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1 NCT and PS1 play important roles in binding amyloid beta
2 NCT and saline groups were treated 10 times for 1 day an
3 NCT at doses that normalize tNEPI may be useful in the t
4 NCT demonstrated antiviral activity against adenovirus i
5 NCT for LTBI reduces its effectiveness.
6 NCT reveals an elongation rate of ~10 amino acids per se
7 NCT-independent gamma-secretase activity can be detected
9 2, Ad5-infected eyes were treated with 1.0% NCT/0.1% ammonium chloride (NH4Cl), 0.1% NCT/1.0% NH4Cl,
15 hyphase (0.7 [95% CI, 0.1 to 0.9]; P = .01), NCT amplitude (0.7 [95% CI, 0.1 to 0.9]; P = .01), and N
17 0% NCT/0.1% NH4Cl, 0.1% NCT/1.0% NH4Cl, 0.1% NCT/0.1% NH4Cl, and cidofovir demonstrated significantly
18 .0% NCT/0.1% ammonium chloride (NH4Cl), 0.1% NCT/1.0% NH4Cl, 0.1% NCT/0.1% NH4Cl, and 0.5% cidofovir
19 Rabbit study 2: 1.0% NCT/0.1% NH4Cl, 0.1% NCT/1.0% NH4Cl, 0.1% NCT/0.1% NH4Cl, and cidofovir demon
20 s to conclude that, although the PS1, APH-1, NCT, and PEN-2 are essential for gamma-secretase activit
21 ll lines that stably overexpress PS1, APH-1, NCT, and PEN-2, PS1 fragment levels are elevated by up t
22 ma-secretase activity, we coexpressed APH-1, NCT, and PS1 together with a series of PEN-2 mutants, wh
23 ibuted to an adverse event [NCT-AE] and 1089 NCT attributed to reasons other than an adverse event [N
25 (3HP-DOT = 6.4% vs 9H-SAT = 5.9%; P = .23); NCT-O was higher among participants enrolled in 9H-SAT (
26 (22.6%) did not complete LTBI treatment (317 NCT attributed to an adverse event [NCT-AE] and 1089 NCT
32 is highly correlated with nodal status after NCT, and the risk for missing nodal metastases without a
33 ude (0.7 [95% CI, 0.1 to 0.9]; P = .01), and NCT midline estimating statistic of rhythm (0.9 [95% CI,
36 e that in cells coexpressing PS1, APH-1, and NCT, full-length PS1 accumulates to high levels and is f
37 in regulation of cellular RanGTP levels and NCT, RCC1 expression enables the proliferation of cells
39 ylated and disulfide-bonded proteins such as NCT, we produced chimeras between human (hNCT) and Caeno
40 ves itself during its maturation and because NCT-E333A also shows defects in gamma-secretase complex
41 and indicating that the interactions between NCT with PS1 may be indirect or stabilized by the presen
42 duration who were evaluated on admission by NCT, PCT, and CTA, and underwent a follow-up CT/CTA or m
43 tients who receive neoadjuvant chemotherapy (NCT) have a tumor response, a small proportion experienc
44 f the breast after neoadjuvant chemotherapy (NCT) indicates pCR in the breast (hereinafter referred t
45 symbol, block design, and number connection [NCT-A and B]) and the inhibitory control test (ICT).
47 sh that gamma-secretase complexes containing NCT-E333A are indeed deficient in intrinsic activity.
48 assembly, we generated nicastrin-deficient (NCT-/-) mice and derived fibroblasts from NCT-/- embryos
49 HG footprints for four cities (Berlin, Delhi NCT, Mexico City, and New York metropolitan area) applyi
50 5 mg/kg twice daily, n=7) (L-NCT), high-dose NCT (2 mg/kg twice daily, n=7) (H-NCT), L-NCT plus enala
54 ntify predictors of tumor progression during NCT with the ultimate aim of identifying patients who mi
57 that membranes from cells expressing NCT-ER, NCT-TGN, or NCT-WT contain identical levels of PS1 deriv
59 ent (317 NCT attributed to an adverse event [NCT-AE] and 1089 NCT attributed to reasons other than an
62 active gamma-secretase resides, we expressed NCT variants harboring either an endoplasmic reticulum (
64 we show that membranes from cells expressing NCT-ER, NCT-TGN, or NCT-WT contain identical levels of P
68 suggested a substrate binding mechanism for NCT, a bilobar structure that involved rotation of the t
71 high-dose NCT (2 mg/kg twice daily, n=7) (H-NCT), L-NCT plus enalapril (10 mg twice daily, n=8) (L-N
73 and 39+/-17 pg/mL respectively), whereas HD-NCT reduced tNEPI to below normal levels (3+/-10 pg/mL).
76 hereas it is reduced by approximately 50% in NCT+/- cells; the failure to generate Abeta peptides in
77 secretion of Abeta peptides is abolished in NCT-/- fibroblasts, whereas it is reduced by approximate
79 bservation that a critical residue (E332) in NCT, which had been thought to be essential for gamma-se
80 s; the failure to generate Abeta peptides in NCT-/- cells is accompanied by destabilization of the pr
81 activity can be detected in two independent NCT-deficient mouse embryonic fibroblast lines and block
84 low-dose NCT (0.5 mg/kg twice daily, n=7) (L-NCT), high-dose NCT (2 mg/kg twice daily, n=7) (H-NCT),
88 se NCT (2 mg/kg twice daily, n=7) (H-NCT), L-NCT plus enalapril (10 mg twice daily, n=8) (L-NCT+ENA),
94 e "open" and "closed" states of the lid-like NCT with respect to a hydrophilic loop 1 (HL1) on PS1, t
95 ntibody recognized fully glycosylated mature NCT in the active gamma-secretase complex on the cell su
96 a trans-Golgi network (TGN) targeting motif (NCT-TGN) along with PS1, APH-1, and PEN-2 and examined g
97 f therapy with the DBH inhibitor nepicastat (NCT) on the progression of left ventricular (LV) dysfunc
100 rior pharynx-defective 1 (APH-1), nicastrin (NCT), and presenilin enhancer 2 (PEN-2) is of significan
101 f the components of this complex, nicastrin (NCT), functions as a receptor for gamma-secretase substr
102 Here, we show that only a form of nicastrin (NCT) containing N-linked complex oligosaccharides is pre
106 complex, composed of presenilin, nicastrin (NCT), anterior pharynx-defective 1 (APH-1), and presenil
107 exes containing presenilins (PS), nicastrin (NCT), APH-1, and PEN-2 mediate the gamma-secretase cleav
108 , consisting of presenilins (PS), nicastrin (NCT), APH-1, and PEN-2, catalyzes the intramembranous pr
109 cretase complex--presenilin (PS), nicastrin (NCT), Pen2, and Aph1--are all thought to be essential fo
111 ase is composed of four subunits: nicastrin (NCT) in the extracellular (EC) domain, presenilin-1 (PS1
112 Recent studies indicate that nicastrin (NCT) and presenilins form functional components of a mul
114 s key signaling protease: the association of NCT with gamma-secretase is tightly regulated via glycos
115 Ad serotypes with several concentrations of NCT for 1 hour and determining the reduction in Ad titer
118 y A5226A against the extracellular domain of NCT, generated by using a recombinant budded baculovirus
119 of NCT by associating with immature forms of NCT and, consequently, prevents its association with the
120 and TM domains, near the interlobe groove of NCT, emerges as an allo-targeting site that would impact
122 vealed that scFvG9 impairs the maturation of NCT by associating with immature forms of NCT and, conse
123 presenilin severely limits the maturation of NCT, yet combined overexpression of both proteins does n
126 arguing instead that the Glu-333 residue of NCT predicted to participate in substrate recognition on
129 sotropic network model, reveals two types of NCT motions, bending and twisting, with respect to PS1.
130 that lacks the lid entirely, or a variety of NCT variants that harbor mutations at highly conserved r
133 es from cells expressing NCT-ER, NCT-TGN, or NCT-WT contain identical levels of PS1 derivatives that
137 catalytic domain resides within PS proteins, NCT has been suggested to be critical for substrate reco
138 mammalian, and yeast cells suggest that PS, NCT, Aph-1, and Pen-2 are necessary and sufficient to re
139 nine hundred twenty-eight patients received NCT; 1,762 patients (91%) had some response, 107 (6%) ha
142 nges in the activity of the RanGTP-regulated NCT modulate the rate of the cell cycle and the efficien
145 A randomised phase 3 trial of rigosertib (NCT 02562443) is underway in specific subgroups of patie
146 , this site is characterized by the sequence NCT, where the cysteine is thought to be involved in an
147 endoplasmic reticulum (ER) retention signal (NCT-ER) or a trans-Golgi network (TGN) targeting motif (
149 ynthetic antibodies that specifically target NCT and expressed them in the single-chain variable frag
150 ition of gamma-secretase, and that targeting NCT might be a novel therapeutic strategy against cancer
151 ofovir was significantly more effective than NCT in several outcome measures in both rabbit studies.
152 assembly, activity, and stability, and that NCT with the mutation of the proposed pivot rescues gamm
153 RNA knockdown experiments demonstrated that NCT-independent gamma-secretase activity requires the pr
154 Our data provide compelling evidence that NCT is a molecular target for the mechanism-based inhibi
158 ometers: 0.2 mmHg (-3.8 to 4.3 mmHg) for the NCT to 2.7 mmHg (-4.1 to 9.6 mmHg) for the Ocuton S.
164 ify patients among exceptional responders to NCT with a low risk for axillary metastases when breast
165 riables are also associated with response to NCT, novel molecular predictors are needed to identify p
166 mic contour tonometer, noncontact tonometer (NCT), ocular response analyzer, Ocuton S, handheld appla
167 e this, we developed nascent chain tracking (NCT), a technique that uses multi-epitope tags and antib
168 off host cell nucleocytoplasmic trafficking (NCT) by inducing hyperphosphorylation of nuclear pore pr
170 Overall rates of noncompletion of treatment (NCT) for latent tuberculosis infection (LTBI) in the PRE
172 tive, parallel, randomized controlled trial (NCT 01428050), comparing lactated Ringers (LAR) (15 mL/k
177 ective was to assess factors associated with NCT for LTBI among adult participants enrolled at US and
181 hAPH-1 in the absence of PS, consistent with NCT and APH-1 forming a subcomplex prior to association
184 R2+/TN (T1/T2 and N0/N1) cancer treated with NCT followed by standard breast and nodal surgery from J
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