ライフサイエンスコーパス: N. gonorrhoeae

1 N. gonorrhoeae and human papillomavirus 18 (HPV18) infec

2 N. gonorrhoeae can form biofilms on glass and plastic su

3 N. gonorrhoeae cultures were genotyped using multiple-lo

4 N. gonorrhoeae infection also results in the activation

5 N. gonorrhoeae infection initiates at the mucosal epithe

6 N. gonorrhoeae is a human-restricted pathogen that prima

7 N. gonorrhoeae is able to survive the bactericidal activ

8 N. gonorrhoeae liberates a soluble factor that potently

9 N. gonorrhoeae readily forms biofilms over abiotic surfa

10 N. gonorrhoeae strains that carry an inactivated msbB (a

11 N. gonorrhoeae usually causes localized inflammation of

12 N. gonorrhoeae was detected from 30 rectal and 40 pharyn

13 N. gonorrhoeae was thought to lack an SOS system, althou

14 We obtained 278 N. gonorrhoeae-positive isolates from 240 MSM.

15 There were 291 N. gonorrhoeae culture-positive individuals identified.

16 chomatis false-negative results (1.7%) and 3 N. gonorrhoeae false-negative results (0.3%), while Comb

17 Additionally, N. gonorrhoeae activates the cysteine protease cathepsin

18 ike receptor 4 signaling but does not affect N. gonorrhoeae-mediated activation of the inflammasome.

19 ntracellular cIAP2 were detected early after N. gonorrhoeae stimulation, which was followed by a mark

20 Immune Abs against N. gonorrhoeae need to overcome several subversive mecha

21 found to have antimicrobial activity against N. gonorrhoeae, and Nuc expression enhanced N. gonorrhoe

22 914 has potent bactericidal activity against N. gonorrhoeae, including multidrug-resistant strains an

23 ne to protect against serogroup B or against N. gonorrhoeae.

24 ricidal action of normal human serum against N. gonorrhoeae is mediated by the classical complement p

25 phalosporin resistance-comprised 8.9% of all N. gonorrhoeae isolates and were primarily observed in m

26 highest C. trachomatis prevalence (9.2%) and N. gonorrhoeae prevalence (2.2%) were in women <30 years

27 9.0%; P = 0.005), C. trachomatis (6.2%), and N. gonorrhoeae (1.4%).

28 ater than those of C. trachomatis (5.9%) and N. gonorrhoeae (1.5%; P < 0.0002).

29 h focused experimental data from E. coli and N. gonorrhoeae, and we validate our system's ability to

30 ion limit was 10 CFU/mL for both E. coli and N. gonorrhoeae, while commercially available gonorrhea r

31 0.61% for C. trachomatis/N. gonorrhoeae and N. gonorrhoeae/T. vaginalis, and 0.24% for C. trachomati

32 ibed here expresses both N. meningitidis and N. gonorrhoeae 16S rRNA genes, as shown by positive FISH

33 haride (LOS) from Neisseria meningitidis and N. gonorrhoeae engages the TLR4-MD-2 complex.

34 oryl moieties of LA from N. meningitidis and N. gonorrhoeae LOSs play an important role in activation

35 PG fragment release from N. meningitidis and N. gonorrhoeae showed that meningococci release less of

36 iverse strains of Neisseria meningitidis and N. gonorrhoeae specifically using native versus unfracti

37 two pathogenic species (N. meningitidis and N. gonorrhoeae) in addition to a number of commensal spe

38 r discrimination between N. meningitidis and N. gonorrhoeae.

39 seria gonorrhoeae All vaginal microbiota and N. gonorrhoeae efficiently colonized the 3-D surface, lo

40 essfully infected with both C. muridarum and N. gonorrhoeae and that chlamydia-induced alterations in

41 udies of resistance-associated mutations and N. gonorrhoeae multiantigen sequence typing, and challen

42 9 dd-peptidase, Bacillus subtilis PBP4a, and N. gonorrhoeae PBP3).

43 nd (ii) swabs seeded with C. trachomatis and N. gonorrhoeae and then placed in transport medium were

44 ification (TMA) to detect C. trachomatis and N. gonorrhoeae and to determine if TMA could also detect

45 The prevalence rates of C. trachomatis and N. gonorrhoeae by testing of FCU were 6.8% (60/882 speci

46 nal swabs were tested for C. trachomatis and N. gonorrhoeae by using all three NAATs.

47 All C. trachomatis and N. gonorrhoeae Combo2-positive/ProbeTec-negative samples

48 alTime CT/NG assay offers C. trachomatis and N. gonorrhoeae dual detection with high sensitivity and

49 Ts, the sensitivities for C. trachomatis and N. gonorrhoeae for Combo2 were 100% and 100%, while they

50 SDA for the detection of C. trachomatis and N. gonorrhoeae from rectal swab samples.

51 G assay (Xpert) to detect C. trachomatis and N. gonorrhoeae in rectal and pharyngeal samples from 224

52 nded for the detection of C. trachomatis and N. gonorrhoeae in swab and urine specimens of symptomati

53 The prevalence rates of C. trachomatis and N. gonorrhoeae in the rectum were 7.3% (66/907 specimens

54 ture for the detection of C. trachomatis and N. gonorrhoeae in the rectum, with both tests detecting

55 cor PCR) for detection of C. trachomatis and N. gonorrhoeae in vaginal samples obtained via an Intern

56 antly more prevalent than C. trachomatis and N. gonorrhoeae infections, while the M. genitalium infec

57 women of >40 years, while C. trachomatis and N. gonorrhoeae prevalence is lowest in that age group.

58 pert for the detection of C. trachomatis and N. gonorrhoeae were 86%, 99.2%, 92.5%, and 98.4% and 91.

59 For the detection of C. trachomatis and N. gonorrhoeae, all swabs were evaluated by AC2 and SDA,

60 lable testing options for C. trachomatis and N. gonorrhoeae.

61 the Roche assay for both C. trachomatis and N. gonorrhoeae.

62 Overall, T. vaginalis, C. trachomatis, and N. gonorrhoeae prevalences were 8.7%, 6.7%, and 1.7%, re

63 Anti-E. coli or anti-N. gonorrhoeae antibodies were conjugated to submicron p

64 escens) do not activate NLRP3 as robustly as N. gonorrhoeae.

65 All available N. gonorrhoeae isolates (n = 2452) received from Austral

66 onist and unveils the molecular link between N. gonorrhoeae and HIV-1.

67 and the stabilization of cleaved complex by N. gonorrhoeae gyrase increased in a fluoroquinolone-res

68 However, induction of cell death by N. gonorrhoeae has also been reported in other cell type

69 ization of lactobacillus-produced lactate by N. gonorrhoeae balances the detrimental effects of H(2)O

70 ility that peptidoglycan fragment release by N. gonorrhoeae results from defects in peptidoglycan rec

71 is may be an important mechanism utilized by N. gonorrhoeae for microbial survival and immune evasion

72 s in 1102 resistant and susceptible clinical N. gonorrhoeae isolates collected from 2000 to 2013 via

73 The cohort comprised N. gonorrhoeae culture-positive individuals identified b

74 c and conditioned medium from Nuc-containing N. gonorrhoeae degraded human neutrophil DNA and NETs.

75 e in populations at high risk of contracting N. gonorrhoeae induces an increase in MIC and may result

76 e in populations at high risk of contracting N. gonorrhoeae induces an increase in MIC, and may resul

77 We now show that msbB-deficient N. gonorrhoeae induces less inflammatory signaling in hu

78 Interestingly, infection with msbB-deficient N. gonorrhoeae is associated with less localized inflamm

79 low-passage-number clinical-specimen-derived N. gonorrhoeae isolates for Opa expression and assess th

80 ded, the sensitivity of PS testing to detect N. gonorrhoeae infections increased to 94%.

81 leic acid amplification testing would detect N. gonorrhoeae and C. trachomatis (or T. vaginalis if ut

82 collection of urethral discharge to diagnose N. gonorrhoeae and Chlamydia trachomatis infection in ce

83 Distinct N. gonorrhoeae transmission networks were present in a m

84 Eight N. gonorrhoeae isolates collected from 7 patients on Oah

85 We propose that Nuc enables N. gonorrhoeae to escape trapping and killing by NETs du

86 N. gonorrhoeae, and Nuc expression enhanced N. gonorrhoeae survival in the presence of neutrophils t

87 to unsialylated porin (Por) B.1A-expressing N. gonorrhoeae.

88 For N. gonorrhoeae, ProbeTec and Combo2 had sensitivities of

89 For N. gonorrhoeae, ProbeTec, Combo2, and PCR had sensitivit

90 For N. gonorrhoeae, the sensitivity of PS testing (90%) was

91 For N. gonorrhoeae, Xpert had higher sensitivity than Aptima

92 inalis detection rate compared with 2.1% for N. gonorrhoeae and 1.6% for C. trachomatis.

93 ed were >98% for C. trachomatis and 100% for N. gonorrhoeae.

94 % for C. trachomatis and 92.0% and 97.3% for N. gonorrhoeae in this study.

95 % for C. trachomatis and 96.1% and 99.5% for N. gonorrhoeae, and those for the ProbeTec ET assay were

96 matis infection, 0.56 [95% CI, .19-1.67] for N. gonorrhoeae infection, and 0.66 [95% CI, .38-1.15] fo

97 % for C. trachomatis and 96.9% and 99.7% for N. gonorrhoeae, respectively.

98 e was 18.2% for C. trachomatis and 16.7% for N. gonorrhoeae.

99 cts was 8.9% for C. trachomatis and 3.8% for N. gonorrhoeae.

100 A and 82% and 71%, respectively, by AC2; for N. gonorrhoeae, 77% and 68%, respectively, by SDA and 84

101 e agreement and 99.8% negative agreement for N. gonorrhoeae.

102 e agreement and 99.7% negative agreement for N. gonorrhoeae.

103 NAATs), to evaluate prepubertal children for N. gonorrhoeae or C. trachomatis, and the use of HIV pos

104 tabilized the enzyme-DNA cleaved complex for N. gonorrhoeae gyrase and topoisomerase IV.

105 the specificity were as follows: culture for N. gonorrhoeae, 50.0% and 99.4%, respectively; PCR, 80.3

106 and specificity were as follows: culture for N. gonorrhoeae, 65.4% and 99.0%, respectively; PCR, 91.9

107 The test performance of culture for N. gonorrhoeae, the Gen-Probe Aptima Combo 2 transcripti

108 GC assay (Becton Dickinson), and culture for N. gonorrhoeae.

109 (78%) participants had positive cultures for N. gonorrhoeae at the time of enrollment: 24 of the 28 p

110 All patients with positive cultures for N. gonorrhoeae were cured at all sites of infection.

111 uc as a multifunctional virulence factor for N. gonorrhoeae.

112 te that this transition provides a means for N. gonorrhoeae to maintain attachment to its host while

113 FU)/mL for C. trachomatis and 1500CFU/mL for N. gonorrhoeae.

114 inical urine and swab specimens positive for N. gonorrhoeae by the Cobas assay, 71% could be genotype

115 C. trachomatis, 21 (4.2%) were positive for N. gonorrhoeae, 26 (5.2%) were positive for T. vaginalis

116 This explains why the probes for N. gonorrhoeae in the Gen-Probe Aptima assays cross-reac

117 was discontinued due to low specificity for N. gonorrhoeae.

118 Repeat testing for N. gonorrhoeae was undertaken using real-time polymerase

119 The sensitivity of Xpert for N. gonorrhoeae from rectal swabs was 100% (95% CI, 88 to

120 rometry analysis of extensively fractionated N. gonorrhoeae-derived supernatants revealed that the LT

121 Deletion of amiC from N. gonorrhoeae results in severely impaired cell separat

122 Biofilm RNA was extracted from N. gonorrhoeae 1291 grown for 48 h in continuous-flow ch

123 Conditioned medium from N. gonorrhoeae contains factors capable of initiating th

124 doglycan O-acetyltransferase using PatB from N. gonorrhoeae as the model system.

125 rison of the crystal structures of PriB from N. gonorrhoeae and E. coli reveals a well-conserved homo

126 BamA, the central component of BAM, was from N. gonorrhoeae, the etiological agent of the sexually tr

127 The prevalence of mosaic PBP2 harboring N. gonorrhoeae strains highlight the ability for new N.

128 re, we report that Nuc degrades NETs to help N. gonorrhoeae resist killing by neutrophils.

129 different approaches to isolate heterozygous N. gonorrhoeae resulted in the formation of merodiploids

130 In N. gonorrhoeae, lack of TsaP results in the formation of

131 Inhibition of cIAP2 in N. gonorrhoeae-stimulated epithelial cells resulted in i

132 conclude that NER functions are conserved in N. gonorrhoeae and are important for the DNA repair capa

133 and the enhancement of RecA(Ng) function in N. gonorrhoeae.

134 We have also identified a gene in N. gonorrhoeae, which we designated nuc.

135 ing, confirming that all of the NER genes in N. gonorrhoeae are functional.

136 (Ng)) enhances all RecA-related processes in N. gonorrhoeae.

137 ecifically, cN supports nitrite reduction in N. gonorrhoeae strains lacking the cytochromes c5 and Cc

138 spatial profiles of anaerobic respiration in N. gonorrhoeae, using an aniA'-'gfp transcriptional fusi

139 rstand the mechanism of type IV secretion in N. gonorrhoeae, we examined the expression levels and lo

140 Thus, in N. gonorrhoeae, recombinational processes are facilitate

141 membrane topology, and variation of TraG in N. gonorrhoeae.

142 n antimicrobial efflux and iron transport in N. gonorrhoeae.

143 We included N. gonorrhoeae isolates of patients visiting the Amsterd

144 We included N. gonorrhoeae isolates of patients who visited the Amst

145 Three strains, including N. gonorrhoeae FA1090, an nrrF deletion mutant, and a co

146 and mutant gene pools were transformed into N. gonorrhoeae to select for alleles that maintained bac

147 Isolated N. gonorrhoeae lipooligosaccharide, a known virulence fa

148 core component of most lipopolysaccharides, N. gonorrhoeae is peculiar in that it effectively libera

149 Stimulation of End/E6E7 cells with live N. gonorrhoeae induced NF-kappaB activation and resulted

150 d identify multilocus sequence types (MLST), N. gonorrhoeae multiantigen sequence types (NG-MAST), an

151 0 cell line can be used to effectively model N. gonorrhoeae-PMN interactions and that N. gonorrhoeae

152 of the cervicovaginal microbiome can modify N. gonorrhoeae, which will enhance successful transmissi

153 m Campylobacter jejuni, preferred the native N. gonorrhoeae and C. jejuni substrates, respectively.

154 rhoeae strains highlight the ability for new N. gonorrhoeae strains to spread and become established

155 gitidis isolate described must have obtained N. gonorrhoeae-specific DNA through interspecies recombi

156 pecially in the presence of large amounts of N. gonorrhoeae and small amounts of C. trachomatis organ

157 isR or misS severely reduced the capacity of N. gonorrhoeae to colonize mice or maintain infection ov

158 vels following inoculation with 10(6) CFU of N. gonorrhoeae.

159 on of C. trachomatis or for the detection of N. gonorrhoeae in low-risk or asymptomatic patients by A

160 Test sensitivities for the detection of N. gonorrhoeae ranged from 66.7% to 71.9% for culture to

161 itive percent agreement for the detection of N. gonorrhoeae was 100% in both urine and swab specimens

162 ng considered for point-of-care diagnosis of N. gonorrhoeae infection or NGU in men, meatal swabs sho

163 fection and alters the infection dynamics of N. gonorrhoeae in vitro Furthermore, miR-718 regulates t

164 ts indicate that the antiapoptotic effect of N. gonorrhoeae in human endocervical epithelial cells re

165 tudy, we defined the antiapoptotic effect of N. gonorrhoeae infection in human endocervical epithelia

166 ly undergo apoptosis, and thus the effect of N. gonorrhoeae infection on PMN survival has implication

167 ng technology to examine the epidemiology of N. gonorrhoeae and associated AMR in the Australian popu

168 Exposure of N. gonorrhoeae to sublethal hydrogen peroxide revealed t

169 are critical for normal biofilm formation of N. gonorrhoeae.

170 The combined incidence of N. gonorrhoeae and C. trachomatis infection was 7.26 cas

171 compound library for potential inhibitors of N. gonorrhoeae PBP 2, and 32 compounds were identified t

172 fifteen clinical and laboratory isolates of N. gonorrhoeae were tested following the Clinical Labora

173 g solithromycin against clinical isolates of N. gonorrhoeae.

174 The lipooligosaccharide of N. gonorrhoeae has a hexa-acylated lipid A.

175 We have generated a panel of mutants of N. gonorrhoeae strain FA1090 expressing a variety of mut

176 C model for the study of the pathogenesis of N. gonorrhoeae using a well-characterized DeltapilT muta

177 iated with host response and pathogenesis of N. gonorrhoeae.

178 ded that Opa proteins promote persistence of N. gonorrhoeae in the female genital tract and that opa

179 For pharyngeal gonorrhea, positivity of N. gonorrhoeae DNA on both PCR assays was present at day

180 The increasing prevalence of N. gonorrhoeae strains exhibiting decreased susceptibili

181 ion, we compared transcriptional profiles of N. gonorrhoeae biofilms to planktonic profiles.

182 nerated by host innate immune recognition of N. gonorrhoeae by several innate immune signaling pathwa

183 ta suggest that TLR4-mediated recognition of N. gonorrhoeae LOS plays an important role in the pathog

184 s undertaken to reveal which component(s) of N. gonorrhoeae induce HIV-1 expression in CD4(+) T lymph

185 Lipo-oligosaccharide sialylation of N. gonorrhoeae resulted in classical pathway regulation

186 d recD mutants in two independent strains of N. gonorrhoeae (MS11 and FA1090) by indirect methods yie

187 ransformation is variable between strains of N. gonorrhoeae and may influence multiple steps during t

188 Strains of N. gonorrhoeae expressing mutant NG1686 proteins with su

189 PBP2 from penicillin-resistant strains of N. gonorrhoeae harbors an aspartate insertion after posi

190 Strains of N. gonorrhoeae that were genetically deficient in the na

191 stem (T4SS) that is found in most strains of N. gonorrhoeae.

192 creening against highly resistant strains of N. gonorrhoeae.

193 illin- or cephalosporin-resistant strains of N. gonorrhoeae.

194 DNA uptake for several laboratory strains of N. gonorrhoeae.

195 IgA antibodies that bound to the surface of N. gonorrhoeae cells, as shown by indirect fluorescent a

196 e is critical for the growth and survival of N. gonorrhoeae in human cells.

197 n testing to determine the susceptibility of N. gonorrhoeae to ceftriaxone, cefixime, and cefpodoxime

198 cin exposure and decreased susceptibility of N. gonorrhoeae.

199 cin exposure and decreased susceptibility of N. gonorrhoeae.

200 norrhoeae strain MS11 but lower than that of N. gonorrhoeae strain FA1090.

201 erwent pilin Av at a rate similar to that of N. gonorrhoeae strain MS11 but lower than that of N. gon

202 e of clinical failure following treatment of N. gonorrhoeae infections with cefixime was relatively h

203 cular, phenotypic, and epidemiologic data on N. gonorrhoeae infection could help develop a more compl

204 Thus, we also examined the effect of NO on N. gonorrhoeae biofilms.

205 nificantly for C. trachomatis (P = 0.774) or N. gonorrhoeae (P = 0.163).

206 e samples (undiluted) spiked with E. coli or N. gonorrhoeae were incubated for 5 min with 1% Tween 80

207 t bind directly to either N. meningitidis or N. gonorrhoeae but play a crucial role in augmenting AP-

208 than those for women with C. trachomatis or N. gonorrhoeae (22.3 and 21.6, respectively; P < 0.0001)

209 ater than those for Chlamydia trachomatis or N. gonorrhoeae (27.6 and 25.9 years, respectively; P < 0

210 is was more prevalent than C. trachomatis or N. gonorrhoeae in all age groups except the 18- to 19-ye

211 r predictor of concomitant C. trachomatis or N. gonorrhoeae infection (odds ratios of 2.34 and 4.46,

212 on with concomitant Chlamydia trachomatis or N. gonorrhoeae infection overall, a positive T. vaginali

213 standard" for an infected C. trachomatis or N. gonorrhoeae patient was defined as > or = 2 positive

214 ication method (the Aptima C. trachomatis or N. gonorrhoeae test).

215 AC2 assay for detection of C. trachomatis or N. gonorrhoeae was observed, although some mailed swabs

216 samples spiked with either C. trachomatis or N. gonorrhoeae, and also containing both bacteria.

217 sexual contact with either C. trachomatis or N. gonorrhoeae, or had symptoms of an STI.

218 ulture-positive result for C. trachomatis or N. gonorrhoeae, two or more positive nucleic acid amplif

219 ng of the input plasmid pools and the output N. gonorrhoeae genomic DNA pools identified mutations pr

220 However, only infection with pathogenic N. gonorrhoeae and not infection with the other bacteria

221 ests (NAATs) for the diagnosis of pharyngeal N. gonorrhoeae.

222 trospective cohort study of culture-positive N. gonorrhoeae infections at a single sexual health clin

223 ecimens from 10 patients with culture-proven N. gonorrhoeae infection revealed evidence of biofilm fo

224 bal dissemination of antimicrobial-resistant N. gonorrhoeae strains.

225 e emerging threat of antimicrobial-resistant N. gonorrhoeae.

226 Quinolone-resistant N. gonorrhoeae and reduced cefixime susceptibility appea

227 Quinolone-resistant N. gonorrhoeae has arisen multiple times, with extensive

228 After resolving all Roche N. gonorrhoeae-positive results with two additional real

229 We have shown previously that several N. gonorrhoeae Fur-repressed genes are expressed in vivo

230 o the syndrome caused by its sister species, N. gonorrhoeae, the etiologic agent of gonorrhea.

231 clusters of patients infected with specific N. gonorrhoeae genotypes were related to various epidemi

232 d results were obtained with the glans swab: N. gonorrhoeae detection by AC2 and SDA (method 1) had t

233 ept for those from patients with symptomatic N. gonorrhoeae infections.

234 inhibited, although to a lesser extent than N. gonorrhoeae PriA.

235 del N. gonorrhoeae-PMN interactions and that N. gonorrhoeae actively inhibits apoptosis induced by mu

236 We conclude that N. gonorrhoeae causes a productive infection in BALB/c m

237 In this study, we confirmed that N. gonorrhoeae induces production of cIAP2 in human cerv

238 These data demonstrate that N. gonorrhoeae filamentous phage can induce antibodies w

239 These results demonstrate that N. gonorrhoeae has an active peptidoglycan recycling pat

240 We demonstrate that N. gonorrhoeae msbB is dispensable for initiating and ma

241 demiological investigation demonstrated that N. gonorrhoeae infections are dominated by relatively fe

242 Our recent studies have demonstrated that N. gonorrhoeae proactively suppresses host T-helper (Th)

243 We first established that N. gonorrhoeae strain FA1090B failed to induce cell deat

244 es not induce apoptosis and furthermore that N. gonorrhoeae can inhibit both spontaneous apoptosis an

245 Collectively these results indicate that N. gonorrhoeae stimulation of human endocervical epithel

246 th these cells and primary PMNs to show that N. gonorrhoeae infection alone does not induce apoptosis

247 We also show that N. gonorrhoeae infection promotes NLRP3-dependent monocy

248 A::kan insertion mutant, which suggests that N. gonorrhoeae in biofilms may use NO as a substrate for

249 We demonstrate for the first time that N. gonorrhoeae exploits this host strategy in a novel de

250 The N. gonorrhoeae NG0969 open reading frame contains a gene

251 The N. gonorrhoeae Sequence Typing for Antimicrobial Resista

252 a Combo 2 assay, the ProbeTec assay, and the N. gonorrhoeae culture were used as the reference assays

253 C. trachomatis sensitivity was 100% and the N. gonorrhoeae sensitivity was 100%, with specificities

254 stablish quality control (QC) ranges for the N. gonorrhoeae ATCC 49226 control strain for MIC agar di

255 The sensitivity and specificity of the N. gonorrhoeae test were 100% and 100% for AC2 and 76.2%

256 ed force-induced quaternary structure of the N. gonorrhoeae Tfp.

257 ntly thicker and of greater biomass than the N. gonorrhoeae 1291 parent strain.

258 e in males was significantly higher than the N. gonorrhoeae and T. vaginalis infection rates.

259 Our studies indicate that the N. gonorrhoeae biofilm contains DNA and that the Nuc pro

260 We demonstrate that the N. gonorrhoeae chromosomes exist solely as monomers and

261 We demonstrate that the N. gonorrhoeae RecQ helicase can bind and unwind the pil

262 ase D C-terminal" (HRDC) domain, whereas the N. gonorrhoeae RecQ helicase gene encodes three HRDC dom

263 st (muscle) cell lines was observed with the N. gonorrhoeae strain expressing PilA2.

264 This N. gonorrhoeae-derived HMP activates CD4(+) T cells to i

265 The incidences of infection due to N. gonorrhoeae, C. trachomatis, and T. vaginalis were 3.

266 neutrophils released NETs after exposure to N. gonorrhoeae, but NET integrity declined over time wit

267 onses of BALB/c, C57BL/6 and C3H/HeN mice to N. gonorrhoeae.

268 f PG monomers by N. meningitidis relative to N. gonorrhoeae is partly due to ampG, since replacement

269 C3H/HeN mice are inherently resistant to N. gonorrhoeae infection, and this resistance is not due

270 for IL-1beta/IL-18 secretion in response to N. gonorrhoeae in monocytes.

271 ct susceptibility and the immune response to N. gonorrhoeae.

272 Inflammatory responses to N. gonorrhoeae are generated by host innate immune recog

273 ction of 2,408 specimens for C. trachomatis, N. gonorrhoeae, and T. vaginalis TMA screening.

274 ve values for M. genitalium, C. trachomatis, N. gonorrhoeae, and T. vaginalis were 100, 70, 67, and 2

275 idence of any bacterial STI (C. trachomatis, N. gonorrhoeae, or M. genitalium infection) was lower in

276 matis/T. vaginalis, 0.61% for C. trachomatis/N. gonorrhoeae and N. gonorrhoeae/T. vaginalis, and 0.24

277 For the qualitative RealTime C. trachomatis/N. gonorrhoeae assay, the overall agreements between the

278 8 to 89 years old) undergoing C. trachomatis/N. gonorrhoeae screening using the Aptima Combo 2 assay

279 gests that women screened for C. trachomatis/N. gonorrhoeae, whether asymptomatic or symptomatic, sho

280 omen undergoing screening for C. trachomatis/N. gonorrhoeae.

281 e/T. vaginalis, and 0.24% for C. trachomatis/N. gonorrhoeae/T. vaginalis and highest in women <30 yea

282 Ps), and recently we reported that wild-type N. gonorrhoeae strain FA1090 has a survival advantage re

283 We used N. gonorrhoeae multiantigen sequence typing to describe

284 Biochemical assays using N. gonorrhoeae 1291 wild type and isogenic mutant strain

285 e C. trachomatis infected (9.2%) and 15 were N. gonorrhoeae infected (1.5%), and 7 of these were coin

286 N. meningitidis sequences, and 29 (24%) were N. gonorrhoeae sequences.

287 re C. trachomatis infected (9.2%) and 5 were N. gonorrhoeae infected (1.0%), and 3 of these were coin

288 In considering whether N. gonorrhoeae directly influences B cells, we observed

289 The mechanisms by which N. gonorrhoeae modulates cell death are not clear, altho

290 live bacteria and in direct association with N. gonorrhoeae were protected from STS-induced apoptosis

291 eria biofilm formation was demonstrated with N. gonorrhoeae strain 1291-msbB, which shows a markedly

292 infected mice compared to mice infected with N. gonorrhoeae alone.

293 One man initially infected with N. gonorrhoeae multiantigen sequence type 2400 had type

294 B/c mice can be experimentally infected with N. gonorrhoeae, and a vaginal PMN influx occurs in 50 to

295 ian tube epithelial cells were infected with N. gonorrhoeae, and MMP patterns were examined.

296 pecies C. muridarum and then inoculated with N. gonorrhoeae following treatment with water-soluble 17

297 arum-infected mice prior to inoculation with N. gonorrhoeae concurrently with the downregulation of c

298 wever, a significant subset of patients with N. gonorrhoeae remain asymptomatic, without evidence of

299 ently, we demonstrated that stimulation with N. gonorrhoeae protected these cells from staurosporine

300 llus crispatus and then challenged them with N. gonorrhoeae, to measure the effects of H(2)O(2)-produ