ライフサイエンスコーパス: N-type calcium channel

1 IA-sensitive channel can be identified as an N-type calcium channel.

2 ssium channels are exclusively linked to the N-type calcium channel.

3 .005), consistent with preferential block of N-type calcium channels.

4 y rapid SK currents that are associated with N-type calcium channels.

5 not affect alcohol responses in mice lacking N-type calcium channels.

6 an sensory neurons is controlled by Ca(V)2.2 N-type calcium channels.

7 B receptor activation selectively suppresses N-type calcium channels.

8 ed for the inhibitory effects of syntaxin on N-type calcium channels.

9 PKA-dependent phosphorylation of presynaptic N-type calcium channels.

10 ion after selective blockade of P/Q- but not N-type calcium channels.

11 sea snail Conus magus that binds to neuronal N-type calcium channels.

12 voltage-sensitive inhibition of presynaptic N-type calcium channels.

13 ma to induce voltage-dependent modulation of N-type calcium channels.

14 ey mechanisms involved in the trafficking of N-type calcium channels.

15 a-conotoxin GVIA suggesting participation of N-type calcium channels.

16 rticipate in voltage-dependent modulation of N-type calcium channels.

17 L attenuated voltage-dependent inhibition of N-type calcium channels, a Gbetagamma-dependent process,

18 Blocking P/Q- and N-type calcium channels abolished the effect of XE991 on

19 In contrast, N-type calcium channels activate BK channels only, with

20 Finally, N-type calcium channel activity reduces survival, potent

21 pha1B-beta3 subunit interactions and inhibit N-type calcium channel activity.

22 c protein interaction (synprint) site on the N-type calcium channel alpha1B subunit binds to the solu

23 f synprint polypeptides and native rat brain N-type calcium channel alpha1B subunits by PKC and Cam K

24 dual requirement for calcium influx through N-type calcium channels and calcium mobilization from in

25 e mediated by an altered interaction between N-type calcium channels and RIM1, which tethers presynap

26 biochemical switch for interactions between N-type calcium channels and SNARE protein complexes.

27 most of the voltage-dependent inhibition of N-type calcium channels and that the linker between doma

28 n effect was occluded by a previous block of N-type calcium channels and was unaffected by the broad-

29 reased by depolarization, calcium influx via N-type calcium channels, and cAMP analogs, and release i

30 this rapid calcium influx is blocked by the N-type calcium channel antagonist, omega-conotoxin.

31 N-type calcium channels are critical for pain transducti

32 N-type calcium channels are modulated by acute and chron

33 However, N-type calcium channels are primarily inactivated during

34 lts highlight a molecular mechanism by which N-type calcium channels are regulated by Cdk5 to affect

35 n neuromuscular junction have indicated that N-type calcium channels are the sole mediators of stimul

36 N-type calcium channels are thought to be produced by co

37 nel beta subunits, potassium channels, P/Q-, N-type calcium channels, as well as the alpha2/delta-1 c

38 The interaction of the N-type calcium channel beta3 subunit with the alpha1B su

39 diated release was relatively insensitive to N-type calcium channel blockade.

40 Low concentrations of the N-type calcium channel blocker omega-conotoxin GVIA (ome

41 The selective N-type calcium channel blocker omega-conotoxin GVIA (ome

42 High concentrations of the selective N-type calcium channel blocker omega-conotoxin GVIA abol

43 e did not suppress calcium oscillations, the N-type calcium channel blocker omega-conotoxin inhibited

44 TK (20 nM), by 51+/-10% (n=115 cells) by the N-type calcium channel blocker omega-conotoxin-GVIA (100

45 his technique by evaluating SNX-111, a novel N-type calcium channel blocker with potential neuroprote

46 CGRP-IR neurons that developed, although the N-type calcium channel blocker, 2.5 microM omega-conotox

47 blocker, nifedipine (3 micromol/l), nor the N-type calcium-channel blocker, omega-CgTx-GVIA (1 micro

48 ne was abolished by the coperfusion of L- or N-type calcium channel blockers.

49 Phosphorylation of the N-type calcium channel by Cdk5 facilitates neurotransmit

50 Here, we demonstrate a unique modulation of N-type calcium channels by farnesol, a dephosphorylated

51 abolished following irreversible blockade of N-type calcium channels by omega-conotoxin GVIA, whereas

52 es mu-opioid receptor-mediated inhibition of N-type calcium channels by promoting activity-independen

53 en reported to be an irreversible blocker of N-type calcium channels (Ca(V) 2.2).

54 and clinical evidence provide validation for N-type calcium channels (Ca(V)2.2) as therapeutic target

55 n alteration in the functional dependency on N-type calcium channels (Ca(v)2.2).

56 These results demonstrate that N-type calcium channels can directly link phasic membran

57 Hence, although N-type calcium channels can rescue P/Q-dependent synapti

58 on in PG neurons demonstrated that, although N-type calcium channels carried the majority of the high

59 of heterologously expressed PDC and PDCL on N-type calcium channel (CaV2.2) modulation was examined

60 tivation (EC(50) approximately 53 microM) of N-type calcium channels (CaV2.2) and investigate gating

61 Neuronal voltage-gated N-type calcium channels (Cav2.2) are inhibited by activa

62 P/Q-type calcium channels (Cav2.1), in which N-type calcium channels (Cav2.2) supported central synap

63 ce of specific blockade of alpha1 subunit of N-type calcium channel, Cav2.2, in diabetic nephropathy,

64 c action potential or exclusively modulating N-type calcium channels, CB1 receptor activation inhibit

65 These mice also displayed N-type calcium channel compensation at descending thalam

66 Ca(V)2.2 (N-type) calcium channels control the entry of calcium in

67 uggesting that Dyn A modulated predominantly N-type calcium channels coupled to opiate receptors via

68 inactivation, many chromaffin cells exhibit N-type calcium channel currents that show little inactiv

69 ked currents at alpha9alpha10 nAChRs but not N-type calcium channel currents, whereas [2,8]-dicarba a

70 e and an inhibitor of high-voltage-activated N-type calcium channel currents.

71 Ca currents in hypothalamic neurons and N-type calcium channels expressed in HEK-293 cells showe

72 RNA interference reduction of N-type calcium channel expression also reduced synaptic

73 Two isoforms of Ca(v)2.2 alpha1 subunits of N-type calcium channels from rat brain (Ca(v)2.2a and Ca

74 With N-type calcium channels, Gbetagamma wild type and mutant

75 ion mark-4-methyl-pentan-1-one (11), blocked N-type calcium channels (IC(50) = 0.67 microM in the IMR

76 Chromaffin cells express N-type calcium channels identified on the basis of their

77 id (GABA)B receptors couple to Go to inhibit N-type calcium channels in embryonic chick dorsal root g

78 dent neurotransmitter release is mediated by N-type calcium channels in frog but P/Q-type channels in

79 ctivation behavior, we expressed recombinant N-type calcium channels in mammalian HEK 293 cells, perm

80 V)2.2 that regulates the overall activity of N-type calcium channels in nociceptors.

81 annabinoids directly and selectively inhibit N-type calcium channels in presynaptic terminals.

82 Grammotoxin also inhibited N-type calcium channels in rat and frog sympathetic neur

83 after transfection showed that inhibition of N-type calcium channels in response to baclofen, Vc1.1 a

84 a(7) was observed on pre-existing endogenous N-type calcium channels in sympathetic neurones.

85 as charge carrier, omega-CTx-MVIIC block of N-type calcium channels in sympathetic neurons was poten

86 N-type calcium channels inactivate most rapidly in respo

87 As an application, we show that N-type calcium channel inactivation is shifted reversibl

88 In contrast, blockade of high-threshold N-type calcium channels increased the firing rate and ca

89 nnel inhibitor nifedipine (1 mg kg-1) or the N-type calcium channel inhibitor omega-conotoxin GVIA (2

90 cytoplasmic synaptotagmin-binding domain of N-type calcium channels, inhibits transferrin internaliz

91 Here we report that the N-type calcium channel is a substrate for cyclin-depende

92 The pore-forming alpha(1) subunit of the N-type calcium channel is phosphorylated in the C-termin

93 The voltage-gated calcium channel Ca(v)2.2 (N-type calcium channel) is a critical regulator of synap

94 rupt synaptic transmission, an allele of the N-type calcium channel locus (Dmca1A) was identified tha

95 These results demonstrate that N-type calcium channels modulate acute responses to etha

96 Here we report that presynaptic N-type calcium channels not only control neurotransmitte

97 suggesting calcium entry through presynaptic N-type calcium channels, not neurotransmitter release pe

98 u-opioid receptors are negatively coupled to N-type calcium channels on the postsynaptic membrane of

99 val of extracellular calcium, or blockade of N-type calcium channels, prevented BDNF release.

100 Voltage-dependent G-protein inhibition of N-type calcium channels reduces presynaptic calcium entr

101 Rem2 inhibition of N-type calcium channels required both the Ras homology (

102 Spike-triggered exocytosis was preserved by N-type calcium channel rescue, demonstrating that evoked

103 The alpha1B (N-type) calcium channel shows strong G protein modulatio

104 is a structurally and functionally distinct N-type calcium channel splice isoform, Ca(V)2.2e[37a], e

105 sults show that Kv3.2, Kv1, SK potassium and N-type calcium channels strongly regulate thalamic relay

106 receptor antagonist, hexamethonium, and the N-type calcium channel toxin, omega-conotoxin GVIA, each

107 ere, we show that in mice lacking functional N-type calcium channels, voluntary ethanol consumption i

108 of the analogues were assessed; the block of N-type calcium channels was comparable among the analogu

109 ce binding in tsA201 cells stably expressing N-type calcium channels was not altered by Rem2 expressi

110 olecular composition of the non-inactivating N-type calcium channel, we cloned the alpha(1B) and acce

111 To a lesser degree, N-type calcium channels were also involved.

112 e evoked calcium influx was accounted for by N-type calcium channels, whereas L- and P/Q-type calcium

113 om extrinsic nerve terminals is regulated by N-type calcium channels, whereas release of acetylcholin

114 that neonatal rat optic nerve axons express N-type calcium channels, which are subjected to regulati

115 his is because GABAB Rs selectively suppress N-type calcium channels, which in turn are specifically

116 Blocking N-type calcium channels with conotoxin GVIA had only min

117 of the vagal bradycardia after inhibition of N-type calcium channels with omega-conotoxin GVIA (100 n

118 Interaction of the synprint site of N-type calcium channels with syntaxin and SNAP-25 has a

119 Although the function of N-type calcium channels within astrocytes is controversi