ライフサイエンスコーパス: NF-kappa-B

1 NF-kappa B binding activity in ventricular tissues was e

2 NF-kappa B is a family of transcription factors involved

3 NF-kappa B is a heterodimeric transcription activator co

4 NF-kappa B prevents cell death caused by tumor necrosis

5 NF-kappa B seems to play an important role in the develo

6 NF-kappa B was discovered because of its binding to the

7 th domain, TNF receptor-associated factor 2, NF-kappa B-inducing kinase, and IKK, but not that activa

8 e measured Ca(2+) responses by using Fura-2, NF-kappa B-binding activity by electromobility shift ass

9 proach was used to insert a single copy of a NF-kappa B-dependent EGFP reporter gene 5' of the X-link

10 The interleukin (IL)-8 promoter possesses a NF-kappa B-binding site with affinity to p50p65 and p65p

11 ession, SOCS-3 cDNA was cotransfected with a NF-kappa B (NF-kappaB) luciferase construct into culture

12 ed for induction of apoptosis could activate NF-kappa B but not IFN regulatory factor-3, yet the acti

13 that signals emanating from the TCR activate NF-kappa B during iNKT cell development and function.

14 e identity of upstream signals that activate NF-kappa B in this T cell subset remain unknown.

15 d the ability of HDAC inhibitors to activate NF-kappa B and dramatically sensitized NSCLC cells to ap

16 wild-type cells in their ability to activate NF-kappa B signaling in response to the following: human

17 of NF-kappa B is not sufficient to activate NF-kappa B-dependent transcription.

18 Rapidly activated NF kappa B pathways may facilitate prompt antigen recept

19 Activated NF-kappa B was detected predominantly in ER-negative vs.

20 avoid apoptosis, thus implicating activated NF-kappa B as a therapeutic target for distinctive subcl

21 ative tumors, suggesting a role of activated NF-kappa B in intercellular signaling between epithelial

22 results demonstrate association of activated NF-kappa B with a subgroup of human breast tumors and ar

23 To elucidate roles of activated NF-kappa B, we used an ER-negative and ErbB2-positive hu

24 aling pathways and PVQEET(559-564) activates NF-kappa B and p38 pathways in osteoclasts, whereas PVQE

25 from Ucp2-/- cells constitutively activates NF-kappa B, resulting in a "primed" state to both potent

26 ulate skin appendage formation by activating NF-kappa B- and JNK- promoted transcription.

27 VQEQG(604-609) is only capable of activating NF-kappa B pathway.

28 eased nuclear p65, a component of the active NF-kappa B complex, in cytokeratin 19 (CK19)-positive ep

29 B subunits to the nucleus without affecting NF kappa B release from its cytosolic inhibitory sub-uni

30 cally induced apoptosis in T-98G cells after NF-kappa B inhibition.

31 to TNF-alpha-induced cell death, even after NF-kappa B activation is specifically blocked.

32 t to TNF-alpha-induced apoptosis, even after NF-kappa B activation was specifically blocked.

33 l lines have constitutive active alternative NF-kappa B pathway and demonstrate high-level expression

34 d proliferation of PEL cells and alternative NF-kappa B pathway plays a key role in this process.

35 e mechanism of activation of the alternative NF-kappa B pathway in PEL cells, we have investigated th

36 Therapeutic agents targeting the alternative NF-kappa B pathway may have a role in the treatment of K

37 tely 2 times greater expression of IL12B, an NF kappa B-dependent gene.

38 BAY11 effects were similar to those of an NF-kappa B inhibitor, Delta N-I kappa B alpha, in effect

39 onucleotide microarrays and parthenolide, an NF-kappa B-specific inhibitor, to identify the NF-kappa

40 form of mitogen-activated protein kinase and NF kappa B and also increased reactive oxygen species le

41 Soon after infection, AP-1 and NF-kappa B DNA binding activity was increased.

42 its the transcriptional activity of AP-1 and NF-kappa B transcription factors, respectively, both of

43 ot OipA, was involved in activating AP-1 and NF-kappa B.

44 Downmodulation of the ERK1/2 and NF-kappa B pathways inhibits the transcriptional activit

45 ated RIP3 in the regulation of apoptosis and NF-kappa B signaling, but whether RIP3 promotes or atten

46 d cytokine-induced I kappa B degradation and NF-kappa B transcriptional activity in RPE cells and T-9

47 he regulatory cross-talk between the JNK and NF-kappa B pathways appears to be broadly conserved.

48 -1/extracellular signal-regulated kinase and NF-kappa B signaling pathways.

49 induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an

50 ad no effect on TPA-induced NAG-1 levels and NF-kappa B transcriptional activity.

51 n scurfy-derived T cells lowers the NFAT and NF-kappa B transcriptional activity to the physiological

52 y of two key transcription factors, NFAT and NF-kappa B, which are essential for cytokine gene expres

53 clear factor of activated T cells (NFAT) and NF-kappa B transcriptional activity compared with the T

54 en identified by EMSA, including octamer and NF-kappa B family members, and Pax5.

55 de had no effect on both A beta peptides and NF-kappa B.

56 beta/IKK2, receptor-interacting protein, and NF-kappa B-inducing kinase are dispensable for this proc

57 negative regulatory loop involving PTEN and NF-kappa B.

58 t I kappa B-alpha homeostatic regulation and NF-kappa B activity at later time points is perturbed.

59 regions contain functional kappa B sites and NF-kappa B can directly modulate ntl expression.

60 obilization, Ca(2+) influx, trypsinogen, and NF-kappa B activation were all diminished in pancreatic

61 at typical outcomes of BCR signaling such as NF-kappa B activation and cell cycle progression occurre

62 nd concentration-dependent manner as well as NF-kappa B binding/transcriptional activity in LNCaP cel

63 rs197273 near TRAF family member-associated NF-kappa-B activator (TANK) (2p24.2), and rs10163409 in

64 n-2 production, and activation of the NF-AT, NF-kappa B, and AP-1 transcription factors.

65 r IL-8 secretion or nuclear factor- kappa B (NF-kappa B) activation on IL-8 induction by dengue 2 vir

66 ta function involves nuclear factor kappa B (NF-kappa B) activation, these data suggest that this inc

67 ranscription factors nuclear factor kappa B (NF-kappa B) and activator protein-1 (AP-1).

68 PH activates nuclear factor kappa B (NF-kappa B) and Stat3, whereas TCPOBOP is a ligand for t

69 transcription factor nuclear factor-kappa B (NF-kappa B) has a crucial role in osteoclast differentia

70 Nuclear factor kappa B (NF-kappa B) is a transcription factor implicated in the

71 eceptor activator of nuclear factor-kappa B (NF-kappa B) ligand (RANKL) as shown by the use of TWEAK-

72 oligonucleotide for nuclear factor kappa B (NF-kappa B) p65 was given prophylactically or therapeuti

73 yD88 to activate the nuclear factor kappa B (NF-kappa B) pathway, a critical regulator of many proinf

74 Phosphorylation of nuclear factor-kappa B (NF-kappa B) subunits emerges as a mechanism by which tra

75 (RelA) component of nuclear factor-kappa B (NF-kappa B) to the endogenous E-selectin promoter after

76 examine the links of nuclear factor-kappa B (NF-kappa B) to treatment-induced signaling in breast can

77 transcription factor nuclear factor kappa B (NF-kappa B), abnormal Ca(2+) responses, and trypsinogen

78 Because NF-kappa B plays a major role in regulation of apoptosis

79 Besides NF-kappa B, celecoxib also suppressed TNF-induced JNK, p

80 shed the capacity of the inhibitors to block NF-kappa B DNA binding in 293 cells.

81 (mI kappa B alpha M), which is able to block NF-kappa B in zebra fish cells, interferes with the noto

82 Although blocking NF-kappa B had no influence on the ability of TNF alpha

83 in osteoclast differentiation, and blocking NF-kappa B is a potential strategy for preventing inflam

84 nstitutive activation of AKT as well as both NF kappa B- and beta-catenin-dependent transcription.

85 actor alpha (TNFalpha), which activates both NF-kappa B and AP-1, increased MAT2A expression in a dos

86 - and time-dependent manner, binding of both NF-kappa B and AP-1 to the MAT2A promoter and MAT2A prom

87 suppression is critical for antiapoptosis by NF-kappa B.

88 underlying suppression of PTEN expression by NF-kappa B was independent of p65 DNA binding or transcr

89 vival Bcl-2 homologue Bfl-1/A1 is induced by NF-kappa B-activating stimuli, while B and T cells from

90 s activation of protective genes mediated by NF-kappa B transcription factors; however, its basis rem

91 A and are, presumably, directly regulated by NF-kappa B, except, curiously, the cornification markers

92 The COX-2 promoter, which is regulated by NF-kappa B, was also inhibited by celecoxib, and this in

93 protein levels of PTEN are down-regulated by NF-kappa B.

94 ges with age which appear to be regulated by NF-kappa-B.

95 light polypeptide gene enhancer in B-cells (NF-kappa B) leading to transcriptional reactivation of v

96 onal control of NF-kappa B cis elements (cis-NF-kappa B(EGFP)).

97 cytes, and dendritic cells isolated from cis-NF-kappa B(EGFP) mice demonstrated a strong induction of

98 induced EGFP expression in the liver of cis-NF-kappa B(EGFP) mice.

99 In summary, the cis-NF-kappa B(EGFP) mouse will serve as a valuable tool to

100 nalysis demonstrated RelA binding to the cis-NF-kappa B(EGFP) promoter.

101 PTEN strongly inhibits both the constitutive NF kappa B- and beta-catenin-dependent promoter and endo

102 b suppressed both inducible and constitutive NF-kappa B without cell type specificity.

103 apoptosis is via inhibition of constitutive NF-kappa B activity and Bcl-(xL) expression.

104 DETANONOate inhibited the constitutive NF-kappa B activity as assessed by EMSA.

105 By contrast, NF-kappa B activation was inhibited in p110 gamma(-/-) a

106 e proposal is that mutations cause deficient NF-kappa B-dependent T helper type 1 (T(H)1) responses a

107 EMSA analysis demonstrated NF-kappa B binding activity significantly increased in c

108 pression increased to high levels to disrupt NF-kappa B signaling.

109 We have found that the Drosophila NF-kappa B protein Relish plays a crucial role in limiti

110 cornification proteins belong to the "early" NF-kappa B-dependent group, and antigen presentation pro

111 g, we identified cFLIP/CFLAR as an essential NF-kappa B-dependent antiapoptotic gene.

112 tly increased the number of cells expressing NF-kappa B-dependent beta-galactosidase in the magnocell

113 t of the growth-related transcription factor NF-kappa B and cyclin D1 activities that are partly depe

114 anced activation of the transcription factor NF-kappa B in aged cells.

115 ctive activation of the transcription factor NF-kappa B, one proposal is that mutations cause deficie

116 harbours an ROH to which the nuclear factor NF-kappa-B p105 subunit (NFKB1) maps (P = 0.002).

117 Biochemical assays indicate that zebra fish NF-kappa B proteins are able to bind consensus DNA-bindi

118 Although it is essential for NF-kappa B activation, emerging evidence has indicated t

119 Functional NF-kappa B activation was examined by luciferase reporte

120 In mice given NF-kappa B antisense prophylactically, 67% were fibrosis

121 V substitution resulted in 5.5 times greater NF kappa B transcriptional activity and approximately 2

122 Newly identified NF-kappa B-induced, LMP1-induced, and EBV-induced genes

123 Finally, IkB (NF-kappa-B inhibitor), a known substrate of beta-TrCP, w

124 Because the IKK-NF-kappa B module also negatively regulates JNK activati

125 The MAP kinases and the IKK-NF-kappa B molecules play important roles in the initiat

126 ly involved in innate and adaptive immunity, NF-kappa B plays an important role in vertebrate develop

127 transgenic CD4(+) T cells parallels impaired NF-kappa B activity and increased levels of GATA-3, whic

128 Our data implicate NF kappa B transcription factors in the BCR-mediated reg

129 mphoma cells leads sequentially to a drop in NF-kappa B and c-Myc, and induction of the p27(Kip1) cyc

130 prevented the TNF alpha-mediated increase in NF-kappa B binding.

131 itutively active PKCs induced an increase in NF-kappa B transcriptional activity and NAG-1 protein le

132 es through direct chromatin modifications in NF-kappa B target gene promoters.

133 F-kappa B and hence plays a critical role in NF-kappa B activation.

134 of various transcription factors, including NF kappa B, AP1, CRE, and NFAT.

135 IP-1 gamma or RANKL, both of which increased NF-kappa B activation in osteoclasts.

136 Ras can induce NF-kappa B via both the phosphatidylinositol 3-kinase (P

137 onstitutively activated Akt failed to induce NF-kappa B luciferase activity.

138 The sufficiency of PKC delta to induce NF-kappa B nuclear translocation and binding to DNA was

139 ubstance P to enhance B. burgdorferi-induced NF-kappa B activation, as demonstrated by increased nucl

140 Levels of basal and stimulation-induced NF-kappa B activity were significantly decreased in mice

141 s required for T cell receptor (TCR)-induced NF-kappa B activation in T cell leukemia lines.

142 ctivation, which is required for TNF-induced NF-kappa B activation, was also suppressed by this drug.

143 ed apoptosis and contributed to TRIF-induced NF-kappa B activation.

144 NF kappa B inhibitor PTD-p65 peptide inhibit NF kappa B activation and TNF alpha potentiation of glut

145 nhibit IKK activity and consequently inhibit NF-kappa B-dependent antiapoptotic gene induction.

146 horylation inhibitor, Bay 11-7082, inhibited NF-kappa B activation, as well as PGE(2) production, COX

147 Restoration of PTEN expression inhibited NF-kappa B transcriptional activity and augmented TNF-in

148 BAY11 rapidly and irreversibly inhibited NF-kappa B, decreased mitochondrial membrane potential,

149 rceptin, the anti-ErbB2 antibody, inhibited, NF-kappa B activation in SKBr3 cells.

150 alizes to the mammalian nucleus and inhibits NF-kappa B-dependent gene expression.

151 our results indicate that celecoxib inhibits NF-kappa B activation through inhibition of IKK and Akt

152 PFQEP(369-373) initiates NF-kappa B, c-Jun N-terminal kinase, extracellular signa

153 iption factors, such as Cubitus interruptus, NF-kappa B and sterol regulatory element binding protein

154 iation with Raf-1 and nuclear factor kappaB (NF-kappa B)-inducing kinase (NIK), RKIP negatively regul

155 gamma interaction and relieves heat-mediated NF-kappa B suppression.

156 tion, we postulated that celecoxib modulates NF-kappa B.

157 RNAi-mediated knockdown of NEMO (NF-kappa-B essential modulator), a key component of NFka

158 MAS2 encodes the putative ortholog of NKAP (NF-kappa B activating protein), a conserved eukaryotic p

159 NA-processing, and metabolic enzymes are not NF-kappa B-dependent.

160 Identifying novel NF-kappa B-regulated immune genes in the human genome is

161 In contrast, nuclear NF-kappa B was detected mostly in stroma of ER-negative

162 by which transcriptional activity of nuclear NF-kappa B complexes is regulated in an inhibitor kappa

163 the inappropriate constitutive activation of NF kappa B and beta-catenin in CRC cell lines.

164 The constitutive activation of NF kappa B- and beta-catenin-dependent transcription is

165 factor family cytokine receptor activator of NF kappa B ligand.

166 mpartment-associated Bcl-2 prevents entry of NF kappa B subunits to the nucleus without affecting NF

167 oduction reflected differential induction of NF kappa B and STAT6 by the two stimuli (both are in the

168 The inhibition of NF kappa B is not observed in oncogenic Raf-expressing c

169 es and also blocked nuclear translocation of NF kappa B subunit p65.

170 Although the transactivation ability of NF-kappa B has been extensively studied in vitro, limite

171 In mice, the complete absence of NF-kappa B activity leads to prenatal death and neural t

172 K), blocked heregulin-mediated activation of NF-kappa B and cell proliferation, and simultaneously in

173 the effect of this drug on the activation of NF-kappa B by a wide variety of agents.

174 N regulatory factor-3, yet the activation of NF-kappa B could be blocked by superrepressor I kappa B

175 he cell-specific and real-time activation of NF-kappa B during normal and diseased states.

176 R2 and especially TLR4 for the activation of NF-kappa B p65 by human monocytes.

177 ulates IL-8 production through activation of NF-kappa B, as mediated by TLR2 and MyD88.

178 ed Toll-like receptor 2-driven activation of NF-kappa B, particularly of the NF-kappa B subunit c-Rel

179 Toll-like receptor 2-mediated activation of NF-kappa B-c-Rel, and T(H)1 responses were enhanced.

180 ependent pathway involving the activation of NF-kappa B.

181 ligand (RANKL) and its receptor activator of NF-kappa B (RANK) play pivotal roles in osteoclast diffe

182 Receptor activator of NF-kappa B ligand (RANKL) and its receptor activator of

183 The receptor activator of NF-kappa B ligand (RANKL), osteoprotegerin (OPG), and mo

184 kine family member, on receptor activator of NF-kappa B ligand (RANKL)-stimulated osteoclast differen

185 depends to a large extent on the activity of NF-kappa B transcription factors, play important roles i

186 ired for maximal transcriptional activity of NF-kappa B.

187 A matched-pair analysis of NF-kappa B expression was performed in cases with vascul

188 Assessment of NF-kappa B activity demonstrated that MPL utilized TLR2

189 itation assay was used to confirm binding of NF-kappa B subunits to IL-8 and MCP-1 promoters in vivo.

190 ould be counteracted by specific blockade of NF-kappa B.

191 e report the cloning and characterization of NF-kappa B/I kappa B proteins in zebra fish.

192 trates the conservation and compatibility of NF-kappa B/I kappa B proteins among vertebrates and the

193 (EGFP) under the transcriptional control of NF-kappa B cis elements (cis-NF-kappa B(EGFP)).

194 Adenoviral delivery of NF-kappa B-inducing kinase strongly induced EGFP express

195 ment, suggesting that ntl lies downstream of NF-kappa B .

196 The expression of NF-kappa B p65 induced NAG-1 promoter activity, and chro

197 To understand the function of NF-kappa B in TRAIL-induced apoptosis, we have analyzed

198 an outstanding position in the hierarchy of NF-kappa B proteins.

199 eins among vertebrates and the importance of NF-kappa B pathway in mesoderm formation during early em

200 embryonal carcinoma cells by inactivation of NF-kappa B.

201 Importantly, TNF, a potent inducer of NF-kappa B activity, suppressed PTEN gene expression in

202 Therefore, selective inhibition of NF-kappa B activation offers an effective therapeutic ap

203 Inhibition of NF-kappa B activity by the chemical inhibitor Bay 11-708

204 her, these studies reveal that inhibition of NF-kappa B activity in T and NK cells results in defecti

205 udies have shown that targeted inhibition of NF-kappa B can sensitize tumor cells to chemotherapy and

206 Inhibition of NF-kappa B resulted in downregulation of Bcl-(xL) expres

207 these results suggest that the inhibition of NF-kappa B signaling can suppress tumorigenesis of pancr

208 ogeny has been rescued despite inhibition of NF-kappa B signaling, we demonstrate that iNKT cell func

209 ed by DETANONOate resulting in inhibition of NF-kappa B.

210 to block phosphorylation of the inhibitor of NF-kappa B (I kappa B alpha).

211 rine-induced phosphorylation of inhibitor of NF-kappa B alpha (I kappa B alpha) and NF-kappaB nuclear

212 ling leads to activation of the inhibitor of NF-kappa B kinase (IKK) complex via Carma1, Bcl10 and MA

213 f PI3K/Akt signaling decreased the levels of NF-kappa B and c-Myc, which has been shown to repress p2

214 te the kinetics and cellular localization of NF-kappa B-induced transcription, we created a transgeni

215 e differences indicate that the mechanism of NF-kappa B regulation by PI3K gamma differs from those f

216 an exclude RIP3 as an essential modulator of NF-kappa B signaling downstream of several receptor syst

217 ficant correlation between overexpression of NF-kappa B-p65 and the development of vascular factors.

218 The regulation of NF-kappa B and Bcl-(xL) by DETANONOate was corroborated

219 h is under the transcriptional regulation of NF-kappa B.

220 ose further studies to elucidate the role of NF-kappa B in breast cancer response to chemotherapy and

221 However, the precise role of NF-kappa B in iNKT cell function and the identity of ups

222 The role of NF-kappa B in LMP1 and overall EBV latency III transcrip

223 of stimulation with TNFalpha and the role of NF-kappa B in regulating this response, a 23k human cDNA

224 osis, we have analyzed the specific roles of NF-kappa B subunits.

225 the main transactivator, the p65 subunit of NF-kappa B has an outstanding position in the hierarchy

226 ar localization of the p65 (RelA) subunit of NF-kappa B in these cells.

227 eurons immunoreactive for the p65 subunit of NF-kappa B was previously localized within the caudal do

228 r(536) phosphorylation of the p65 subunit of NF-kappa B, an event required for maximal transcriptiona

229 SC-514 inhibits transcription of NF-kappa B-dependent genes in IL-1 beta-induced rheumato

230 a B proteins allows nuclear translocation of NF-kappa B and hence plays a critical role in NF-kappa B

231 bacteria induced the rapid translocation of NF-kappa B and the production of a variety of proinflamm

232 indicated that the nuclear translocation of NF-kappa B is not sufficient to activate NF-kappa B-depe

233 kappa B kinase and nuclear translocation of NF-kappa B subunits, are all remarkably enhanced in Ucp2

234 ade did not inhibit nuclear translocation of NF-kappa B, but did prevent Ser(536) phosphorylation of

235 tion as well as the nuclear translocation of NF-kappa B.

236 of BLT1 deficiency in receptor activator of NF-kappa-B ligand-induced activation of intracellular ca

237 scription is independent of their effects on NF kappa B.

238 at this enhancement of IRF-7 is dependent on NF-kappa B activation.

239 kappa B2 protein p100, which is dependent on NF-kappa B-inducing kinase (NIK) and IKK alpha.

240 of all TNF alpha-regulated genes depends on NF-kappa B; 17% are regulated early (1-4 h post-treatmen

241 signaling through TLR4 via their effects on NF-kappa B activation.

242 sis that certain breast cancer cells rely on NF-kappa B for aberrant cell proliferation and simultane

243 o activate either IFN regulatory factor-3 or NF-kappa B but was dependent on the presence of an intac

244 he phosphoinositide 3-kinase/Akt pathway, or NF-kappa B itself blocked the ability of HDAC inhibitors

245 Engagement of both receptors promotes NF-kappa B activity, which contributes to B-cell surviva

246 vivo and that it is correlated with reduced NF-kappa B activation.

247 to I kappa B alpha and negatively regulates NF kappa B transcriptional activity.

248 B kinase (IKK) pathway positively regulates NF kappa B and beta-catenin, both important transcriptio

249 iNKT lymphocyte ontogeny absolutely requires NF-kappa B signaling.

250 demonstrate that iNKT cell function requires NF-kappa B in a lymphocyte-intrinsic manner.

251 ) and that these proteins are able to rescue NF-kappa B activity in I kappa B alpha(-/-) MEFs.

252 e chemoattractant protein (MCP)-1 promoter's NF-kappa B-binding site has exclusive affinity to p50p65

253 In skin, NF-kappa B is implicated in epidermal homeostasis as wel

254 inding activity by treatment with a specific NF-kappa B inhibitor, MG-132, inhibited cell migration d

255 was conducted to determine whether specific NF-kappa B blockade by mutant inhibitory (I)-kappa B (I

256 The peptide inhibited RANKL-stimulated NF-kappa B activation and osteoclastogenesis both in vit

257 We studied NF-kappa B activation in human breast tumors and in carc

258 We found that celecoxib suppressed NF-kappa B activation induced by various carcinogens, in

259 on experiments, the CARD6 protein suppressed NF-kappa B induction by Nod1 or Cardiak but did not inte

260 IEP-binding transcription factors other than NF-kappa B.

261 Thus, we conclude that NF-kappa B signaling plays a crucial role at distinct le

262 These findings indicated that NF-kappa B activation was necessary and sufficient for i

263 mmunoprecipitation assay for p65 showed that NF-kappa B binds the NAG-1 promoter in LNCaP cells.

264 These results suggest that NF-kappa B expressing cells within the lateral hypothala

265 al. in this issue of Immunity suggests that NF-kappa B regulates Ig kappa rearrangement after all, b

266 idant butylated hydroxytoluene (BHT) and the NF kappa B inhibitor PTD-p65 peptide inhibit NF kappa B

267 The NF-kappa B essential modulator (NEMO)-binding domain (NB

268 The NF-kappa B inhibitors MG132 and pyrrolidinedithiocarbama

269 Celecoxib abrogated the NF-kappa B-dependent reporter gene expression activated

270 , TWEAK binding to Fn14/TweakR activated the NF-kappa B and c-Jun N-terminal kinase pathways but indu

271 signal-regulated kinase1/2 (ERK1/2) and the NF-kappa B pathways, respectively.

272 ti-CD3, or TNF-alpha that was blocked by the NF-kappa B inhibitors BAY 11-7082 and NEMO-binding pepti

273 ression of the NK-1R gene is mediated by the NF-kappa B transcription factor.

274 lytic event could be actively induced by the NF-kappa B-inducing kinase and the human T-cell leukemia

275 -kappa B-specific inhibitor, to identify the NF-kappa B-dependent set of the TNF alpha-regulated gene

276 beta(-/-) cells, which are deficient in the NF-kappa B activation pathway.

277 clusive affinity to p50p65 and to mutate the NF-kappa B binding motif in the wild-type MCP-1 reporter

278 f wild-type promoters was used to mutate the NF-kappa B-binding motif in the wild-type IL-8 reporter

279 blocked by site-directed mutagenesis of the NF-kappa B and AP-1 binding sites.

280 IP3 promotes or attenuates activation of the NF-kappa B family of transcription factors has been cont

281 In chicks, the inactivation of the NF-kappa B pathway induces functional alterations of the

282 uld be rescued by specific inhibition of the NF-kappa B pathway with I kappa B overexpression as well

283 is a required step in the activation of the NF-kappa B signaling pathway and the subsequent expressi

284 domethacin by blocking the activation of the NF-kappa B significantly reduces the amyloid pathology i

285 ctivation of NF-kappa B, particularly of the NF-kappa B subunit c-Rel.

286 Inhibition of the NF-kappa B, c-jun N-terminal kinase, p38 MAPK, and phosp

287 n, apoptosis, and differentiation are on the NF-kappa B pathway, and cell cycle, metabolism, and RNA

288 ch may represent a mechanism to regulate the NF-kappa B transcription activity by LPS.

289 esis of pancreatic cancer cells and that the NF-kappa B signaling pathway is a potential target for a

290 dhesion molecule type 1 (ICAM-1) through the NF-kappa B and c-Jun N-terminal kinase pathways.

291 ri, HEK293 cells were cotransfected with the NF-kappa B-Luc reporter, CD14 and MD2 expression plasmid

292 ously expressed among the embryonic tissues, NF-kappa B/I kappa B members present distinct patterns o

293 tion from proinflammatory stimuli leading to NF-kappa B-dependent gene expression is mediated by the

294 component of signal transduction pathways to NF-kappa B.

295 ice deficient in MyD88 failed to translocate NF-kappa B and produced virtually no cytokines in respon

296 this study was to determine whether the two NF-kappa B sites play a role in the capacity of tumor ne

297 Whereas NF-kappa B-inducing kinase-mediated p100 processing requ

298 n factors; (b) Bcl-2 does not interfere with NF kappa B activation but prevents entrance of its activ

299 y Nod1 or Cardiak but did not interfere with NF-kappa B activation by the CARD-containing adapter pro

300 activity and cellular damage associated with NF-kappa-B and TNF signaling pathways.