ライフサイエンスコーパス: NLV

1 NLV capsid primers demonstrated a greater specificity of

2 NLVs also have been found to be a cause of acute gastroe

3 NLVs were a major cause of both outbreaks and sporadic d

4 NLVs were detected by reverse transcription-polymerase c

5 erologic evidence of infection with > or = 1 NLV was detected in 61 (56%) of 109 patients tested agai

6 ding frame 2 (ORF2) were used to analyze 101 NLV strains, including 2 bovine strains.

7 in 61 (56%) of 109 patients tested against 3 NLV antigens (i.e., Norwalk, Hawaii, and Toronto viruses

8 Unpublished data from laboratories of 4 NLV researchers were also used.

9 elected CMV-specific CD8(+) T cells (HLA-A02/NLV peptide), conferring resistance to glucocorticoids.

10 with genogroup I strains causing 26% of all NLV-positive outbreaks.

11 en (80%) outbreaks met the definition for an NLV outbreak.

12 August 1993 and July 1997, we identified an NLV strain that predominated during the 1995-1996 season

13 g a newly developed and sensitive method, an NLV G2 strain was identified in 2 oyster samples implica

14 he genetic relationship between NLV-BECs and NLV-HuCVs but with the NLV-BECs comprising two clusters

15 sensitive and specific detection of NLV-BEC (NLV-BEC Jena and NA-2) and BEC-NB-like viruses, respecti

16 formation, a functional relationship between NLV p41 and enterovirus 2C is discussed in regard to the

17 ata support the genetic relationship between NLV-BECs and NLV-HuCVs but with the NLV-BECs comprising

18 NLV-BECs, the genetic relationships between NLV from humans and the NLV-BECs commonly circulating in

19 known genotype 2 BoNVs than to genotype 1 Bo/NLV/Jena/80/DE.

20 ene were more closely related to those of Bo/NLV/Jena/80/DE (77 and 87% identities, respectively) tha

21 dentities, respectively) than to those of Bo/NLV/Newbury-2/76/UK (69 and 69% identities, respectively

22 4%, respectively) with the capsid gene of Bo/NLV/Newbury-2/76/UK, whereas the nucleotide and amino ac

23 uses (BoNVs) were more closely related to Bo/NLV/Newbury-2/76/UK (GIII/2) and other known genotype 2

24 The C7.NLV.HLA-A2 and C25.NLV.HLA-A2 complexes exhibit divergent TCR footprints on

25 The C7.NLV.HLA-A2 and C25.NLV.HLA-A2 complexes exhibit divergen

26 n of improved molecular techniques to detect NLVs demonstrates that most outbreaks of nonbacterial ga

27 cent improvements to the method of detecting NLVs in shellfish include enhanced processing of virus a

28 the reverse), giving rise to highly diverse NLV-specific TCR repertoires.

29 ns, suggesting that different mechanisms for NLV attachment likely exist.

30 uct, a regimen similar to current models for NLV vaccination.

31 tool sample from the infant was positive for NLV by RT-PCR, and the sequence of the amplified product

32 taminated shellfish serve as the vehicle for NLV transmission.

33 illness and should encourage monitoring for NLVs in drinking water.

34 , and, of these, 217 (93%) were positive for NLVs.

35 setting, these data support a major role for NLVs as etiologic agents of gastroenteritis in elderly p

36 an assay for the rapid identification of G1 NLVs in fecal specimens.

37 irus (genus Lagovirus), Norwalk virus (genus NLV), and Sapporo virus (genus SLV).

38 veys using electron microscopy often grouped NLVs with other unrelated viruses.

39 transcription-PCR (RT-PCR) primers for human NLV recognize NLV-BECs, the genetic relationships betwee

40 bservation supports the subdivision of human NLVs into two genogroups and provides an assay for the r

41 mer sets designed for the detection of human NLVs or BECs.

42 and from patients involved in a genogroup I NLV outbreak were also tested.

43 ajor capsid protein from another genogroup I NLV strain (NCFL) isolated from a recent outbreak.

44 Ltd., Tokyo, Japan) and IDEIA NLV (DakoCytomation Ltd., Ely, United Kingdom) kits, tha

45 t least 1 year, that specifically identified NLVs.

46 s establishing the diagnosis as genogroup II NLV infection.

47 s specific for the diagnosis of genogroup II NLV infections.

48 gastroenteritis were tested for genogroup II NLV Mexico virus-specific immunoglobulin M (IgM) by use

49 n sera from those infected with genogroup II NLVs in volunteer and outbreak studies, 28 of 47 were rM

50 variable alpha and variable beta regions in NLV-specific T cell repertoires.

51 This multistrain NLV outbreak investigation illustrates the importance of

52 consisted of fractional anisotropy of NAWM, NLV, and patient age and sex (adjusted R(2) = 0.32, P <

53 ze the immunodominant CMV epitope NLVPMVATV (NLV).

54 ss-reactive HLA-A*02:01 (A2) CMV (NLVPMVATV [NLV])-specific CD8(+) T cells recognizing a specific arr

55 (BECs) have been identified: the norovirus (NLV) Jena and Newbury Agent-2 (NA-2) BECs, which are gen

56 a powerful approach for the design of novel NLV vaccines, either alone or in combination with curren

57 NWMV, NLV, and patient sex were the explanatory variables for

58 The final model for NGMV consisted of NWMV, NLV, and patient age and sex (adjusted R(2) = 0.58, P <

59 ific basis for the unified classification of NLV strains detected around the world.

60 for the sensitive and specific detection of NLV-BEC (NLV-BEC Jena and NA-2) and BEC-NB-like viruses,

61 The small infectious dose of NLV, the large quantity of virus particles in stool, and

62 Expression of NLV VLPs in mammalian cells offers a powerful approach f

63 investigation illustrates the importance of NLV as a cause of waterborne illness and should encourag

64 otide sequencing, and increased knowledge of NLV genetic diversity.

65 es, reported sporadic cases and outbreaks of NLV-associated gastroenteritis among all age groups.

66 omparison between the consensus sequences of NLV p41 and enterovirus protein 2C revealed regions of h

67 During molecular surveillance of NLV strains from 152 outbreaks of gastroenteritis that o

68 tablish a global network for surveillance of NLV strains that would highlight the importance of NLVs

69 ools, allowing us type-specific detection of NLVs.

70 Two features of NLVs have hindered the development of simple methods for

71 rains that would highlight the importance of NLVs worldwide and allow molecular identification of com

72 rect electron microscopy for the presence of NLVs.

73 a from those infected with genogroup I NV or NLVs in volunteer and outbreak studies, only 3 of 25 wer

74 In these outbreaks, NLVs were identified as the probable cause, and crowding

75 of target cells pulsed with the CMV peptide NLV in the presence of dexamethasone (DEX).

76 capsid gene of Norwalk virus, the prototype NLV, has been cloned and expressed in mammalian cells us

77 l infection, the frequency of cross-reactive NLV-specific CD8(+) T cells reduced to previremia levels

78 ed a dynamic expansion of the cross-reactive NLV-specific TCR repertoire before CMV reactivation.

79 ge, of the same A2-restricted cross-reactive NLV-specific TCR-alpha/beta signature (TRAV3TRAJ31_TRBV1

80 PCR (RT-PCR) primers for human NLV recognize NLV-BECs, the genetic relationships between NLV from hum

81 is the first demonstration linking a single NLV strain globally and suggests that the circulation of

82 These data indicate that NLV infection is a major cause of acute morbidity in mil

83 tine shipboard deployment also suggests that NLVs cause sporadic gastroenteritis.

84 The NLV-specific T cell repertoire is characterized by a hig

85 elationships between NLV from humans and the NLV-BECs commonly circulating in cattle is undefined.

86 osely related to the Camberwell virus in the NLV GII/4 genetic cluster was the predominant strain.

87 s more focused on the central portion of the NLV peptide than is C7.

88 stine (duodenum and jejunum), similar to the NLV BEC strains.

89 Caliciviruses genetically related to the NLV-BEC Jena and NA-2 strains or to the recently charact

90 se viruses to be most closely related to the NLV-BEC Jena and NA-2 strains.

91 between NLV-BECs and NLV-HuCVs but with the NLV-BECs comprising two clusters within a third NLV geno

92 Further study of the antigenicity of the NLVs by use of VLPs should allow us to design new detect

93 c clusters within genogroups I and II of the NLVs were detected; a genogroup II (GII) virus closely r

94 -BECs comprising two clusters within a third NLV genogroup.

95 ated gastroenteritis outbreaks attributed to NLV occurred in Louisiana.

96 Extended 3'-terminal genome sequences of two NLV-BECs, designated CV95-OH and CV186-OH, encoding the

97 , and testing identified Norwalk-like virus (NLV) in 8 of 13 stool samples and 1 well.

98 The impact of Norwalk-like virus (NLV) infection on military forces is evaluated in this r

99 ide for the diagnosis of Norwalk-like virus (NLV) infection, yet a commonly accepted genetic classifi

100 Norwalk-like viruses (NLVs) are a diverse group of single-stranded, nonenvelop

101 Norwalk-like viruses (NLVs) are the most common cause of acute nonbacterial ga

102 ham showed evidence of Norwalk-like viruses (NLVs) by reverse-transcriptase (RT) polymerase chain rea

103 The three distinct Norwalk-like viruses (NLVs) have various capacities for binding ABH histo-bloo

104 In the 1990s, Norwalk-like viruses (NLVs) were identified in patient specimens as the primar

105 Lagovirus, Vesivirus, "Norwalk-like viruses (NLVs), and "Sapporo-like viruses (SLVs); the latter 2 ge

106 ated with genogroup II Norwalk-like viruses (NLVs), Hawaii virus, and Snow Mountain virus and from pa

107 52%) were positive for Norwalk-like viruses (NLVs), members of the family Caliciviridae.

108 HV) is a member of the Norwalk-like viruses (NLVs), one of four genera of the family Caliciviridae.

109 Norwalk-like viruses (NLVs), or small round structured viruses, are known to c

110 strain of genogroup I Norwalk-like viruses (NLVs), was expressed as virus-like particles using a bac

111 oup within the genus "Norwalk-like viruses" (NLV) of the family Caliciviridae.

112 "Norwalk-like viruses" (NLVs) are the most common cause of outbreaks of nonbacte

113 and to characterize "Norwalk-like viruses" (NLVs) in these outbreaks.

114 "Norwalk-like viruses" (NLVs), members of a newly defined genus of the family Ca

115 tion for testing for "Norwalk-like viruses" (NLVs).

116 not genogroup 2 (G2) "Norwalk-like viruses" (NLVs).

117 cal thickness, and normalized lesion volume (NLV) were quantified.

118 two public TCRs (C7 and C25) in complex with NLV.HLA-A2.

119 re ORF-1 nonstructural-protein sequence with NLV, SLV, vesivirus, and lagovirus strains, while the ov

120 astroenteritis resulting from infection with NLVs, we previously used recombinant-expressed capsid an