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1 Studies of thiol post-
activated NCS-Chrom binding to the DNA oligomers show that the dru
2 the DNA sugar-specific probe thiol-
activated NCS-Chrom, induced strand cleavage at T22.
3 A mutually induced-fit
between NCS-Chrom and the oligomer resulting in optimal stabiliz
4 sidues was also cleaved exclusively at C3
by NCS-Chrom, generating fragments having 5' phosphate ends
5 Neocarzinostatin
chromophore (
NCS-Chrom) induces highly efficient site-specific strand
6 Neocarzinostatin
chromophore (
NCS-Chrom) induces strong cleavage at a single site (C3)
7 isolated from anaerobic reactions
containing NCS-Chrom and a bulge duplex substrate made up of a 10-m
8 These studies establish the usefulness
of NCS-Chrom as a probe for single-base bulges in DNA.
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