ライフサイエンスコーパス: NADH dehydrogenase

1 thesis of two isoforms of the ND3 subunit of NADH dehydrogenase.

2 -cytochrome P450 reductase and mitochondrial NADH dehydrogenase.

3 ND1 and ND3) encoding additional subunits of NADH dehydrogenase.

4 ts defective in the energy-conserving type I NADH dehydrogenase.

5 rovides further evidence for the presence of NADH dehydrogenase.

6 ster, which encodes the proton-translocating NADH dehydrogenase.

7 itch from transcription of type I to type II NADH dehydrogenase.

8 and major Amb a 1 allergens, and as unique, NADH dehydrogenases.

9 itochondrial DNA: the matR gene found within NADH dehydrogenase 1 (nad1) intron 4.

10 ated from the heavy strand promoter 2 [i.e., NADH dehydrogenase 1 (ND1) by 11-fold, P < 0.005; cytoch

11 assessed by measuring the copy number of the NADH dehydrogenase 1 gene using quantitative real-time P

12 t on mtRNA expression and that expression of NADH dehydrogenase 1, 3, and 6 (ND-1, ND-3, ND-6) and AT

13 ins including the phosphate carrier protein, NADH dehydrogenase 1alpha subcomplexes 2 and 3, transloc

14 Silencing of the phosphate carrier or NADH dehydrogenase 1alpha subcomplexes 2 or 3 in 3T3-L1

15 change from threonine to alanine within the NADH dehydrogenase 3 (ND3) of complex I.

16 ochrome c oxidase-IV, ATP synthase-beta, and NADH dehydrogenase-3 decreased markedly in FPG, and thes

17 A novel mitochondrial NADH dehydrogenase 5 (ND5) m.12955A > G mutation was ide

18 the hepatoma cytochrome c oxidase I, II, and NADH dehydrogenase 5, 6, the downstream targets of Tfam,

19 of somatic truncating mutations occurred in NADH dehydrogenase 5.

20 ng mitochondrial genes encoded in the mtDNA [NADH dehydrogenase 6 (ND6) and cytochrome c oxidase subu

21 region of the mtDNA that contained the gene NADH dehydrogenase 6 (ND6), which encodes an essential c

22 it 6 (ATP6) by 6.5-fold, P < 0.005); but not NADH dehydrogenase 6 (ND6)], which is initiated from the

23 Their NADH dehydrogenase activities were almost normal.

24 Mutations that reduce NADH dehydrogenase activity (Ndh; type II) cause multipl

25 Thus, aberration in mitochondrial complex I NADH dehydrogenase activity can profoundly enhance the a

26 a threefold reduction in total mitochondrial NADH dehydrogenase activity in cells cultivated with glu

27 cerevisiae (NDI1) can completely restore the NADH dehydrogenase activity in mutant human cells that l

28 detection of a 700 kDa subcomplex retaining NADH dehydrogenase activity indicates an arrest in the a

29 phenotype analyses suggest that the external NADH dehydrogenase activity of Ndh1p is important for op

30 contrary, no decrease in rotenone-sensitive NADH dehydrogenase activity, using a water-soluble ubiqu

31 In terms of immunochemical and NADH dehydrogenase activity-staining analyses, all site-

32 n of a mouse A9 cell derivative defective in NADH dehydrogenase activity.

33 metformin inhibits mitochondrial complex I (NADH dehydrogenase) activity and cellular respiration.

34 are consistent with a protective role of the NADH dehydrogenases against oxidative stress, thus, when

35 atory electron transport chain that included NADH dehydrogenase, alternative complex III and cytochro

36 s of rotenone (an inhibitor of mitochondrial NADH dehydrogenase and a naturally occurring toxicant) o

37 Thus, multiple hits in NADH dehydrogenase and COX activity-impairing genes repr

38 e pathogenic mtDNA point mutations affecting NADH dehydrogenase and COX genes as well as regulatory e

39 are decreased by about 90%, whereas that of NADH dehydrogenase and cytochrome c reductase are unchan

40 and acetic acid tolerance; overexpression of NADH dehydrogenase and methylmalonyl-CoA epimerase impro

41 strains expressed binary combinations of one NADH dehydrogenase and one quinol oxidase.

42 The proton-pumping type-I NADH dehydrogenase and the aa3-type cytochrome c oxidase

43 , suggesting that the external mitochondrial NADH dehydrogenase and the malate-aspartate shuttle may

44 rrected by expression of one of two enzymes: NADH dehydrogenase and the NADH-dependent malate dehydro

45 not caspase 3, and significantly suppressed NADH dehydrogenases and cytochrome c oxidases, consisten

46 t low RSV doses (1-5 muM) directly stimulate NADH dehydrogenases and, more specifically, mitochondria

47 (ND2 and ND5) encode interacting subunits of NADH dehydrogenase, and amino residues that were inferre

48 uo genes not present in C. jejuni encode the NADH dehydrogenase, and in their place in the operon are

49 of flavoenzymes, including xanthine oxidase, NADH dehydrogenase, and NADPH oxidase.

50 native oxidase activity and that alternative NADH dehydrogenases are also up-regulated in these plant

51 e or when devoid of quinones, implicating an NADH dehydrogenase as their source.

52 ochondrial genes, those encoding subunits of NADH-dehydrogenase as well as cytochrome c oxidase subun

53 ays (additional photosystem genes, duplicate NADH dehydrogenase, ATP synthases), whose functionality

54 ransport proteins from Arabidopsis thaliana, NADH dehydrogenase B14.7 like (B14.7 [encoded by At2g422

55 tered respiratory function, as inhibition of NADH dehydrogenase brought ROS levels back to wild-type

56 er, in permeabilized cells NDI1 (alternative NADH dehydrogenase) bypassed complex I inhibition, where

57 t represents a minor form of the respiratory NADH dehydrogenase complex (complex I).

58 Defects of the NADH dehydrogenase complex are predominantly manifested

59 proteins and to a subunit of the eukaryotic NADH dehydrogenase complex I.

60 mutant lacking nuoG, a subunit of the type I NADH dehydrogenase complex, exhibits attenuated growth i

61 systems but up-regulation of the chloroplast NADH dehydrogenase complex, plastocyanin, and Ca(2+) sen

62 nd to those of the isolated P. denitrificans NADH-dehydrogenase complex.

63 ely 40 subunits of the mammalian respiratory NADH dehydrogenase (Complex I) are encoded in mitochondr

64 nate, which suggests that rotenone-sensitive NADH dehydrogenase (complex I) is present in these mitoc

65 en observed in the level of the mRNA for the NADH dehydrogenase (complex I) ND6 subunit gene, which i

66 Enzymologic analysis of mitochondrial NADH dehydrogenase (complex I) with submitochondrial par

67 ha blocked electron transfer at three sites, NADH dehydrogenase (complex I), succinate dehydrogenase

68 inhibition of the respiratory chain enzymes NADH-dehydrogenase (complex I) and succinate dehydrogena

69 ulation of the chloroplast photosystem I and NADH dehydrogenase complexes and had been proposed to fa

70 hat functional variation in cytochrome b and NADH dehydrogenase could mechanistically contribute to l

71 n transport chain, a large membrane-embedded NADH dehydrogenase, couples electron transfer to the rel

72 c for each type of mitochondrial lesion: the NADH dehydrogenase-defective NCS2 mutant has high expres

73 e was just sufficient to support the maximum NADH dehydrogenase-dependent respiration rate, with no u

74 However, NADH dehydrogenase-dependent respiration, as measured in

75 Saccharomyces cerevisiae is catalyzed by an NADH dehydrogenase designated Ndi1p.

76 rity to the 18-kD Fe-S subunit of complex I (NADH dehydrogenase, EC 1.6.5.3) in the mitochondrial ele

77 le-genome scanning technique to identify the NADH dehydrogenase gamma subunit (nuoG) primer set that

78 NADH dehydrogenase gene mutations preferentially accumul

79 We report the first molecular defect in an NADH-dehydrogenase gene presenting as isolated myopathy.

80 iochlorophyll biosynthesis, cbb3 oxidase and NADH dehydrogenase genes, as well as genes for autotroph

81 l DNA-encoded ND5 subunit of the respiratory NADH dehydrogenase has been isolated and characterized.

82 A rotenone-insensitive NADH dehydrogenase has been isolated from the mitochondr

83 tides (CsmR, CsmS, CsmT, CsmU, and a type II NADH dehydrogenase homolog).

84 lcarbodiimide, an inhibitor of mitochondrial NADH dehydrogenase I (also called complex I), inhibits t

85 ase A, and FNR) and membrane-bound proteins (NADH dehydrogenase I and succinate dehydrogenase).

86 nic message with the putative nuoF (encoding NADH dehydrogenase I chain F), secF (encoding protein ex

87 ansport chain, especially those encoding the NADH dehydrogenase I complex.

88 -containing aconitase, serine deaminase, and NADH dehydrogenase I enzymes of S. Typhimurium under bas

89 energetically efficient proton-translocating NADH dehydrogenase I is used in preference to the non-pr

90 DH-quinone oxidoreductase (energy-conserving NADH dehydrogenase I) from various eukaryotic and prokar

91 Aer-mediated responses were linked to NADH dehydrogenase I, although there was no absolute req

92 port chain, including cytochrome bo oxidase, NADH dehydrogenase I, NADH dehydrogenase II, and succina

93 Thus NADH dehydrogenase II but not NADH dehydrogenase I, respiratory quinones, or cytochrom

94 oxygen are associated with redox changes in NADH dehydrogenase I.

95 ssed the proton pumps cytochrome o (cyo) and NADH dehydrogenases I and II.

96 However, mutants that lacked NADH dehydrogenase II and fumarate reductase, the most o

97 Null mutations in the gene encoding NADH dehydrogenase II averted autoxidation of vesicles,

98 Thus NADH dehydrogenase II but not NADH dehydrogenase I, resp

99 NADH dehydrogenase II did generate substantial H2O2 when

100 n preference to the non-proton translocating NADH dehydrogenase II during periods of rapid growth, by

101 ne that encodes the non-proton-translocating NADH dehydrogenase II of Escherichia coli is anaerobical

102 NADH dehydrogenase II that was purified from both wild-t

103 cytochrome bo oxidase, NADH dehydrogenase I, NADH dehydrogenase II, and succinate dehydrogenase.

104 ided additional evidence for the presence of NADH dehydrogenase in bloodstream forms of T. brucei.

105 ine, coding for ND5, a subunit of complex I (NADH dehydrogenase) in the electron transport chain.

106 on in the subunit for respiratory complex I, NADH dehydrogenase, in the ND6 gene.

107 terized the iron-sulfur protein required for NADH dehydrogenase (INDH) in the model plant Arabidopsis

108 where ndhF is the ND5 protein of chloroplast NADH dehydrogenase) indicate that Hesperomannia belongs

109 ion to MPP(+) by a monoamine oxidase and (b) NADH dehydrogenase inhibition by MPP(+).

110 itochondrial ATP production, and rotenone, a NADH dehydrogenase inhibitor, were also tested.

111 ent of intact mitochondria revealed that the NADH dehydrogenase is located in the inner membrane/matr

112 ncentrations of digitonin suggested that the NADH dehydrogenase is loosely bound to the inner mitocho

113 spectively, by rotenone, which suggests that NADH dehydrogenase is present in these cells.

114 onella strain bearing mutations in complex I NADH dehydrogenases is refractory to the early NADPH oxi

115 Mitochondrial complex I (NADH dehydrogenase) is a major contributor to neuronal e

116 Chloroplast NADH dehydrogenase-like (NDH) complex mediates cyclic el

117 y plays a role in the down-regulation of the NADH dehydrogenase-like complex-dependent plastoquinone

118 mplex (PGR) and one that is dependent of the NADH dehydrogenase-like complex.

119 ROS are produced from complex I by the NADH dehydrogenase located in the matrix side of the inn

120 xidized PQ pool upon inactivation of type II NADH dehydrogenase may be related to the facts that the

121 lasmic mtDNA mutations affecting subunits of NADH dehydrogenase may play a synergistic role in the es

122 alternative NADH:ubiquinone oxidoreductases (NADH dehydrogenases) may protect against oxidative stres

123 Here we describe a novel NADH dehydrogenase module of respiratory complex I that

124 n regulatory mtDNA elements, but only rarely NADH dehydrogenase mutations.

125 The sodium-dependent NADH dehydrogenase (Na(+)-NQR) is a key component of the

126 The sodium-dependent NADH dehydrogenase (Na(+)-NQR) is the main ion transport

127 ith no change in CcO activity, and inhibited NADH dehydrogenase (NADH-DH) activity (P<0.01) without a

128 the ATPase 6 subunit gene (ATP), ATC for the NADH dehydrogenase (ND) 2 subunit gene, and ATT for the

129 perfectly conserved regions upstream of two NADH dehydrogenase (ND) genes are transcribed and likely

130 ncoding subunit ND4 of the respiratory chain NADH dehydrogenase (ND), did not affect the synthesis, s

131 We determined the activities of NADH dehydrogenase (ND), succinate dehydrogenase, and cy

132 gene for subunit 1 of the respiratory chain NADH dehydrogenase (ND1), complete genes for cytochrome

133 In contrast, deletion of the external NADH dehydrogenases NDE1 and NDE2, which feed electrons

134 both major clades of Erodium contain intact NADH dehydrogenase (ndh) genes, but the 11 ndh genes are

135 While NADH dehydrogenase (NDH) is a critical site of this O(2)

136 Exposure of NADH dehydrogenase (NDH), the flavin subcomplex of compl

137 type 2 NADH:quinone oxidoreductase complex (NADH dehydrogenase [NDH]) from M. capsulatus Bath, along

138 metformin-resistant Saccharomyces cerevisiae NADH dehydrogenase NDI1 was overexpressed.

139 s rescued by bypassing complex I using yeast NADH dehydrogenase Ndi1.

140 restored by ectopic expression of the yeast NADH dehydrogenase Ndi1.

141 nteny group of THRSP and its flanking genes [NADH dehydrogenase (NDUFC2) and glucosyltransferase (ALG

142 with the rotenone-insensitive single-subunit NADH dehydrogenase of Saccharomyces cerevisiae (NDI1), w

143 s, which encode the major, energy-generating NADH dehydrogenase of the cell.

144 NADH dehydrogenase or complex I (CI) is affected in most

145 Mutations of respiratory NADH dehydrogenases prevent nitrotyrosine formation and

146 enol and the presence of subunits 7 and 8 of NADH dehydrogenase provided additional evidence for the

147 g human cell lines carrying a frame-shift at NADH dehydrogenase (respiratory complex I) subunit 5 gen

148 Mutants that lacked both NADH dehydrogenases respired very slowly, as expected; h

149 lipolytica carrying an internal alternative NADH dehydrogenase resulted in slower growth and strongl

150 itochondrial genes (cytochrome b (Cytb), the NADH dehydrogenase subunit 1 (ND1) and cytochrome oxidas

151 nding peptides allowed us to characterize an NADH dehydrogenase subunit 1 (ND1)-derived peptide as th

152 Here, we demonstrate that the NADH dehydrogenase subunit 1 self-peptide is seen by mat

153 s allowed us to characterize a mitochondrial NADH dehydrogenase subunit 1-derived 9-mer peptide as th

154 transversion in the mitochondrially encoded NADH dehydrogenase subunit 2 (mt-ND2, human; mt-Nd2, mou

155 n unusual ATC (non-AUG) codon initiating the NADH dehydrogenase subunit 2 (ND2) gene.

156 l function of the mtDNA mutations, we cloned NADH dehydrogenase subunit 2 (ND2) mutants based on prim

157 By using mitochondrial NADH dehydrogenase subunit 2 (ND2) sequences and 467 amp

158 rial genes, namely, cytochrome b (CYT B) and NADH dehydrogenase subunit 2 (ND2), from 383 archived sp

159 europilin (ESDN), prostatic binding protein, NADH dehydrogenase subunit 2, and an unknown protein.

160 NADH dehydrogenase subunit 2, encoded by the mtDNA, has

161 s (cardiac alpha-actin, cyclin G1, stathmin, NADH dehydrogenase subunit 2, titin and prostatic bindin

162 3'-terminal sequence of mitochondria-encoded NADH dehydrogenase subunit 3 (ND-3).

163 We sequenced the NADH dehydrogenase subunit 3 (ND3) gene from a sample of

164 nce, containing part of the tRNA glycine and NADH dehydrogenase subunit 3 genes, is the target of our

165 scripts in a 24-hour time course showed that NADH dehydrogenase subunit 4 mRNA decreased by 2-fold as

166 id evolutionary rates, 16S rRNA (379 bp) and NADH dehydrogenase subunit 5 (NADH-5, 318 bp), from mult

167 the cytochrome c oxidase subunit I (COI) and NADH dehydrogenase subunit 5 (ND5) genes each include a

168 for cytochrome c oxidase subunit I (COI) and NADH dehydrogenase subunit 5 (ND5) of the sea anemone Me

169 acids in cytochrome c oxidase subunit 1 and NADH dehydrogenase subunit 5.

170 within the mitochondrial DNA (mtDNA)-encoded NADH dehydrogenase subunit 6 (ND6) gene has been identif

171 g CO2/HCO3 (-)-uptake mutant DeltandhD3 (for NADH dehydrogenase subunit D3)/ndhD4 (for NADH dehydroge

172 or NADH dehydrogenase subunit D3)/ndhD4 (for NADH dehydrogenase subunit D4)/cmpA (for bicarbonate tra

173 creased mRNA levels from both mitochondrial (NADH dehydrogenase subunit IV) and nuclear [cytochrome c

174 anscripts nicotinamide adenine dinucleotide (NADH) dehydrogenase subunit 4 and cytochrome b were down

175 rring peptide derived from the mitochondrial NADH-dehydrogenase subunit 1 gene (9-mer peptide).

176 t low peptide concentrations, shortening the NADH-dehydrogenase subunit 1 gene 9-mer peptide or mutat

177 ng events in cytochrome oxidase subunit2 and NADH dehydrogenase subunit4 transcripts, encoding subuni

178 the slo3 mutant was defective in splicing of NADH dehydrogenase subunit7 (nad7) intron 2.

179 ial for the translation of the mitochondrial NADH dehydrogenase subunit7 (nad7) mRNA.

180 3.8-kb mtDNA deletion in the region encoding NADH dehydrogenase subunits 1 and 2 and cytochrome c oxi

181 We observed that transcripts of most NADH dehydrogenase subunits are edited inefficiently in

182 f the mitochondrial genes encoding the seven NADH-dehydrogenase subunits showed a G-to-A transition a

183 sidered to be the minimal form of the type I NADH dehydrogenase, the first enzyme complex in the resp

184 A new family of NADH dehydrogenases, the flavin oxidoreductase (FlxABCD,

185 fully reduced in the mutant without type II NADH dehydrogenase, thus causing regulatory inhibition.

186 in vitro, in the gene for the ND4 subunit of NADH dehydrogenase) to undergo transcomplementation of t

187 Multiple NADH dehydrogenases, transcription factors of unknown fu

188 mical reduction of the plastoquinone pool by NADH dehydrogenases type-1 and type-2 (NDH-1 and NDH-2).

189 ncoding a nuclear DNA-encoded subunit of CI (NADH dehydrogenase ubiquinone Fe-S protein 4), typically

190 (ubiquinone) 1beta subcomplex subunit 8, and NADH dehydrogenase (ubiquinone) 1alpha subcomplex subuni

191 rogenase (ubiquinone) iron-sulfur protein 3, NADH dehydrogenase (ubiquinone) 1beta subcomplex subunit

192 e show that human fibroblasts mutant for the NADH dehydrogenase (ubiquinone) Fe-S protein 1 (NDUFS1)

193 ochondrial respiratory chain subunit Ndufs4 [NADH dehydrogenase (ubiquinone) Fe-S protein 4], delays

194 chondrial membranes, decreased levels of the NADH dehydrogenase (ubiquinone) iron-sulfur protein 3, N

195 Loss of murine Ndufs4, which encodes NADH dehydrogenase (ubiquinone) iron-sulfur protein 4, r

196 Furthermore, we also identified NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subun

197 he unexpected loss of respiratory complex I (NADH dehydrogenase), universally present in all 300+ oth

198 As anticipated, however, NADH dehydrogenase was inhibited by these rotenoids.

199 The presence of three subunits of NADH dehydrogenase was observed in immunoblots of mitoch

200 ochondrial proteins, including aconitase and NADH dehydrogenases, were oxidized and their activities