ライフサイエンスコーパス: NEK1

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1 n otherwise identical fibroblasts expressing Nek1.

2 cribed sequences from this region identified Nek1, a NIMA (never in mitosis A)-related kinase as a ca

3 acterized the dynamic protein interactome of NEK1 after DNA damage challenge with cisplatin.

4 identification of heterozygous mutations in NEK1 and DYNC2H1 in an additional family.

5 Our data suggest that NEK1 and its interaction partners trigger the DNA damage

6 activation relies on the kinase activity of Nek1 and its interaction with ATR-ATRIP.

7 d ubiquitination and that the interaction of Nek1 and TAZ maintain PC2 at the level needed for proper

8 drome Majewski type to identify mutations in NEK1 as an underlying cause of this lethal osteochondrod

9 ated with ALS (MATR3, CHCHD10, TBK1, TUBA4A, NEK1, C21orf2, and CCNF), all of which were identified b

10 These data suggest that TAZ and Nek1 constitute a negative feedback loop linked through

11 Nek1 deficiency as well as expression of unphosphorylata

12 Finally, Nek1-deficient fibroblasts are much more sensitive to th

13 NEK1 encodes a serine/threonine kinase with proposed fun

14 Thus, as an ATR-associated kinase, Nek1, enhances the stability and activity of ATR-ATRIP b

15 activity is increased within 4 minutes, and Nek1 expression is up-regulated shortly thereafter and s

16 Upon DNA damage, cells lacking Nek1 failed to efficiently phosphorylate multiple ATR su

17 Furthermore, TAZ targets Nek1 for degradation.

18 Further analysis of the Nek1 gene from both kat/kat and kat(2J)/kat(2J) mutant a

19 NEK1 has been linked to several cellular functions, incl

20 Never-in-mitosis A-related kinase 1 (Nek1) has established roles in apoptosis and cell cycle

21 nctions of the NimA-related mammalian kinase Nek1 have not been demonstrated to date.

22 the structure of the kinase domain of human NEK1 in its apo- and ATP-mimetic inhibitor bound forms.

23 s identify a previously unsuspected role for Nek1 in the kidney and open a new avenue for studying cy

24 NEK1 is essential for the ionizing radiation DNA damage

25 induced by ionizing radiation (IR) and that Nek1 is important for cells to repair and recover from D

26 Here we show that Nek1 is involved early in the DNA damage response induce

27 Importantly, even in undamaged cells, Nek1 is required for maintaining the levels of ATRIP, th

28 (never in mitosis A)-related kinase family, Nek1, is critical for initiating the ATR response.

29 mary or transformed cells are exposed to IR, Nek1 kinase activity is increased within 4 minutes, and

30 Loss of Nek1 leads to underphosphorylation of TAZ, thereby promo

31 th p.Arg261His (10,589 samples analyzed) and NEK1 LOF variants (3,362 samples analyzed).

32 HR and rescues the HR defect associated with Nek1 loss.

33 These results suggest that Nek1 may function as a kinase early in the DNA damage re

34 ed community in the Netherlands identified a NEK1 p.Arg261His variant as a candidate risk factor.

35 report that the nimA-related protein kinase Nek1 phosphorylates TAZ at a site essential for the ubiq

36 hus, G2-specific phosphorylation of Rad54 by Nek1 promotes Rad51 chromatin removal during HR in G2 ph

37 e homozygous mutant animals suggest that the NEK1 protein participates in different signaling pathway

38 its kinase activity is highest, a portion of Nek1 redistributes in cells from cytoplasm to discrete n

39 We show that human Nek1 regulates homologous recombination (HR) by phosphor

40 In summary, Nek1 regulates Rad51 removal to orchestrate HR and repli

41 In total, we observed NEK1 risk variants in nearly 3% of ALS cases.

42 found that absence of functional full-length NEK1 severely reduces cilia number and alters ciliar mor

43 NEK1 shows pleiotropic functions and has been found to b

44 y of axonemal microtubules through targeting Nek1, the ciliary kinase, for proteolysis.

45 The ability of Nek1 to promote ATR activation relies on the kinase acti

46 at inhibiting the set of four kinases AURKB, NEK1, TTK, and WEE1 causes simulated HeLa cells to accum

47 t association between loss-of-function (LOF) NEK1 variants and FALS risk.

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