ライフサイエンスコーパス: NF-kappaB-inducing kinase

1 associated with the upstream activator NIK (NF-kappaB-inducing kinase).

2 c mutation in the MAP3K14 gene encoding NIK (NF-kappaB-inducing kinase).

3 nd induce proteasome-mediated degradation of NF-kappaB inducing kinase.

4 sociated kinase, TNFR-associated factor, and NF-kappaB-inducing kinase.

5 -kappaB activation but were not dependent on NF-kappaB-inducing kinase.

6 nd prevents Monarch-1-induced proteolysis of NF-kappaB-inducing kinase.

7 inducing proteasome-mediated degradation of NF-kappaB-inducing kinase.

8 ty against IkappaBalpha or its activation by NF-kappaB-inducing kinase.

9 Finally, overexpression of NF-kappaB-inducing kinase, a kinase that has recently be

10 nant negative (DN) inhibitors DN-TRAF2 or DN-NF-kappaB-inducing kinase also abolished VP8*-, VP4-, or

11 duced NF-kappaB reporter activity induced by NF-kappaB inducing kinase and IkappaB alpha kinase but n

12 Recently components of this pathway, NF-kappaB-inducing kinase and IkappaB kinases, IKKalpha

13 esults suggest roles for the IkappaB kinases NF-kappaB-inducing kinase and mitogen-activated protein

14 cting protein (RIP), which in turn activates NF-kappaB-inducing kinase and phosphorylates IkappaB.

15 B kinase-alpha and several fold increases in NF-kappaB-inducing kinase and RelB, which were predomina

16 his transcription factor may be regulated by NF-kappaB-inducing kinase and/or IKKalpha.

17 ated kinase 1, receptor-interacting protein, NF-kappaB-inducing kinase, and IkappaB kinase beta was a

18 th domain protein, TNFR-associated factor-2, NF-kappaB-inducing kinase, and IkappaBalpha kinase but n

19 th domain, TNF receptor-associated factor-2, NF-kappaB-inducing kinase, and IkappaBalpha kinase, were

20 ated death domain, TNFR-associated factor 2, NF-kappaB-inducing kinase, and IkappaBalpha kinase.

21 th domain protein, TNFR-associated factor 2, NF-kappaB-inducing kinase, and IKK, but not that activat

22 ceptor-associated death domain, TRAF2, TAK1, NF-kappaB-inducing kinase, and IKKbeta was inhibited by

23 strate that receptor-interacting protein and NF-kappaB-inducing kinase are dispensable for vFLIP K13-

24 ion, including TRAF2, TRAF6, RIP, IRAK2, and NF-kappaB-inducing kinase as well as the IkappaB kinases

25 4-induced macrophage fusion were impaired in NF-kappaB-inducing kinase(-/-) BMM.

26 sion of TNFR1, TNFR-associated factor-2, and NF-kappaB-inducing kinase, but not that activated by the

27 ILF were present in the small intestine from NF-kappaB-inducing kinase-deficient alymphoplasia mice,

28 r-3 to the Toll-like receptor/MyD88 complex, NF-kappaB-inducing kinase-dependent IkappaB kinase-alpha

29 potentiated by TRIM28 knockdown in ECs in an NF-kappaB-inducing kinase-dependent manner.

30 HVEM enhances immune responses by NF-kappaB-inducing kinase-dependent Stat3 activation, wh

31 Furthermore, CTLA-4 induces IDO in cDCs in a NF-kappaB-inducing kinase-dependent way.

32 ding, and IL-8 secretion, whereas IKK1dn and NF-kappaB-inducing kinase dominant negative do not have

33 s by not requiring the presence of an intact NF-kappaB-inducing kinase gene.

34 Here we show that mice deficient in NF-kappaB-inducing kinase have a complex phenotype consi

35 ation, such as receptor-interacting protein, NF-kappaB-inducing kinase, IkappaB kinase (IKK) 1, IKK2,

36 mor necrosis factor receptor (TNFR)1, TNFR2, NF-kappaB-inducing kinase, IkappaB kinase complex (IKK),

37 Rituximab decreased the phosphorylation of NF-kappaB-inducing kinase, IkappaB kinase, and IkappaB-a

38 paB translocation-dependent pathway involves NF-kappaB-inducing kinase-IkappaB kinase beta/gamma-depe

39 th domain, TNF receptor-associated factor-2, NF-kappaB-inducing kinase, IkappaBalpha kinase, and p65

40 eath domain, TNF receptor-associated factor, NF-kappaB-inducing kinase, IkappaBalpha kinase, and p65.

41 ssion activated by TNF, TNFR1, TRADD, TRAF2, NF-kappaB-inducing kinase, IkappaBalpha kinase, and the

42 eath domain/TNF receptor-associated factor 2/NF-kappaB-inducing kinase/IkappaBalpha kinase was interr

43 n and TRAF2 plasmids; NF-kappaB activated by NF-kappaB-inducing kinase, IKK or p65, however, was mini

44 ponse to tumor necrosis factor (TNF) and the NF-kappaB-inducing kinase-IKKalpha signaling pathway.

45 omponents (Fas receptor-interacting protein, NF-kappaB-inducing kinase, IKKbeta) of the NF-kappaB act

46 d factor-6, TGF-beta-activated kinase-1, and NF-kappaB-inducing kinase in an IL-1-dependent manner, s

47 of TRAF3 results in profound accumulation of NF-kappaB-inducing kinase in TRAF3-/- cells.

48 atory importance of the survival kinase NIK (NF-kappaB-inducing kinase) in genetically engineered mur

49 sense RNA into 293 or HeLa cells blocks NIK (NF-kappaB-inducing kinase)-induced phosphorylation of th

50 ibitors or transfection of dominant negative NF-kappaB inducing kinase mutants.

51 horylation and subsequent degradation of the NF-kappaB-inducing kinase NIK.

52 d induce proteasomal-mediated degradation of NF-kappaB Inducing Kinase (NIK) and repress non-canonica

53 NF-kappaB inducing kinase (NIK) is a central component o

54 NF-kappaB inducing kinase (NIK) is required for osteocla

55 ing relB activation further, we found stable NF-kappaB inducing kinase (NIK) protein in several HL ce

56 non-canonical NF-kappaB via accumulation of NF-kappaB inducing kinase (NIK).

57 the absence of TRAF3 were all dependent upon NF-kappaB inducing kinase (NIK).

58 Nuclear factor-kappaB (NF-kappaB) inducing kinase (NIK) is a MAP3K that regulat

59 am signaling targets, nuclear factor-kappaB (NF-kappaB)-inducing kinase (NIK) and p65 nuclear factor

60 Nuclear factor kappaB (NF-kappaB)-inducing kinase (NIK) has been implicated as

61 Nuclear factor kappaB (NF-kappaB)-inducing kinase (NIK) participates in the act

62 e identified hepatic nuclear factor kappa B (NF-kappaB)-inducing kinase (NIK), a Ser/Thr kinase, as a

63 endent degradation of nuclear factor-kappaB (NF-kappaB)-inducing kinase (NIK), an action required for

64 lve TNFR-associated factor 2 (TRAF2) [7] and NF-kappaB-inducing kinase (NIK) [8].

65 ns in endothelial cells (ECs) by stabilizing NF-kappaB-inducing kinase (NIK) and activating noncanoni

66 cytokines requires the successive action of NF-kappaB-inducing kinase (NIK) and an IKB-kinase (IKK)

67 ue pathway by extracellular stimuli requires NF-kappaB-inducing kinase (NIK) and de novo protein synt

68 RP3 increased the levels of NF-kappaB-inducing kinase (NIK) and did not activate NF-

69 Transient overexpression of kinase-deficient NF-kappaB-inducing kinase (NIK) and IkappaB kinase (IKK)

70 cytokines requires the successive action of NF-kappaB-inducing kinase (NIK) and IkappaB kinase-alpha

71 the sequential activation of the downstream NF-kappaB-inducing kinase (NIK) and IkappaB-specific kin

72 eceptor- or CD40L-activated association with NF-kappaB-inducing kinase (NIK) and interleukin-1 recept

73 hysiological processing of p100 triggered by NF-kappaB-inducing kinase (NIK) and its downstream kinas

74 controlled event is regulated positively by NF-kappaB-inducing kinase (NIK) and its downstream kinas

75 NF-kappaB-inducing kinase (NIK) and mitogen-activated pr

76 as absent in alymphoplasia mice deficient in NF-kappaB-inducing kinase (NIK) and NIK knockout mice.

77 rmore, we show that the EGFR associates with NF-kappaB-inducing kinase (NIK) and provide evidence sug

78 ciated factor-1 (TRAF-1) that directly binds NF-kappaB-inducing kinase (NIK) and stabilizes it from d

79 This pathway involves NF-kappaB-inducing kinase (NIK) and the tumor necrosis f

80 on of receptor-interaction protein 1 (RIP1), NF-kappaB-inducing kinase (NIK) and themselves, and regu

81 ed in the noncanonical pathway downstream of NF-kappaB-inducing kinase (NIK) and TNF receptor family

82 cytokines involves the successive action of NF-kappaB-inducing kinase (NIK) and two IkappaB kinases,

83 Recent studies have identified the NF-kappaB-inducing kinase (NIK) as a key component of th

84 The NF-kappaB-inducing kinase (NIK) associates with TRAF2 an

85 LT) lymphoma induces proteolytic cleavage of NF-kappaB-inducing kinase (NIK) at arginine 325.

86 CTAR1-mediated EGFR induction required the NF-kappaB-inducing kinase (NIK) but not the IkappaB kina

87 NF-kappaB-inducing kinase (NIK) controls processing of p

88 the serine/threonine-specific protein kinase NF-kappaB-inducing kinase (NIK) develop a HES-like disea

89 armacological activation of the noncanonical NF-kappaB-inducing kinase (NIK) disrupts glucose homeost

90 A recent study reports that NF-kappaB-inducing kinase (NIK) expression in thymic str

91 paB) signaling in resting cells by targeting NF-kappaB-inducing kinase (NIK) for ubiquitin-dependent

92 NF-kappaB-inducing kinase (NIK) has been implicated as a

93 The role of NF-kappaB-inducing kinase (NIK) in cytokine signaling re

94 Although the role of NF-kappaB-inducing kinase (NIK) in immunity is well esta

95 en-activated protein kinase kinase kinase 14/NF-kappaB-inducing kinase (NIK) in the activation of NF-

96 The exact physiological role of NF-kappaB-inducing kinase (NIK) in the NF-kappaB activat

97 ble to synergistic effects on phosphorylated NF-kappaB-inducing kinase (NIK) in the non-canonical pat

98 a dominant negative mutant of IKKbeta or the NF-kappaB-inducing kinase (NIK) inhibited pIC-induced ge

99 n contrast, a kinase-deficient mutant of the NF-kappaB-inducing kinase (NIK) inhibits both CD3/CD28 a

100 Although NF-kappaB-inducing kinase (NIK) interacts with and activ

101 NF-kappaB-inducing kinase (NIK) is a central component i

102 NF-kappaB-inducing kinase (NIK) is a key trigger in the

103 NF-kappaB-inducing kinase (NIK) is a primary regulator o

104 NF-kappaB-inducing kinase (NIK) is an essential upstream

105 NF-kappaB-inducing kinase (NIK) is responsible for activ

106 However, most mutations affecting NF-kappaB-inducing kinase (NIK) levels (NIK, TRAF2, TRAF

107 -kappaB pathway, either by overexpression of NF-kappaB-inducing kinase (NIK) or by treatment with the

108 A small-molecule inhibitor of NF-kappaB-inducing kinase (NIK) protects liver from toxi

109 We have previously shown that NF-kappaB-inducing kinase (NIK) protein and its associat

110 oncanonical NF-kappaB pathway as measured by NF-kappaB-inducing kinase (NIK) protein levels and proce

111 We tested the hypothesis that NF-kappaB-inducing kinase (NIK) regulates COX-2 gene exp

112 Homozygosity for the aly point mutation in NF-kappaB-inducing kinase (NIK) results in alymphoplasia

113 1/I kappa B kinase alpha (IKK1/IKKalpha) and NF-kappaB-inducing kinase (NIK) to direct processing of

114 Here we show that NF-kappaB-inducing kinase (NIK), a central component of

115 receptor-associated factor 5 (TRAF5), TRAF6, NF-kappaB-inducing kinase (NIK), and IkappaB kinase (IKK

116 uced by TNFR1, TNFR-associated factor 2, and NF-kappaB-inducing kinase (NIK), but not that activated

117 ced the CGN-induced increases in KC, phospho-NF-kappaB-inducing kinase (NIK), cytoplasmic NF-kappaB p

118 olism or overexpression of dominant negative NF-kappaB-inducing kinase (NIK), IkappaB kinase (IKK), o

119 ppaBalpha degradation and depended on TRAF2, NF-kappaB-inducing kinase (NIK), IKK1, and IKK2.

120 mphoplasia (aly/aly) mice, which lack active NF-kappaB-inducing kinase (NIK), show mild osteopetrosis

121 re, we show that IKKalpha and its activator, NF-kappaB-inducing kinase (NIK), support the expansion o

122 deficient cells results from accumulation of NF-kappaB-inducing kinase (NIK), the essential kinase me

123 ent of the noncanonical NF-kappaB pathway is NF-kappaB-inducing kinase (NIK), which functions togethe

124 appaB pathway hinges on the stability of the NF-kappaB-inducing kinase (NIK), which is kept at low le

125 We show here that NF-kappaB-inducing kinase (NIK), which is known to regul

126 showed that RA ST contains ECs that express NF-kappaB-inducing kinase (NIK), which is pivotal in LTb

127 alternative or second pathway proceeded via NF-kappaB-inducing kinase (NIK)-, IKKalpha-, and protein

128 IKK-alpha was independently discovered as a NF-kappaB-inducing kinase (NIK)-associated protein in a

129 NF-kappaB-inducing kinase (NIK)-mediated IKKalpha phosph

130 nsulin resistance; however, the noncanonical NF-kappaB-inducing kinase (NIK)-NF-kappaB2 pathway is no

131 trigger p100 processing requires functional NF-kappaB-inducing kinase (NIK).

132 ion by upstream kinases, one of which may be NF-kappaB-inducing kinase (NIK).

133 within p100 and positively regulated by the NF-kappaB-inducing kinase (NIK).

134 arently distinct from that involving Cot and NF-kappaB-inducing kinase (NIK).

135 TNF receptor-associated factors (TRAFs) and NF-kappaB-inducing kinase (NIK).

136 diated NF-kappaB signaling also requires the NF-kappaB-inducing kinase (NIK).

137 (TNF) and interleukin-1 (IL-1) requires the NF-kappaB-inducing kinase (NIK).

138 on factors, p100 and RelB, by regulating the NF-kappaB-inducing kinase (NIK).

139 s is dependent on the presence of functional NF-kappaB-inducing kinase (NIK).

140 KKalpha), IkappaB kinase beta (IKKbeta), and NF-kappaB-inducing kinase (NIK).

141 ith TRADD, RIP, and TRAF2; activation of the NF-kappaB-inducing kinase (NIK); activation of the Ikapp

142 NF-kappaB-inducing kinase [(NIK), MAP3K14] is an essenti

143 activate NF-kappaB by acting upstream of the NF-kappaB-inducing kinase, NIK, and the IkB kinase, IKKa

144 Overexpression of a kinase-dead mutant of NF-kappaB-inducing kinase or IkappaB kinase-beta but not

145 of dominant negative mutants of either NIK (NF-kappaB-inducing kinase) or IKKbeta (IkappaB kinase be

146 g protein, TNF receptor-associated factor 2, NF-kappaB-inducing kinase, or MyD88, we hypothesized tha

147 been suggested through indirect studies that NF-kappaB-inducing kinase, or NIK, may be involved in No

148 rowth factor beta-activated kinase-1 (TAK1), NF-kappaB-inducing kinase, or phosphatidylinositol 3-kin

149 shown that NF-kappaB is activated through a NF-kappaB-inducing kinase/p21-activated kinase 1 pathway

150 inally, the Src/Rac1/MKK3/6/p38 and Src/TAK1/NF-kappaB-inducing kinase pathways exhibited cross-talk

151 gnaling via the serine/threonine kinase NIK (NF-kappaB-inducing kinase) remains unclear.

152 blocked TNF receptor-associated factor-2 and NF-kappaB-inducing kinase reporter gene expression, hCG

153 rimarily activates NF-kappaB through a TRAF2-NF-kappaB-inducing kinase signaling pathway and that VP4

154 at the TNF receptor-associated factor 2 and NF-kappaB-inducing kinase sites by oleandrin, thus suppr

155 kinases of the NF-kappaB activation pathway, NF-kappaB-inducing kinase, transforming growth factor be

156 TNFR1, TNF receptor-associated factor 2, and NF-kappaB-inducing kinase was also abrogated by IFN-alph

157 Activation of IKKalpha and NF-kappaB-inducing kinase was detected by d5.5, implicat

158 The NF-kappaB-inducing kinase was found to act downstream of

159 a, such as IkappaB kinase alpha and beta and NF-kappaB-inducing kinase, were also shown to interact w

160 IRAK, TNF receptor-associated factor 6, and NF-kappaB-inducing kinase, when coexpressed with TLR2, a

161 Similarly, a kinase-deficient mutant of NIK (NF-kappaB-inducing kinase), which represents an upstream

162 Moreover, deletion of the gene encoding NF-kappaB-inducing kinase, which is known to modulate IK