ライフサイエンスコーパス: NGF receptor

1 o effect on the density of the high-affinity NGF receptor.

2 ding is mediated by the p75 component of the NGF receptor.

3 te the expression of TrkA, the high-affinity NGF receptor.

4 in PC12nnr5 cells, which lack the p140(trk) NGF receptor.

5 ect cell expression of wild-type and mutated NGF receptors.

6 as a major mediator of signaling by FGF and NGF receptors.

7 al to SNT, the long-sought target of FGF and NGF receptors.

8 n NGF actions were reflected at the level of NGF receptors.

9 ffect of ethanol on the nerve growth factor (NGF) receptor.

10 Recent studies have suggested that NGF receptor activation may occur in caveolae or caveola

11 NGF receptor activation was assessed by western analysis

12 ion of phosphatidylinositol-3 kinase and the NGF receptor after tFCI.

13 elucidated inhibitory signaling link between NGF receptors and RhoA.

14 Since nerve growth factor (NGF) receptor and brain-derived neurotrophic factor rece

15 rane region of the TrkA nerve growth factor (NGF) receptor and has been implicated in NGF signaling.

16 y against the mouse p75 nerve growth factor (NGF) receptor (anti-murine-p75).

17 Low-affinity nerve growth factor (NGF) receptors are present on the cholinergic neurons of

18 y NT-3 receptor, and trkA, the high-affinity NGF receptor, are both expressed from the early OLP thro

19 12) were treated with K252a, a high-affinity NGF receptor blocker.

20 he MAP kinase cascade downstream of the TrkA NGF receptor but upstream or at the level of the B-Raf k

21 ED cells engineered to express the human p75 NGF receptor (D283p75) also did not undergo apoptosis.

22 sing both TrkC and TrkA/nerve growth factor (NGF) receptors, different morphological changes occur up

23 could suppress the increased, AF64A-induced NGF receptor expression in the medial septal nucleus.

24 NGF receptor expression was not consistently altered in

25 this hypothesis, we measured NGF content and NGF receptor expression, p75(NTR) (low affinity neurotro

26 tor of HSV entry, is a new member of the TNF/NGF receptor family.

27 r necrosis factor (TNF)-nerve growth factor (NGF) receptor family have been shown to be important cos

28 d JNK pathways collaborate downstream of the NGF receptor for regulation of the NFLC promoter.

29 K252a, a selective inhibitor for NGF receptor gp140trk, had no effect on acrylamide induc

30 oding the high-affinity nerve growth factor (NGF) receptor (GT1-trk) could also be persistently infec

31 NGF receptor immunohistochemistry revealed that AF64A in

32 f RTA showed significantly more low affinity NGF receptor immunoreactive (p75NGFR-IR) neurons on the

33 a short-lasting hypertrophy of low affinity NGF receptor immunoreactive neurons within the nucleus b

34 Here we report that activation of the TrkA NGF receptor in oligodendrocytes negates cell death by t

35 cellular signaling mediated by both EGF and NGF receptors in PC12 cells.

36 high-affinity (TrkA) and low-affinity (p75) NGF receptors in PTEN-overexpressing clones.

37 al effects on both the low and high affinity NGF receptors in terms of cell body size and staining de

38 urotrophin receptor) and trkA (high affinity NGF receptor), in control and diabetic rat SMG, CG and s

39 embers Trk B and Trk C, and the low-affinity NGF receptor (INGFR) are all detected within both mature

40 The effect of key mutations along the NGF receptor interface are transmitted inside the cell t

41 sh the effect of C3 on the expression of the NGF receptor-IR elements, C3 was administered orally (25

42 evealed that AF64A induced the appearance of NGF-receptor-IR axonal varicosities in the rat medial se

43 The TrkA/NGF receptor is essential for the survival and different

44 The high-affinity NGF receptor is thought to be a complex of two receptors

45 The nerve growth factor (NGF) receptor is a complex of two proteins, gp75 and the

46 a potential link to AD pathogenesis, TrkA, a NGF receptor, is expressed in cholinergic forebrain neur

47 lts reveal that IRAK is recruited to the p75-NGF receptor leading to formation of a complex between I

48 at hippocampus, raising the possibility of a NGF-receptor mediated neuroprotection.

49 e, and Akt are significantly attenuated, and NGF receptor-mediated neurite outgrowth is blocked.

50 NGF in the keratinocytes and upregulation of NGF receptor (NGF-R) in the cutaneous nerves of psoriati

51 Mice carrying a mutation in the low-affinity NGF receptor (NGFR) gene possess deficits in sensory inn

52 High-affinity nerve growth factor (NGF) receptor (NGFR-TrkA) expression in DRGs was signifi

53 educed the density of the low-affinity (p75) NGF receptor on PC12 cells, but had no effect on the den

54 o a complex with TrkA to dephosphorylate the NGF receptor on Ser/Thr residues and to potentiate its i

55 s of nerve growth factor (NGF) that bind the NGF receptor p140 TrkA was evaluated and compared with t

56 ly transfected with either the high affinity NGF receptor p140(trk) (3T3-Trk) or the low affinity NGF

57 ptor p140(trk) (3T3-Trk) or the low affinity NGF receptor p75(NGFR) (3T3-p75).

58 on coexpression of the nerve growth factor (NGF) receptors p75(NTR) and TrkA, which bind NGF in cort

59 e the physiological role of the low affinity NGF receptor (p75) has not been clearly defined, this re

60 scent protein driven by the Chat promoter or NGF receptor (p75) immunostaining.

61 phic factor is a ligand for the low-affinity NGF receptor, p75, and for the high-affinity neurotrophi

62 The low-affinity NGF receptor, p75, has long been thought merely to facil

63 have localized the binding sites of the two NGF receptors, p75 and TrkA, to other regions of the NGF

64 Immunotoxic lesions targeting low-affinity NGF receptor (p75NGF receptor)-bearing CBF neurons provi

65 These results suggest that NGF receptor-positive, cholinergic basal forebrain neuro

66 IgG-saporin, a specific immunotoxin for the NGF receptor-positive, cholinergic basal forebrain neuro

67 To test the molecular nature of the NGF receptor responsible for the ability of NGF to rescu

68 ward sensitization was inhibited by blocking NGF receptor signaling in the CeA.

69 functions for the high affinity heteromeric NGF receptor site: (a) integration of both the MAPK and

70 d in aged animals, suggesting that decreased NGF receptor stimulation may be one factor contributing

71 To examine their roles in the TRK NGF receptor, these residues (Tyr-670, Tyr-674, and Tyr-

72 nting the high-affinity nerve growth factor (NGF) receptor Trk A, its family members Trk B and Trk C,

73 on of the high-affinity nerve growth factor (NGF) receptor Trk occurs through multiple processes cons

74 NGF effect is mediated by the high affinity NGF receptor, Trk A and that neurotrophin binding to the

75 , and into PC12 variants expressing specific NGF receptor/Trk mutants, we show that transcriptional r

76 forms a novel multiprotein complex with the NGF receptor TrkA and the PI3K regulatory subunit p85, w

77 n of anti-NGF antibody, or inhibition of the NGF receptor trkA by k252a or antisense oligonucleotides

78 or the local activation of the high-affinity NGF receptor trkA was suggested by a strong inhibition o

79 onal death in mice that lack BAX, NGF or the NGF receptor TrkA, alone and in combination.

80 differentiation and survival, associate with NGF receptor TrkA, and be tyrosyl-phosphorylated in resp

81 half of unmyelinated nociceptors express the NGF receptor TrkA, and half express the GDNF family liga

82 ssing neurons also express the high-affinity NGF receptor TrkA, and only a small proportion bind to I

83 PC12nnr5 cells, which lack the high affinity NGF receptor TrkA, ii) srcDN2 cells, which overexpress k

84 tiation through anterograde transport of the NGF receptor TRKA.

85 to mutations in the NTRK1 gene encoding the NGF receptor TrkA.

86 support many DRG neurons via actions on the NGF receptor TrkA.

87 e epidermis, and postnatal extinction of the NGF receptor TrkA.

88 rough TLRs, upregulate the expression of the NGF receptor TrkA.

89 d nerve growth factor (NGF), and BAX and the NGF receptor TrkA.

90 wn to bind to activated nerve growth factor (NGF) receptor TrkA and has been implicated in NGF-induce

91 Activation of the nerve growth factor (NGF) receptor trkA and tissue acidosis are critically li

92 it binds and activates nerve growth factor (NGF) receptor TrkA in neuronal cells.

93 The nerve growth factor (NGF) receptor TrkA is widely expressed in non-neural tis

94 Trypanosoma cruzi binds nerve growth factor (NGF) receptor TrkA, increasing receptor autophosphorylat

95 NGF-induced tyrosine phosphorylation of NGF receptors (TrkA) is also consistently suppressed.

96 most NB, while loss of nerve growth factor (NGF) receptor (trkA) gene expression correlates with an

97 ve shown that the activation kinetics of the NGF receptor, TrkA, and downstream protein kinases appea

98 al axons requires the kinase activity of the NGF receptor, TrkA, in both distal axons and cell bodies

99 domain that is 45% identical to that of the NGF receptor, TrkA.

100 ent on the levels of mRNA and protein of the NGF receptors, trkA and p75NTR, in normal and diabetic r

101 more, by expressing the nerve growth factor (NGF) receptor, TrkA, and the epidermal growth factor (EG

102 The nerve growth factor (NGF) receptor, trkA, the tumour suppressor p53 and the p

103 ting endocytosis of the nerve growth factor (NGF) receptor, TrkA.

104 ol the subcellular localization of activated NGF receptors (Trks).

105 mice, and proNGF does not phosphorylate the NGF receptor tyrosine kinase TrkA.

106 ons, both of which express the transmembrane NGF receptor tyrosine kinase, trkA.

107 ic antibodies to TRPV1; nerve growth factor (NGF) receptor tyrosine kinase A; glial cell line-derived

108 S12 associates with the nerve growth factor (NGF) receptor tyrosine kinase TrkA, activated H-Ras, B-R

109 d that downregulate the nerve growth factor (NGF) receptor tyrosine kinase, TrkA, after birth.

110 C3aR) and high affinity nerve growth factor (NGF) receptor tyrosine kinase, TrkA.

111 f low and high affinity nerve growth factor (NGF) receptors was investigated in the basal forebrain d

112 for both the low-affinity and high-affinity NGF receptors were unaffected by ethanol.

113 cing the sensitisation of TRPV1 by TrkA, the NGF receptor, were characterised by observing the effect

114 These studies show that either NGF receptor will support increases in intracellular cal