ライフサイエンスコーパス: NCT

1 NCT and PS1 play important roles in binding amyloid beta

2 NCT and saline groups were treated 10 times for 1 day an

3 NCT at doses that normalize tNEPI may be useful in the t

4 NCT demonstrated antiviral activity against adenovirus i

5 NCT for LTBI reduces its effectiveness.

6 NCT reveals an elongation rate of ~10 amino acids per se

7 NCT-independent gamma-secretase activity can be detected

8 Rabbit study 1: 2.5%, 2.0%, 1.0% NCT, and cidofovir demonstrated significantly fewer posi

9 2, Ad5-infected eyes were treated with 1.0% NCT/0.1% ammonium chloride (NH4Cl), 0.1% NCT/1.0% NH4Cl,

10 Rabbit study 2: 1.0% NCT/0.1% NH4Cl, 0.1% NCT/1.0% NH4Cl, 0.1% NCT/0.1% NH4Cl

11 eyes were treated with 2.5%, 2.0%, and 1.0% NCT; 0.5% cidofovir; or saline.

12 que identifiers: NCT 00289822, NCT 00284713, NCT 00326989, NCT 00962364.

13 Unique identifiers: NCT 00289822, NCT 00284713, NCT 00326989, NCT 00962364.

14 s: NCT 00289822, NCT 00284713, NCT 00326989, NCT 00962364.

15 hyphase (0.7 [95% CI, 0.1 to 0.9]; P = .01), NCT amplitude (0.7 [95% CI, 0.1 to 0.9]; P = .01), and N

16 chloride (NH4Cl), 0.1% NCT/1.0% NH4Cl, 0.1% NCT/0.1% NH4Cl, and 0.5% cidofovir or saline.

17 0% NCT/0.1% NH4Cl, 0.1% NCT/1.0% NH4Cl, 0.1% NCT/0.1% NH4Cl, and cidofovir demonstrated significantly

18 .0% NCT/0.1% ammonium chloride (NH4Cl), 0.1% NCT/1.0% NH4Cl, 0.1% NCT/0.1% NH4Cl, and 0.5% cidofovir

19 Rabbit study 2: 1.0% NCT/0.1% NH4Cl, 0.1% NCT/1.0% NH4Cl, 0.1% NCT/0.1% NH4Cl, and cidofovir demon

20 s to conclude that, although the PS1, APH-1, NCT, and PEN-2 are essential for gamma-secretase activit

21 ll lines that stably overexpress PS1, APH-1, NCT, and PEN-2, PS1 fragment levels are elevated by up t

22 ma-secretase activity, we coexpressed APH-1, NCT, and PS1 together with a series of PEN-2 mutants, wh

23 ibuted to an adverse event [NCT-AE] and 1089 NCT attributed to reasons other than an adverse event [N

24 linicalTrial.gov Registration Dec 3, 2008: # NCT 00803907.

25 (3HP-DOT = 6.4% vs 9H-SAT = 5.9%; P = .23); NCT-O was higher among participants enrolled in 9H-SAT (

26 (22.6%) did not complete LTBI treatment (317 NCT attributed to an adverse event [NCT-AE] and 1089 NCT

27 T ranged from 33% (Ocuton S) to 66% and 59% (NCT and HAT, respectively).

28 acokinetic evaluation of selected analog 64 (NCT-501) is also highlighted.

29 We show that expression of a NCT-specific scFv clone, G9, in HEK293 cells decreased t

30 ular Ran GTPase, a critical factor of active NCT.

31 ence of axillary lymph node metastases after NCT.

32 is highly correlated with nodal status after NCT, and the risk for missing nodal metastases without a

33 ude (0.7 [95% CI, 0.1 to 0.9]; P = .01), and NCT midline estimating statistic of rhythm (0.9 [95% CI,

34 These findings suggest that APH-1 and NCT are necessary for stabilization of full-length PS1 a

35 APH-1 and NCT stabilize the PS1 holoprotein, whereas PEN-2 is crit

36 e that in cells coexpressing PS1, APH-1, and NCT, full-length PS1 accumulates to high levels and is f

37 in regulation of cellular RanGTP levels and NCT, RCC1 expression enables the proliferation of cells

38 In PS1(-/-)/PS2(-/-) and NCT(-/-) fibroblasts, gamma-secretase components that st

39 ylated and disulfide-bonded proteins such as NCT, we produced chimeras between human (hNCT) and Caeno

40 ves itself during its maturation and because NCT-E333A also shows defects in gamma-secretase complex

41 and indicating that the interactions between NCT with PS1 may be indirect or stabilized by the presen

42 duration who were evaluated on admission by NCT, PCT, and CTA, and underwent a follow-up CT/CTA or m

43 tients who receive neoadjuvant chemotherapy (NCT) have a tumor response, a small proportion experienc

44 f the breast after neoadjuvant chemotherapy (NCT) indicates pCR in the breast (hereinafter referred t

45 symbol, block design, and number connection [NCT-A and B]) and the inhibitory control test (ICT).

46 ing three different tonometers: non-contact (NCT), the ICare and Goldmann applanation (GAT).

47 sh that gamma-secretase complexes containing NCT-E333A are indeed deficient in intrinsic activity.

48 assembly, we generated nicastrin-deficient (NCT-/-) mice and derived fibroblasts from NCT-/- embryos

49 HG footprints for four cities (Berlin, Delhi NCT, Mexico City, and New York metropolitan area) applyi

50 5 mg/kg twice daily, n=7) (L-NCT), high-dose NCT (2 mg/kg twice daily, n=7) (H-NCT), L-NCT plus enala

51 Dogs were randomized to low-dose NCT (0.5 mg/kg twice daily, n=7) (L-NCT), high-dose NCT

52 Hourly awakening during NCT IOP measurements did not significantly change the me

53 ase, and 59 (3%) had PD at some point during NCT.

54 ntify predictors of tumor progression during NCT with the ultimate aim of identifying patients who mi

55 lls expressing PS1, APH-1, PEN-2, and either NCT-WT or NCT-ER.

56 ween human (hNCT) and Caenorhabditis elegans NCT (ceNCT).

57 that membranes from cells expressing NCT-ER, NCT-TGN, or NCT-WT contain identical levels of PS1 deriv

58 Two neuroradiologists evaluated NCT for hypodensity, PCT for infarct core and salvageabl

59 ent (317 NCT attributed to an adverse event [NCT-AE] and 1089 NCT attributed to reasons other than an

60 uted to reasons other than an adverse event [NCT-O]).

61 To validate this proposal, we expressed NCT that lacks the lid entirely, or a variety of NCT var

62 active gamma-secretase resides, we expressed NCT variants harboring either an endoplasmic reticulum (

63 In cells expressing NCT-ER and the other components, PS1 fragments hyperaccu

64 we show that membranes from cells expressing NCT-ER, NCT-TGN, or NCT-WT contain identical levels of P

65 D or NICD, respectively, in cells expressing NCT-ER.

66 A can function as a boron delivery agent for NCT.

67 ide exchange factor for Ran, is critical for NCT activity.

68 suggested a substrate binding mechanism for NCT, a bilobar structure that involved rotation of the t

69 t (NCT-/-) mice and derived fibroblasts from NCT-/- embryos.

70 trial registered with www.clinicaltrial.gov (NCT 00422747).

71 high-dose NCT (2 mg/kg twice daily, n=7) (H-NCT), L-NCT plus enalapril (10 mg twice daily, n=8) (L-N

72 ic volume and end-systolic volume, whereas H-NCT did not

73 and 39+/-17 pg/mL respectively), whereas HD-NCT reduced tNEPI to below normal levels (3+/-10 pg/mL).

74 Unique identifier: NCT 00351260.

75 Unique identifiers: NCT 00289822, NCT 00284713, NCT 00326989, NCT 00962364.

76 hereas it is reduced by approximately 50% in NCT+/- cells; the failure to generate Abeta peptides in

77 secretion of Abeta peptides is abolished in NCT-/- fibroblasts, whereas it is reduced by approximate

78 Moreover, APP trafficking analysis in NCT-/- fibroblasts revealed a significant delay in the r

79 bservation that a critical residue (E332) in NCT, which had been thought to be essential for gamma-se

80 s; the failure to generate Abeta peptides in NCT-/- cells is accompanied by destabilization of the pr

81 activity can be detected in two independent NCT-deficient mouse embryonic fibroblast lines and block

82 L-NCT alone and L-NCT+ENA reduced tNEPI toward normal (28+

83 L-NCT and L-NCT+ENA prevented progressive LV remodeling, a

84 low-dose NCT (0.5 mg/kg twice daily, n=7) (L-NCT), high-dose NCT (2 mg/kg twice daily, n=7) (H-NCT),

85 T plus enalapril (10 mg twice daily, n=8) (L-NCT+ENA), or placebo (PL, n=8).

86 L-NCT and L-NCT+ENA prevented progressive LV remodeling, as evidence

87 L-NCT alone and L-NCT+ENA reduced tNEPI toward normal (28+/-4 and 39+/-17

88 se NCT (2 mg/kg twice daily, n=7) (H-NCT), L-NCT plus enalapril (10 mg twice daily, n=8) (L-NCT+ENA),

89 The addition of ENA to L-NCT afforded a greater increase in LV systolic function.

90 ogs, LVEF decreased but was unchanged with L-NCT and increased with L-NCT+ENA.

91 In dogs with HF, therapy with L-NCT prevented progressive LV dysfunction and remodeling.

92 as unchanged with L-NCT and increased with L-NCT+ENA.

93 a-dependent nuclear import of 53BP1, a large NCT cargo.

94 e "open" and "closed" states of the lid-like NCT with respect to a hydrophilic loop 1 (HL1) on PS1, t

95 ntibody recognized fully glycosylated mature NCT in the active gamma-secretase complex on the cell su

96 a trans-Golgi network (TGN) targeting motif (NCT-TGN) along with PS1, APH-1, and PEN-2 and examined g

97 f therapy with the DBH inhibitor nepicastat (NCT) on the progression of left ventricular (LV) dysfunc

98 Nicastrin (NCT) is a crucial component of the gamma-secretase (GS)

99 Nicastrin (NCT) is a type I integral membrane protein that is one o

100 rior pharynx-defective 1 (APH-1), nicastrin (NCT), and presenilin enhancer 2 (PEN-2) is of significan

101 f the components of this complex, nicastrin (NCT), functions as a receptor for gamma-secretase substr

102 Here, we show that only a form of nicastrin (NCT) containing N-linked complex oligosaccharides is pre

103 ghly glycosylated, mature form of nicastrin (NCT), Aph-1, and Pen-2.

104 F), a mature glycosylated form of nicastrin (NCT), Aph-1, and Pen-2.

105 protease comprised of presenilin, nicastrin (NCT), anterior pharynx defective 1 and PEN-2.

106 complex, composed of presenilin, nicastrin (NCT), anterior pharynx-defective 1 (APH-1), and presenil

107 exes containing presenilins (PS), nicastrin (NCT), APH-1, and PEN-2 mediate the gamma-secretase cleav

108 , consisting of presenilins (PS), nicastrin (NCT), APH-1, and PEN-2, catalyzes the intramembranous pr

109 cretase complex--presenilin (PS), nicastrin (NCT), Pen2, and Aph1--are all thought to be essential fo

110 consisting of presenilins (PSs), nicastrin (NCT), APH-1, and PEN-2.

111 ase is composed of four subunits: nicastrin (NCT) in the extracellular (EC) domain, presenilin-1 (PS1

112 Recent studies indicate that nicastrin (NCT) and presenilins form functional components of a mul

113 The in vitro activity of NCT was evaluated by incubating different Ad serotypes w

114 s key signaling protease: the association of NCT with gamma-secretase is tightly regulated via glycos

115 Ad serotypes with several concentrations of NCT for 1 hour and determining the reduction in Ad titer

116 Further development of NCT as a topical antimicrobial is indicated.

117 th the PS holoprotein in complexes devoid of NCT and Aph-1.

118 y A5226A against the extracellular domain of NCT, generated by using a recombinant budded baculovirus

119 of NCT by associating with immature forms of NCT and, consequently, prevents its association with the

120 and TM domains, near the interlobe groove of NCT, emerges as an allo-targeting site that would impact

121 to be a pivot around which the two lobes of NCT rotate.

122 vealed that scFvG9 impairs the maturation of NCT by associating with immature forms of NCT and, conse

123 presenilin severely limits the maturation of NCT, yet combined overexpression of both proteins does n

124 Overexpression of NCT does not generate more of this mature protein, a phe

125 The proportion of NCT-AE was similar with both regimens (3HP-DOT = 6.4% vs

126 arguing instead that the Glu-333 residue of NCT predicted to participate in substrate recognition on

127 The role of NCT has been challenged recently by the observation that

128 vide further evidence supporting the role of NCT in substrate recognition.

129 sotropic network model, reveals two types of NCT motions, bending and twisting, with respect to PS1.

130 that lacks the lid entirely, or a variety of NCT variants that harbor mutations at highly conserved r

131 The sensitivity and versatility of NCT make it a powerful new tool for quantifying mRNA tra

132 One NCT was found to be consistently mutated in a panel of e

133 es from cells expressing NCT-ER, NCT-TGN, or NCT-WT contain identical levels of PS1 derivatives that

134 sing PS1, APH-1, PEN-2, and either NCT-WT or NCT-ER.

135 When performing NCT measurements in 1 eye and CLS measurements in the co

136 Pre-NCT T status, race, and ER status were independent predi

137 catalytic domain resides within PS proteins, NCT has been suggested to be critical for substrate reco

138 mammalian, and yeast cells suggest that PS, NCT, Aph-1, and Pen-2 are necessary and sufficient to re

139 nine hundred twenty-eight patients received NCT; 1,762 patients (91%) had some response, 107 (6%) ha

140 th stage I to III breast cancer who received NCT (anthracycline and/or taxane based).

141 y ill trauma patients cannot be recommended (NCT 01180894).

142 nges in the activity of the RanGTP-regulated NCT modulate the rate of the cell cycle and the efficien

143 an impact on the AL rate after EC resection (NCT 01927016).

144 or contain cysteine as the internal residue (NCT/S).

145 A randomised phase 3 trial of rigosertib (NCT 02562443) is underway in specific subgroups of patie

146 , this site is characterized by the sequence NCT, where the cysteine is thought to be involved in an

147 endoplasmic reticulum (ER) retention signal (NCT-ER) or a trans-Golgi network (TGN) targeting motif (

148 patients at risk for progression on standard NCT.

149 ynthetic antibodies that specifically target NCT and expressed them in the single-chain variable frag

150 ition of gamma-secretase, and that targeting NCT might be a novel therapeutic strategy against cancer

151 ofovir was significantly more effective than NCT in several outcome measures in both rabbit studies.

152 assembly, activity, and stability, and that NCT with the mutation of the proposed pivot rescues gamm

153 RNA knockdown experiments demonstrated that NCT-independent gamma-secretase activity requires the pr

154 Our data provide compelling evidence that NCT is a molecular target for the mechanism-based inhibi

155 Here, we report that NCT is dispensable for gamma-secretase activity.

156 The NCT and HAT seem to achieve a measurement closest to the

157 The NCT and saline groups were treated five times daily for

158 ometers: 0.2 mmHg (-3.8 to 4.3 mmHg) for the NCT to 2.7 mmHg (-4.1 to 9.6 mmHg) for the Ocuton S.

159 Among those in the NCT-AE group, being non-Hispanic and receiving 3HP-DOT,

160 Among those in the NCT-O group, receiving 9H-SAT, missing >/=1 early visit,

161 These findings indicate that the NCT lid is not an essential element necessary for gamma-

162 We also demonstrate that the NCT-E333A mutant is deficient in its binding to substrat

163 Thus, NCT acts to stabilize gamma-secretase but is not require

164 ify patients among exceptional responders to NCT with a low risk for axillary metastases when breast

165 riables are also associated with response to NCT, novel molecular predictors are needed to identify p

166 mic contour tonometer, noncontact tonometer (NCT), ocular response analyzer, Ocuton S, handheld appla

167 e this, we developed nascent chain tracking (NCT), a technique that uses multi-epitope tags and antib

168 off host cell nucleocytoplasmic trafficking (NCT) by inducing hyperphosphorylation of nuclear pore pr

169 ase-regulated nuclear-cytoplasmic transport (NCT).

170 Overall rates of noncompletion of treatment (NCT) for latent tuberculosis infection (LTBI) in the PRE

171 er, parallel treatment group clinical trial (NCT 00344643).

172 tive, parallel, randomized controlled trial (NCT 01428050), comparing lactated Ringers (LAR) (15 mL/k

173 m was found in 31 of 36 sessions (86%) using NCT and in all sessions (100%) using CLS.

174 of the fellow eye was measured hourly using NCT.

175 In vitro, NCT demonstrated concentration-dependent direct inactiva

176 The mechanism by which NCT associates with the gamma-secretase complex and regu

177 ective was to assess factors associated with NCT for LTBI among adult participants enrolled at US and

178 Factors associated with NCT, such as missing a clinic visit early during treatme

179 concomitant medication were associated with NCT-AE.

180 ing 9H-SAT, and smoking were associated with NCT-O.

181 hAPH-1 in the absence of PS, consistent with NCT and APH-1 forming a subcomplex prior to association

182 asurements in only 1 eye, and 1 session with NCT measurements in both eyes were performed.

183 Two sessions with NCT measurements in 1 eye and CLS measurements in the fe

184 R2+/TN (T1/T2 and N0/N1) cancer treated with NCT followed by standard breast and nodal surgery from J

185 cells in a manner indistinguishable from WT NCT.