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1 NAAT identified 13 (0.1%) of the 12,338 HIV antibody-neg
2 NAAT is significantly (P<0.0001) more sensitive than cel
3 NAATs are both rapid and sensitive.
4 NAATs perform well for detection of chlamydia and gonorr
5 NAATs were performed on FCU, urethral, cervical, self- a
8 and 1 in-house HIV test (6 EIA, 4 RT, and 3 NAAT) on panels of plasma samples from HIV-infected (n =
9 AT cost of US$25, NAAT specificity of 99.6%, NAAT sensitivity of 100% for infants infected in pregnan
11 on, who has been a consistent advocate for a NAAT-only approach for CDI diagnosis, will discuss the v
12 r CDI diagnosis, will discuss the value of a NAAT-only approach, while Christopher Polage of the Univ
22 will update us on the commercially available NAAT systems and explain what their role should be in th
23 performance of three commercially available NAATs (Becton-Dickinson ProbeTec SDA, Gen-Probe Aptima C
29 cutive days, and analyzed using an RNA-based NAAT (Aptima Combo 2) and a DNA-based NAAT (Cobas 4800).
31 ositive with an alternative target TMA-based NAAT, APTIMA C. trachomatis, suggesting that they may ha
34 improved sensitivities compared to DNA-based NAATs; and the progression of scarring has now been char
35 on of Altona with a laboratory-developed BKV NAAT assay in IU/ml versus copies/ml using Passing-Bablo
36 ble to the primary standard to harmonize BKV NAAT results, we anticipate improved interassay comparis
40 e percent and 22% of the samples positive by NAAT and TC, respectively, were negative by the toxin B
41 -positive samples, 24 (96%) were positive by NAAT, whereas 25 of 25 true-negative samples (100%) show
49 samples that were C. trachomatis negative by NAATs, 33/45 and 197/212 were correctly identified by th
50 1,000 self-collected vaginal swabs tested by NAATs, the sensitivities for C. trachomatis and N. gonor
52 clearly visualizing the effects of changing NAAT-based infected-patient gold standards and should be
53 ens were tested using culture and commercial NAATs employing transcription-mediated amplification (TM
56 CSF of immunocompetent adults for viral CSF NAAT assays would increase clinical specificity and pres
58 AC2, SDA, or PCR were retested by different NAATs (SDA, PCR, AC2, and Aptima Neisseria gonorrhoeae a
59 C2; Digene Corp.) were retested by different NAATs (SDA, PCR, AC2, and the APTIMA assay for C. tracho
60 clear how many test results run by different NAATs and what combinations of specimens comprise the be
61 positive results were confirmed by different NAATs, but that some NAATs cannot be used to confirm oth
64 urine comparator results with two different NAATs, The effect of changing the infected-patient gold
66 prospectively by toxin EIA, by C. difficile NAAT, and with a reference standard toxigenic culture.
67 T (ACT) and APTIMA GC (AGC) are two discrete NAATs for C. trachomatis and N. gonorrhoeae detection th
68 , cytomegalovirus (CMV), or enterovirus (EV) NAAT with CSF samples between 2008 and 2013 were include
71 study, we evaluated the performance of four NAATs, qPCR, dPCR, real-time quantitative loop mediated
74 s the role of future iterations of influenza NAATs and whether this testing would be available in a c
76 evidence for the timing of TOC using modern NAATs is limited, we performed a prospective cohort stud
77 Previously, our group described a multiplex NAAT for the detection of dengue virus, Leptospira, and
78 such as S. pyogenes, or commercial multiplex NAATs for detection of a variety of pathogens in gastroi
85 lyzed data from a head-to-head comparison of NAATs on female FCU specimens and found that the volume
86 detection of TV by routine implementation of NAATs should result in better control of this common, tr
88 ted diagnostic testing with increased use of NAATs when appropriate; routine follow-up visits within
90 carriage, the diagnostic predictive value of NAATs is limited when used in patients with a low probab
91 specimen sensitivity and specificity for one NAAT method were created by varying the number and combi
106 Patel of the Mayo Clinic, where S. pyogenes NAATs have been used for well over a decade with great s
110 investigational/research use only (IUO/RUO) NAATs for the detection of C. difficile toxin genes, the
113 g results for retested samples from a second NAAT (Xpert C. difficile/Epi test; Cepheid, Sunnyvale, C
114 ion recommends that infants undergo a second NAAT to confirm any positive test result, but implementa
115 ith presumptive PTB in a low-burden setting, NAAT can reduce AII and is comparably sensitive, more sp
116 plification test (NAAT) results, or a single NAAT-positive result confirmed by an alternate amplifica
118 However, for all other specimen types, some NAATs cannot be used to confirm positive results from ot
121 n of Trichomonas vaginalis by vaginal swabs; NAATs for detection of Neisseria gonorrhoeae and Chlamyd
122 that were negative by cytotoxicity assay/TC/NAAT, clinical cutoffs were set at 29.4 pg/ml (toxin A)
123 rming nucleic acid amplification techniques (NAATs) in digital format using limiting dilution provide
124 FDA-cleared nucleic acid amplification test (NAAT) but were negative for stx1 and stx2 following nucl
125 ion-cleared nucleic acid amplification test (NAAT) for the detection of Chlamydia trachomatis and Nei
126 assay is a nucleic acid amplification test (NAAT) for the detection of Mycobacterium tuberculosis co
127 rmance of a nucleic acid amplification test (NAAT) for the diagnosis of Mycobacterium tuberculosis ba
128 re positive nucleic acid amplification test (NAAT) results, or a single NAAT-positive result confirme
129 ])-positive nucleic acid amplification test (NAAT) results: (i) repeating the original test on the or
132 eening, all nucleic acid amplification test (NAAT)-positive respiratory specimens should be universal
135 n of BKV nucleic acid amplification testing (NAAT) and enabling comparisons of biological measurement
137 ecessary nucleic acid amplification testing (NAAT) for viral pathogens in cerebrospinal fluid (CSF) s
141 cost of nucleic acid amplification testing (NAAT) makes individual testing of at-risk individuals pr
144 However, nucleic acid amplification testing (NAAT) with the Xpert MTB/RIF assay (Xpert) may be more e
145 tions by nucleic acid amplification testing (NAAT), as they involve a less invasive collection method
146 ation of nucleic acid amplification testing (NAAT; Gen-Probe Aptima Combo 2 assay) for detection of C
147 [TC] and nucleic acid amplification testing [NAAT]) are confounded by asymptomatic colonization by to
148 doption of nucleic acid amplification tests (NAAT) for Clostridium difficile diagnosis and their impa
149 duction of nucleic acid amplification tests (NAAT), we surveyed laboratories in Washington State abou
151 performance of nucleic acid amplified tests (NAAT) for Chlamydia trachomatis at the cervix and in uri
152 Commercial nucleic acid amplification tests (NAATs) are becoming available, and their use in screenin
153 bacterium, nucleic acid amplification tests (NAATs) are necessary for its detection in patient specim
156 s (EIA) to nucleic acid amplification tests (NAATs) as the primary diagnostic test for Clostridium di
158 Because nucleic acid amplification tests (NAATs) do not distinguish Clostridium difficile infectio
159 itivity of nucleic acid amplification tests (NAATs) for Chlamydia trachomatis and Neisseria gonorrhoe
160 g positive nucleic acid amplification tests (NAATs) for Chlamydia trachomatis: (i) repeat the origina
161 ude use of nucleic acid amplification tests (NAATs) for detection of Trichomonas vaginalis by vaginal
162 d value of nucleic acid amplification tests (NAATs) for detection of TV in men and women at high risk
165 ization of nucleic acid amplification tests (NAATs) for near-patient applications is not the amplific
166 ulture and nucleic acid amplification tests (NAATs) for rectal chlamydial and gonococcal diagnosis.
168 A-approved nucleic acid amplification tests (NAATs) for the detection or confirmation of HIV-2 infect
169 ulture and nucleic acid amplification tests (NAATs) for the diagnosis of pharyngeal N. gonorrhoeae.
170 available nucleic acid amplification tests (NAATs) for trichomoniasis are accurate, quick and confir
171 ocessed by nucleic acid amplification tests (NAATs) has significantly increased the utilization of no
172 Recently, nucleic acid amplification tests (NAATs) have been approved for testing for the presence o
173 RNA-based nucleic acid amplification tests (NAATs) have demonstrated improved sensitivities compared
176 and rapid nucleic acid amplification tests (NAATs) in children and adults with suspected influenza.
177 o, CA) are nucleic acid amplification tests (NAATs) that detect Chlamydia trachomatis AC2 also detect
178 A)-cleared nucleic acid amplification tests (NAATs) to culture using 314 vaginal/rectal swabs after 1
179 The use of nucleic acid amplification tests (NAATs) to diagnose Neisseria gonorrhoeae infections comp
180 ificity of nucleic acid amplification tests (NAATs) used for early infant diagnosis (EID) of HIV infe
182 ccus (GBS) nucleic acid amplification tests (NAATs) were compared to that of enriched culture for det
183 that time, nucleic acid amplification tests (NAATs) were just becoming commercially available, and th
184 e compared nucleic acid amplification tests (NAATs) with diagnostic tests other than those by culture
185 s, such as nucleic acid amplification tests (NAATs), to evaluate prepubertal children for N. gonorrho
190 with VS (93%) was as high as or higher than NAAT sensitivity with cervical swabs (91%) or FCU (80.6%
191 e is a body of literature that suggests that NAATs lack clinical specificity and thus inflate CDI rat
193 beneficial for public health programs if the NAAT manufacturers sought FDA clearance for this specime
199 pecimens were tested simultaneously with the NAATs, following 18 to 24 h of Lim broth enrichment; 15%
203 ere tested for C. trachomatis with the three NAATs, and a true-positive result was defined as any two
204 omatis detection in urine samples with three NAATs: the Abbott LCx (LCx), BD ProbeTec ET (ProbeTec),
207 ents (3821 women and 2514 men) received a TV NAAT on endocervical, urethral, or urine specimens.
209 ive performance characteristics of these two NAATs were assessed with genital specimens from 284 wome
211 irmatory testing remained cost-saving unless NAAT cost exceeded US$400 or the HIV-uninfected status o
219 ostatistical models of specimen pooling with NAAT for the identification of AHI cases; these models i
220 erves further evaluation and comparison with NAATs and may well offer an attractive alternative for d
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