ライフサイエンスコーパス: NLS

1 NLS induced a significant decrease in cell viability and

2 NLS induced cell apoptosis and cell cycle G1/S phase arr

3 NLS mutant mice had no gross changes in immunophenotype

4 NLS peptide also attenuated pro-inflammatory gene expres

5 NLS peptide significantly inhibited lesion development a

6 These results indicate that the VP1-2 NLS is not required for the known assembly functions of

7 The NRF-2beta NLS contains only two lysine/arginine residues, unlike o

8 We conclude that the NRF-2beta NLS is an unusual but is, nevertheless, a bona fide mono

9 equired for the recognition of the NRF-2beta NLS.

10 TDP-43-NLS accumulation in retinal cells was counteracted by HS

11 n in the nuclear localization signal (TDP-43-NLS).

12 ormational flexibility therefore enables 627-NLS to bind importin through conformational selection fr

13 The molecular basis of the affinity of 627-NLS for importins remained unclear from these structures

14 nce energy transfer (FRET), we show that 627-NLS populates a temperature-dependent dynamic equilibriu

15 y a tripartite salt bridge involving the 627-NLS interface and the linker, that becomes flexible in t

16 ion studies in nulliparous mice that carry a NLS-lacZ transgene downstream of the Mmp14 promoter reve

17 ne substitution being sufficient to abrogate NLS function and virus growth.

18 trate experimentally that the atypical ADAR1-NLS is bimodular and is formed by the combination of the

19 In addition, NLS treatment significantly decreased cell migration and

20 ha, sequence variation at the importin-alpha NLS-binding sites and tissue-specific expression levels

21 ignal (NLS) motif, whilst Cry3 lacks both an NLS motif and a protein-protein interaction domain.

22 which was rescued by the introduction of an NLS onto APLF.

23 mes flexible in the open state, with 627 and NLS dislocating into a highly dynamic ensemble.

24 36-759) reveal two globular domains, 627 and NLS, that form a tightly packed heterodimer.

25 expression between cells expressing CD24 and NLS-CD24 revealed a unique nucCD24 transcriptional signa

26 scopy, we demonstrated that NOTP-PGK-GFP and NLS-PGK-GFP are localized in the cytoplasm and nucleus,

27 When NOTP-PGK-GFP and NLS-PGK-GFP are transiently expressed, we observed a red

28 (NPC) barrier selectivity, Kap traffic, and NLS-cargo release are systematically linked and simultan

29 rmed by fluorescent imaging of wild-type and NLS-mutated pol beta(R4S,K5S) in mouse embryonic fibrobl

30 rtite NLSs, such as c-myc and SV40 T-antigen NLSs.

31 nal sequences that reconstitute classical AR NLS activity.

32 Three of the elements showed autonomous NLS activity and the fourth served as a nuclear localiza

33 eta-propeller, or inserting a linker between NLS and beta-propeller, disrupts specificity for importi

34 We propose NLS1 and NLS2 form a bipartite NLS in trans, which ensures high avidity for importin al

35 f FlbB into the nucleus requires a bipartite NLS, that FlbB localization at the tip requires actin an

36 ic section defining the motif as a bipartite NLS.

37 ion elements defined a new form of bipartite NLS consisting of a triplet of basic residues followed b

38 t receptor, KPNA2, which binds the bipartite NLS in Tpr with nanomolar affinity.

39 minal monopartite NLS and a unique bipartite NLS closer to the C terminus.

40 calization, and mutation or deletion of both NLS renders CAPN5 exclusively cytosolic.

41 n at 197 (BRMS1(DeltaNLS) which removes both NLS) promoted cytoplasmic localization.

42 cohort of 12 unrelated families affected by NLS, we provide evidence that NLS is genetically heterog

43 in three consanguineous families affected by NLS.

44 NES (N-NES) and a distinct C-terminal NLS (C-NLS).

45 to be nuclear through the activity of the C-NLS.

46 localization signal (NLS)-specific cargoes (NLS-cargoes) into the nucleus.

47 Nuclear-specific expression of CD24 (NLS-CD24) increased anchorage-independent growth in vitr

48 differ from conventional well-characterized NLSs from mammals and yeast.

49 Although a classical NLS and importin alpha/beta mediated nuclear import path

50 ontrast, small terminase exposes a classical NLS at the far C terminus of its helical structure that

51 In addition, we predicted a classical NLS in the third terminase subunit that is partially con

52 g does not affect the transport of classical NLS cargo.

53 3 evolved to recognize topologically complex NLSs that lie next to bulky domains or are masked by qua

54 e fed a high-fat diet), i.p., 0.13 mumol/day NLS peptide administration for 5 weeks attenuated NF-kap

55 DCL4(NLS) functions in a noncanonical siRNA pathway, producin

56 biotic stress correlates with enhanced DCL4(NLS) expression, while hypermethylation of a DCL4 transg

57 t of 21-nucleotide-long "disiRNAs," for DCL4(NLS) isoform-dependent siRNAs, through the nuclear RdDM

58 a DCL4 transgene causes a reduction in DCL4(NLS) expression.

59 using the methylation-state-responsive DCL4(NLS).

60 encoding a nuclear localization signal, DCL4(NLS), is present in Arabidopsis, but DNA methylation nor

61 ively charged residues in a Dia2 degradation/NLS domain.

62 om all herpesvirus subfamilies, demonstrated NLS function, dissected key residues, and showed functio

63 ke other known importin-alpha:beta-dependent NLSs.

64 ew class of multiple import factor-dependent NLSs with an internal structural component that may regu

65 nctions of M1 in the presence of a disrupted NLS but also resulted in a strong association of M1 with

66 del showing how Trn1 can recognize the dsRBD-NLS and how dsRNA binding can interfere with Trn1 bindin

67 Here, we report the structure of the dsRBD-NLS, which reveals an unusual dsRBD fold extended by an

68 yrosine-NLS, which is missing from the dsRBD-NLS.

69 This dsRBD-NLS is recognized by the nuclear import receptor transpo

70 Dual NLS motifs are common among transcription factors.

71 ut they nevertheless functioned as efficient NLS motifs both in heterologous transfer assays and in H

72 Here we mutated all eight NLS/NoLSs individually and in groups and showed, via tra

73 s of Phi29 TP led us to identify a bona fide NLS within residues 1-37.

74 Plaques from NLS-treated mice contained fewer macrophages of pro-infl

75 RBM45 mutants that lack a functional NLS accumulate in the cytoplasm and form TDP-43 positive

76 SAMHD1 lacking a functional NLS localized to the cytoplasm but retained its triphosp

77 t not 3 or less, can constitute a functional NLS-NoLS; AAP2BR1 and AAP2BR2 play the most influential

78 arily in the nucleus, requiring a functional NLS.

79 Functional NLSs, NES, and GSK3-beta-dependent phosphorylation regul

80 rescued by the addition of the wild-type FUS NLS to mutant proteins.

81 onsensus elements is critical for huntingtin NLS function.

82 d in rosette leaves have an almost identical NLS-binding site.

83 although the two isoforms share an identical NLS-binding groove.

84 Importantly, the IFI16 NLS was acetylated in lymphocytes, as well as in macroph

85 ucine-lysine nuclear localization signal (IK-NLS) motif at residues 35-40.

86 ined that srp1 mutants that failed to import NLS-containing proteins (srp1-31 and srp1-55) successful

87 (srp1-49 and srp1-E402Q) were able to import NLS-containing proteins.

88 From 39 genes differentially expressed in NLS-CSU when compared with HCs, 31 (79.48%) were confirm

89 h precise knock-in mutations to incapacitate NLS function.

90 Analyses including NLS swapping revealed Progerin did not cause global inhi

91 Thus a Cdk-inhibited NLS goes along with Cdk-inhibited APC/C binding sites in

92 consistent with a requirement for an intact NLS in this interaction.

93 eveals the organization of the intermingling NLSs and NoLSs in AAP2 and provides insights into their

94 cancer cells expressing K17 mutations in its NLS or NES signals exhibited an increase in levels of nu

95 lication defect of an HSV mutant lacking its NLS motif.

96 V solitons) or envelope quasi-solitons (like NLS solitons).

97 and nucleus due to its nuclear localization (NLS) and export sequences (NES).

98 The resultant M1 triple mutant M(NLS-88R) regained replication efficiency in vitro while

99 Unlike the other M1 triple mutants, M(NLS-88R) replicated more efficiently in vitro and in viv

100 ctron microscope, only the M1 layer of the M(NLS-88R) virion exhibited discontinuous fingerprint-like

101 ascular smooth muscle cells and macrophages, NLS peptide specifically blocked the importin alpha-medi

102 ng sequences binding to both minor and major NLS binding sites.

103 alpha show preferential binding to the major NLS binding site.

104 large T-antigen preferentially at the major NLS binding site.

105 NLS2 revealed NLS2 primarily binds the major-NLS binding site of importin alpha, unlike NLS1 that ass

106 RTT-causing mutations overlap with the MeCP2 NLS, suggesting that they may alter nuclear localization

107 ortin-alpha show that they bind to the minor NLS binding site.

108 , unlike NLS1 that associates with the minor NLS-pocket.

109 We found a monopartite NLS at the N terminus of large terminase, flanking the A

110 The motif in HSV functioned as a monopartite NLS, while in varicella-zoster virus (VZV) activity requ

111 ion signals (NLS): an N-terminal monopartite NLS and a unique bipartite NLS closer to the C terminus.

112 for the recognition of classical monopartite NLSs by generating apolar pockets for the P3 and the P5

113 ffinity to that of the classical monopartite NLSs, such as c-myc and SV40 T-antigen NLSs.

114 MRE11-NLS was unable to rescue the xrs2Delta defects in Tel1/A

115 te that nuclear localization of Mre11 (Mre11-NLS) is able to bypass several functions of Xrs2, includ

116 hat AAP2(144-184) has redundant multipartite NLSs and that any combinations of 4 AAP2BRs, but not 3 o

117 In this model, the mutant NLS (mNLS)-I2 (PP2A) (I2 (PP2A)AA-AAA) was retained in t

118 ional strong NLS in the N-terminal region (N-NLS), which, intriguingly, overlaps with the N-NES.

119 novel nuclear trafficking module where the N-NLS is inactive in P1 but becomes activated in P3, conco

120 arrangement of overlapping, co-regulated NES/NLS sequences is vital to delineating the critical role

121 er eukaryotes was abandoned, whereas the new NLS was evolved from an anticodon-binding hexapeptide mo

122 R), relevant genes expressed in nonlesional (NLS-CSU) and lesional skin (LS-CSU) and peripheral blood

123 fy and characterize AAV2 AAP (AAP2) nuclear (NLS) and nucleolar (NoLS) localization signals near the

124 The Nurr1 NLS sequence, when fused to green fluorescent protein, l

125 In order to identify the cause of NLS, we conducted a positional-mapping study combining a

126 A colony of NLS mutant mice was successfully generated with precise

127 og recapitulates many of the key features of NLS.

128 intracellular proteolysis and the import of NLS-containing proteins.

129 easome localization defect and the import of NLS-containing proteins.

130 fected cells, we employed the interaction of NLS-GFP-MS2 (phage MS2 coat protein) with the modified B

131 The pathogenesis of NLS remains unclear despite extensive clinical and patho

132 ecific knockdown of TORC1 in the striatum of NLS-N171-82Q HD transgenic mice induced neurodegeneratio

133 ls expressing mutant Htt, in the striatum of NLS-N171-82Q, R6/2 and HdhQ111 HD transgenic mice and in

134 Our findings expand our understanding of NLS as a disorder of the L-serine biosynthesis pathway a

135 s revealed that both location and potency of NLSs in terminase subunits evolved more rapidly than the

136 NBS1, the individual deletions of PS and one NLS (KRMK) robustly reduced the interaction.

137 esent, resulting in 3 different, overlapping NLS motifs; and the NoLS is shared redundantly among the

138 is development and identifies cell-permeable NLS peptide as a potential anti-atherosclerotic agent.

139 A potent NLS was found at the C-terminus, which is required for n

140 es insights into the nature of the potential NLS and the mechanistic relationship between I2 (PP2A)-i

141 We predicted NLSs within the TPs of bacteriophages from diverse famil

142 mics abrogates nuclear transport, preventing NLS (nuclear localisation signal)-cargo release from Ran

143 (775)KKARL functioned as the primary NLS, but (737)KRK and (754)KK also contributed to the nu

144 , rice importin-alpha binds the prototypical NLS from simian virus 40 large T-antigen preferentially

145 bidopsis thaliana RPL23aA has eight putative NLSs/NoLSs (pNLSs/NoLSs).

146 We show that the (putative) NLSs of metazoan HsSun2, MmLem2, HsLBR, and HsLap2beta a

147 1q-c were increased in neurons expressing PV.NLS-mC, causing a reduction in the density and size of d

148 ted form of parvalbumin fused to mCherry (PV.NLS-mC) led to a reduction in VEGFD expression and, as a

149 in the cell nucleus, which in the case of PV.NLS-mC can be reversed by nuclear calcium transients tri

150 iated viruses expressing either CaMBP4 or PV.NLS-mC.

151 nuclear targeted version of parvalbumin (PV.NLS-mC) led to a build-up of HDAC4 and HDAC5 in the cell

152 pherin beta2-dependent proline-tyrosine (PY)-NLS in the amino terminus of the protein.

153 Unlike the classic PY-NLS, which has an unstructured intervening sequence betw

154 e report the crystal structure of the FUS PY-NLS bound to its nuclear import receptor Karyopherinbeta

155 The Kapbeta2-binding epitopes of the FUS PY-NLS consist of an N-terminal PGKM hydrophobic motif, a c

156 The huntingtin PY-NLS is also capable of import through the importin/karyo

157 We propose that this huntingtin PY-NLS may comprise a new class of multiple import factor-d

158 ine-tyrosine nuclear localization signal (PY-NLS) in DJ-1, and we found that nuclear monomeric DJ-1 i

159 ine/tyrosine-nuclear localization signal (PY-NLS) of the Fused in Sarcoma protein (FUS) cause amyotro

160 the PY-type nuclear localization signal (PY-NLS)/karyopherinbeta2 (Kapbeta2) nuclear import system r

161 Mutating the PY-NLS in Gli or knockdown of Kapbeta2 diminished Gli cilia

162 Unlike other PY-NLSs, which generally bind Kapbeta2 in fully extended co

163 a cells expressing the ALS-causing FUS R495X NLS mutation, and mislocalization of Sm proteins is RRM-

164 ernal structural component that may regulate NLS activity.

165 ee techniques; which are nonlinear sampling (NLS), forward maximum (FM) entropy reconstruction, and J

166 sor ion scan (PIS) or neutral ion loss scan (NLS), using appropriate class specific lipid standards.

167 used n-butyl alcohol extract of Litchi seed (NLS) to treat prostate cancer PC3, DU145, RM1 and C4-2B

168 an N-terminal nuclear localisation sequence (NLS) and is trafficked to the nucleus.

169 al, bipartite nuclear localization sequence (NLS) and controls JMY's subcellular localization.

170 d a bipartite nuclear localization sequence (NLS) and thereby controlled the partitioning of Cdh1 bet

171 the bipartite nuclear localization sequence (NLS) and two Lys residues outside of but adjacent to the

172 y a bipartite nuclear-localization sequence (NLS) located at the C-terminus.

173 te C-terminal nuclear localization sequence (NLS) motifs conserved in H03-IPSE, SKRRRKY, and H06-IPSE

174 dentified the nuclear localization sequence (NLS) of SAMHD1 as a conserved KRPR sequence at amino aci

175 hin two HMGB1 nuclear localization sequence (NLS) sites.

176 with the SV40 nuclear localization sequence (NLS) was generated to preclude its cytoplasmic localizat

177 due candidate nuclear localization sequence (NLS) was identified based on sequence analysis.

178 al a putative nuclear localization sequence (NLS), 'RPRK', within CXCR4 that contributed to nuclear l

179 e lysine-rich nuclear localization sequence (NLS), located between lysine 6 and lysine 12.

180 t resembles a nuclear localization sequence (NLS).

181 the NF-kappaB nuclear localization sequence (NLS).

182 wo predicted nuclear localization sequences (NLS) that are located near the C-terminus (amino acids 1

183 t domain via nuclear localization sequences (NLSs), short amino acids motifs enriched in Lys and Arg

184 ese proteins, a nuclear localization signal (NLS) and an intrinsically disordered linker encode the s

185 that acts as a nuclear localization signal (NLS) and in template binding is also involved in nucleot

186 ins a conserved nuclear localization signal (NLS) at its C-terminus that binds to importin-beta and i

187 ue nonclassical nuclear localization signal (NLS) binding site on KPNA5 that is necessary for efficie

188 have a defined nuclear localization signal (NLS) consensus.

189 rbours a robust nuclear localization signal (NLS) directing SerRS to the nucleus where it attenuates

190 g the canonical nuclear localization signal (NLS) in the AR hinge region.

191 of a potential nuclear localization signal (NLS) in the C-terminal region of I2 (PP2A) containing a

192 that contain a nuclear localization signal (NLS) into the nucleus.

193 n sequence, the nuclear localization signal (NLS) is reported to reside between amino acids 255-271,

194 ctionality of a nuclear localization signal (NLS) located at the N-terminal region of the foot-and-mo

195 rom a bipartite nuclear localization signal (NLS) located in the tail domain [14].

196 t a monopartite nuclear localization signal (NLS) may reside in the N-terminal lyase domain.

197 e presence of a nuclear localization signal (NLS) motif within the GmHSP40.1 coding sequence, GFP-GmH

198 does possess a nuclear localization signal (NLS) motif, whilst Cry3 lacks both an NLS motif and a pr

199 addition to the nuclear localization signal (NLS) of XPA, importin-alpha4 or/and importin-alpha7 are

200 d in a putative nuclear localization signal (NLS) on the Drosophila melanogaster PER protein.

201 ant lacking the nuclear localization signal (NLS) on the ICP0 gene (0DeltaNLS) is sensitive to inhibi

202 of Skp2 in the nuclear localization signal (NLS) promotes its cytoplasmic retention, and cytoplasmic

203 emarkably, this nuclear localization signal (NLS) sequence motif is also important for interacting wi

204 conservation of nuclear localization signal (NLS) sequences previously identified in herpes simplex v

205 s an N-terminal nuclear localization signal (NLS) that is critical for capsid routing to the nuclear

206 arries a unique nuclear localization signal (NLS) that overlaps one of its double-stranded RNA-bindin

207 ins a bipartite nuclear localization signal (NLS) that targets this effector to plant cell nuclei.

208 fusion assays a nuclear localization signal (NLS) that was mapped to a 23-amino-acid sequence at the

209 WSN/33 when its nuclear localization signal (NLS) was disrupted by R101S and R105S substitutions.

210 ), in which the nuclear localization signal (NLS) was inactivated to prevent nuclear translocation of

211 ins a bipartite nuclear localization signal (NLS) within its DNA binding domain and two leucine-rich

212 HDAgs contain a nuclear localization signal (NLS), but only HDAg-L contains a CRM1-independent nuclea

213 preserving the nuclear localization signal (NLS), enhances the decatenation checkpoint and sensitivi

214 e nucleus via a nuclear localization signal (NLS), specific among keratins, where it bound p27(KIP1)

215 leus to release nuclear localization signal (NLS)-containing cargo from import receptors, and, under

216 otably, the PB2 nuclear localization signal (NLS)-containing domain translocates approximately 90 A t

217 he nucleus in a nuclear localization signal (NLS)-dependent manner, where it localized to novel F-act

218 nt that imports nuclear localization signal (NLS)-specific cargoes (NLS-cargoes) into the nucleus.

219 ions in the FUS nuclear localization signal (NLS).

220 s not possess a nuclear localization signal (NLS).

221 as an efficient nuclear localization signal (NLS).

222 ed multipartite nuclear localization signal (NLS).

223 tions disrupt the nuclear localizing signal (NLS) of FUS resulting in cytoplasmic accumulation in tra

224 The functional nuclear location signal (NLS) mapped to 3 clusters of basic residues.

225 us location mutant (nuclear location signal [NLS]-PGK-GFP).

226 domain and two nuclear localization signals (NLS).

227 possesses two nuclear localization signals (NLS): an N-terminal monopartite NLS and a unique biparti

228 des containing nuclear localization signals (NLSs) 1 and 2 were non-acetylated, and all cysteine resi

229 ora sojae uses nuclear localization signals (NLSs) for translocation of proteins into the nucleus tha

230 mport pathway, nuclear localization signals (NLSs) in cargo proteins are recognized by the import rec

231 inactivate the nuclear localization signals (NLSs) of Apc (Apc(mNLS)).

232 ogues, possess nuclear localization signals (NLSs) to enter the cell nucleus during ribosome assembly

233 es contain two nuclear localization signals (NLSs): a well-studied monopartite NLS1 and a less-charac

234 tain intrinsic nuclear localization signals (NLSs): the Ets domain within NRF-2alpha and the NLS with

235 cids-nuclear/nucleolar localization signals (NLSs/NoLSs).

236 emonstrate that pol beta contains a specific NLS sequence in the N-terminal lyase domain that promote

237 me that RabV P contains an additional strong NLS in the N-terminal region (N-NLS), which, intriguingl

238 We propose that swapping NLSs among terminase subunits is a regulatory mechanism

239 Neu-Laxova syndrome (NLS) is a rare autosomal-recessive disorder characterize

240 Neu-Laxova syndrome (NLS) is a rare autosomal-recessive disorder characterize

241 l lines that express a fusion protein termed NLS.GFP.SAM595 in which the Vpx binding domain of SAMHD1

242 rminal NES (N-NES) and a distinct C-terminal NLS (C-NLS).

243 The C-terminal NLS contains a SUMO-interacting motif that contributes t

244 Retention of the C-terminal NLS in anillin homologues suggests that this is a conser

245 Endowed by a C-terminal NLS, TgEB1 resides in the nucleoplasm in interphase and

246 nstrating the structural context rather than NLS sequence determines selectivity for isoform 3.

247 es affected by NLS, we provide evidence that NLS is genetically heterogeneous and can be caused by mu

248 This study shows that NLS represents the extreme end of a known inborn error o

249 These findings suggest that NLS has potential for development into a safe and potent

250 serine biosynthesis pathway and suggest that NLS represents the severe end of serine-deficiency disor

251 terial and eukaryotic ribosomes to show that NLSs appear in conserved ribosomal proteins via remodell

252 s): the Ets domain within NRF-2alpha and the NLS within NRF-2beta (amino acids 311/321: EEPPAKRQCIE)

253 s NLS of Pom121 adapts a similar fold as the NLS of Heh2 when transport factor bound and rescues the

254 A-GTP binding domain, which autoinhibits the NLS and the neighboring microtubule-binding domain, and

255 tion of a membrane protein in yeast, but the NLS from RnPom121 is.

256 f Vpx-containing virions with the cells, the NLS.GFP.SAM595 fusion protein was degraded over several

257 vasculature abnormalities either deleted the NLS or have the NLS sequestered in an alternative confor

258 o wedge the RCC1 beta-propeller flanking the NLS against its lateral surface, preventing steric clash

259 y the virus as a compensatory change for the NLS loss and resultant replication deficiency, three mor

260 rmalities either deleted the NLS or have the NLS sequestered in an alternative conformation.

261 ependent nuclear export signal; however, the NLS and exact pathway of import have remained elusive.

262 tion to R101S and R105S substitutions in the NLS were generated.

263 ltaneous R101S and R105S replacements in the NLS.

264 the entire N-terminal domain, including the NLS, interacted with TCPs but did not destabilize them.

265 A Nurr1 mutant lacking the NLS failed to enter the nucleus.

266 of TAP, whereas an HDAg-L mutant lacking the NLS failed to interact with full-length TAP.

267 Mutating the NLS decreases anillin's cortical affinity, causing it to

268 ent with the conservation of these NLSs, the NLS and linker of Heh2 support INM localization in HEK29

269 Mutation of the NLS led to a loss of beta-arrestin-1 nuclear localizatio

270 ry for its function, because deletion of the NLS or addition of a nuclear export signal abolished its

271 duced by bradykinin, whereas mutation of the NLS reduced this effect by two-thirds relative to wild t

272 2alphabeta becomes strictly dependent on the NLS within NRF-2beta.

273 rolled by tRNA(Tyr) in higher organisms, the NLS of lower eukaryotes was abandoned, whereas the new N

274 the CTD of topo IIbeta, while preserving the NLS, and mutation of Y640 in topo IIalpha and Y656 in to

275 Surprisingly, the NLS-associated locus identified in this study was solved

276 R/Cas9 to make inactivating mutations to the NLS on the Il1a gene.

277 Lys residues outside of but adjacent to the NLS, and their SUMOylation was catalyzed by Ubc9.

278 rated to bind small domains connected to the NLS.

279 of Tau by expressing I2 (PP2A) in which the NLS was inactivated by (179)RKR(181) --> AAA along with

280 we isolated proteins that interact with the NLS and identified karyopherin alpha 3 (KPNA3 or Kap-alp

281 e 1 IFN-induced HMGB1 acetylation within the NLS sites.

282 Here, we have characterized in depth the NLSs of a P. sojae basic leucine zipper transcription fa

283 The conserved features of the NLSs of ScHeh1, ScHeh2, and RnPom121 and the effective s

284 Consistent with the conservation of these NLSs, the NLS and linker of Heh2 support INM localizatio

285 This NLS comprises three consensus components: a basic charge

286 This NLS of Pom121 adapts a similar fold as the NLS of Heh2 w

287 The role of this NLS was confirmed by fluorescent imaging of wild-type an

288 Despite loss of this NLS, we show that diverse truncated AR variant species h

289 dependent manner that is directly coupled to NLS-cargo release and NPC barrier function.

290 hat, apart from promoting protein transport, NLSs may facilitate folding of ribosomal RNA.

291 The MP(TVCV) NLS appeared to be conserved in the subgroup 3 tobamovir

292 as an RNA-sensing scaffold, allowing the two NLS modules to be properly positioned for interacting wi

293 NLS2 bind weakly to importin alpha, the two NLSs synergize in the context of the full length NP to c

294 , nevertheless, a bona fide monopartite-type NLS.

295 s bear a well-characterized proline-tyrosine-NLS, which is missing from the dsRBD-NLS.

296 ng enabled us to identify previously unknown NLSs in ribosomal proteins from humans, and suggests tha

297 ar localization of JMY requires both the WH2/NLS region and importin beta.

298 From the analysis comparing LS-CSU with NLS-CSU, a selection of 142 genes was studied with qPCR,

299 n of importin-alpha operates in plants, with NLS-mimicking sequences binding to both minor and major

300 inally, PC3 xenograft nude mice treated with NLS in vivo showed a significant decrease in tumor size