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1 enetrating cation-dependent mechanism in its N-terminal region.
2 rom the presence of an acidic residue at its N-terminal region.
3 cent segment (positions 61-67) in the FLIL33 N-terminal region.
4 tremely transient helices are present in the N-terminal region.
5 rimental evidence of O-linked glycans in the N-terminal region.
6 binding protein C (cMyBP-C), focusing on the N-terminal region.
7 tructure of a stable domain (CHD4-N) in this N-terminal region.
8 activity, and a functionally uncharacterized N-terminal region.
9 clease domain, but instead binds to the EsaD N-terminal region.
10 es against Plasmodium should include the CSP N-terminal region.
11 Lhcb1 and Lhcb2 can be phosphorylated in the N-terminal region.
12 ike domain at the C terminus and an extended N-terminal region.
13 hanges of negatively charged residues of the N-terminal region.
14 ssociated with conformational changes in the N-terminal region.
15 Arnt-Sim (PAS) domain in their intracellular N-terminal region.
16 vivo through direct recognition of the MinD N-terminal region.
17 the sequence differences are located in the N-terminal region.
18 those of peptides corresponding to the CCR1 N-terminal region.
19 ding cytochrome domain is fused to the AfGDH N-terminal region.
20 ttributable to conformational changes in the N-terminal region.
21 the orientation of the helices (alpha1-3) in N-terminal region.
22 yte-binding domains were mapped within their N-terminal regions.
24 beta8.1, 8.2(+) immune T cells recognize the N-terminal region (aa 41-152) of dense granule protein 6
25 n fold has no impact on oligomerization, but N-terminal regions affect the dimer-tetramer equilibrium
27 P1BP3 to chromatin depends on both its C and N terminal regions and is affected by the cell cycle and
29 onal analysis suggests the involvement of an N-terminal region and a proximal C-terminal region that
30 d of two monomers that each contain a folded N-terminal region and an intrinsically disordered C-term
31 c), has a CaM-binding peptide located in its N-terminal region and displays peculiar biochemical prop
37 mokine N-loop/beta3 region to the receptor's N-terminal region and subsequent insertion of the chemok
38 ed form higher-order oligomers through their N-terminal region and that the same AT-rich site is reco
39 king of the [4Fe-4S] cluster by the flexible N-terminal region and the associated inhibition of the a
43 tions in GNPTAB uncovered amino acids in the N-terminal region and within the DMAP domain involved in
44 ective groups of hnRNP proteins, through its N-terminal region, and directly regulates pre-mRNA splic
45 changes that affect the solvent exposure of N-terminal region, and hence the redox sensitivity of th
46 molecular rationale for the function of the N-terminal region, and support the idea that Cerberus co
47 ns a newly defined ILT7-binding surface, the N-terminal region appears to suppress ILT7 activation.
49 itinating activity, revealing a role for the N-terminal region as a regulatory module in the control
50 f-mediated cleavage mechanism, featuring the N-terminal region as an anchor for at least one of the D
51 he structure and dynamics of the p150(Glued) N-terminal region, both free and in complex with polymer
52 i activation required not only the conserved N-terminal region but also permissive communication of t
53 a protein that may be cleaved in vivo at the N-terminal region by neutrophil proteases including elas
55 that serine phosphorylation within the ICAP1 N-terminal region can prevent nuclear ICAP1 accumulation
57 ased rates of MT polymerization, whereas the N-terminal region cannot bind to MT plus ends but can ac
58 is the presence of two conserved regions: an N-terminal region codifying for signal peptide and a C-t
59 rin homology (PH) domains interacts with the N-terminal region comprising ARL8- and kinesin-1-binding
60 allographic structure of the Arabidopsis TPL N-terminal region comprising the LisH and CTLH (C-termin
61 ed missense mutations in the RING domain and N-terminal region compromise its activity, and therefore
63 the C-terminal region rather than the nearby N-terminal region, consistent with an allosteric effect
64 for DNA binding and, in combination with the N terminal region, constitute a functional transactivato
65 with a C-terminal RING domain and disordered N-terminal region containing SUMO Interactions Motifs (S
66 of a C-terminal helical bundle and a dynamic N-terminal region containing two disulfide linkages.
67 he three-dimensional structure of the Xyn10C N-terminal region, containing the xylan-binding CBM22-1-
71 rthermore, we found that deletion of the F1L N-terminal region does not impede F1L antiapoptotic acti
73 by leucine-rich repeats (LRRs) and having an N-terminal region enriched in alternating lysine and glu
74 an intrinsically disordered, low-complexity N-terminal region flanking the coil-coiled self-associat
76 ball and tether, consisting of a disordered N-terminal region followed by a compact globular C-termi
79 and release the processed Nrf1 (lacking its N-terminal region) from the ER, which allows it to enter
81 ngement of RNA-binding sites, although these N-terminal regions have only limited sequence conservati
82 phosphorylation sites and truncations of the N-terminal region highlighted reduced lipid accumulation
83 f leucine-rich repeats domain also binds the N-terminal region, highlighting a possible mechanism for
84 munodominant B cell epitope derived from the N-terminal region I and to repeat sequences representing
86 Nase R, whereas the Walker B motif is in its N-terminal region implying that the two parts of the pro
87 to regulate DNA-damage responses through its N-terminal region in a poly(ADP-ribose) polymerase-depen
88 demonstrate that the established role of the N-terminal region in dimerization is not conserved; inst
90 er are partially understood, the role of the N-terminal region in the metazoan replicative mtDNA heli
91 or to a lesser extent at Ser-25, within this N-terminal region inhibit ICAP1 nuclear accumulation.
92 on and subsequent insertion of the chemokine N-terminal region into the transmembrane helical bundle
94 site-directed mutagenesis, we show that the N-terminal region is essential for ADP-ribosylating acti
95 ed chromatin-stimulated ATPase activity, the N-terminal region is required for ATP-dependent chromati
97 conserved membrane-proximal amino-terminal (N-terminal) region, is distinct from other lipid-activat
98 pper-dependent conformational changes in the N-terminal region lead to hyperphosphorylation at C-term
100 he best-scoring receptor structures have the N-terminal region lid region bound in a helical conforma
101 channel that otherwise binds ppGpp, and its N-terminal region, like the coiled-coil tip of DksA, eng
102 alyses over the N terminus revealed that the N-terminal region may also harbor a subfamily recognitio
103 ther RALF peptides that share this conserved N-terminal region may be perceived by LLG proteins in a
104 ngal or bacterial GEs, with a large inserted N-terminal region neighboring the active site and a diff
108 e of an auto-regulatory motif, AutoN, in the N-terminal region (NTR) of ISWI, indicating that AutoN d
110 kinetic techniques to show that the myosin-I N-terminal region (NTR) plays a critical role in tuning
111 ure shows the stalk region and the essential N-terminal region (NTR) previously unseen in our DNA unb
112 In the human sHSP HSPB1, the disordered N-terminal region (NTR) represents nearly 50% of the seq
113 revealed that PA2588 has a novel fold at the N-terminal region (NTR), and its C-terminal HTH (helix-t
116 at serine 8 causes structural changes in the N-terminal region of Abeta aggregates in favor of less c
118 ough sequential truncation, we show that the N-terminal region of Abeta contributes to the enhanced f
119 stigated metal ions bind specifically to the N-terminal region of Abeta, forming a dynamic, partially
121 Using biochemical assays, we found that the N-terminal region of AKAP8L binds to mTORC1 in the cytop
123 modeling revealed that two residues near the N-terminal region of alpha-helix 1 in GPPrP might mediat
126 ions to refine structure and topology of the N-terminal region of alphaS bound to the surface of syna
133 by binding of the Hsp90 middle domain to an N-terminal region of Caenorhabditis elegans Cdc37 (CeCdc
137 activation of myocardial contraction by the N-terminal region of cMyBP-C in its different phosphoryl
138 t a structural description of the Fn binding N-terminal region of CshA, derived from a combination of
139 Heat shock protein 90 (HSP90) binds to the N-terminal region of CTA1 and facilitates its ER-to-cyto
140 ational analysis predicted that the extended N-terminal region of CYP144A1-FLV is largely unstructure
143 ion at Y102 disrupts the helical fold of the N-terminal region of E2 and its interaction with key cel
144 re we show that the intrinsically disordered N-terminal region of E7 from high-risk HPV16 binds the T
146 e non-synonymous substitution (A120G) in the N-terminal region of eIF2Bbeta was responsible for the T
149 le played by a stretch of 17 residues in the N-terminal region of EZH2, we call the activation loop,
150 p57 and found that Cys(6) and Cys(23) in the N-terminal region of ficolin-3 form the intermolecular d
151 t Lsm11, in addition to interacting with the N-terminal region of FLASH, also contacts the C-terminal
155 l characterization of the previously unknown N-terminal region of HAI-1, we provide new insight into
156 tation experiments, we demonstrated that the N-terminal region of HNF6 was responsible for its inhibi
158 nd sedimentation analysis, we found that the N-terminal region of Hsp27 and the terminal regions of a
160 -L in the endoplasmic reticulum (ER) via the N-terminal region of human invariant chain p33, with or
161 to be important for biological activity: the N-terminal region of human neuropeptide Y (NPY1-9, Tyr(1
162 e rate of amyloid formation, even though the N-terminal region of IAPP is believed to be flexible in
164 ombine the CsgG nanopore with the 35-residue N-terminal region of its extracellular interaction partn
165 We conclude that Delta-JDBD, and not the N-terminal region of JBP1 alone, is a distinct folding u
167 -interacting motif 2 (PAM2w) featured in the N-terminal region of LARP4A was found to be important fo
170 ng interface to a few acidic residues in the N-terminal region of MAD1, and point mutations in this s
171 the interaction domain with Mec3 within the N-terminal region of Mcm10 and demonstrate that its trun
173 sharp contrast, recombinant proteins of the N-terminal region of MUC5B (D1-D2-D'-D3 domains, NT5B),
177 shallow pocket adjacent to the groove in the N-terminal region of NHR trimer as a new drug target, an
180 the SHFV PLP1s cleaving at sites within the N-terminal region of nsp1beta were produced in the in vi
181 ons involve the intrinsically disordered and N-terminal region of NUP98 with over 30 partner genes.
184 alysis suggested at least one epitope on the N-terminal region of PEDV/TGEV N protein that contribute
185 structure of the complex between PcrH and an N-terminal region of PopB (residues 51-59), which reveal
186 interacts directly with pUL96; however, the N-terminal region of pp150 and the C-terminal region of
188 1 cleaved eight amino acid residues from the N-terminal region of Prx1 inside the matrix, without int
190 y binding to polar residues in the conserved N-terminal region of PulG, we propose that PulM acts as
198 an artificial fusion substrate in which the N-terminal region of securin was linked to an APC/C core
200 icroscopy, we demonstrate that the conserved N-terminal region of SPR1 and its GGG motif are necessar
204 ted versions of SS4 and a fusion between the N-terminal region of SS4 and GS in the Arabidopsis ss4 m
207 ion mutants, we further demonstrate that the N-terminal region of TALEs is required for the initial n
210 f SH2D5 and an NxxF motif located within the N-terminal region of the breakpoint cluster region.
211 ever, addition of dynactin together with the N-terminal region of the cargo adaptor BICD2 (BICD2N) gi
213 ssed in eukaryotic cells, the TMH-containing N-terminal region of the CbuD1884 protein trafficked to
214 e observed that HCV1, a bNAb recognizing the N-terminal region of the CD81bs, bound a soluble E2 core
215 me families revealed two insertions into the N-terminal region of the CYP125 family (residues 58-67 a
216 ear localization signal (NLS) located at the N-terminal region of the foot-and-mouth disease viral po
219 nonneutralizing CD4-induced epitopes in the N-terminal region of the HIV-1 gp120 (A32-like epitopes)
220 d we identified a distinct domain within the N-terminal region of the HSP-16.48 protein that specifie
224 ant toxicity of the polyglutamine-containing N-terminal region of the huntingtin protein encoded by e
229 ntibodies reported thus far to recognize the N-terminal region of the membrane-proximal external regi
230 Here, we show that phosphorylation at the N-terminal region of the mitochondrial calcium uniporter
234 novel RNA recognition features involving the N-terminal region of the protein that exists in a semi-d
235 over that the major ATRX RBR lies within the N-terminal region of the protein, distinct from its PHD
240 ch reveals that FliD is pentameric, with the N-terminal region of the protomer forming an extensive s
242 tudy, we found that a 197-aa deletion in the N-terminal region of the S protein did not alter virus (
243 is enhanced by the presence of the unfolded N-terminal region of the sequence and by destabilization
245 o characterise the mechano-sensitive compact N-terminal region of the talin rod, and show that the th
246 with double cysteine substitutions near the N-terminal region of the TMD to study the effect of alte
249 es in the juxtaposition of the less ordered, N-terminal region of their capsid proteins, VP1/2/3.
251 PrS-YjhX specifically interacts with the N-terminal region of TopA (TopA67) but not full-TopA in
255 vo missense variants predicted to affect the N-terminal region of WDR37-p.Ser119Phe, p.Thr125Ile, p.S
257 o evaluate pairwise interactions between the N-terminal regions of CESA1, CESA3, CESA5, CESA6 and the
260 ghly conserved amino acid differences in the N-terminal regions of Pgamma isoforms, demonstrating for
267 Although the extended transmembrane Orai N-terminal region (Orai1 amino acids 73-91; Orai3 amino
268 ts viral membrane fusion by lifting the MPER N-terminal region out of the viral membrane, mandating t
269 ese results confirm the influential roles of N-terminal region (positions 7 and 8) and the loop 40-60
270 h cMyBP-C antibody against the actin-binding N-terminal region reduced ADP sensitivity, indicative of
271 rotein is composed of a largely unstructured N-terminal region (residues 1-71) and a well-folded C-te
272 ight binding interaction with LcrV while the N-terminal region (residues 7-51) shows weaker interacti
273 ing CyRPA and RIPR, and contains a conserved N-terminal region (RH5Nt) of unknown function that is cl
275 paramagnetic lanthanide ion attached to its N-terminal region shows a decrease in alignment as the d
276 C) has a highly disordered conformation, its N-terminal region shows resonance broadening consistent
277 osine A3 receptor (A3AR) having an identical N-terminal region shows similar biological profiles to T
278 he formation of an AcAS-Cu(I) complex at the N-terminal region stabilizes local conformations with al
279 s CH1 to bind actin aided by an unstructured N-terminal region that becomes alpha-helical upon bindin
280 of troponin I (cTnI) has a unique 31-residue N-terminal region that binds cardiac troponin C (cTnC) t
281 whereas reintroduction of AKAP8L missing the N-terminal region that confers the interaction with mTOR
282 combination and identify regions of the RAG1 N-terminal region that control nucleolar association and
283 AFF4 consists of an intrinsically disordered N-terminal region that interacts with other super-elonga
284 ubiquitin E3 ligase activity, located in an N-terminal region that is not strictly required for the
285 localization signal within an unstructured, N-terminal region that is rich in serine and threonine r
286 ends on the presence of a basic unstructured N-terminal region that tethers SpaI to the membrane.
287 ly, the structures contain a large, flexible N-terminal region that was investigated by gel-filtratio
290 n Nrd1 can partially substitute for the Set1 N-terminal region to restore CTD interactions and histon
292 hoGAP domain, induces strong binding of that N-terminal region to the RhoGAP domain, converting DLC1
293 kappaB activation by vFLIP only requires the N-terminal region up to the transition between the regis
295 e from the proline-glutamine-rich repetitive N-terminal region was identified as the immunodominant I
296 he T-tubule membrane through their cytosolic N-terminal region, which contains 8 lipid-binding (MORN)
297 erminal catalytic domain but differ in their N-terminal region, which is composed of 4 repeats of sca
298 has RNA methyltransferase activities at its N-terminal region, which is responsible for capping the
299 associates with LDs through its hydrophobic N-terminal region, which is sufficient to demarcate site