a very stable "cl

53 ubiquitination of bacterially expressed IRS1 N-terminal fragment by CRL7 but at low levels.

54 lyzed post-MI in humans, which results in an N-terminal fragment, C0-C1f.

55 The resulting N-terminal fragment, called fragment N, stimulates anti-

56 A specific N-terminal fragment, called the PF-AB domain, becomes pr

57 n cleavage and N-glycosylation, and that the N-terminal fragment can be released from the cell surfac

58 We show that an N-terminal fragment comprising the catalytic domain can

59 The three-dimensional structure of an N-terminal fragment comprising the first 51 amino acids

60 A chimeric N-terminal fragment containing residues from Venus and y

61 The N-terminal fragment containing the bZIP domain is then t

62 se-3 into two fragments during apoptosis, an N-terminal fragment containing the O-GlcNAcase active si

63 ate that TMEM106B is readily processed to an N-terminal fragment containing the transmembrane and int

64 Crystal structures of N-terminal fragments containing the VWA and TSR1 domains

65 on resonance measurements indicated that the N-terminal fragment contributes to the folding and incre

66 tic cleavage of the channel because a mutant N-terminal fragment deficient in proteolytic activity is

67 mHTT N-terminal fragments detected in HD PBMCs may explain th

68 Unexpectedly, a shorter N-terminal fragment did not displace tropomyosin or acti

69 anslocation into plant cells and that longer N-terminal fragments direct progressively stronger trans

70 the Q193-G194 pair, resulting in a truncated N-terminal fragment disrupted for inducing cell pyroptos

71 inal (57K), and a chondroitin-sulfate-linked N-terminal fragment (DMP1-PG)], we predicted that each w

72 The Set1p N-terminal fragment does not exhibit significant homolog

73 s studies have shown that the aggregation of N-terminal fragments (encoded by HTT exon 1) underlies t

74 ng staurosporine-induced apoptosis, yielding N-terminal fragments encompassing the ligand-binding dom

75 Likewise, the N-terminal fragments extracted from axonemes contained L

76 showed reduced LTA binding, while a purified N-terminal fragment from amino acids 44-331 had high LTA

77 it undergoes auto-processing to release its N-terminal fragment from the ER, which enters the nucleu

78 In particular, release of N-terminal fragments from the beta-chain of fibrin, whic

79 This sequence corresponds to a N-terminal fragment generated by the combined action of

80 erates two biologically active fragments, an N-terminal fragment (GrB-EH(ITSN)) with EC proliferative

81 The crystal structure of a mtMCM N-terminal fragment has been solved, but surprisingly on

82 However, the importance of smaller N-terminal fragments has been highlighted by their prese

83 linositol anchor-free) prion protein and its N-terminal fragment have a strong effect on the aggregat

84 sparaginyl endopeptidase at Asn-175 into the N-terminal fragment (I2NTF) and the C-terminal fragment

85 this model in the context of the htt exon-1 N-terminal fragment in both mammalian cell culture and c

86 7 supported efficient ubiquitination of IRS1 N-terminal fragment in hyperphosphorylated form, which w

87 r, addition of the C-terminal fragment to an N-terminal fragment in trans did not improve the aminoac

88 The role of these N-terminal fragments in disease pathogenesis has been qu

89 addition, there was distinct lack of NOTCH3 N-terminal fragments in the cerebral microvasculature of

90 expectedly consists of two polypeptides; the N-terminal fragment includes residues 1-116, and the C-t

91 Moreover, the N-terminal fragment inhibits the transcriptional activit

92 The light chain yields mainly N-terminal fragment ions due to the protection of the in

93 , we use this approach to distinguish b-type N-terminal fragment ions from both internal fragment ion

94 The N-terminal fragment is further processed into a small, r

95 sults indicate that overexpression of a Bub1 N-terminal fragment is insufficient to impair the spindl

96 type A (VWA) domain within the cleaved CLCA1 N-terminal fragment is necessary and sufficient for this

97 Proteolytic cleavage of Htt into toxic N-terminal fragments is believed to be a key aspect of p

98 th threshold of about 37, aggregation of htt N-terminal fragments is so rapid that it is difficult to

99 y 50% of its activity when normalized to PS1 N-terminal fragment levels.

100 The N-terminal fragment, LL-37(1-12), was not active, while

101 echanism in which caspase-6, or other larger N-terminal fragments, mediate a neurotoxic process befor

102 he possibility of a functional role for such N-terminal fragment-membrane interactions.

103 d2L1-RACK1 interaction, we found that Pkd2L1 N-terminal fragment Met(1)-Pro(45), but not Ile(40)-Ile(

104 for the ATP7B variant that lacks the 29 kDa N-terminal fragment (mostly likely comprised of MBD1-3).

105 Both myristoylated N-terminal fragment mu1N and C-terminal fragment phi are

106 nd to L1 and that full-length Reelin and its N-terminal fragment N-R6 proteolytically cleave L1 to ge

107 e, we report that full-length Reelin and its N-terminal fragments N-R2 and N-R6 bind to L1 and that f

108 oresistant cells to CDDP, intact GSN and its N-terminal fragment (N-GSN) attenuated this response.

109 The resulting N-terminal fragments (N-ATF6 alpha and N-ATF6 beta) have

110 between residues 111/112 to yield a soluble N-terminal fragment (N1) and a membrane-anchored C-termi

111 Alpha- and beta-cleavage of PrP produces two N-terminal fragments, N1 and N2, respectively, which int

112 It was shown previously that an N-terminal fragment (nM60) that encompasses amino acid r

113 a1 Nrg1 isoform by Bace1 releases a secreted N-terminal fragment (Nrg1-ntfbeta), which can bind to a

114 e natriuretic peptide (BNP) and its inactive N-terminal fragment (NT-pro-BNP)and to determine whether

115 eptide (BNP) concentration or its precursor (N-terminal fragment [NT-proBNP]) is recommended in patie

116 h undergoes autoproteolytic cleavage into an N-terminal fragment (NTF) and a seven-transmembrane-cont

117 lytically cleaved at their GPS sites into an N-terminal fragment (NTF) and C-terminal fragment.

118 ural crest cell EMT, which generates a Cad6B N-terminal fragment (NTF) and two C-terminal fragments (

119 y that clearance of the final membrane-bound N-terminal fragment (NTF) of CD74 is mediated by the int

120 ymphocytes of SPPL2a(-/-) mice accumulate an N-terminal fragment (NTF) of CD74, which severely impair

121 aved full-length Pc1 (Pc1(cFL)) in which the N-terminal fragment (NTF) remains noncovalently associat

122 DAM10 and BACE1 released a signaling-capable N-terminal fragment (ntf), either Nrg1-ntfalpha or Nrg1-

123 In their absence, CD74 N-terminal fragments (NTFs) accumulate.

124 Exon 1 spanning N-terminal fragments (NTFs) of the Htt protein result fr

125 The N-terminal fragments (NTFs) resemble cell-adhesion prote

126 re included in this study and troponin I and N terminal fragment of B-type natriuretic peptide levels

127 r maximum AR transcriptional activation, the N terminal fragment of p44 alone maintains the basic eff

128 experiments the levels of the cleaved 22-kDa N-terminal fragment of alpha was low and did not match t

129 Vv into host cells either as a fusion to the N-terminal fragment of anthrax toxin lethal factor or wh

130 In addition, an N-terminal fragment of apoE that also contains this bind

131 -secretase cleavage of APP and binding of an N-terminal fragment of APP to DR6 is required for their

132 l-d-aspartate (NMDA) receptor to generate an N-terminal fragment of approximately 65 kDa.

133 which posttranslational modifications of the N-terminal fragment of ataxin-7 modulate turnover and to

134 Under salt stress conditions, the N-terminal fragment of AtbZIP17 tagged with GFP was tran

135 ragment of BNP pro-hormone (NT-pro-BNP), and N-terminal fragment of atrial natriuretic peptide pro-ho

136 ouble Lansbury glycosylation en route to the N-terminal fragment of beta-hCG and the sequential insta

137 B-type natriuretic peptide (BNP), N-terminal fragment of BNP pro-hormone (NT-pro-BNP), and

138 Additionally, the N-terminal fragment of Brd4 binds to both DNA and acetyl

139 roteins including antibody heavy chains, the N-terminal fragment of Cfa exhibits increased expression

140 Furthermore, an N-terminal fragment of Chmp6 inhibited both HIV-1 and AS

141 C activation requires cleavage to unmask the N-terminal fragment of CLCA1, which can independently ga

142 mapped the K7-binding region to a 30-residue N-terminal fragment of DDX3, ahead of the core RNA helic

143 is constitutively cleaved by ADAM12, and the N-terminal fragment of Dll1 is released to medium.

144 way determined previously for a similarsized N-terminal fragment of Drosophila conventional kinesin.

145 and apoE4 conferred protection but the major N-terminal fragment of each isoform did not.

146 e present a protocol for isolating the large N-terminal fragment of enhanced green fluorescent protei

147 FAK and p53 proteins, we determined that the N-terminal fragment of FAK directly interacts with the N

148 fferences were seen in binding of the 70-kDa N-terminal fragment of fibronectin that recognizes fibro

149 induced neuronal death, and expression of an N-terminal fragment of FISH reduces Abeta toxicity.

150 Expression of the 70 kD N-terminal fragment of FN blocks FN fibril assembly at g

151 We demonstrated that the N-terminal fragment of Fnm is required for full fibronec

152 we report a crystal structure of Get4 and an N-terminal fragment of Get5 from Saccharomyces cerevisae

153 ted inositol phosphate production, as did an N-terminal fragment of GRK2 previously characterized as

154 fragment of hGal-3 (hGal-3C), hGal-7, and an N-terminal fragment of hGal-9 (hGal-9N), were measured u

155 A 17-residue N-terminal fragment of htt(e1) (N17) has been suggested

156 R6/2 mice contain an N-terminal fragment of human huntingtin with an expanded

157 hermocellum ATCC 27405, with both SAM and an N-terminal fragment of its peptidyl-substrate at 2.04 A

158 main of KChIP1 (KChIP1*) in complex with the N-terminal fragment of Kv4.2 (Kv4.2N30).

159 Pores were inhibited by an N-terminal fragment of LF and by micromolar concentratio

160 Cys-508, resulting in the dislocation of the N-terminal fragment of MAVS from the mitochondria.

161 TGATCATTGTG), the guests, complexed with the N-terminal fragment of MMLV reverse transcriptase, the h

162 drug-DNA interactions in which the host, the N-terminal fragment of Moloney murine leukemia virus rev

163 The crystal structure of the N-terminal fragment of mtMCM reveals a stable dHex archi

164 nsgenic mice that express a caspase-6 length N-terminal fragment of mutant htt (N586) with both norma

165 one important example, mice that express an N-terminal fragment of mutant htt terminating at the C-t

166 , we examine possible mechanisms by which an N-terminal fragment of mutant huntingtin (htt; N-htt) in

167 overexpressed reduce the toxic effects of an N-terminal fragment of mutant huntingtin with 103 Q.

168 ting proteins to IBs that are composed of an N-terminal fragment of mutant huntingtin, the causative

169 Ectopic expression of an N-terminal fragment of NleE (NleE(34-52)) in HeLa cells

170 her subunits of the CAF-1 complex because an N-terminal fragment of p150 (p150N) that cannot interact

171 Small linear peptides mimicking the N-terminal fragment of p53 have been shown to be potent

172 Here we report that an N-terminal fragment of p65 (amino acids 21-186) can sele

173 is in primary striatal neurons exposed to an N-terminal fragment of polyglutamine-expanded huntingtin

174 Control proteins, the N-terminal fragment of polymorphic membrane protein 8 an

175 report the structure of alpha4 bound to the N-terminal fragment of PP2Ac.

176 ty probe E2012-BPyne specifically labels the N-terminal fragment of presenilin-1 (PS1-NTF) in cell me

177 Levels of N-terminal fragment of prohormone B-type natriuretic pep

178 g, and diabetes) and newer CHD risk factors (N-terminal fragment of prohormone B-type natriuretic pep

179 on blood pressure (BP) and relationship with N-terminal fragment of prohormone B-type natriuretic pep

180 d by PS2 but not PS1 and is dependent on the N-terminal fragment of PS2 but not gamma-secretase activ

181 creen for this receptor that used a modified N-terminal fragment of PTH as a probe for small molecule

182 The N-terminal fragment of PTH(1-34) is critical for PTH1 re

183 idues) are natural agonists of PTHR1, and an N-terminal fragment of PTH, PTH(1-34), is used clinicall

184 the preferred bioactive conformation of the N-terminal fragment of PTH.

185 Ca(2+)-bound recoverin bound to a functional N-terminal fragment of rhodopsin kinase (residues 1-25,

186 The reconstituted highly conserved N-terminal fragment of RNase E (NRne, residues 1-499) bi

187 We found that an N-terminal fragment of RNF168 (1-220/N221*) efficiently

188 ogenous rVR1 in dorsal root ganglia or to an N-terminal fragment of rVR1, indicating a direct interac

189 AA) amyloid deposits typically consist of an N-terminal fragment of SAA1 or SAA2, here, abundant C-te

190 Here, we present the crystal structure of an N-terminal fragment of Saccharomyces cerevisiae Hsp104 w

191 ive vaccine candidate, we have expressed the N-terminal fragment of SARS-CoV S protein (S1) in tomato

192 here the structure of a complex formed by an N-terminal fragment of Scm3 with the histone-fold domain

193 d to express Slit2 and Robo-1, the bioactive N-terminal fragment of Slit2 inhibited TGF-beta-induced

194 We find that a short palmitoylated N-terminal fragment of Sonic Hedgehog binds Patched1 and

195 m a duplication of the sequence encoding the N-terminal fragment of talin (the talin head domain) wit

196 luster region and result in expression of an N-terminal fragment of the APC protein.

197 n self-catalytically form within an isolated N-terminal fragment of the enhanced green fluorescent pr

198 tigens and milk oligosaccharides, against an N-terminal fragment of the family 51 carbohydrate-bindin

199 of HAX-1 were mediated by its binding to the N-terminal fragment of the heat shock protein 90 (Hsp90)

200 The active cDNA encodes an N-terminal fragment of the heterogeneous nuclear ribonuc

201 rid assays showed that retinoschisin and the N-terminal fragment of the L-VGCCalpha1 subunit physical

202 Here, we show that an N-terminal fragment of the long CRMP-2 splice variant (C

203 p Fusion, using as a model system a 17.5 kDa N-terminal fragment of the mitotic regulator Bora.

204 Earlier, we reported an N-terminal fragment of the p160 coactivator TIF2, called

205 The complex includes the N-terminal fragment of the ribosomal protein S4, which i

206 The replacement of the N-terminal fragment of the VEEV capsid by its Sindbis vi

207 The N-terminal fragment of the Venus fluorescent protein fus

208 ial, viral, and human proteins, fused to the N-terminal fragment of the Yersinia enterocolitica T3S s

209 In this study, we investigated whether an N-terminal fragment of TLR9 could be responsible for reg

210 The structure of the 61 kDa N-terminal fragment of topoisomerase V reveals no struct

211 interaction between zebrafish Pcdh15a and an N-terminal fragment of transmembrane channel-like 2a (Tm

212 We genetically fused the N-terminal fragment of ultrafast split intein to the C t

213 In contrast, the N-terminal fragment of uPA, which binds to uPAR, but lac

214 The N-terminal fragment of wild-type huntingtin did not affe

215 As proof of concept, we used the N-terminal fragment of yellow fluorescent protein- or nV

216 ansverse sections, co-localization images of N-terminal fragments of amelogenin and ameloblastin arou

217 The resulting N-terminal fragments of both ATF6 isoforms, which have c

218 However, N-terminal fragments of CC2D1A that did not interact wit

219 tural observations of F-actin decorated with N-terminal fragments of cMyBP-C suggest that cMyBP-C bin

220 Accordingly, N-terminal fragments of each ATF6 isoform (N-ATF6alpha a

221 or the enzymatic reaction to take place, the N-terminal fragments of GNMT must have a significant deg

222 untingtin protein (HTT), studies reveal that N-terminal fragments of HTT containing the expanded Poly

223 mouse models generated by expressing mutant N-terminal fragments of htt.

224 omes are not directly impaired by aggregated N-terminal fragments of htt; instead, our data suggest t

225 The formation of short N-terminal fragments of huntingtin (cp-1/cp-2, cp-A/cp-B

226 The proteolytic enzymes generating short N-terminal fragments of huntingtin remain unknown.

227 N-terminal fragments of increasing length, in conjunctio

228 d this issue by NMR analysis of apomyoglobin N-terminal fragments of increasing length, taken as mode

229 eled inositol 1,4,5-trisphosphate (IP(3)) to N-terminal fragments of IP(3) receptors can be character

230 have expressed heterodimeric full-length and N-terminal fragments of Manduca sexta sGC in Escherichia

231 Expression of soluble, N-terminal fragments of Mga2p stabilize the transcript b

232 ts with menin in a bivalent mode involving 2 N-terminal fragments of MLL.

233 ronal degeneration and inclusions containing N-terminal fragments of mutant htt are present in the co

234 em of patients have been found to accumulate N-terminal fragments of mutant htt in nuclear and cytopl

235 N-terminal fragments of mutant htt, which contain a poly

236 N-terminal fragments of mutant huntingtin (htt) that ter

237 Accumulation of N-terminal fragments of mutant huntingtin (mHTT) in the

238 Protein inclusions comprised of N-terminal fragments of mutant huntingtin are a characte

239 generation and protein inclusions containing N-terminal fragments of mutant huntingtin.

240 Analysis of PapC-FimD chimeras and N-terminal fragments of PapC localized the chaperone-sub

241 paran sulfate to induce amyloid formation in N-terminal fragments of proIAPP.

242 Vasoinhibins are N-terminal fragments of prolactin that prevent BRB break

243 Overproduction of N-terminal fragments of S1 in Escherichia coli displaces

244 Here, we show that overexpression of N-terminal fragments of Sir3 in strains lacking the full

245 We describe structures of N-terminal fragments of smooth muscle Tmalpha and Tmbeta

246 reviously shown that constructs representing N-terminal fragments of tau, which resemble the naturall

247 zed pathologically by aggregates composed of N-terminal fragments of the mutant form of the protein h

248 N-terminal fragments of the mutant Htt (mHtt) proteins c

249 beta and c-Myc are fused with C-terminal and N-terminal fragments of the split FL, respectively.

250 The AP-1 core comprises N-terminal fragments of the two large chains, beta1 and

251 ipopeptides corresponding to the triacylated N-terminal fragments of three outer membrane proteins (O

252 echanotransduction in vivo, we overexpressed N-terminal fragments of Tmc2a in zebrafish hair cells.

253 MR to study the interactions between several N-terminal fragments of TnI, residues 1-18 (I1-18), resi

254 vation of OLE1 transcription is dependent on N-terminal fragments of two membrane proteins, Mga2p and

255 mbin- and carboxypeptidase B2-double-cleaved N-terminal fragment (OPN-L), and C-terminal fragment (OP

256 Full-length OPN (OPN-FL), thrombin-cleaved N-terminal fragment (OPN-R), thrombin- and carboxypeptid

257 This cleavage generates an N-terminal fragment, p50 N-LOK, containing the kinase do

258 Pih1(1-230) as well as a shorter Pih1 N-terminal fragment Pih1(1-195) is able to bind Rvb1/Rvb

259 nking the polyQ sequence in huntingtin (htt) N-terminal fragments plays a crucial role in initiating

260 However, unlike the N-terminal fragment produced by caspase-1 cleavage, this

261 This cleavage generates a soluble N-terminal fragment (PrPN1) and a glycosylphosphatidylin

262 nstrated specific labeling of the presenilin N-terminal fragment (PS1-NTF) within the gamma-secretase

263 ese regions showed labeling for presenilin-1 N-terminal fragments (PS1-NTFs).

264 important co-factor of AVP, the role of the N-terminal fragment, pVIn, is currently elusive.

265 proteolytic processing, the liberated amino (N)-terminal fragment remains bound to the C terminus thr

266 The binding affinity of UDP-GalNAc to a K4CP N-terminal fragment (residues 58-357) was profoundly dec

267 Slit processing generates an N-terminal fragment (SlitN) that binds to Robo1 and Robo

268 roteinases, and the approximately 17-kDa PRL N-terminal fragment so produced is demonstrated to have

269 This cleavage produces a shorter N-terminal fragment spanning amino acids 1 to 193 (GSDMD

270 Recombinant N-terminal fragments such as C0-C1, C0-C4, and C0-C5 cos

271 x polyQ proteins, the behavior of huntingtin N-terminal fragments, such as exon-1, receives special a

272 ed by the human antibodies was mapped to the N-terminal fragment T22-S69.

273 Recently, a 236-residue N-terminal fragment, termed "L6," that spans the first L

274 B cleaves Hax-1 into two major fragments: an N-terminal fragment that localizes to mitochondria and a

275 htt is important for the generation of small N-terminal fragments that are able to accumulate in the

276 eavage of mutant htt yields polyQ-containing N-terminal fragments that are prone to misfolding and ag

277 In the absence of the N-terminal fragment, the C-terminal fragment is redirect

278 tivity is not rescued by coexpression of the N-terminal fragment (TLR9(1-440)), inclusion of the hing

279 Of tropomodulin 1's 359 amino acids, an N-terminal fragment (Tmod1(1)(-)(92)) suffices for in vi

280 Both intact TnT and TnT N-terminal fragment (TnT N47) bound terbium with high af

281 improve the aminoacylation efficiency of the N-terminal fragment to the level of the full-length enzy

282 s differences between the golden ions allows N-terminal fragments to be readily identified while othe

283 LC8 enhanced the binding of RSP3 N-terminal fragments to purified axonemes.

284 se of very short polyQ repeat lengths in htt N-terminal fragments to slow this disease-associated agg

285 t) protein with polyglutamine repeats, whose N-terminal fragment translocates to the nucleus to elici

286 icted to generate a glycosaminoglycan-bereft N-terminal fragment, versikine Myeloma-associated macrop

287 The inhibition of proliferation by the N-terminal fragment was independent of its mitochondrial

288 th bound with similar affinities to LPL, the N-terminal fragment was more potent in inactivating both

289 A 406-residue long N-terminal fragment was shown by sedimentation equilibri

290 res continuity of the polypeptide chain, the N-terminal fragment was spared.

291 tions, the expression of either one of these N-terminal fragments was sufficient to delocalize Plk4 f

292 Aromatic-aromatic interactions in the N-terminal fragment were proposed to be essential for LL

293 n, IgG and IgM titers against a unique Set1p N-terminal fragment were significantly higher among pati

294 While the N-terminal fragments were active in adenylate synthesis,

295 mbrane and that they are cleaved into active N-terminal fragments, which then translocate into the nu

296 cused on proteolytic steps producing shorter N-terminal fragments, which we term cp-1 and cp-2 (disti

297 and antimicrobial activity as a 16-residue, N-terminal fragment, while further shortening led to a m

298 The interaction of the N-terminal fragment with p65 enhanced entrance of p65 in

299 endoplasmic reticulum where co-expression of N-terminal fragments with hERG1 subunits disrupted oligo

300 The crystal structures show that the N-terminal fragment wraps around the TcrPDEC catalytic d