ライフサイエンスコーパス: N. meningitidis

1 N. meningitidis abundance was negatively correlated with

2 N. meningitidis abundance was positively correlated with

3 N. meningitidis endotoxin was a potent agonist of both t

4 N. meningitidis has been considered a paradigmatic case

5 N. meningitidis incidence was 1.5 in Burkina Faso, 2.7 i

6 N. meningitidis MC58 NMB0419 encodes a Sel1-like repeat

7 N. meningitidis outbreak-related strains were distinguis

8 N. meningitidis strain 8047 was subjected to serial pass

9 N. meningitidis subverts immune responses by hijacking a

10 ve species (58.0%), followed by GBS (18.1%), N. meningitidis (13.9%), H. influenzae (6.7%), and L. mo

11 fold-more Stase activity than extracts of 16 N. meningitidis clinical isolates, representing several

12 Of 25 N. meningitidis isolates obtained, 15 (60%) were nongrou

13 From 1997 to 2002, 1,298 N. meningitidis isolates, collected in the United States

14 in several Neisseria isolates showed that 5 N. meningitidis strains contain a 107-bp CREE in this re

15 identification of at least 90% of the 1,605 N. meningitidis core genome loci for 50% of the specimen

16 93246, and the results were compared with 7 N. meningitidis strains, 13 N. polysaccharea strains, an

17 A N. meningitidis mutant with decreased expression of PorA

18 era mediated bactericidal activity against a N. meningitidis group C strain with human complement.

19 utant library was constructed in serogroup A N. meningitidis and screened for clones with increased p

20 mutability in a collection of 95 serogroup A N. meningitidis invasive isolates was determined.

21 ssay, (ii) for bactericidal activity against N. meningitidis serogroup C strain C11, and (iii) for th

22 ety of comparative sequence analyses against N. meningitidis reference genome sequences of known sero

23 liciting broadly protective immunity against N. meningitidis strains.

24 is vital for protecting individuals against N. meningitidis.

25 d carriage prevalence and acquisition of all N. meningitidis and individual disease-causing genogroup

26 We demonstrate here that although N. meningitidis fails to grow under strictly anaerobic c

27 Similar studies established that an N. meningitidis luxS mutant also has metabolite pool cha

28 ratorian who had occupational exposure to an N. meningitidis isolate of the same serogroup within 14

29 says for PorA (encoding porin protein A) and N. meningitidis genogroups.

30 he shared function of fHbp in N. cinerea and N. meningitidis and cross-reactive responses elicited by

31 experiments demonstrate that the E. coli and N. meningitidis protein homologs are functionally conser

32 In E. coli and N. meningitidis, the predominant lipid is a lysophosphat

33 mophilus influenzae cases were confirmed and N. meningitidis/H. influenzae were serogrouped/serotyped

34 r fractions of N. gonorrhoeae strain F62 and N. meningitidis strain MC58 not subset 3 (an acapsulate

35 lation of LOS can protect N. gonorrhoeae and N. meningitidis from complement-mediated serum killing a

36 Stase expression between N. gonorrhoeae and N. meningitidis is due at least in part to differential

37 stream (5'lst) regions of N. gonorrhoeae and N. meningitidis revealed striking sequence differences c

38 lst transcript levels in N. gonorrhoeae and N. meningitidis revealed that N. gonorrhoeae strains exp

39 ng analysis revealed that N. gonorrhoeae and N. meningitidis use different promoters with different s

40 e, Neisseria spp. (Neisseria gonorrhoeae and N. meningitidis), Serratia marcescens, and other gram-ne

41 pecific pathogens, Neisseria gonorrhoeae and N. meningitidis, are Gram-negative bacteria that have so

42 s surface exposed in both N. gonorrhoeae and N. meningitidis.

43 H. influenzae and N. meningitidis accounted for 6.8% (5 of 73) and 21.9% (

44 tural analysis of LPS from H. influenzae and N. meningitidis strains where lpt6 had been insertionall

45 capsular polysaccharides from E. coli K1 and N. meningitidis group B and the heparosan-like capsular

46 Abs that can be protective against MenB and N. meningitidis group C strains.

47 of 95.7% and 85.7%, and L. monocytogenes and N. meningitidis were not observed in the study.

48 magnitude than N. meningitidis organisms and N. meningitidis PorB (published elsewhere as Nme PorB).

49 been switched between N. lactamica PorB and N. meningitidis PorB, we identified residues in loop 5 a

50 2 copies in N. meningitidis strain Z2491 and N. meningitidis strain MC58, respectively) than 105- to

51 ved > or =0.031 micro g of human infant anti-N. meningitidis serogroup C PS IgG, 75 (94.9%) had a > o

52 relationship between concentrations of anti-N. meningitidis serogroup C PS-specific IgG and serum SB

53 Each pool was assayed (i) for the anti-N. meningitidis serogroup C capsular polysaccharide (PS)

54 It was concluded that the anti-N. meningitidis serogroup C PS IgG antibody induced by t

55 s who were not previously immunized with any N. meningitidis serogroup C vaccine served as a negative

56 en available, of which 26% were confirmed as N. meningitidis (n = 2433; 56%), S. pneumoniae (n = 1758

57 This isolate was identified as N. meningitidis by biochemical identification methods bu

58 ently enrich, sequence, and de novo assemble N. meningitidis DNA from clinical specimens with low bac

59 ed allelic patterns in urethritis-associated N. meningitidis strains may reflect genetic diversity in

60 mouse intranasal challenge model for group B N. meningitidis to evaluate potential vaccine candidates

61 eactive with heterologous strains of group B N. meningitidis.

62 ed with the two different strains of group B N. meningitidis.

63 is a potential vaccine candidate for group B N. meningitidis.

64 y, the transcriptome of adherent serogroup B N. meningitidis strain MC58 was determined at intervals

65 xygenase (HO), from the pathogenic bacterium N. meningitidis(NmHO), which secures host iron, shares m

66 ygenase, HO, from the pathological bacterium N. meningitidis have been investigated to assess the pro

67 share the same loci) and differences between N. meningitidis strains and N. gonorrhoeae FA1090 (only

68 egions that allow for discrimination between N. meningitidis and N. gonorrhoeae.

69 scents is due largely to interaction between N. meningitidis and other members of the upper respirato

70 inical isolate described here expresses both N. meningitidis and N. gonorrhoeae 16S rRNA genes, as sh

71 sseriae, as a target for C4b and C3b on both N. meningitidis and N. gonorrhoeae.

72 actamica is not associated with disease, but N. meningitidis occasionally invades the host, causing m

73 enital colonization and urethritis caused by N. meningitidis are possible across a range of meningoco

74 no cases of meningococcal disease caused by N. meningitidis B were reported among vaccinated student

75 revention of meningococcal disease caused by N. meningitidis serogroup B (NmB).

76 Meningitis caused by N. meningitidis was more common in West-Central than Sou

77 andidate for prevention of disease caused by N. meningitidis.

78 may explain adolescent/adult colonization by N. meningitidis.

79 A and B, outer membrane porins expressed by N. meningitidis, do not contribute significantly to fH b

80 ommon pathogen detected (n = 17) followed by N. meningitidis (n = 13).

81 The decreased release of PG monomers by N. meningitidis relative to N. gonorrhoeae is partly due

82 ow that the utilization of carbon sources by N. meningitidis determines its ability to withstand comp

83 Binding to serogroups A, B, and C N. meningitidis strains was detected by FACS and Far Wes

84 ant with the polyST genes from groups B or C N. meningitidis and the control E. coli K92 polymerase g

85 We have identified three serogroup C N. meningitidis (MenC) isolates recovered from patients

86 he prevalence of carriage of disease-causing N. meningitidis between the vaccination group (2.55%; 32

87 risk factors for carriage of disease-causing N. meningitidis included later year of schooling (adjust

88 NmC is the predominant serogroup causing N. meningitidis meningitis.

89 effect of purified PorB in vitro, a chimeric N. meningitidis strain expressing N. lactamica PorB indu

90 om complement attack achieved by circulating N. meningitidis therefore depends on the relative levels

91 lysaccharide synthesis (cps) locus, classify N. meningitidis serogroups, and identify mechanisms for

92 with S. pneumoniae, S. agalactiae, E. coli, N. meningitidis, or H. influenzae in combination with ce

93 exposure to droplets or aerosols containing N. meningitidis.

94 ime PCR assays have been developed to detect N. meningitidis ctrA, H. influenzae hpd, and S. pneumoni

95 Y synF showed 100% specificity for detecting N. meningitidis species, with high sensitivity (serogrou

96 nsitive as conventional methods in detecting N. meningitidis (13.2% versus 5.7%; P < 0.0001).

97 Here, we analyzed the genomes of 39 diverse N. meningitidis isolates associated with urethritis, col

98 of properdin do not bind directly to either N. meningitidis or N. gonorrhoeae but play a crucial rol

99 on against bacteremia caused by encapsulated N. meningitidis strains expressing GNA1870 subvariant 1

100 s to study the geographic spread of epidemic N. meningitidis strains or other microbes of clinical im

101 To assess ongoing risk, we evaluated N. meningitidis carriage among US travelers to the 2001

102 gesting fluorescently labeled, ethanol-fixed N. meningitidis organisms (phagocytic activity) in the p

103 clonal antibody (MAb) B5 is bactericidal for N. meningitidis strain 8047 when PEtn is present in the

104 nditions that are more or less favorable for N. meningitidis carriage.

105 Average annual incidences for N. meningitidis, S. pneumoniae, and H. influenzae, respe

106 erogroup-specific genes in the cap locus for N. meningitidis serogroups A, B, C, W135, X, and Y.

107 This was particularly relevant for N. meningitidis, as only 1/13 cases was culture positive

108 om 0.18 to 17.31 micro g of IgG specific for N. meningitidis serogroup C PS per ml.

109 While vaccines are routinely used for N. meningitidis, no vaccine is available for N. gonorrho

110 ection of a few DNA copies per LAMP zone for N. meningitidis, S. pneumoniae and Hib were achieved wit

111 ccines are available to protect against four N. meningitidis serogroups, there is currently no commer

112 ructure of an ADEP-ClpP complex derived from N. meningitidis was solved.

113 the second highest incidence of disease from N. meningitidis.

114 The Cas9 RNA-guided endonuclease from N. meningitidis (NmCas9) recognizes a 5'-NNNNGATT-3' pro

115 All four opa genes from N. meningitidis strain H44/76 were sequentially disrupte

116 structure by complementation with kdtA from N. meningitidis or Escherichia coli.

117 suggest that phosphoryl moieties of LA from N. meningitidis and N. gonorrhoeae LOSs play an importan

118 rsible "aging" of native heme oxygenase from N. meningitidis, NmHO.

119 and chimeric forms of the IgA1 protease from N. meningitidis strain NMB.

120 he interactions between 11 Pil proteins from N. meningitidis.

121 Comparison of PG fragment release from N. meningitidis and N. gonorrhoeae showed that meningoco

122 Furthermore, N. meningitidis, unlike enteric Gram-negative bacteria,

123 ave functional activity against heterologous N. meningitidis strain, as demonstrated via bactericidal

124 ntibody responses to a panel of heterologous N. meningitidis strains than did a control multicomponen

125 One hundred N. meningitidis samples were typed by comparing MALDI-TO

126 ex real-time PCR assays for detection of (i) N. meningitidis ctrA, H. influenzae hpd, and S. pneumoni

127 pd, and S. pneumoniae lytA (NHS assay); (ii) N. meningitidis serogroups A, W135, and X (AWX assay); a

128 groups A, W135, and X (AWX assay); and (iii) N. meningitidis serogroups B, C, and Y (BCY assay).

129 In N. meningitidis, a weak sigma 70 promoter at the 3' term

130 In N. meningitidis, NalP is secreted at distinct sites arou

131 NO inhibits oxidase activity in N. meningitidis with an apparent Ki NO = 380 nM measured

132 d lgt-1 in strain 93246, were the same as in N. meningitidis.

133 pid A indicates that lipid A biosynthesis in N. meningitidis can proceed without the addition of Kdo

134 manno-octulosonic acid (Kdo) biosynthesis in N. meningitidis.

135 y a genomic island (the prp gene cluster) in N. meningitidis that enables this species to utilize pro

136 f 154- to 156-bp CREE (163 and 152 copies in N. meningitidis strain Z2491 and N. meningitidis strain

137 Novel aspects of the methylcitrate cycle in N. meningitidis include a propionate kinase which was pu

138 t such a system has not been demonstrated in N. meningitidis.

139 ntrol point for sialic capsule expression in N. meningitidis.

140 DsbA-catalysed oxidative protein folding in N. meningitidis.

141 similar to pacA and pacB were also found in N. meningitidis and N. lactamica strains, and an inserti

142 nces a wide range of biological functions in N. meningitidis either directly or via intermediate regu

143 of the iron-activated nspA and secY genes in N. meningitidis occur by Fur-dependent and -independent

144 studies have identified a number of genes in N. meningitidis that are iron and Fur activated, demonst

145 o be associated with phase variable genes in N. meningitidis.

146 the first observation of heteroresistance in N. meningitidis.

147 lons (phasevarions), have been identified in N. meningitidis.

148 fication is a pathway of major importance in N. meningitidis.

149 be lst, whereas this promoter is inactive in N. meningitidis.

150 coding the CMP-Kdo synthetase (kpsU/kdsB) in N. meningitidis resulted in expression of a lipooligosac

151 ence of Fur-regulated small RNA molecules in N. meningitidis MC58.

152 t response regulator, encoded by NMB0595, in N. meningitidis strain NMB resulted in the loss of all P

153 d all 13 N. polysaccharea strains but not in N. meningitidis and N. gonorrhoeae strains.

154 patterns of MAb reactivity were observed in N. meningitidis by Western blot, depending on the relati

155 ide consists of polyhexosamine phosphates in N. meningitidis serogroups A and X.

156 s study is the first report of small RNAs in N. meningitidis and the first to use a bioinformatics ap

157 uptake via GltT-GltM plays multiple roles in N. meningitidis internalization into HBMEC.

158 r1 transposon mutant library was screened in N. meningitidis serogroup A strain IR4162.

159 e for the lack of -35 consensus sequences in N. meningitidis.

160 he regulation of LOS inner core structure in N. meningitidis through an environmental sensing two-com

161 ne, resulted in loss of functional traits in N. meningitidis and E. coli Our study indicates that the

162 endent, iron-activated gene transcription in N. meningitidis.

163 olonizers of the human nasopharynx increased N. meningitidis switching frequencies, indicating that h

164 duction are observed aerobically, indicating N. meningitidis can act as an aerobic denitrifier.

165 fhbp genes were obtained from 1837 invasive N. meningitidis serogroup B (MnB) strains from the Unite

166 In susceptibility testing of invasive N. meningitidis isolates from the Active Bacterial Core

167 identify the recognition site for three key N. meningitidis methyltransferases: ModA11 (exemplified

168 f human C3 complement on the surface of live N. meningitidis bacteria and greater passive protective

169 Neisseria meningitidis (N. meningitidis), Streptococcus pneumoniae (S. pneumonia

170 is-causing bacteria, Neisseria meningitidis (N. meningitidis).

171 In all infected mice, N. meningitidis targeted the human vasculature, leading

172 Recombinant native N. meningitidis FBA was purified and used in a coupled e

173 At baseline, natural N. meningitidis carriage in the control group was 22.4%

174 suggest that strain 93246 is nonencapsulated N. meningitidis but has the ability to produce extracell

175 ain 93246 identical to other nonencapsulated N. meningitidis strains.

176 Of N. meningitidis cases, 53% were NmC, 30% NmW, and 13% Nm

177 NmX increased from 0.6% of N. meningitidis cases in 2015 to 27% in 2017.

178 bacterium and contributes to the ability of N. meningitidis to avoid complement-mediated killing in

179 ltransferase responsible for biosynthesis of N. meningitidis group B capsule was detected in strain 9

180 CoA to decorate the D-mannosamine capsule of N. meningitidis serogroup A.

181 The capsule of N. meningitidis serogroup B, (alpha2-->8)-linked polysia

182 Natural carriage of N. meningitidis and related bacteria leads to the develo

183 Carriage of N. meningitidis serogroup W-135 increased significantly

184 Carriage of N. meningitidis was investigated by using three differen

185 Lst rabbit antiserum bound to whole cells of N. meningitidis MC58 not subset 3 and wild-type N. gonor

186 ed to construct all possible combinations of N. meningitidis strains deficient in one, two, three, or

187 Thus, the observed growth defect of N. meningitidis pfs and luxS mutants is not due to quoru

188 The limit of detection of N. meningitidis is about 3 copies per LAMP zone within 4

189 proach for fast instrument-free diagnosis of N. meningitidis in resource-limited settings.

190 ransferase (Stase) activity than extracts of N. meningitidis strain MC58 [symbol: see text]3 a serogr

191 d LPS extracted from an LPS mutant (galE) of N. meningitidis strain MC58 (B:15:P1.7,16:L3).

192 ciated genomes from the 4 carried genomes of N. meningitidis, which is far more than can be expected

193 Rapid and reliable identification of N. meningitidis serogroups is crucial for judicious and

194 We screened 126 isolates of N. meningitidis and found the GGI in 17.5% of strains, w

195 n disease-associated and carried isolates of N. meningitidis at the level of individual nucleotide va

196 n disease-associated and carried isolates of N. meningitidis may provide critical insight into mechan

197 The strains tested included isolates of N. meningitidis serogroups A, B, C, W135, and Y, Neisser

198 disease-associated and 4 carried isolates of N. meningitidis to search for SNPs that show mutually ex

199 isk diffusion method for testing isolates of N. meningitidis.

200 The number of N. meningitidis serogroup A (NmA) among confirmed bacter

201 surface outer membrane protein 85 (OMP85) of N. meningitidis as an immobilized selective layer.

202 t phenotypes and hence invasive potential of N. meningitidis strains.

203 SWGA increased the mean proportion of N. meningitidis reads by 2 to 3 orders of magnitude, ena

204 y as single elements in the 5'lst regions of N. meningitidis isolates.

205 In addition, the 5'lst regions of N. meningitidis strains have 105-bp transposon-like Corr

206 island is absent from the close relative of N. meningitidis, the commensal Neisseria lactamica, whic

207 Last, we revisit the species status of N. meningitidis, N. gonorrheae, and N. lactamica in the

208 f wild-type and NMB0573 knock-out strains of N. meningitidis has shown that NMB0573 is associated wit

209 first time, that PorB2-expressing strains of N. meningitidis regulate the AP of baby rabbits and rats

210 available vaccine for serogroup B strains of N. meningitidis, this kind capsule-switching event could

211 e GGI has also been found in some strains of N. meningitidis.

212 found throughout the population structure of N. meningitidis (genetic distance, >0.425), whereas exl2

213 Here we report the crystal structures of N. meningitidis heme oxygenase (nm-HO) in the Fe(II), Fe

214 e vital to molecular epidemiology studies of N. meningitidis, including outbreak investigations and p

215 PorB is located on the surface of N. meningitidis and can be recognized by receptors of th

216 polysialic acid expressed on the surface of N. meningitidis and in the absence of specific antibody

217 LP2086 is localized on the outer surface of N. meningitidis.

218 nding protein, are essential for survival of N. meningitidis group B strain H44/76 in normal human se

219 tance of binding of human fH for survival of N. meningitidis in vitro and in vivo.

220 Both enzymes are necessary for survival of N. meningitidis under oxidative stress and during bloods

221 ive damage, are not required for survival of N. meningitidis under oxidative stress.

222 The mismatch repair system of N. meningitidis was found to play an important role in d

223 tide resolution the primary transcriptome of N. meningitidis strain 8013.

224 ultures grown overnight doubled the yield of N. meningitidis carriage isolates compared with conventi

225 d, showed that the Mu SGS and the E. coli or N. meningitidis sequences allowed an enhancement of proc

226 ccus-like and distinguishing them from other N. meningitidis strains.

227 ngitidis serogroups) or endogenous (in other N. meningitidis serogroups) sources of 5'-cytidinemonoph

228 istance, and virulence in the human pathogen N. meningitidis.

229 cantly increases detection of S. pneumoniae, N. meningitidis, and H. influenzae in CSF, and that appl

230 s that were qPCR positive for S. pneumoniae, N. meningitidis, and H. influenzae, only 10 were culture

231 typing/grouping of Streptococcus pneumoniae, N. meningitidis, and H. influenzae were done.

232 in (fHbp), a virulence factor which protects N. meningitidis from innate immunity by binding the huma

233 We examined the ability of purified N. meningitidis PorB to induce maturation of murine sple

234 iliar with current recommendations regarding N. meningitidis.

235 ther than sequences from the closely related N. meningitidis.

236 Ps of the pathophysiologically less relevant N. meningitidis serogroup L, is one of the smallest know

237 Three representative N. meningitidis strains (8047, M986, and 2996) were inve

238 Ciprofloxacin-resistant N. meningitidis has emerged in North America.

239 To assess local carriage of resistant N. meningitidis, we conducted a pharyngeal-carriage surv

240 s responsible for 59% (10/17) of serogrouped N. meningitidis meningitis.

241 nous (in all N. gonorrhoeae strains and some N. meningitidis serogroups) or endogenous (in other N. m

242 it biochemically from the pathogenic species N. meningitidis.

243 cluding those of three well-defined species (N. meningitidis; N. gonorrhoeae; and Neisseria polysacch

244 s Neisseria contains two pathogenic species (N. meningitidis and N. gonorrhoeae) in addition to a num

245 genomes of two pathogenic Neisseria species, N. meningitidis (Nm) and N. gonorrhoeae (Ng).

246 The capsular polysaccharide surrounding N. meningitidis is a major virulence factor.

247 beta-galactosidase (beta-gal) activity than N. meningitidis 5'lst::lacZ fusions in a host-independen

248 flammatory responses of lower magnitude than N. meningitidis organisms and N. meningitidis PorB (publ

249 eae strains express more lst transcript than N. meningitidis strains.

250 data are at odds with this proposal and that N. meningitidis fits the criteria that we have proposed

251 These data demonstrate that N. meningitidis targets human endothelial cells in vivo

252 de several lines of supporting evidence that N. meningitidis colonization is correlated with propioni

253 We found that N. meningitidis recycles PG fragments via the selective

254 gonorrhea and increases the probability that N. meningitidis might exit the oral cavity to produce sy

255 In this study, we show that N. meningitidis binds fH to its surface.

256 The N. meningitidis isolate described must have obtained N.

257 Because the N. meningitidis serogroup L capsule polymer consists of

258 The translated amino acid sequences from the N. meningitidis and H. influenzae lpt6 genes have conser

259 u derivative lacking the SGS, those from the N. meningitidis prophages allowed a small enhancement, a

260 its distinct protospacer adjacent motif, the N. meningitidis CRISPR-Cas machinery increases the seque

261 ovides comprehensive characterization of the N. meningitidis capsule, which is critical for meningoco

262 we report a 1.44 A crystal structure of the N. meningitidis major pilin PilE and a approximately 6 A

263 ar typing and vaccine antigen profile of the N. meningitidis pathogen, thus enabling thorough charact

264 the ratio of species-specific sequences, the N. meningitidis strain seems to have replaced one of its

265 We were unable to serogroup the N. meningitidis cases by PCR.

266 e P1.14 monoclonal antibodies and showed the N. meningitidis L1(8) lipo-oligosaccharide immunotype.

267 en-Probe Aptima assays cross-react with this N. meningitidis isolate.

268 However, most of the time N. meningitidis is carried as a commensal not associated

269 prp genes provides a metabolic advantage to N. meningitidis in the adult oral cavity, which is rich

270 Binding to N. meningitidis was specific for human fH (low for chimp

271 We show that these proteins bind directly to N. meningitidis Cas9 (NmeCas9) and can be used as potent

272 ed with common homozygotes after exposure to N. meningitidis.

273 like Neisseria gonorrhoeae, binding of fH to N. meningitidis was independent of sialic acid on the ba

274 difies cellular TNF secretion in response to N. meningitidis and may influence susceptibility to meni

275 talyze the synthesis of the complex trimeric N. meningitidis serogroup L capsule polymer repeating un

276 n of CREE lengths is similar between the two N. meningitidis genomes, with a greater number of 154- t

277 p CREE also shows similarity between the two N. meningitidis strains (15 copies share the same loci)

278 bination of vaccines prepared from wild-type N. meningitidis and recombinant protein.

279 ne or an OMV vaccine prepared from wild-type N. meningitidis or a combination of vaccines prepared fr

280 as much lower than that within the wild-type N. meningitidis strain only upon HBMEC infection and was

281 nterleukin 8 (IL-8) secretion than wild-type N. meningitidis, suggesting a role for PorB in induction

282 , and in urogenitally-adapted versus typical N. meningitidis, providing evidence for a model in which

283 confirmed in 273 patients: 48% (131/273) was N. meningitidis, 45% (123/273) S. pneumoniae, and 7% (19

284 crete sequences were obtained; 92 (76%) were N. meningitidis sequences, and 29 (24%) were N. gonorrho

285 toskeleton linker, were more pronounced when N. meningitidis formed larger colonies on HBMEC under ph

286 findings on the diverse mechanisms by which N. meningitidis avoids complement-mediated killing, and

287 s are commonly found in dental plaque, while N. meningitidis is primarily found in the pharynx, sugge

288 er mechanism toward our understanding of why N. meningitidis is strictly a human pathogen.

289 With N. meningitidis and Haemophilus, higher levels of recove

290 molecules on Neisseria meningitidis As with N. meningitidis NspA (Nm-NspA), N. gonorrhoeae NspA (Ng-

291 ed abundance of SNO during coincubation with N. meningitidis, S. enterica, or E. coli.

292 ies had positive abundance correlations with N. meningitidis, including Aggregatibacter aphrophilus,

293 Conflicting data with N. meningitidis indicate that Omp85 functions either in

294 of cytokines produced during infection with N. meningitidis and may be involved in the inflammatory

295 mice were then challenged intranasally with N. meningitidis strain H355 or M982, and the colonizatio

296 ethal intraperitoneal challenge of mice with N. meningitidis serogroup B, and sera raised against the

297 However, strain 93246 reacted with N. meningitidis serotype 4 and serosubtype P1.14 monoclo

298 In contrast to previous reports with N. meningitidis, loss of phosphoethanolamine attached to

299 drophobic agent resistance mechanisms within N. meningitidis.

300 Serogroup X N. meningitidis (NmX) dominated in both vaccinated and u