ライフサイエンスコーパス: N-terminally

1 cetylase (Nt-acetylase) and therefore cannot N-terminally acetylate a majority of normally N-terminal

2 lpha-synuclein (alphaS) has been shown to be N terminally acetylated in its physiological state.

3 Although many eukaryotic proteins are amino (N)-terminally acetylated, structural mechanisms by which

4 Here, we report fibril structures of three N-terminally acetylated (Ac) alpha-syn constructs, Ac1-1

5 strated that the physiological form of AS is N-terminally acetylated (AcAS).

6 alphaS in humans is constitutively N-terminally acetylated (alphaSacetyl), although the imp

7 (Met) residue of a nascent protein is often N-terminally acetylated (Nt-acetylated).

8 the acetylated proteins yields a mixture of N-terminally acetylated (true N-terminal) and non-acetyl

9 Furthermore, the novel BOG-bound state of N-terminally acetylated alpha-synuclein may serve as a m

10 has an N-terminal amphipathic helix that is N-terminally acetylated and mediates association with th

11 le from those recorded for the corresponding N-terminally acetylated and nonacetylated 15-residue syn

12 We obtained curated N-terminally acetylated and unacetylated sequences from

13 uin deacylase CobB long isoform (CobB(L)) is N-terminally acetylated by the YiaC protein of this bact

14 Thus, the naturally occurring N-terminally acetylated form of alpha-synuclein exhibits

15 NMR) spectroscopy to probe the nature of the N-terminally acetylated form of alphaS (NTAc-alphaS) bou

16 ilure of Der1, a Hrd1 complex subunit, to be N-terminally acetylated in NatB mutant yeast.

17 cal oligomeric forms of alpha-synuclein, the N-terminally acetylated protein adopts a novel conformat

18 -terminally acetylate a majority of normally N-terminally acetylated proteins, including Hsp90 and mo

19 We chemically synthesized the N-terminally acetylated psoriasin of 100 amino acid resi

20 tes, only ribosomal proteins are known to be N-terminally acetylated, and the acetyltransferases resp

21 Parkinson disease protein alpha-synuclein is N-terminally acetylated, but most in vitro studies have

22 lpha-syn from Escherichia coli, which is not N-terminally acetylated.

23 d that the native and expressed proteins are N-terminally acetylated.

24 e prepared by solid phase synthesis and were N-terminally acylated with 6-azidohexanoic acid.

25 N-terminally anchored constructs tethered only if the C

26 Cytochromes P450 are monotopic hemoproteins N-terminally anchored to the ER membrane with their prot

27 Complexes containing a series of N-terminally and C-terminally truncated Swr1 subunits re

28 mer's disease-associated fragment of APP, is N-terminally arginylated in the brains of 5xFAD mice and

29 molecules in which this core region extends N-terminally as far as to residue approximately 145, and

30 h the human telomerase RNA component and the N-terminally biotinylated human telomerase reverse trans

31 We then synthesized N-terminally biotinylated peptidyl phosphonates to ident

32 ubiquitination, we generated lysine-less and N-terminally blocked versions of one substrate, the poly

33 be2w can ubiquitinate a lysine-less, but not N-terminally blocked, ataxin-3.

34 dentify a heretofore unknown modification-an N-terminally bound glyoxylyl group-in the poorly charact

35 mponent RcoM transcription factor couples an N-terminally bound heme cofactor with a C-terminal "LytT

36 icelles, the transmembrane domain is flanked N-terminally by an alpha-helix that forms a ring around

37 expressing Foxp3 species engineered to mimic N-terminally, C-terminally, or N- and C-terminally cleav

38 f a H-bond observed in crystal structures of N-terminally capped peptides.

39 nship between cellular SUMO-modified Sp1 and N-terminally cleaved Sp1.

40 lude hyperphosphorylated, ubiquitinated, and N-terminally cleaved TDP-43.

41 ally ubiquitinated, hyperphosphorylated, and N-terminally cleaved to generate C-terminal fragments (C

42 In vivo Sp1 was determined to be N-terminally cleaved, while Sp1(K16R) could not be cleav

43 We previously discovered that an N-terminally-cleaved form of RXRalpha (tRXRalpha), produ

44 shaped dimer in the apo state and a twisted, N-terminally closed dimer with ATP.

45 e consistent with the destabilization of the N-terminally coordinated structure due to the increasing

46 thionine is used to produce an undetectable, N terminally deleted ORC5, the protein would lack 80% of

47 In contrast to several other N-terminally deleted forms of PrP, the C1 fragment does

48 An N-terminally deleted HA-TPD52 mutant (residues 40-184) a

49 on is highlighted by the observation that an N-terminally deleted mutant of RalGDS that retains the a

50 PG deletion mutants restored adhesion, only N-terminally deleted PG, but not C-terminally deleted PG

51 dence indicates that DeltaNp63 proteins, the N-terminally deleted versions of p63, are essential for

52 o circumvent this problem, multiply charged, N-terminally derivatized peptides were subjected to elec

53 e position, and in polyubiquitin chains, the N-terminally derived fragments from each constituent mon

54 f these co-chaperones bind preferentially to N-terminally dimerized Hsp90, the buffering effect of th

55 Thus, these N-terminally directed antibodies can differentially reco

56 yses demonstrated that the 3D6 and 10D5, two N-terminally directed antibodies, bound with high affini

57 Several N-terminally engineered analogs of C-C chemokine ligand

58 Activator BH3s remain associated with the N-terminally exposed BAX through the BH1 domain to drive

59 Novel exon 1 protein-coding regions N-terminally extend human KCNE3 and KCNE4.

60 After recently uncovering novel, N-terminally extended (L) KCNE3 and KCNE4 isoforms and d

61 rocessing, here we generated a nested set of N-terminally extended 10-20-mer peptides (RA) (n) AAKKKY

62 eoprotein (NP) 383-391 epitope is made as an N-terminally extended 14-mer before it is trimmed by ERA

63 Peptide 1 was N-terminally extended as well as truncated and subjected

64 ulation was elicited with specificity for an N-terminally extended epitope.

65 e mRNA 5' cap4 structure, the trypanosomatid N-terminally extended form of eIF4E acts as the core mol

66 However, N-terminally extended forms of Abeta (NTE-Abeta) were re

67 analyses of mouse brain extracts identified N-terminally extended forms of Hp containing either thre

68 ERAP1 and ERAP2 heterodimers (ERAP1/2), and N-terminally extended model and natural peptides in thei

69 e reports the NMR solution structures of two N-terminally extended mycolactone mACP constructs, mH0AC

70 However, mutant N-terminally extended peptides exhibited significantly i

71 ass spectrometry approach, a whole family of N-terminally extended peptides in addition to RVD-Hpalph

72 udy examined the structure and biophysics of N-terminally extended peptides in complex with MHC-I, re

73 The N-terminally extended peptides N+1, N+2, N+4, N+6, N+8,

74 guing that MHC class I molecules can present N-terminally extended peptides on the cell surface that

75 ; however, such binding is not restricted to N-terminally extended peptides, suggesting that the resu

76 ction of the mutgp100209-217 epitope and its N-terminally extended peptides.

77 (hsp60) molecule that has been shown to bind N-terminally extended precursors of OVA-derived SIINFEKL

78 postproteasomal step: hsp90 associates with N-terminally extended precursors of the SIINFEHL epitope

79 ion, this treatment induced the synthesis of N-terminally extended proteins and elevated stop codon r

80 matic capabilities of different truncated or N-terminally extended variants of nsP2 revealed that the

81 nucleation, elongation) are reduced for the N-terminally extended variants.

82 a wider CD8(+) T cell response also towards N-terminally extended versions of the minimal epitope.

83 iral "untranslated regions" (UTRs) to create N-terminally extended viral proteins or entirely novel p

84 reveal that Leishmania has a unique type of N-terminally-extended cap-binding protein (eIF4E4) that

85 sfected bovine aortic endothelial cells with N-terminally FLAG-tagged MGP and used immunoprecipitatio

86 g the protease with 4 residues (SFNF) of its N-terminally flanking sequence in the Gag-Pol precursor

87 N-terminally formylated signal peptide fragments with va

88 region of F1L spanning residues 1-50 located N-terminally from the Bcl-2 fold is an intrinsically uns

89 C-terminally fused (gp20-GFP, gp20-HOC) and N-terminally fused (GFP-gp20 and HOC-gp20) portal fusion

90 mutation in dfer (dfergof) that expresses an N-terminally fused form of the protein, similar to oncog

91 ic yellow fluorescent protein (mCitrine) was N-terminally fused to a small (approximately 6 kD) membr

92 ue light photoreceptor domain, PYP, which is N-terminally fused to the bacteriophytochrome domain (Bp

93 zed as preproteins, carrying signal peptides N-terminally fused to their mature domains.

94 f enhanced green fluorescent proteins (eGFP) N-terminally fused with KISD in HEK293T cells indicates

95 aliana ARF1, and find that the half-lives of N-terminally HA-tagged ARF1 and C-terminally luciferase-

96 A purified N-terminally hexahistidinyl-tagged AtPCS1 truncate conta

97 oxygenase was purified as a stable colorless N-terminally His-tagged protein.

98 The crystal structure of the N-terminally histidine-tagged epoxidase component of thi

99 a small residue preceding the cleavage site N-terminally (i.e., at the P1 position) and a hydrophobi

100 N-terminally labeled proteins can be selectively conjuga

101 Real-time changes in FRET between N-terminally labeled SNAP-25 and VAMP reported a reorien

102 ariant of an evolved sortase A (SrtA 7M) was N-terminally labeled with lithocholic acid (LA)-an inexp

103 eins that are anchored to a cell membrane by N-terminally linked fatty acids.

104 The artificial beta-sheet consists of two N-terminally linked peptide strands that are linked with

105 owever, while NudC and NudCL dimerize via an N-terminally located coiled coil, the smaller NudCL2 lac

106 ing A1 domain of VWF is connected to the VWF N-terminally located D'D3 domain through a relatively un

107 ally located transmembrane helix and in more N-terminally located helices can be detected already at

108 All fungal and animal N-terminally methylated proteins contain a unique N-term

109 om the skin secretion of arboreal frogs, was N-terminally modified (MsrA2) and evaluated in vitro for

110 ainly composed of intact ADan-(1-34) and its N-terminally modified (pyroglutamate) counterpart togeth

111 zed using the L209A mutant of P450 2B1 in an N-terminally modified construct with a C-terminal His ta

112 ircumvent these problems, two novel acylated N-terminally modified GIP analogues, N-pGluGIP(LysPAL(16

113 f the nitroxide when compared to that of the N-terminally modified Proxyl-Gtalpha(340-350) analogue.

114 However, PFA1 binds the toxic N-terminally modified pyroglutamate peptide pyro-Glu3-Ab

115 vitro was drastically decreased for both the N-terminally mutated and dimethylated variants, and both

116 Immunological analyses using an N-terminally myc-tagged mK44 construct demonstrated endo

117 Membrane targeting is mediated by the N-terminally myristoylated matrix (MA) domain of Gag and

118 l-(4,5)-bisphosphate (PI(4,5)P(2)) and Gag's N-terminally myristoylated matrix (MA) domain.

119 dependent on calcium and is mediated by the N-terminally myristoylated matrix (myr(+)MA) domain.

120 (3) N-Terminally myristoylated NCS-1 dimerizes in a calcium-

121 ic cleavage in mu1 allows the release of its N-terminally myristoylated peptide, mu1N (4 kDa), which

122 Previous findings showed that N-terminally myristoylated peptides constituting a recep

123 In most retroviruses, retroviral MAs are N-terminally myristoylated.

124 an inhibitory segment that flanks the kinase N-terminally (N-linker) and that acts synergistically wi

125 ll unknown beta-CN A hexa-phosphorylated and N-terminally-nicked beta-CN A phosphorylated forms prese

126 tigated systems, nucleotides can bind to the N-terminally open and closed state without strictly forc

127 In this signaling pathway, the N-terminally palmitoylated and C-terminally cholesteryla

128 during cerebellar development, and identify N-terminally phosphorylated c-Jun as an important substr

129 ein levels of the Fbw7 substrates Notch1 and N-terminally phosphorylated c-Jun were upregulated in fb

130 Bag1-L preferentially interacts with N-terminally phosphorylated c-Jun, and Bag1-L greatly au

131 Here we show that unphosphorylated, but not N-terminally phosphorylated c-Jun, interacts with Mbd3 a

132 the transcription factors active Notch1 and N-terminally phosphorylated c-Jun.

133 We show that axin, APC2, GSK-3beta and N-terminally phosphorylated forms of beta-cat can locali

134 NAc-O-Thr, whereas ppGalNAc T3 and T6 prefer N-terminally placed GalNAc-O-Thr.

135 rthermore, the findings demonstrate that the N-terminally placed signaling helix domain is not requir

136 For N-terminally placed tags, lipophilicity promoted liver u

137 nd specifically to telomeric DNA using their N-terminally positioned myb-like domain of the same type

138 psid protein and the scaffolding protein are N-terminally processed in both 80alpha and SaPI1 procaps

139 rozoite invasion, we show that native CSP is N-terminally processed in the mosquito host and undergoe

140 lular LOXL2 (~75-kDa) is nonglycosylated and N-terminally processed, and is primarily associated with

141 s study, we show that the ATPase activity of N-terminally purified Drs2p associates primarily with a

142 Extending mutagenesis N-terminally revealed a second functionally critical reg

143 Thus, IDPR acts on NUDT9H rather than N-terminally, revealing a regulatory function of NUDT9H

144 4 MyBP-C isoforms (1 fast-type MyBP-C and 3 N-terminally spliced slow-type MyBP-C) were expressed in

145 e additionally use CRISPR/Cas9 technology to N-terminally tag Rab8, which is then used to address end

146 In the NanoBRET-based binding assay, SMO is N terminally tagged with nanoluciferase (Nluc) and bindi

147 D into bacterial or mitochondrial membranes, N-terminally tagged AIF and AMID displayed substantial N

148 Overexpressing N-terminally tagged AIF and AMID enhanced the growth of

149 tagged AIF and NADH-binding site mutants of N-terminally tagged AIF and AMID failed to show both NAD

150 prisingly found that the redox activities of N-terminally tagged AIF and AMID were sensitive to roten

151 While the N-terminally tagged ICP27 virus behaved like wild-type H

152 SP5 dramatically increased the solubility of N-terminally tagged NSP5 and prevented NSP5 hyperphospho

153 , GFP fluorescence, and activity relative to N-terminally tagged Rem (GFPRem).

154 Moreover, after SigT was N-terminally tagged with 3xFLAG and C-terminally tagged

155 ly-UBQ gene encoding ubiquitin (Ub) monomers N-terminally tagged with hexahistidine.

156 proteoliposomes reconstituted with purified, N-terminally TAP-tagged Drs2p, both ATPase and flippase

157 interacts with Mcm1p through a motif located N terminally to its homeodomain.

158 n physiologic substrate for APCE, is cleaved N-terminally to Asn-alpha(2)AP that is rapidly cross-lin

159 protein fusion consisting of ubiquitin fused N-terminally to RalA) leads to RalA enrichment at the pl

160 ibrils contain an altered beta-core extended N-terminally to residue approximately 106, encompassing

161 urified from Akkermansia muciniphila cleaves N-terminally to serine and threonine residues that are m

162 ELR CXC chemokines CXCL1, -2, -3, -5, and -8 N-terminally to the ELR motif, thereby generating agonis

163 ons between basic (Arg/Lys) residues located N-terminally to the phosphorylated Ser/Thr residues in t

164 res dropped below -4 degrees C, the specific N-terminally triply phosphorylated LHCB1 isoform (3p-LHC

165 N-terminally truncated (96-585) GAD65 (tGAD65) autoantib

166 640R) in the context of both full-length and N-terminally truncated (DeltaNT) G1.

167 Multiple Msp2(P44) and N-terminally truncated 25- to 27-kDa isoforms having var

168 As a consequence, N-terminally truncated Abeta will accelerate fiber forma

169 N-terminally truncated Abeta(11-40) and Abeta(11-42) mak

170 Naturally occurring N-terminally truncated Abeta(11-40/42) is found in the c

171 al fragments and secreting intact as well as N-terminally truncated Abeta.

172 Intact, native alpha-defensins, N-terminally truncated alpha-defensins, and alpha-defens

173 Here we report an N-terminally truncated alternative splice variant of Chk

174 Thus, we compared the accumulation of N-terminally truncated amyloid-beta and full-length amyl

175 fraction, cerebrospinal fluid largely lacked N-terminally truncated amyloid-beta species and exhibite

176 across disease stages and brain areas, while N-terminally truncated amyloid-beta40 and full-length am

177 N-terminally truncated amyloid-beta42 accumulation showe

178 by APOE) were more strongly correlated with N-terminally truncated amyloid-beta42 accumulation than

179 Cortical N-terminally truncated amyloid-beta42 accumulation was i

180 We observed that N-terminally truncated amyloid-beta42 and full-length am

181 clinical records showed that accumulation of N-terminally truncated amyloid-beta42 in cortical areas

182 Collectively, N-terminally truncated amyloid-beta42 species have spati

183 ss spectrometry analysis showed that several N-terminally truncated amyloid-beta42 species, represent

184 Moreover, N-terminally truncated amyloid-beta42 were more likely t

185 The resultant eIF4A protein is N-terminally truncated and acts as eIF4A inhibitor.

186 racterized full-length murine Trbeta2 and an N-terminally truncated and exclusively cytoplasmic 46-kD

187 Although both N-terminally truncated and full-length MCL1 contain sequ

188 N-terminally truncated and pyroglutamated Abeta peptides

189 peptides, including full-length p19(Arf) and N-terminally truncated and unstable p15(smArf) ("small m

190 0-kDa protein and a constitutively expressed N-terminally truncated approximately 110-kDa protein.

191 hosphatidyl inositol 3,4,5-trisphosphate and N-terminally truncated Arf6-GTP reveals a large conforma

192 Coexpression of AtPRK2a with an N-terminally truncated AtRopGEF12 did not induce isotrop

193 um-mediated transient expression analysis of N-terminally truncated AvrRPS4 mutants revealed that the

194 Lef-1 FL) while decreasing expression of the N-terminally truncated beta-catenin-independent isoform.

195 Most of the proteins were N-terminally truncated by endoproteases or exopeptidases

196 mplex between the full-length protein and an N-terminally truncated C-terminal cell wall binding doma

197 N-terminally truncated CAF-1 p150 was deficient in proli

198 Autoactivation of N-terminally truncated cationic trypsinogen is stimulate

199 autoinhibitory region is deleted, to give an N-terminally truncated CAX (sCAX), or altered through sp

200 In addition, N-terminally truncated CCL15/MIP-1delta and CCL23/CKbeta

201 We solved the 2.0 A crystal structure of N-terminally truncated CofB, revealing a pilin-like prot

202 cause of weakened microtubule binding, as an N-terminally truncated complex with similar binding affi

203 In the present studies, C-terminally and N-terminally truncated constructs were characterized in

204 ant betaA3- and betaB1-crystallins and their N-terminally truncated counterparts (betaA3DeltaN30 and

205 In addition, N-terminally truncated cytoplasmic isoforms of LANA, res

206 ed via the cag pathogenicity island, induces N-terminally truncated Delta133p53 and Delta160p53 isofo

207 ing functions: the full-length TAp73 and the N-terminally truncated DeltaNp73.

208 s of proteins: the full-length TAp73 and the N-terminally truncated DeltaNp73.

209 elastase (ELANE) result in the production of N-terminally truncated elastase, which mislocates to the

210 sion results in expression of full-length or N-terminally truncated ERG protein in prostate epithelia

211 t when expressed in stable S2 cell lines, an N-terminally truncated ESC (FLAG-ESC61-425), like full-l

212 However, incorporation of this N-terminally truncated ESC into E(Z) complexes prevents

213 kinase activity, c-Src is associated with an N-terminally truncated estrogen receptor alpha variant (

214 N-terminally truncated EYFP-CENH3(C) is deposited to and

215 In contrast, the N-terminally truncated form of Abeta, known as "p3," for

216 ne that encodes ICP22, produces an in-frame, N-terminally truncated form of ICP22, known as US1.5.

217 The N-terminally truncated form of MCL1 was expressed to var

218 tion-dependent manner with MrpC or MrpC2, an N-terminally truncated form of MrpC.

219 nsmissible disease in mice overexpressing an N-terminally truncated form of PrP(C).

220 Tg(PrPDelta32-134) mice, which express an N-terminally truncated form of PrP, spontaneously develo

221 LPS also induces expression of Ron and an N-terminally truncated form of Ron, Sf-Ron, in primary m

222 We have previously reported an N-terminally truncated form of tau in human brain that i

223 We have expressed and purified an N-terminally truncated form of the 580-residue UL25 prot

224 n in the colons of mutant mice expressing an N-terminally truncated form of ZBP-89 was not observed a

225 f p63 expressed in SCC is DeltaNp63alpha, an N-terminally truncated form which functions as a key SCC

226 nd p63, express multiple splice variants and N-terminally truncated forms initiated from an alternati

227 the six most abundant known Crps, as well as N-terminally truncated forms of each, and that the pepti

228 In the absence of N-terminally truncated forms, blocking Nix-mediated mito

229 levant signals in GADA RBAs and suggest that N-terminally truncated GAD labels will enable more speci

230 ull-length GAD, suggesting that assays using N-terminally truncated GAD should be used to select part

231 ily study were reassayed with full-length or N-terminally truncated GAD using the National Institute

232 This finding prompted development of an N-terminally truncated GAD65 radiolabel, (35)S-GAD65(96-

233 to assay type and indicated that the use of N-terminally truncated GAD65 radiolabels in GADA radiobi

234 t both full-length/glycosylated beta1ARs and N-terminally truncated glycosylation-defective beta1ARs

235 all angle x-ray scattering experiments on an N-terminally truncated Gt CsoR (Delta2-10) reveal that t

236 The complex comprises one subunit each of an N-terminally truncated Ino80, actin, Arp4, Arp5, Arp8, I

237 s of p73 and reduced levels of the oncogenic N-terminally truncated isoform DeltaNp73 in Aldefluor(+)

238 Moreover, the accumulation of StpX and an N-terminally truncated isoform is differentially coordin

239 ly, we along with others have found that the N-terminally truncated isoform of p73, DeltaNp73, has po

240 DeltaNp73alpha is an N-terminally truncated isoform of p73.

241 at this IRES drives expression of a shorter, N-terminally truncated isoform of TDP2, DeltaN-TDP2, whi

242 ly, inhibition of hair follicle formation by N-terminally truncated Lef1 results in upregulation of C

243 A full-length pre-protein (66 kDa) and an N-terminally truncated mature form (55 kDa) have been de

244 response to UV light appears to be normal in N-terminally truncated mcm10 mutants, we propose that Mc

245 As a consequence, N-terminally truncated Mdm2 binds p53 and promotes its s

246 id not seem to affect the association of the N-terminally truncated minireceptors with WT-M, except t

247 We report here that human p75(MDM2) is an N-terminally truncated mixture of protein isoforms produ

248 ed into transgenic (Tg) 9949 mice expressing N-terminally truncated MoPrP(Delta23-88) and WT FVB mice

249 ere involved in this regulation, a series of N-terminally truncated mutants were constructed which co

250 Pan-neuronal expression of full-length or N-terminally truncated mutHtt recapitulates sleep phenot

251 mutant/mutant (NBS1m/m) mice that express an N-terminally truncated NBS1 at lower levels.

252 An N-terminally truncated NKCC1 (nttNKCC1), in which the fi

253 The N-terminally truncated NS1 encoded by the H1N1 PR8 strai

254 lgC in 1991, all subsequent studies utilized N-terminally truncated open reading frames.

255 expression of full-length P protein (P1) and N-terminally truncated P proteins (tPs), designated P2,

256 d C-terminal transmembrane domain, and is an N-terminally truncated paralog of two other EFC proteins

257 Here we report the crystal structure of an N-terminally truncated PCV2 virus-like particle at 2.3-A

258 nd telcagepant (K(D) < 0.02 muM), as well as N-terminally truncated peptides and peptide analogues (1

259 The four N-terminally truncated peptides showed increased oligome

260 ion to Abeta n-40 and Abeta n-42, as well as N-terminally truncated peptides, suggesting anomalous pr

261 garnered no information on the import of an N-terminally truncated PEX5 (PEX5C) receptor construct o

262 ocesses it to a unique, triple-sulfated, and N-terminally truncated product distinct from intestinal

263 rnal ORFs within existing ORFs, resulting in N-terminally truncated products, as well as internal out

264 in translation re-start and production of a N-terminally truncated protein (p.M1_E165del) that is un

265 eurons (MN-1), and is predicted to encode an N-terminally truncated protein isoform.

266 g full-length PrP (residues 23-231, FL_PrP), N-terminally truncated PrP (residues 90-231, T_PrP), and

267 In contrast, coexpression of N-terminally truncated PrP(Delta23-88) did not affect di

268 N-terminally truncated PrP(Sc), denoted PrP 27-30, retai

269 able to the presence of miniscule amounts of N-terminally truncated PrPs, where a PrP encompassing re

270 The N-terminally truncated PTBP3 isoforms lack nuclear local

271 deposition both in vitro and in vivo Because N-terminally truncated pyroglutamate (pE)-modified Abeta

272 Here, we show that M. genitalium expresses N-terminally truncated RecA isoforms via alternative tra

273 ost factor required for the activation of an N-terminally truncated recombinant TBSV RdRp.

274 inant mouse PrP [denoted recPrP(23-230)] and N-terminally truncated recPrP(89-230), as well as their

275 d in the same reading frame and MCM3AP is an N-terminally truncated region of GANP.

276 ately 50% of LANA1 is naturally generated as N-terminally truncated shoulder proteins that are detect

277 hanisms, translation reinitiation leading to N-terminally truncated target proteins or skipping of th

278 S and FTLD-U, aggregated, ubiquitinated, and N-terminally truncated TDP-43 can be isolated from brain

279 he shorter transcript (Tet1(S) ) encoding an N-terminally truncated TET1 protein and a full-length Te

280 hereas the more distal disulfide bond of the N-terminally truncated Topo70-clamp(499) did not.

281 N-terminally truncated TPC2 (TPC2delN), which is targete

282 ceptor potential melastatin-8 (TRPM8) and an N-terminally truncated TRPM8 variant (TRPM8-Delta801) ar

283 lobulin (hbeta2m) can co-polymerize with its N-terminally truncated variant (DeltaN6) in vitro to for

284 sphate dehydrogenase (G6PDH) by ClpB and its N-terminally truncated variant ClpBDeltaN in the presenc

285 en cross-seeded with fibrils formed from the N-terminally truncated variant DeltaN6-hbeta(2)m.

286 the 2.0 A resolution crystal structure of an N-terminally truncated variant of EpsH, a minor pseudopi

287 ometry, and this complex is not formed by an N-terminally truncated variant of gp42.

288 pH 7.7, but not at pH 5.5 or 2.5, while both N-terminally truncated variants can form fibrils at thes

289 Either the full-length CRD-BP or the N-terminally truncated version can rescue the clonogenic

290 We found that an N-terminally truncated version of FOG1 is produced from

291 Similarly, both an N-terminally truncated version of Gag that is missing th

292 ated fibres consist almost completely of the N-terminally truncated version, suggesting that the prot

293 The great majority of AD plaque consists of N-terminally truncated versions of Abeta(1-40/1-42), wit

294 ng the Galpha portion, but not Gsalpha or an N-terminally truncated XLalphas mutant unable to interac

295 Notably, N-terminally truncated YscF induced significantly higher

296 t translationally regulates expression of an N-terminally truncated, cytoplasmic isoform of TDP2.

297 A major fraction of secreted FGE is N-terminally truncated, lacking residues 34-72.

298 he reproductive and gestational tissues were N-terminally truncated, similar to urine PrP.

299 are able to target oligomers assembled from N-terminally ubiquitinated proteins.

300 ned with cerulean fluorescent protein tagged N-terminally with a GAP43 motif and C-terminally with a