ライフサイエンスコーパス: NICU

1 NICU treatments used to improve neurodevelopmental outco

2 In 2012, there were 43.0 NICU admissions per 1000 normal-birth-weight infants (25

3 Combined BPD or death rates across 116 NICUs varied from 17.7% to 73.4% (interquartile range, 3

4 tational age (OR = 1.10; 95% CI, 1.05-1.16), NICU admission (OR = 1.12; 95% CI, 1.07-1.17), hyperbili

5 167 NICUs participated in the survey, representing 28 Europe

6 1.8% vs 17.2%; RR, 1.48; 95% CI, 1.00-2.19), NICU admission (12.1% vs 17.7%; RR, 1.54; 95% CI, 1.05-2

7 30, 2013, 6680 neonates were enrolled in 243 NICUs in 18 European countries.

8 1, 2007, through December 31, 2012, from 348 NICUs managed by the Pediatrix Medical Group.

9 ole-genome sequencing (STATseq) in a level 4 NICU and PICU to assess the rate and types of molecular

10 It took 3 years before 445 NICUs (75.0%) achieved the 2005 shrunken adjusted rate f

11 pidemiologique de la flore), in 20 of the 64 NICUs, analyzed the intestinal microbiota by culture and

12 Most (78%) NICUs were interested in participating in a trial evalua

13 t-level demographic and outcomes data from 8 NICUs who were long term CQI collaborators within the Ve

14 Hospital length of stay increased in the 8 NICUs 64 to 71 days (P <.001), and a similar increase wa

15 9% vs 2.5%; adjusted odds ratio [OR], 1.92), NICU or neonatology service admission (8.8% vs 5.3%; adj

16 ing the study period, newborns admitted to a NICU were larger and less premature, although no consist

17 are increasingly likely to be admitted to a NICU, which raises the possibility of overuse of neonata

18 It is challenging to know whether a NICU is becoming more proficient, and it is not usually

19 Analysis within a NICU showed that exposure of an infant to a specific ant

20 investigate the impact of cleaning within a NICU, a high-throughput short-amplicon-sequencing approa

21 Additional NICU samples were included from 14/29 infants.

22 Risk-adjusted NICU ranks were computed for each of 8 measures of quali

23 onatal intensive care unit (NICU) admission, NICU length of stay, hyperbilirubinemia, respiratory dis

24 CCC occurred in 0.1% of all NICU admissions (21 of 19 303) and 0.6% of infants <1000

25 centers reporting that more than 20% of all NICU days were attributed to the care of these infants i

26 parents of sick children and who were also "NICU parents." We have developed an etiquette-based syst

27 h very low birth weight (below 1500 g) among NICUs with various levels of care and different volumes

28 cal and molecular epidemiology of MRSA in an NICU between 2003 and 2013, in the decade following the

29 1000 admissions among infants admitted to an NICU.

30 olates were obtained from patients within an NICU.

31 ficantly different from hospitals without an NICU, and was significantly higher than hospitals with l

32 Compared with hospitals without an NICU, infants born in a hospital with a level III NICU w

33 Hospital administrators and NICU managers should assess their staffing decisions to

34 life environment factors (breast-feeding and NICU admission) might contribute to EoE susceptibility.

35 atory complications, hyperbilirubinemia, and NICU admission, were increased in association with mater

36 = .02) and rs17815905 (LOC283710/KLF13) and NICU admission (P = .02) but not with any of the factors

37 <34 weeks), the number of neonatologist and NICU beds, 25.2% and 58.7% of the HSA-level variance in

38 itivity or detectable C-reactive protein and NICU admission and length of stay.

39 This report focuses on safety and NICU deaths by marginal comparisons of 72 hours' vs 120

40 ), but resulted in less probability that any NICU infant received a lumbar puncture (p = .0001) or pe

41 spital with a level III NICU with an average NICU census of at least 15 patients per day had signific

42 ifferent Shannon diversity was shown between NICU and PD samples.

43 dation and analgesia practices occur between NICUs and countries.

44 f etiquette are not always applied in a busy NICU or in the hospital at large.

45 nfants born at hospitals with a level IIIB/C NICU and lowest among infants born at hospitals with a l

46 s delivered at hospitals with a level IIIB/C NICU.

47 d respected as they go through a challenging NICU stay.

48 Significant decreases in common NICU organisms including K. oxytoca and E. faecalis and

49 ematurely and/or with medical complications (NICU children) and 25 control children born at term were

50 e" combined outcome (early preterm delivery, NICU, SGA).

51 general" combined outcome (preterm delivery, NICU, SGA); and "severe" combined outcome (early preterm

52 imate standardized morbidity ratios for each NICU.

53 nd resource utilization scores that estimate NICU CQI proficiency.

54 longer cooling, deeper cooling, or both for NICU death was less than 2%.

55 the odds ratio (95% confidence interval) for NICU admission was 2.14 (1.01 to 4.54); for a length of

56 ure to oral pathogens increases the risk for NICU admission and the length of stay.

57 ission (p = .003) and a 12% greater risk for NICU discharge (p = .02) were found in the after period

58 rm births (38.4%) and increased the risk for NICU or neonatology service admission (12.2%) and morbid

59 The adjusted risk ratio (RR) for NICU deaths for the 120 hours group vs 72 hours group wa

60 first, to our knowledge, web-based tool for NICUs to calculate their own composite morbidity and res

61 erculosis, longer hospital stays, and/or ICU/NICU admission.

62 care unit/neonatal intensive care unit (ICU/NICU) admissions (OR = 1.5; CI, 1.4-1.6; P < .0001) were

63 atients who eventually die in neonatal ICUs (NICUs) and adult medical ICUs (MICUs).

64 e of sedation or analgesia in neonatal ICUs (NICUs) in European countries.

65 in this study who had been in the NICU (ie, NICU graduates).

66 fants born at hospitals with a level I or II NICU compared with infants delivered at hospitals with a

67 k for developing BPD was higher for level II NICUs (odds ratio, 1.23; 95% CI, 1.02-1.49) and similar

68 vel III NICUs, and in level II+ and level II NICUs, regardless of size, was not significantly differe

69 er of hospitals that could provide level III NICU care has the potential to decrease neonatal mortali

70 infants born in a hospital with a level III NICU with an average NICU census of at least 15 patients

71 95% CI, 1.02-1.49) and similar for level III NICUs (odds ratio, 1.04; 95% CI, 0.95-1.14).

72 fants born at hospitals with large level III NICUs were not more than those for infants born at other

73 tality for infants born in smaller level III NICUs, and in level II+ and level II NICUs, regardless o

74 rage census, >15 patients per day) level III NICUs.

75 infants born at hospitals with a level IIIA NICU.

76 pitals (low-volume level IIIB and level IIIA NICUs) had odds of death ranging from 1.42 (95% CI, 1.08

77 impetus for the regionalization of important NICU resources.

78 mework for precision medicine for infants in NICU and PICU who are diagnosed with genetic diseases to

79 nosocomial bacteraemia was less frequent in NICUs with low neonatal consultant provision (odds ratio

80 edominant mode of acquisition by neonates in NICUs at this hospital; mothers may be colonized with mu

81 rces dedicated to critically ill neonates in NICUs nationwide.

82 l not survive than does care for newborns in NICUs.

83 ent of sedation and analgesia in patients in NICUs.

84 approaches used for heelsticks performed in NICUs.

85 Heelstick was very frequently performed in NICUs.

86 8 drugs studied in neonates were not used in NICUs; 8 (29%) were used in fewer than 60 neonates.

87 r the support and survival of these infants, NICU sensory environments are dramatically different fro

88 Significant inter-NICU variation in both composite scores was noted in the

89 ediate NICU: level II; expanded intermediate NICU: level II+: tertiary NICU: level III) and by the av

90 re available (no NICU: level I; intermediate NICU: level II; expanded intermediate NICU: level II+: t

91 Compared with level IV NICUs, the risk for developing BPD was higher for level

92 e of VLBW infant deliveries and a high-level NICU.

93 ese infants, 53229 were classified as likely NICU admissions.

94 term led to an improved version of the Mayo NICU model.

95 , relative mortality reduction 21%) and mean NICU LOS from 3.5 to 2.9 days (95% confidence interval,

96 red for at 756 Vermont Oxford Network member NICUs in the United States were evaluated.

97 fied by the level of NICU care available (no NICU: level I; intermediate NICU: level II; expanded int

98 cci are the most common causes of nosocomial NICU infections.

99 the risk of death during the first 3 days of NICU admission (p = .003) and a 12% greater risk for NIC

100 When the effects of NICU level and annual volume of VLBW infant deliveries w

101 ionship was observed in the smaller group of NICU women (r = .40, p = .099).

102 Patient volume and level of NICU care at the hospital of birth both had significant

103 Hospitals were classified by the level of NICU care available (no NICU: level I; intermediate NICU

104 al workload was operationalized as number of NICU infants cared for by the individual houseofficer on

105 that increased clinical workload (number of NICU infants) resulted in a significantly greater probab

106 ie (birth weight < 751 g), the percentage of NICU bed-days allocated to nonsurviving infants was less

107 significantly larger than the percentage of NICU bed-days devoted to nonsurviving babies (7.8%).

108 The total percentage of NICU days nationwide that were attributed to the neonata

109 From 2004 through 2013, the rate of NICU admissions for the neonatal abstinence syndrome inc

110 es (6.8%) had a significantly higher rate of NICU or neonatology service admission compared with term

111 gs suggest that increased regionalization of NICU care may reduce BPD among VLBW infants.

112 Only 38% of NICUs had a protocol for BPD prevention and 47% routinel

113 Within 8 years, 75% of NICUs achieved rates of performance from the best quarti

114 5 and the number of years it took for 75% of NICUs to achieve the 2005 rates from the best quartile w

115 retrospective cohort study was conducted of NICUs in California.

116 means of managing the microbial ecosystem of NICUs and of future opportunities to minimize exposures

117 sed with increasing workload in all types of NICUs.

118 ber 31, 2011, at each of the 8 participating NICUs.

119 In the participating NICUs, the median use of sedation or analgesia was 89.3%

120 ssociated with higher risks for prematurity, NICU admission, and SGA status compared with longer inte

121 t 33.5 degrees C for 72 hours did not reduce NICU death.

122 5% confidence interval, 0.2 to 0.9, relative NICU LOS reduction 17%).

123 tive including more than 90% of California's NICUs.

124 nsecutively admitted to 54 randomly selected NICUs.

125 sis in term newborns could result in shorter NICU stays and less antibiotic usage.

126 1-3 years post discharge (PD) from a single NICU.

127 Why some NICUs improve their scores more successfully than others

128 or DCDD among neonates who died in the study NICU.

129 Substantial NICU nurse understaffing relative to national guidelines

130 nts without diagnosed BPD, and six full-term NICU patients (gestational ages, 23-39 wk) at near term-

131 anded intermediate NICU: level II+: tertiary NICU: level III) and by the average patient census in th

132 The NICU admission rate was not significantly higher for tho

133 The NICU death rates were 7 of 95 neonates (7%) for the 33.5

134 Comparisons between the NICU and control groups on the CANTAB subscales indicate

135 ly be due to the better documentation by the NICU team in the after period.

136 ixed models to account for clustering by the NICU.

137 e neonate, and the distinct environment, the NICU, is imperative.

138 rd genetic testing in a case series from the NICU and PICU of a large children's hospital between Nov

139 l 24 strains could be distinguished from the NICU isolates by at least one genomic marker.

140 Overall mortality in the NICU (66/827; 7.9%) was significantly lower than in the

141 of babies in this study who had been in the NICU (ie, NICU graduates).

142 after period, fewer of them occurred in the NICU (odds ratio, 0.2; 95% confidence interval, 0.08 to

143 5 p = .017, respectively) and for men in the NICU (r = .55, p = .003) and the SICU (r = .29, p = .036

144 relationships between procedural pain in the NICU and early brain development in very preterm infants

145 s cross transmission between patients in the NICU and other wards.

146 ency in the infants during their stay in the NICU and persisted in a proportion of infants.

147 The clinical workload of housestaff in the NICU can affect decisions to perform procedures on infan

148 The unadjusted mortality in the NICU decreased from 8% to 6.3% (95% confidence interval,

149 cent (37/66) of all neonates who died in the NICU did so within the first 48 hr of life.

150 al opportunistic yeasts were detected in the NICU environment, demonstrating that these NICU surfaces

151 All ELBW infants in the NICU had an increased incidence of sepsis evaluations an

152 who acquired C. albicans colonization in the NICU had C. albicans-positive mothers; specimens from al

153 The 136 deaths that occurred in the NICU of the Primary Children's Hospital, Salt Lake City,

154 ses altered the management of infants in the NICU or PICU.

155 of an infant to a specific antibiotic in the NICU was not a risk factor for the carriage of a strain

156 All newborns in the NICU with a maximum corrected age of 44 weeks +6 days of

157 Of 136 deaths in the NICU, 60 (44.1%) met criteria for DCDD; however, fewer t

158 Pneumothorax, mortality in the NICU, and antenatal corticosteroid use loaded on factor

159 life, chronic lung disease, mortality in the NICU, and discharge on any human breast milk.

160 proach to communication with families in the NICU.

161 fant was not affected by the workload in the NICU.

162 e effects of workload on patient care in the NICU.

163 ions to perform procedures on infants in the NICU.

164 II) and by the average patient census in the NICU.

165 e average severity-of-illness of each of the NICU infants, the experience and residency program of th

166 ted an antibiogram identical to those of the NICU isolates, all 24 strains could be distinguished fro

167 l by neonatologists and other members of the NICU team would likely result in a significant increase

168 receiving increased antibiotics while on the NICU did not significantly impact the microbiome PD.

169 All 31 housestaff rotating on the NICU service during the academic year 1993 to 1994 were

170 s on the CANTAB subscales indicated that the NICU children had a shorter spatial memory span length a

171 These results suggest that the NICU isolates had a common origin and that genomic finge

172 mples collected from infants admitted to the NICU for suspected sepsis were analyzed for bacterial gr

173 Admission to the NICU in those without the susceptibility gene variant at

174 Admission to the NICU or neonatology service.

175 disposition of all patients admitted to the NICU were compared between two 19-month periods, before

176 650 infants, 45 (6.9%) were admitted to the NICU.

177 nfants; neurobehavior was assessed using the NICU Network Neurobehavioral Scales (NNNS) in an indepen

178 The NICUs varied substantially in their clinical performance

179 and serious morbidities decreased among the NICUs in this study.

180 ix infants acquired C. albicans during their NICU stay.

181 Hospitals understaffed 31% of their NICU infants and 68% of high-acuity infants relative to

182 rom their admission to the 14th day of their NICU stay or discharge, whichever occurred first.

183 e NICU environment, demonstrating that these NICU surfaces represent a potential vector for spreading

184 perinatal databases, and data pertaining to NICU or neonatology service admissions were extracted fr

185 red during the first 28 days of admission to NICUs.

186 All neonates admitted to NICUs during 1 month were included in this study.

187 Among 674,845 infants admitted to NICUs, we identified 10,327 with the neonatal abstinence

188 186 UK NICUs were stratified according to volume of patients, n

189 e prematurity, neonatal intensive care unit (NICU) admission, congenital malformation, small for gest

190 resuscitation, neonatal intensive care unit (NICU) admission, NICU length of stay, hyperbilirubinemia

191 pathogens and neonatal intensive care unit (NICU) admission.

192 ital ized in a neonatal intensive care unit (NICU) after birth.

193 cedures in the neonatal intensive care unit (NICU) during a period of rapid brain development.

194 erm gut on the neonatal intensive care unit (NICU) impacted the gut microbiota and metabolome long-te

195 infants in the neonatal intensive care unit (NICU) is associated with adverse events, including fever

196 risk than does neonatal intensive care unit (NICU) level.

197 s and from the neonatal intensive care unit (NICU) room environment.

198 lation between neonatal intensive care unit (NICU) strategies concerning the rate of progression of e

199 dmitted to the neonatal intensive care unit (NICU), and one of them had bilateral hearing impairment.

200 ner within our neonatal intensive care unit (NICU), diagnostic-quality MRIs using commercially availa

201 ction with the neonatal intensive care unit (NICU), it is often not because they think their baby has

202 fection in the neonatal intensive care unit (NICU), often associated with significant morbidity.

203 institutional neonatal intensive care unit (NICU), whose gestational age at birth was 30 or more wee

204 infants in the neonatal intensive care unit (NICU).

205 outbreak in a neonatal intensive care unit (NICU).

206 SGA); need for neonatal intensive care unit (NICU); new onset of hypertension; new onset/doubling of

207 reast-feeding, neonatal intensive care unit [NICU] admission, and absence of pets in the home).

208 d death in the neonatal intensive care unit [NICU]) after the first 50 neonates were enrolled, then a

209 eonatal and paediatric intensive care units (NICU and PICU) is not sufficiently timely to guide acute

210 e admitted to neonatal intensive care units (NICU) annually.

211 infants at 16 neonatal intensive care units (NICU) within the NICHD Neonatal Research Network.

212 mitted to 290 neonatal intensive care units (NICUs) (the Pediatrix Data Warehouse) in the United Stat

213 irst weeks in neonatal intensive care units (NICUs) [1].

214 h 2013 in 299 neonatal intensive care units (NICUs) across the United States.

215 re infants in neonatal intensive care units (NICUs) are highly susceptible to infection due to the im

216 om 2 academic neonatal intensive care units (NICUs) from 2004 to 2015.

217 st that large neonatal intensive-care units (NICUs) have better outcomes than small units, although t

218 proportion of neonatal intensive care units (NICUs) in 2014 that achieved rates for death and major m

219 the number of neonatal intensive care units (NICUs) in community hospitals and the complexity of the

220 nursed in two neonatal intensive care units (NICUs) in East London, United Kingdom.

221 and midlevel neonatal intensive care units (NICUs) in recent decades.

222 361) from 32 neonatal intensive care units (NICUs) in the United States were randomly assigned to re

223 aureus in the neonatal intensive care units (NICUs) of two hospitals.

224 taffing in US neonatal intensive care units (NICUs) relative to national guidelines.

225 difficult for neonatal intensive care units (NICUs) to determine the overall efficacy of multiple con

226 surveys from neonatal intensive care units (NICUs), offices and molecular biology laboratories, and

227 e in European neonatal intensive care units (NICUs).

228 n neonates in neonatal intensive care units (NICUs).

229 cedure in the neonatal intensive care units (NICUs).

230 ss the importance of neuroimmune cell units (NICUs) in intestinal development, homeostasis and diseas

231 Data were collected from all infants until NICU discharge or death (last day of data collected, Dec

232 dy included 972 VLBW infants treated in 6 US NICUs, with admission dates from January 1, 2006, to Dec

233 ied are either not used or rarely used in US NICUs.

234 High-volume NICUs treated the sickest infants and had highest crude

235 When NICU graduates were included in the comparison, a signif

236 ciated with high neonatal morbidity and with NICU or neonatology service admission.

237 eight deliveries occurred in facilities with NICUs that offered a high level of care and had a high v

238 r deliveries that occurred in hospitals with NICUs that had both a high level of care and a high volu

239 ose for infants born at other hospitals with NICUs.