ライフサイエンスコーパス: NIMA

1 NIMA (never in mitosis arrest)-related kinase 2 (Nek2) i

2 NIMA appears to be particularly important.

3 NIMA expression also induces Ser-10 phosphorylation inap

4 NIMA is also required for TINA, a NIMA-interacting prote

5 NIMA promotes entry into mitosis in late G2 by some mech

6 NIMA promotes NPC disassembly in a spatially regulated m

7 NIMA protein instability during S phase and G2 was also

8 NIMA(d)-exposed splenocytes exhibited bystander suppress

9 NIMA, as well as its most closely related human ortholog

10 NIMA-exposed neonates also developed vigorous primary an

11 NIMA-related protein kinase 2 (Nek2), which regulates ce

12 NIMA-specific Tregs expand during pregnancies sired by m

13 Some (40%) NIMA(d)-exposed mice accepted a DBA/2 allograft while ot

14 and a majority (61%) of adults; nursing by a NIMA+ mother was essential for preserving MMc into adult

15 iated organelle, the spindle pole body, in a NIMA-dependent manner.

16 icate that bimAAPC3 regulates the APC/C in a NIMA-dependent manner.

17 Nek2 is a NIMA-related kinase implicated in regulating centrosome

18 equences from this region identified Nek1, a NIMA (never in mitosis A)-related kinase as a candidate

19 of jck mutation on the expression of Nek8, a NIMA-related (never in mitosis A) kinase, and polycystin

20 terminal noncatalytic tail of Nercc1/Nek9, a NIMA family protein kinase that is activated in mitosis.

21 Genetic analysis now shows that a NIMA-related kinase helps to regulate the size of cilia

22 NIMA is also required for TINA, a NIMA-interacting protein, to locate to SPBs during initi

23 k7, a member of the Never in Mitosis Gene A (NIMA) kinase family, as a regulator of telomere integrit

24 homology with the Never In Mitosis, gene A (NIMA) kinase from the filamentous fungus Aspergillus nid

25 suppression of the Never in Mitosis Gene A (NIMA)-related protein kinase gene NEK4 disrupted timely

26 NEK2, which encodes the never in mitosis A (NIMA)-related kinase, by 5aza-dC is context-specific as

27 Rejector and acceptor NIMA(d)-exposed mice had reduced T effector responses an

28 duced cell cycle oscillations require active NIMA, because a nimA5 + bimA1(APC3) double mutant arrest

29 ying tolerance to noninherited maternal Ags (NIMA) are not fully understood.

30 n of tolerance to noninherited maternal Ags (NIMA) is poorly understood.

31 ental exposure to noninherited maternal Ags (NIMA) results in alloantigen-specific natural and adapti

32 the hypothesized direction of effect for all NIMA in women, indicating that increased body iron statu

33 e in the kinase activities of NIMX(cdc2) and NIMA occurs.

34 compatibility, parent-of-origin effects, and NIMA effects at DRB1 are unlikely to play a role in SLE.

35 compatibility, parent-of-origin effects, and NIMA effects at DRB1 in SLE.

36 ctivities of maturation promotion factor and NIMA are coincidentally regulated in A. nidulans and sug

37 esized directions of effect between iron and NIMA, except for rs651007, associated with decreased fer

38 n coordinating the functions of NIMXCDC2 and NIMA in the regulation of mitosis.

39 1, the physical interaction between PINA and NIMA is primarily dependent upon the prolylisomerase dom

40 ositive genetic interaction between PINA and NIMA.

41 es of the APC/C, such as cyclin B, Polo, and NIMA, causing mitotic delay.

42 two nuclear pore complex (NPC) proteins and NIMA is required for mitotic localization of the Cdk1 ki

43 TINA and NIMA preferentially interact in interphase and larger fo

44 Nercc1 binds to another NIMA-like kinase, Nek6, and also binds specifically to t

45 ission rates (noninherited maternal antigen [NIMA] effects) in other autoimmune diseases have been re

46 ffect of noninherited maternal HLA antigens (NIMA) and double-unit cord blood transplantation (CBT).

47 lly foreign non-inherited maternal antigens (NIMA) that persists into adulthood.

48 we investigated the functions of Arabidopsis NIMA-related kinase 6 (NEK6), which regulates microtubul

49 Nek2, Nek6, Nek7, and Nek9 are NIMA-related kinases essential for proper mitotic progre

50 ression of a single Ag, K(b), that served as NIMA.

51 whose products interact with the Aspergillus NIMA cell cycle regulatory protein kinase, reveals that

52 on-invasive measurements of atherosclerosis (NIMA), i.e., presence of plaque, intima media thickness

53 Because NIMA triggers nuclear pore complex opening during mitosi

54 We conclude that the beneficial NIMA effect is due to induction of NIMA-specific T(R) ce

55 Specifically, phosphorylation of Sid4 by NIMA(Fin1) reduces Sid4 affinity for its SPB anchor, Ppc

56 mpared offspring exposed to maternal H-2(d) (NIMA(d)) with nonexposed controls.

57 The key features distinguishing NIMA(d)-exposed acceptors from all other mice were: 1) h

58 Importantly, at low doses, NIMA-expressing cells induced the development of in vivo

59 hymena thermophila contains 39 loci encoding NIMA-related kinases (NRKs), an extraordinarily large nu

60 ows activation of this prematurely expressed NIMA by phosphorylation.

61 phatase (PP1) from the spindle pole by Fin1 (NIMA) kinase ensures switch-like activation of Cyclin B-

62 Finally, NIMA can phosphorylate histone H3 Ser-10 in vitro, sugge

63 e noncatalytic region, a region critical for NIMA function in Aspergillus nidulans.

64 (high) T cell expressing Foxp3 isolated from NIMA mice.

65 Furthermore, NIMA locates to the NPC during entry into mitosis, and a

66 ne H3 kinase, perhaps helping to explain how NIMA promotes chromatin condensation in A. nidulans and

67 Here, we demonstrate that human NIMA-related kinase 6 (Nek6) is required for mitotic pro

68 In support of this hypothesis, NIMA inactivation is shown to promote interphase septal

69 -negative breast cancer cells, we identified NIMA (never in mitosis gene A)-related kinase 9 (NEK9) a

70 substrates of CDK5, casein kinases I and II, NIMA, calmodulin-dependent kinases, Erk1, and phosphoryl

71 To investigate this possibility, we imaged NIMA-green fluorescent protein (GFP) using four-dimensio

72 cells responding to H-2(d)-expressing APC in NIMA(d)-exposed vs control mice.

73 A/2 heart transplant, but were controlled in NIMA(d)-exposed mice by T(R) cells to varying degrees.

74 ing of a peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) to p53-RS, but not the p53 for

75 Its NIMA-like catalytic domain is followed by a noncatalytic

76 ial but functionally enigmatic fungal kinase NIMA.

77 tein (Pin2) that can bind the mitotic kinase NIMA and suppress its ability to induce mitotic catastro

78 The protein kinase NIMA is an indispensable pleiotropic regulator of mitoti

79 The Aspergillus nidulans protein kinase NIMA regulates mitotic commitment, while the human and X

80 otein (Pin2) that associates with the kinase NIMA and suppresses its mitosis inducing activity.

81 nt kinases, polo kinases and Aurora kinases, NIMA-related kinases are emerging as critical regulators

82 Furthermore, when overexpressed, MLK3, like NIMA, localizes to the centrosomal region, induces profo

83 udy of endogenous MLK3 and report that, like NIMA, MLK3 phosphorylation and activity are enhanced dur

84 sis, and TINA is then necessary for locating NIMA back to SPBs during mitotic progression.

85 racterization of human Nek8, a new mammalian NIMA-related kinase, and its candidate substrate Bicd2.

86 of NEK7, a member of the family of mammalian NIMA-related kinases (NEK proteins), as an NLRP3-binding

87 Although several mammalian NIMA-like kinases (Neks) are known, none appears to have

88 rin beta3-binding protein (ITGB3BP), MAP3K8, NIMA-related kinase (NEK2), and SHC-transforming protein

89 At mitosis NIMA-GFP locates to spindle pole bodies (SPBs), which co

90 At mitosis, NIMA becomes enriched on chromatin and subsequently loca

91 nd Nek6 represent a novel cascade of mitotic NIMA family protein kinases whose combined function is i

92 Of importance, the mitotic NIMA kinase locates to forming septa and surprisingly th

93 The family of human Nek (NIMA Related Kinase) kinases currently contains 11 membe

94 Hec1 (highly expressed in cancer 1) or Nek2 (NIMA-related kinase 2) is often overexpressed in cancers

95 Recent advances in understanding Nek2 (NIMA related kinase 2) biology suggest that the kinase p

96 NEK6 (NIMA-related kinase 6) is a homologue of the Aspergillus

97 Nercc1 is a new NIMA-like kinase that regulates chromosome alignment and

98 The Aspergillus nidulans NIMA kinase is essential for mitotic entry.

99 alleles arrest in G2, before accumulation of NIMA in the nucleus.

100 f PINA and the C-terminal 303 amino acids of NIMA.

101 est but had little effect on the activity of NIMA.

102 ctive CaMK also results in the appearance of NIMA kinase activity within 1 h of the germinating signa

103 ace TGF-beta expression on CD4(+) T cells of NIMA(d)-exposed vs control splenocytes.

104 maternal cells that promote conservation of NIMA and enforce cross-generational reproductive benefit

105 hat partial NPC disassembly under control of NIMA and Cdk1 in A. nidulans may represent a new mechani

106 kinases, and accumulation and degradation of NIMA, which all coordinately cycle multiple times withou

107 s that received a transplant of low doses of NIMA-like alloantigens develop vigorous memory cytotoxic

108 l, we conclude that exposure to low doses of NIMA-like alloantigens induces robust in vivo cytotoxic

109 An effect of NIMA was also found to extend the survival of skin graft

110 n of p34cdc2 allows precocious expression of NIMA during S-phase arrest, and lack of BIME then allows

111 condensation, activation and inactivation of NIMA and p34(cdc2) kinases, and accumulation and degrada

112 Although inactivation of NIMA using either the nimA1 or nimA5 temperature-sensiti

113 Most strikingly, ectopic induction of NIMA promotes mitotic-like changes in NPC structure and

114 eneficial NIMA effect is due to induction of NIMA-specific T(R) cells during ontogeny.

115 We investigated the influence of NIMA exposure on the offspring thymic T cell selection d

116 suggest that early exposure to low levels of NIMA may lead to long-term immunologic priming of all ar

117 flects differences in the relative levels of NIMA-specific T regulatory (T(R)) versus T effector (T(E

118 The chromatin-like localization of NIMA early in mitosis is tightly correlated with histone

119 We hypothesized that maintenance of NIMA-specific T(R) cells in the adult requires continuou

120 ) tests to detect MMc in different organs of NIMA(d)-exposed H2(b) mice.

121 with homology to the noncatalytic region of NIMA and identified mixed lineage kinase 3 (MLK3).

122 ertebrate systems as a negative regulator of NIMA, a Ser/Thr protein kinase that regulates the G(2)/M

123 mitosis, and a dominant-negative version of NIMA that causes G2 delay dwells at the NPC.

124 n in a cyclic manner; these cycles depend on NIMA.

125 ells without markedly increasing NIMXCDC2 or NIMA kinase activity.

126 s nidulans by inactivating either p34cdc2 or NIMA.

127 les expressing alloantigens with overlapping NIMA specificity, thereby averting fetal wastage trigger

128 e mutations in the Schizosaccharomyces pombe NIMA homologue, Fin1, blocked spindle formation at 37 de

129 The mitosis-promoting NIMA kinase is thus a target for S-phase checkpoint cont

130 The Aspergillus nidulans protein NIMA (never in mitosis, gene A) is a protein kinase requ

131 omologue of the Aspergillus nidulans protein NIMA (never in mitosis, gene A).

132 h PINA is essential and positively regulates NIMA function, A. nidulans is most sensitive to a reduct

133 sequence to the essential mitotic regulator NIMA of Aspergillus nidulans.

134 ructurally related to the mitotic regulator, NIMA, of Aspergillus nidulans.

135 Mitotic modification of the NPC requires NIMA and Cdk1 kinase activation.

136 ain homology to NIMA, none of these resemble NIMA within its extensive noncatalytic region, a region

137 Two of six NIMA-related SNPs showed association with the ratio hepc

138 Here, we show that another APC/C substrate, NIMA-related kinase 2A (Nek2A), is also destroyed in pro

139 rnal cells and/or soluble MHC Ags suppresses NIMA-allospecific T cells of the offspring, predisposing

140 ecipitation assays, we demonstrate here that NIMA (never in mitosis gene A)-related kinase 2 (NEK2) i

141 These results indicate that NIMA promotes the nuclear localization of the NIMXCDC2/

142 histone H3 Ser-10 in vitro, suggesting that NIMA is a mitotic histone H3 kinase, perhaps helping to

143 The NIMA family protein kinases Nek9/Nercc1, Nek6, and Nek7

144 The NIMA kinase is essential for progression through mitosis

145 The NIMA kinase is required for mitotic nuclear pore complex

146 To analyze the NIMA effect C57BL/6 (H-2(b/b)) males were mated with B6D

147 tion between the two elements by MPF and the NIMA kinase Fin1 blocked PP1(Dis2) recruitment, thereby

148 leoporins SONA(GLE2) and SONB(NUP98) and the NIMA kinase interact and regulate nuclear accumulation o

149 urified from rat liver and identified as the NIMA-related kinases NEK6 and NEK7.

150 To help expand the NIMA-TINA pathway, we affinity purified TINA and found i

151 In this study, we identified the NIMA kinase Nek4 in a genetic screen for mediators of th

152 However, if the NIMA mitosis-promoting kinase is inactivated then non-ty

153 Recent work has implicated the NIMA (never in mitosis, gene A)-related kinase-6 (NEK6)

154 Interestingly, the NIMA kinase of Aspergillus nidulans interacts with two n

155 -ATRIP, we found that a single member of the NIMA (never in mitosis A)-related kinase family, Nek1, i

156 rylation is dependent upon activation of the NIMA kinase in Aspergillus nidulans.

157 ted prematurely by ectopic expression of the NIMA kinase.

158 d a mutation affecting NEK2, a member of the NIMA-like serine-threonine kinase family, in a patient w

159 Nek5 is a poorly characterized member of the NIMA-related kinase family, other members of which play

160 st in part, with decreased expression of the NIMA-related kinase NEK2.

161 The localization of the NIMA-related kinase, Fin1, reveals further complexity in

162 a bifurcation in a signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 that is

163 unit CBT and the correlation of MMc with the NIMA effect.

164 ns encodes a protein that interacts with the NIMA mitotic protein kinase in a cell cycle-specific man

165 we identify a new pathway that acts through NIMA-related kinase 6 (Nek6) and Hsp72 to promote centro

166 ortance for mitotic regulation attributed to NIMA.

167 In contrast to NIMA and the closely related mammalian Nek2 kinase, whic

168 Strikingly, adult mice exposed to NIMA accepted permanently K(b+) heart allografts despite

169 ed that anti-K(b) thymocytes were exposed to NIMA and became activated during fetal life but were not

170 owed that both oral and in utero exposure to NIMA are required for this tolerogenic effect.

171 Therefore, exposure to NIMA selectively enhances reproductive success in second

172 In the absence of neonatal exposure to NIMA via breastfeeding, MMc was lost, which was accompan

173 identified with catalytic domain homology to NIMA, none of these resemble NIMA within its extensive n

174 n amino-terminal catalytic domain related to NIMA, an Aspergillus kinase involved in the control of s

175 t, which was accompanied by sensitization to NIMA in some offspring, indicating a role of oral exposu

176 In addition, we observed that tolerance to NIMA K(b) was abrogated via depletion of CD4(+) but not

177 Nek2B is a vertebrate NIMA-related protein kinase required for centrosome asse

178 However, during mitosis, when NIMA transiently locates to nuclei to promote mitosis, i

179 ize them to the graft, may determine whether NIMA-specific tolerance is achieved.

180 A model is proposed in which NIMA helps keep septal pores open during interphase and

181 es during the cell cycle and associates with NIMA-related kinase 2 (NEK2), which is able to phosphory

182 lates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity.

183 is-trans isomerase (PPIase) interacting with NIMA-1 (Pin1) catalyzes the cis-trans isomerization of p

184 ond nucleoporin genetically interacting with NIMA.

185 trans isomerase (PPIase) that interacts with NIMA.

186 he relevance of the interaction of PINA with NIMA in this fungus.

187 SNPs and quartiles of a multi-SNP score with NIMA.

188 suppressive regulatory T cells (Tregs) with NIMA specificity.