ライフサイエンスコーパス: NBI

1 NBI 35965 (10 mg/kg) administered p.o. or subcutaneously

2 NBI 35965 (20 mg/kg s.c.) significantly reduced the defe

3 NBI 35965 accelerated (125)I-astressin dissociation and

4 NBI 35965 administered per orally (p.o.) in rats (1, 3,

5 NBI 35965 did not completely inhibit (125)I-sauvagine bi

6 NBI did not result in better detection of adenomas by an

7 NBI endoscopy may represent a significant improvement ov

8 NBI with ME was the ideal screening tool (sensitivity, s

9 NBI-12i is a recently developed small molecule MC4-R ant

10 NBI-27914 (100 microg/rat) injected peripherally did not

11 NBI-35965 (10 mg/kg, iv) prevented the 2nd CRD- and ic C

12 NBI-5788-reactive T-cell lines generated from NBI-5788-t

13 NBI-ME surveillance of esophagus should be done in newly

14 p henyl)-6-methylpyrimidin-2,4-dione (R-13b, NBI 42902) displayed subnanomolar binding affinity (K(i)

15 onpeptide antagonists antalarmin, NBI 27914, NBI 35965, and DMP-696 only partially inhibited (125)I-a

16 ons at residues 16 and 19 (16Y-->A, 19C-->A; NBI-6024) was further characterized for its therapeutic

17 ults indicate that systemically administered NBI-80713 dose-dependently decreased heroin self-adminis

18 tween structure and CRF(1) binding affinity, NBI 35965 (12a) was identified as a high-affinity antago

19 developed and established the validity of an NBI classification system that can be used to diagnose c

20 o[2,3-d]pyrimidin-4-y l]amino-1-butanol, and NBI-27914 at doses (30 mg/kg, i.p.) that did not alter n

21 ed structure containing two basic groups and NBI-74330 [(R)-N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydr

22 that of mUcn 2, while the CRF(1) antagonist NBI-35965 had no effect.

23 enge and treatment with the CRFR1 antagonist NBI-27914 revealed a decreased respiratory exchange rati

24 vel water-soluble tricyclic CRF1 antagonist, NBI 35965 was developed that displayed a high affinity f

25 ceived DR infusions of the CRFr1 antagonist, NBI 35965, or CRF and were evaluated for stress responsi

26 The CRF receptor 1 (CRF-R1) antagonist, NBI-27914 (50-100 microg/rat) injected i.c.v., abolished

27 xamined the effects of a HCRT-R2 antagonist, NBI-80713, on heroin self-administration in rats allowed

28 he water-soluble CRF(1) receptor antagonist, NBI-35965.

29 n of the CRF1 receptor selective antagonist, NBI 35965.

30 R state, nonpeptide antagonists antalarmin, NBI 27914, NBI 35965, and DMP-696 only partially inhibit

31 lar masses of 210, 190, and 160 kD, and anti-NBI-1 and anti-NBI-2 specifically recognize 190-kD alpha

32 1A subunits recognized by anti-CNA3 and anti-NBI-2 are associated with syntaxin in a stable, SDS-resi

33 10, 190, and 160 kD, and anti-NBI-1 and anti-NBI-2 specifically recognize 190-kD alpha 1A polypeptide

34 CNA3) and for rabbit BI (anti-NBI-1 and anti-NBI-2) isoforms of alpha 1A.

35 rat rbA (anti-CNA3) and for rabbit BI (anti-NBI-1 and anti-NBI-2) isoforms of alpha 1A.

36 In rabbit brain, anti-NBI-1 or anti-NBI-2 specifically detect alpha 1A polypep

37 eal that calcium channels recognized by anti-NBI-2 are localized predominantly in dendrites and nerve

38 In rabbit brain, anti-NBI-1 or anti-NBI-2 specifically detect alpha 1A polypeptides with app

39 VIIC (Kd approximately 100 pM), whereas anti-NBI-2 immunoprecipitates two distinct affinity receptor

40 sponse to i.c.v. CRF and stress similarly as NBI-27914 injected i.c.v. at 100 microg/rat.

41 n community practice must be achieved before NBI-based optical biopsy methods can be used routinely t

42 gly electron-accepting naphthalene bisimide (NBI) derivative functionalized with a new environmentall

43 of the CRH receptor type 1 (CRFR(1)) blocker NBI 30775 directly into the brain prevented the stress-i

44 retreatment with the selective CRF1 blocker (NBI 27914) increased the latency and decreased the durat

45 duced visceral hyperalgesia was abolished by NBI 35965 (20 mg/kg, s.c.).

46 y standard white light endoscopy followed by NBI.

47 Higher grades of dysplasia were found by NBI in 12 patients (18%), compared with no cases (0%) in

48 The features seen only by NBI were compared between GERD patients and controls.

49 1h restraint stress were antagonized only by NBI-35965 while stimulation induced by mUcn 2 was equall

50 and reliability of histologic prediction by NBI-experienced colonoscopists; (2) development of a cla

51 ) validation of the classification system by NBI-trained gastroenterology fellows, using still images

52 -induced delayed gastric emptying while i.c. NBI-27914 (50 or 100 microg) had no effect.

53 recommendations informed by high-confidence NBI analysis of diminutive polyps and results from histo

54 g semifluorinated groups and the dendronized NBI with m = 1 and 2 self-organize into lamellar crystal

55 The dendronized NBI with m = 3 self-assembles into an unprecedentedly co

56 At the highest doses, NBI 35965 completely prevented [125I]sauvagine labeling

57 ated for Barrett's esophagus with dysplasia, NBI detected significantly more patients with dysplasia

58 For NBI, overall sensitivity was 91.0% (95% CI 88.6-93.0), s

59 BI-5788-reactive T-cell lines generated from NBI-5788-treated patients exhibited an increased frequen

60 secretion by APL-reactive T-cell lines from NBI-5788-treated MS patients was more frequently T-helpe

61 Furthermore, NBI-12i-treated uremic mice gained lean body mass, fat m

62 ed binding (by 13-40%) and accelerated [(3)H]NBI 35965 dissociation.

63 at the R state were demonstrated using [(3)H]NBI 35965: agonist peptides only partially inhibited bin

64 Narrow-band imaging (NBI) allows real-time histologic classification of color

65 analysis of polyps with narrow band imaging (NBI) by community-based gastroenterologists.

66 Narrow band imaging (NBI) endoscopy system enhances visualization of microvas

67 solution endoscopy with narrow band imaging (NBI) enhances the visualization of mucosal glandular and

68 Narrow band imaging (NBI) might highlight adenomas and lead to higher rates o

69 th white-light imaging, narrow-band imaging (NBI) with magnifying endoscopy (ME), and chromoendoscopy

70 he validity of a simple narrow-band imaging (NBI)-based classification system for differentiating hyp

71 wed spectrum endoscopy (narrow-band imaging [NBI], image-enhanced endoscopy [i-scan], and Fujinon int

72 stroenterologists without prior expertise in NBI were able to meet the negative predictive value and

73 ether endoscopists without prior training in NBI can achieve the following thresholds recommended by

74 e centers underwent standardized training in NBI interpretation.

75 dies using the nonselective IGFBP inhibitor, NBI-31772, generated a K(i) value of 47 nM.

76 ere compared to proteins (navy bean isolate (NBI) and 7S globulin) prepared using a wet process.

77 re the identification of a nonpeptide ligand NBI-31772, which displaces IGF-I from all six IGF-bindin

78 locked by intra-BLA treatment with NBI27914 (NBI), a CRF-sub-1 antagonist, but not Astressin 2B, a CR

79 Intraperitoneal administration of NBI-12i stimulated food intake and weight gain in uremic

80 esult does not exclude a possible benefit of NBI in reducing variation between endoscopists in detect

81 The higher doses of NBI 27914 blocked the behavioral seizures and prevented

82 The mean frequency of NBI-5788-responsive T cells (stimulation index > 3) in M

83 ary-adrenal axis responses to DR infusion of NBI 35965 and CRF, whereas females were minimally respon

84 Subcutaneous injections of NBI-6024 to NOD mice administered either before or after

85 inclusion when the diagnostic performance of NBI, i-scan, FICE, autofluorescence imaging, or CLE had

86 The protein profile of NBI and 7S globulin was found to be devoid of certain pr

87 This study assessed the utility of NBI in patients with gastroesophageal reflux disease (GE

88 luded 91 studies in our analysis: 56 were of NBI, ten of i-scan, 14 of FICE, 11 of CLE, and 11 of aut

89 d surveillance interval predictions based on NBI.

90 ia by people not experienced in endoscopy or NBI analysis (25 medical students, 19 gastroenterology f

91 ple sclerosis (MS) patients who had received NBI-5788, an altered peptide ligand (APL) designed from

92 We found that NBI-12i normalizes the expression of uncoupling protein,

93 The data show that NBI 35965 is a novel water-soluble selective CRF1 antago

94 Here we show that NBI-74330 is anchored in the transmembrane minor pocket

95 The NBI-containing semifluorinated groups and the dendronize

96 dron was attached to the imide groups of the NBI via one, two, and three (m = 1, 2, 3) methylenic uni

97 Amino acid analysis revealed that the NBI and 7S globulin had a lower content of sulfur-contai

98 Thus, NBI-31772 could serve as a valuable lead molecule for th

99 in the DR, where blunted female responses to NBI 35965 and CRF suggest unique stress modulation of th

100 yp predictions (74.3% high confidence) using NBI.

101 Valbenazine (NBI-98854) is a novel, highly selective vesicular monoam

102 the interobserver agreement for the various NBI findings was very good, the intraobserver agreement

103 he entire cohort in white light (67%) versus NBI (65%) (P = .61) or in the subset of 257 patients wit

104 colonoscopy withdrawal in white light versus NBI in 434 patients aged 50 years or older with intact c

105 We tested whether NBI-12i would also be effective in attenuating uremia-as

106 ctivity with MBP peptide 83-99 compared with NBI-5788-reactive lines from control MS patients.

107 The surface pit pattern was determined with NBI or FICE in all patients.

108 ratio of these mice that was normalized with NBI-27914.

109 -time optical biopsy analysis of polyps with NBI, only 25% of gastroenterologists assessed polyps wit

110 by CRF, were abolished by pretreatment with NBI 27914, consistent with their dependence on CRF1 acti

111 d, after biopsy of the lesions targeted with NBI.

112 s are prevented by pre-stress treatment with NBI but not Astressin 2B.