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1 NLS induced a significant decrease in cell viability and
2 NLS induced cell apoptosis and cell cycle G1/S phase arr
3 NLS mutant mice had no gross changes in immunophenotype
4 NLS peptide also attenuated pro-inflammatory gene expres
5 NLS peptide significantly inhibited lesion development a
12 ormational flexibility therefore enables 627-NLS to bind importin through conformational selection fr
13 The molecular basis of the affinity of 627-NLS for importins remained unclear from these structures
14 nce energy transfer (FRET), we show that 627-NLS populates a temperature-dependent dynamic equilibriu
15 y a tripartite salt bridge involving the 627-NLS interface and the linker, that becomes flexible in t
16 ion studies in nulliparous mice that carry a NLS-lacZ transgene downstream of the Mmp14 promoter reve
18 trate experimentally that the atypical ADAR1-NLS is bimodular and is formed by the combination of the
20 ha, sequence variation at the importin-alpha NLS-binding sites and tissue-specific expression levels
25 expression between cells expressing CD24 and NLS-CD24 revealed a unique nucCD24 transcriptional signa
26 scopy, we demonstrated that NOTP-PGK-GFP and NLS-PGK-GFP are localized in the cytoplasm and nucleus,
28 (NPC) barrier selectivity, Kap traffic, and NLS-cargo release are systematically linked and simultan
29 rmed by fluorescent imaging of wild-type and NLS-mutated pol beta(R4S,K5S) in mouse embryonic fibrobl
33 eta-propeller, or inserting a linker between NLS and beta-propeller, disrupts specificity for importi
34 We propose NLS1 and NLS2 form a bipartite NLS in trans, which ensures high avidity for importin al
35 f FlbB into the nucleus requires a bipartite NLS, that FlbB localization at the tip requires actin an
37 ion elements defined a new form of bipartite NLS consisting of a triplet of basic residues followed b
42 cohort of 12 unrelated families affected by NLS, we provide evidence that NLS is genetically heterog
50 ontrast, small terminase exposes a classical NLS at the far C terminus of its helical structure that
53 3 evolved to recognize topologically complex NLSs that lie next to bulky domains or are masked by qua
54 e fed a high-fat diet), i.p., 0.13 mumol/day NLS peptide administration for 5 weeks attenuated NF-kap
56 biotic stress correlates with enhanced DCL4(NLS) expression, while hypermethylation of a DCL4 transg
57 t of 21-nucleotide-long "disiRNAs," for DCL4(NLS) isoform-dependent siRNAs, through the nuclear RdDM
60 encoding a nuclear localization signal, DCL4(NLS), is present in Arabidopsis, but DNA methylation nor
62 om all herpesvirus subfamilies, demonstrated NLS function, dissected key residues, and showed functio
64 ew class of multiple import factor-dependent NLSs with an internal structural component that may regu
65 nctions of M1 in the presence of a disrupted NLS but also resulted in a strong association of M1 with
66 del showing how Trn1 can recognize the dsRBD-NLS and how dsRNA binding can interfere with Trn1 bindin
67 Here, we report the structure of the dsRBD-NLS, which reveals an unusual dsRBD fold extended by an
71 ut they nevertheless functioned as efficient NLS motifs both in heterologous transfer assays and in H
77 t not 3 or less, can constitute a functional NLS-NoLS; AAP2BR1 and AAP2BR2 play the most influential
86 ined that srp1 mutants that failed to import NLS-containing proteins (srp1-31 and srp1-55) successful
88 From 39 genes differentially expressed in NLS-CSU when compared with HCs, 31 (79.48%) were confirm
93 eveals the organization of the intermingling NLSs and NoLSs in AAP2 and provides insights into their
94 cancer cells expressing K17 mutations in its NLS or NES signals exhibited an increase in levels of nu
100 ctron microscope, only the M1 layer of the M(NLS-88R) virion exhibited discontinuous fingerprint-like
101 ascular smooth muscle cells and macrophages, NLS peptide specifically blocked the importin alpha-medi
105 NLS2 revealed NLS2 primarily binds the major-NLS binding site of importin alpha, unlike NLS1 that ass
106 RTT-causing mutations overlap with the MeCP2 NLS, suggesting that they may alter nuclear localization
110 The motif in HSV functioned as a monopartite NLS, while in varicella-zoster virus (VZV) activity requ
111 ion signals (NLS): an N-terminal monopartite NLS and a unique bipartite NLS closer to the C terminus.
112 for the recognition of classical monopartite NLSs by generating apolar pockets for the P3 and the P5
115 te that nuclear localization of Mre11 (Mre11-NLS) is able to bypass several functions of Xrs2, includ
116 hat AAP2(144-184) has redundant multipartite NLSs and that any combinations of 4 AAP2BRs, but not 3 o
118 ional strong NLS in the N-terminal region (N-NLS), which, intriguingly, overlaps with the N-NES.
119 novel nuclear trafficking module where the N-NLS is inactive in P1 but becomes activated in P3, conco
120 arrangement of overlapping, co-regulated NES/NLS sequences is vital to delineating the critical role
121 er eukaryotes was abandoned, whereas the new NLS was evolved from an anticodon-binding hexapeptide mo
122 R), relevant genes expressed in nonlesional (NLS-CSU) and lesional skin (LS-CSU) and peripheral blood
123 fy and characterize AAV2 AAP (AAP2) nuclear (NLS) and nucleolar (NoLS) localization signals near the
130 fected cells, we employed the interaction of NLS-GFP-MS2 (phage MS2 coat protein) with the modified B
132 ecific knockdown of TORC1 in the striatum of NLS-N171-82Q HD transgenic mice induced neurodegeneratio
133 ls expressing mutant Htt, in the striatum of NLS-N171-82Q, R6/2 and HdhQ111 HD transgenic mice and in
134 Our findings expand our understanding of NLS as a disorder of the L-serine biosynthesis pathway a
135 s revealed that both location and potency of NLSs in terminase subunits evolved more rapidly than the
137 esent, resulting in 3 different, overlapping NLS motifs; and the NoLS is shared redundantly among the
138 is development and identifies cell-permeable NLS peptide as a potential anti-atherosclerotic agent.
140 es insights into the nature of the potential NLS and the mechanistic relationship between I2 (PP2A)-i
142 mics abrogates nuclear transport, preventing NLS (nuclear localisation signal)-cargo release from Ran
144 , rice importin-alpha binds the prototypical NLS from simian virus 40 large T-antigen preferentially
147 1q-c were increased in neurons expressing PV.NLS-mC, causing a reduction in the density and size of d
148 ted form of parvalbumin fused to mCherry (PV.NLS-mC) led to a reduction in VEGFD expression and, as a
149 in the cell nucleus, which in the case of PV.NLS-mC can be reversed by nuclear calcium transients tri
151 nuclear targeted version of parvalbumin (PV.NLS-mC) led to a build-up of HDAC4 and HDAC5 in the cell
154 e report the crystal structure of the FUS PY-NLS bound to its nuclear import receptor Karyopherinbeta
155 The Kapbeta2-binding epitopes of the FUS PY-NLS consist of an N-terminal PGKM hydrophobic motif, a c
158 ine-tyrosine nuclear localization signal (PY-NLS) in DJ-1, and we found that nuclear monomeric DJ-1 i
159 ine/tyrosine-nuclear localization signal (PY-NLS) of the Fused in Sarcoma protein (FUS) cause amyotro
160 the PY-type nuclear localization signal (PY-NLS)/karyopherinbeta2 (Kapbeta2) nuclear import system r
163 a cells expressing the ALS-causing FUS R495X NLS mutation, and mislocalization of Sm proteins is RRM-
165 ee techniques; which are nonlinear sampling (NLS), forward maximum (FM) entropy reconstruction, and J
166 sor ion scan (PIS) or neutral ion loss scan (NLS), using appropriate class specific lipid standards.
167 used n-butyl alcohol extract of Litchi seed (NLS) to treat prostate cancer PC3, DU145, RM1 and C4-2B
170 d a bipartite nuclear localization sequence (NLS) and thereby controlled the partitioning of Cdh1 bet
171 the bipartite nuclear localization sequence (NLS) and two Lys residues outside of but adjacent to the
173 te C-terminal nuclear localization sequence (NLS) motifs conserved in H03-IPSE, SKRRRKY, and H06-IPSE
174 dentified the nuclear localization sequence (NLS) of SAMHD1 as a conserved KRPR sequence at amino aci
176 with the SV40 nuclear localization sequence (NLS) was generated to preclude its cytoplasmic localizat
178 al a putative nuclear localization sequence (NLS), 'RPRK', within CXCR4 that contributed to nuclear l
182 wo predicted nuclear localization sequences (NLS) that are located near the C-terminus (amino acids 1
183 t domain via nuclear localization sequences (NLSs), short amino acids motifs enriched in Lys and Arg
184 ese proteins, a nuclear localization signal (NLS) and an intrinsically disordered linker encode the s
185 that acts as a nuclear localization signal (NLS) and in template binding is also involved in nucleot
186 ins a conserved nuclear localization signal (NLS) at its C-terminus that binds to importin-beta and i
187 ue nonclassical nuclear localization signal (NLS) binding site on KPNA5 that is necessary for efficie
189 rbours a robust nuclear localization signal (NLS) directing SerRS to the nucleus where it attenuates
191 of a potential nuclear localization signal (NLS) in the C-terminal region of I2 (PP2A) containing a
193 n sequence, the nuclear localization signal (NLS) is reported to reside between amino acids 255-271,
194 ctionality of a nuclear localization signal (NLS) located at the N-terminal region of the foot-and-mo
197 e presence of a nuclear localization signal (NLS) motif within the GmHSP40.1 coding sequence, GFP-GmH
198 does possess a nuclear localization signal (NLS) motif, whilst Cry3 lacks both an NLS motif and a pr
199 addition to the nuclear localization signal (NLS) of XPA, importin-alpha4 or/and importin-alpha7 are
201 ant lacking the nuclear localization signal (NLS) on the ICP0 gene (0DeltaNLS) is sensitive to inhibi
202 of Skp2 in the nuclear localization signal (NLS) promotes its cytoplasmic retention, and cytoplasmic
203 emarkably, this nuclear localization signal (NLS) sequence motif is also important for interacting wi
204 conservation of nuclear localization signal (NLS) sequences previously identified in herpes simplex v
205 s an N-terminal nuclear localization signal (NLS) that is critical for capsid routing to the nuclear
206 arries a unique nuclear localization signal (NLS) that overlaps one of its double-stranded RNA-bindin
207 ins a bipartite nuclear localization signal (NLS) that targets this effector to plant cell nuclei.
208 fusion assays a nuclear localization signal (NLS) that was mapped to a 23-amino-acid sequence at the
209 WSN/33 when its nuclear localization signal (NLS) was disrupted by R101S and R105S substitutions.
210 ), in which the nuclear localization signal (NLS) was inactivated to prevent nuclear translocation of
211 ins a bipartite nuclear localization signal (NLS) within its DNA binding domain and two leucine-rich
212 HDAgs contain a nuclear localization signal (NLS), but only HDAg-L contains a CRM1-independent nuclea
213 preserving the nuclear localization signal (NLS), enhances the decatenation checkpoint and sensitivi
214 e nucleus via a nuclear localization signal (NLS), specific among keratins, where it bound p27(KIP1)
215 leus to release nuclear localization signal (NLS)-containing cargo from import receptors, and, under
216 otably, the PB2 nuclear localization signal (NLS)-containing domain translocates approximately 90 A t
217 he nucleus in a nuclear localization signal (NLS)-dependent manner, where it localized to novel F-act
218 nt that imports nuclear localization signal (NLS)-specific cargoes (NLS-cargoes) into the nucleus.
223 tions disrupt the nuclear localizing signal (NLS) of FUS resulting in cytoplasmic accumulation in tra
227 possesses two nuclear localization signals (NLS): an N-terminal monopartite NLS and a unique biparti
228 des containing nuclear localization signals (NLSs) 1 and 2 were non-acetylated, and all cysteine resi
229 ora sojae uses nuclear localization signals (NLSs) for translocation of proteins into the nucleus tha
230 mport pathway, nuclear localization signals (NLSs) in cargo proteins are recognized by the import rec
232 ogues, possess nuclear localization signals (NLSs) to enter the cell nucleus during ribosome assembly
233 es contain two nuclear localization signals (NLSs): a well-studied monopartite NLS1 and a less-charac
234 tain intrinsic nuclear localization signals (NLSs): the Ets domain within NRF-2alpha and the NLS with
236 emonstrate that pol beta contains a specific NLS sequence in the N-terminal lyase domain that promote
237 me that RabV P contains an additional strong NLS in the N-terminal region (N-NLS), which, intriguingl
241 l lines that express a fusion protein termed NLS.GFP.SAM595 in which the Vpx binding domain of SAMHD1
247 es affected by NLS, we provide evidence that NLS is genetically heterogeneous and can be caused by mu
250 serine biosynthesis pathway and suggest that NLS represents the severe end of serine-deficiency disor
251 terial and eukaryotic ribosomes to show that NLSs appear in conserved ribosomal proteins via remodell
252 s): the Ets domain within NRF-2alpha and the NLS within NRF-2beta (amino acids 311/321: EEPPAKRQCIE)
253 s NLS of Pom121 adapts a similar fold as the NLS of Heh2 when transport factor bound and rescues the
254 A-GTP binding domain, which autoinhibits the NLS and the neighboring microtubule-binding domain, and
256 f Vpx-containing virions with the cells, the NLS.GFP.SAM595 fusion protein was degraded over several
257 vasculature abnormalities either deleted the NLS or have the NLS sequestered in an alternative confor
258 o wedge the RCC1 beta-propeller flanking the NLS against its lateral surface, preventing steric clash
259 y the virus as a compensatory change for the NLS loss and resultant replication deficiency, three mor
261 ependent nuclear export signal; however, the NLS and exact pathway of import have remained elusive.
264 the entire N-terminal domain, including the NLS, interacted with TCPs but did not destabilize them.
268 ent with the conservation of these NLSs, the NLS and linker of Heh2 support INM localization in HEK29
270 ry for its function, because deletion of the NLS or addition of a nuclear export signal abolished its
271 duced by bradykinin, whereas mutation of the NLS reduced this effect by two-thirds relative to wild t
273 rolled by tRNA(Tyr) in higher organisms, the NLS of lower eukaryotes was abandoned, whereas the new N
274 the CTD of topo IIbeta, while preserving the NLS, and mutation of Y640 in topo IIalpha and Y656 in to
279 of Tau by expressing I2 (PP2A) in which the NLS was inactivated by (179)RKR(181) --> AAA along with
280 we isolated proteins that interact with the NLS and identified karyopherin alpha 3 (KPNA3 or Kap-alp
282 Here, we have characterized in depth the NLSs of a P. sojae basic leucine zipper transcription fa
284 Consistent with the conservation of these NLSs, the NLS and linker of Heh2 support INM localizatio
292 as an RNA-sensing scaffold, allowing the two NLS modules to be properly positioned for interacting wi
293 NLS2 bind weakly to importin alpha, the two NLSs synergize in the context of the full length NP to c
296 ng enabled us to identify previously unknown NLSs in ribosomal proteins from humans, and suggests tha
298 From the analysis comparing LS-CSU with NLS-CSU, a selection of 142 genes was studied with qPCR,
299 n of importin-alpha operates in plants, with NLS-mimicking sequences binding to both minor and major
300 inally, PC3 xenograft nude mice treated with NLS in vivo showed a significant decrease in tumor size
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