1 out the domain, as determined by (2)H methyl
NMR relaxation.
2 tional molecular dynamics is not detected by
NMR relaxation.
3 different backbone mobility, as monitored by
NMR relaxation.
4 G4T4G4) is slow on the timescale of the 23Na
NMR relaxation.
5 h measures of side-chain motion derived from
NMR relaxation.
6 ized using (15)N nuclear magnetic resonance (
NMR) relaxation.
7 Here we show that solid-state (2)H
NMR relaxation allows investigation of light-induced cha
8 onditions studied, the order parameters from
NMR relaxation analysis are uniformly high (>0.8) for mo
9 ers, structure-based calculations, and (15)N
NMR relaxation analysis highlights the energetic contrib
10 ents, multiangle light scattering, and (15)N
NMR relaxation analysis indicate that AtraPBP1 forms a s
11 d gradient NMR diffusion experiments and 15N
NMR relaxation analysis indicate that Ca2+-bound DREAM f
12 NMR relaxation analysis revealed that protein dynamics w
13 ysis combined with dynamic measurements from
NMR relaxation and diffusion data provides direct eviden
14 Hydrodynamic parameters from
NMR relaxation and diffusion measurements showed that fA
15 adapted version of H/D exchange experiment,
NMR relaxation and diffusion measurements, dynamic light
16 gnetometers as detectors for ultra-low-field
NMR relaxation and diffusion measurements.
17 NMR relaxation and dispersion experiments compare fast (
18 udies of conformational flexibility from 15N
NMR relaxation and H/D exchange experiments.
19 and RLP2-bound SH3 were performed via (15)N
NMR relaxation and hydrogen-deuterium (H/(2)H) exchange
20 Our
NMR relaxation and hydrogen-deuterium exchange studies t
21 Using (15)N
NMR relaxation and hydrogen/deuterium exchange, we demon
22 ions proposed on the basis of recent elegant
NMR relaxation and line-shape analyses, the energetics o
23 in of Trp102 obtained from the fluorescence,
NMR relaxation and minimum perturbation data are consist
24 in (ABP) with its ligand, d-galactose, using
NMR relaxation and molecular dynamics simulation.
25 T antigens have been investigated using 15N
NMR relaxation and molecular dynamics simulation.
26 d electron spin resonance spectroscopy, (1)H
NMR relaxation,
and (19)F NMR spectroscopy experiments w
27 re further studied by X-ray crystallography,
NMR relaxation,
and pulse-EPR methods, in conjunction wi
28 ptor-like kinase partner, according to (15)N
NMR relaxation at 11.7 and 14.1 T.
29 o barnase, is investigated with (15)N, (13)C
NMR relaxation at 11.74 and 18.78 T and with a 1.1 ns mo
30 Unlike solution
NMR relaxation-
based order parameters, order parameters
31 We report a (129)Xe
NMR relaxation-
based sensing approach that exploits chan
32 These results suggest that F- 19F
NMR relaxation can be used to predict the reactivities o
33 nce is much stronger than the case for other
NMR relaxation constants, including the "conventional" r
34 thermore, analyses of the spin-label induced
NMR relaxation corroborates the presence of a discrete t
35 The (15)N
NMR relaxation data ((15)N-T(1), (15)N-T(2), and heteron
36 bling may be determined by analysis of (15)N
NMR relaxation data according to the Lipari-Szabo model
37 al diffusion model is generally required for
NMR relaxation data analysis in single-domain proteins,
38 (15)N
NMR relaxation data and RDCs show that TM is highly orde
39 NMR relaxation data and structural studies of the folded
40 As shown by
NMR relaxation data collected at two fields, several cle
41 This method offers the possibility to use
NMR relaxation data for detailed structure characterizat
42 The interpretation of
NMR relaxation data for macromolecules possessing slow i
43 lography data on the free protein, and (15)N
NMR relaxation data for the uncomplexed and HA(8)-bound
44 Proper analysis of
NMR relaxation data for these systems in solution has to
45 (15)N
NMR relaxation data identify significant motion occurrin
46 ide bases is important for interpretation of
NMR relaxation data in terms of local dynamic properties
47 eloped by Freed and others, we interpret the
NMR relaxation data in terms of localized water translat
48 ynamic properties were determined from (15)N
NMR relaxation data in terms of the extended model-free
49 The 13C
NMR relaxation data indicate substantial dynamic fluctua
50 parameters of polyunsaturated chains and the
NMR relaxation data indicate that both DHA and DPA under
51 structure of this helix is well formed, but
NMR relaxation data indicate that there is considerable
52 (31)P-
NMR relaxation data indicated a change in lipid headgrou
53 ework is presented for the interpretation of
NMR relaxation data of proteins.
54 The approach was applied to
NMR relaxation data of ubiquitin collected at multiple m
55 Our analysis of the
NMR relaxation data quantifies subtle changes in the int
56 NMR relaxation data reveal a role for conformational pla
57 NMR relaxation data reveal that the source of the differ
58 Our structural analysis and
NMR relaxation data show that these motifs do not intera
59 Analysis of
NMR relaxation data shows that the chemical exchange exh
60 NMR relaxation data suggest that structural dynamics are
61 n of the novel RED results and corresponding
NMR relaxation data suggests that the loss of collective
62 nt of a peptide sequence, we have used (15)N
NMR relaxation data to characterize the backbone motions
63 Detailed analysis of backbone 15N
NMR relaxation data using both the Lipari-Szabo model-fr
64 namics of eotaxin-3 were determined from 15N
NMR relaxation data using the extended model free dynami
65 NMR relaxation data were analyzed by the model-free appr
66 s, their eigenvalues, and correlation times,
NMR relaxation data were calculated in accordance with B
67 characterized based on an analysis of (15)N
NMR relaxation data which we have interpreted using the
68 ze our simulation trajectories, we reproduce
NMR relaxation data without fitting any parameters of ou
69 (13)C-
NMR relaxation data, analyzed using the model-free forma
70 Comparison of (15)N
NMR relaxation data, reduced spectral density profiles,
71 On the basis of
NMR relaxation data, the alpha2 helix as well as the bet
72 in via a hydrophilic interface and, based on
NMR relaxation data, undergoes inter-domain motions enab
73 that provide a microscopic interpretation of
NMR relaxation data.
74 etation of dynamics parameters obtained from
NMR relaxation data.
75 near models and the distances implied by the
NMR relaxation data.
76 or 64TC lesions were investigated using 15N
NMR relaxation data.
77 the (3)J(NzetaCgamma)-coupling constants and
NMR-relaxation-
derived S(2) order parameters of the NH(3
78 arrowed linewidths, and accurate analysis of
NMR relaxation dispersion (CPMG) and TROSY-based CEST ex
79 NMR relaxation dispersion (RD) spectroscopy based on a C
80 By applying a combination of
NMR relaxation dispersion and fluorescence kinetics meth
81 The combination of
NMR relaxation dispersion Carr-Purcell-Meiboom-Gill (CPM
82 ermined from a linear dependence of the (1)H
NMR relaxation dispersion drawn as a function of the squ
83 millisecond dynamics that can by measured by
NMR relaxation dispersion experiments and shows a linear
84 Solution
NMR relaxation dispersion experiments performed under ph
85 Data gathered from
NMR relaxation dispersion experiments show that a subset
86 NMR relaxation dispersion experiments with that enzyme s
87 NMR relaxation dispersion experiments, coupled with conc
88 in Pol beta have been determined by solution
NMR relaxation dispersion for the apo and substrate-boun
89 and off-resonance carbon and nitrogen R1rho
NMR relaxation dispersion in concert with mutagenesis an
90 at Carr-Purcell-Meiboom-Gill (CPMG) 13Calpha
NMR relaxation dispersion measurements are a viable mean
91 NMR relaxation dispersion measurements indicate that res
92 NMR relaxation dispersion measurements of millisecond ti
93 ynamics of these states have been studied by
NMR relaxation dispersion measurements of the methyl gro
94 Based on these results and pH-dependent
NMR relaxation dispersion measurements, we estimate that
95 Here, we use side-chain proton
NMR relaxation dispersion measurements, X-ray crystallog
96 ysis using the Modelfree approach and by the
NMR relaxation dispersion measurements.
97 ange broadening effects (R(ex)) as probed by
NMR relaxation dispersion measurements.
98 We recently used
NMR relaxation dispersion methods and computational tech
99 apture key properties previously measured by
NMR relaxation dispersion methods including the structur
100 Studies employing
NMR relaxation dispersion recently showed that wobble dG
101 In the present work,
NMR relaxation dispersion spectroscopy is used to direct
102 ogical function, as demonstrated by numerous
NMR relaxation dispersion studies.
103 We applied
NMR relaxation dispersion to investigate the role of bou
104 Here we use
NMR relaxation dispersion to probe conformational exchan
105 In this study, we use a combination of
NMR relaxation dispersion, model-free analysis, and liga
106 Using
NMR relaxation dispersion, we have measured the temperat
107 Using
NMR relaxation dispersion, we show here that wobble dG*d
108 ed with intrinsic millisecond dynamics using
NMR relaxation dispersion.
109 the contacts in detail, we used paramagnetic
NMR relaxation enhancements, in combination with single-
110 A ligand-observed (1)H
NMR relaxation experiment is introduced for measuring th
111 13C-
NMR relaxation experiments (T(1), T(2), T(1)(rho), and N
112 NMR relaxation experiments and other biophysical measure
113 and side-chain order parameters derived from
NMR relaxation experiments are in excellent agreement wi
114 NMR relaxation experiments clarified the hypothesis abou
115 (19)F
NMR relaxation experiments employing an active-site inhi
116 Solution
NMR relaxation experiments identify a cluster of residue
117 NMR relaxation experiments indicated that a flexible loo
118 NMR relaxation experiments indicated that the peptide wa
119 (15)N
NMR relaxation experiments of the (15)N-labeled recombin
120 NMR relaxation experiments often require site-specific i
121 Two-dimensional 1H-15N
NMR relaxation experiments on [alpha-15N]histidine-label
122 NMR relaxation experiments reveal that HisJ becomes more
123 NMR relaxation experiments sensitive to motions of methy
124 (15)N
NMR relaxation experiments show that PTB1:34 has slow, m
125 Complementary cross-linking and
NMR relaxation experiments show that the OmpA beta-barre
126 The kinetics and
NMR relaxation experiments suggest that the weak binding
127 Moreover, we carry out
NMR relaxation experiments to characterize the picosecon
128 We have used
NMR relaxation experiments to determine the molecular ba
129 We have used (13)C
NMR relaxation experiments to examine changes in the mot
130 In this study, we used 15N
NMR relaxation experiments to probe the fast (i.e., ps-n
131 In addition, by using (15)N
NMR relaxation experiments, we find that binding ubiquit
132 Furthermore, using (15)N
NMR relaxation experiments, we show that, in the mutant
133 ributions to side-chain dynamics measured by
NMR relaxation experiments.
134 and during catalysis were characterized with
NMR relaxation experiments.
135 monitored by hydrogen/deuterium exchange and
NMR relaxation experiments.
136 sin inhibitor (BPTI) were examined using 15N
NMR relaxation experiments.
137 and two-dimensional (1)H-(15)N heteronuclear
NMR relaxation experiments.
138 ired mobility by both molecular dynamics and
NMR relaxation experiments.
139 Nuclear magnetic resonance (
NMR) relaxation experiments show that TF interacts with
140 Most theoretical models for
NMR relaxation in liquids assume that overall rotational
141 NMR relaxation indicates compensatory changes in loop fl
142 obility gradient similar to that observed in
NMR relaxation,
indicating that side chain motions mirro
143 NMR relaxation is used here to monitor the effects of hi
144 hly dynamic and mostly extended according to
NMR relaxation measurements and analytical ultracentrifu
145 ex with DNA have been characterized by (15)N
NMR relaxation measurements and model-free analysis.
146 ere investigated at 30 degrees C using (15)N
NMR relaxation measurements and NMR monitored hydrogen-d
147 Interestingly,
NMR relaxation measurements and the results of a model b
148 ely) of carboxyl side chains, based on (13)C
NMR relaxation measurements as a function of pH.
149 analogue were determined from heteronuclear
NMR relaxation measurements at similar solution conditio
150 Historically,
NMR relaxation measurements have played a dominant role
151 NMR relaxation measurements have suggested that changes
152 By use of heteronuclear (15)N
NMR relaxation measurements in a series (n = 1-6) of (15
153 ned rotational diffusion tensor derived from
NMR relaxation measurements in macromolecular structure
154 NMR relaxation measurements of 15N spin-lattice relaxati
155 motion was investigated by 1H, 13C, and 15N
NMR relaxation measurements on a DNA decamer d(CATTTGCAT
156 (2)H
NMR relaxation measurements revealed an additional water
157 (15)N
NMR relaxation measurements show that full-length HMGB1
158 Here we use
NMR relaxation measurements to address the kinetics of e
159 Here we use
NMR relaxation measurements to explore the role of the l
160 hydroxylation and epoxidation, paramagnetic
NMR relaxation measurements were conducted.
161 lectron spin resonance spectroscopy and (1)H
NMR relaxation measurements, including spin-lattice rela
162 23Na
NMR relaxation measurements, performed as a function of
163 w temperature as identified by heteronuclear
NMR relaxation measurements, secondary chemical shifts,
164 ating those that could be obtained from (1)H-
NMR relaxation measurements, were calculated between lig
165 ith a long insertion shown to be flexible by
NMR relaxation measurements.
166 ts (CTPR2 and CPTR3, respectively) using 15N
NMR relaxation measurements.
167 st equivalent of metal through heteronuclear
NMR relaxation measurements.
168 ains on a fast timescale was confirmed using
NMR relaxation measurements.
169 namics of TRX(HE) were investigated by (15)N
NMR relaxation measurements.
170 ts, PrP(29-231) and PrP(90-231), using (15)N
NMR relaxation measurements.
171 m B. fragilis have been examined using (15)N
NMR relaxation measurements.
172 bound form of Bcl-x(L) was investigated from
NMR relaxation measurements.
173 idaredoxin (Pdx) have been studied by 2D 15N
NMR relaxation measurements.
174 scale were compared with those obtained from
NMR relaxation measurements.
175 nidulans flavodoxin at pH 6.6, 303 K by 15N
NMR relaxation measurements.
176 ligands, which are less commonly analyzed by
NMR relaxation measurements.
177 were investigated using backbone amide (15)N-
NMR relaxation measurements.
178 Here,
NMR relaxation methods for characterizing thermal motion
179 of the RNA in the loop and in the stem, 13C
NMR relaxation methods have been used to describe the dy
180 es sampled during enzymatic reactions, while
NMR relaxation methods reveal the rates of interconversi
181 the unfolded monomer for each variant using
NMR relaxation methods revealed that all variants contai
182 Toward this end, we present new
NMR relaxation methods that describe ligand flexibility
183 Here, we have used mutagenesis and
NMR relaxation methods to investigate the scope and natu
184 combine high resolution field-cycling (31)P
NMR relaxation methods with spin-labeled proteins to del
185 ic group-bearing proteins studied with these
NMR relaxation methods, the side chains of oxidized flav
186 hey become invisible to traditional solution
NMR relaxation methods.
187 in the enzyme dihydrofolate reductase using
NMR relaxation methods.
188 hich has not been previously investigated by
NMR relaxation methods.
189 ht chain kinase is examined using 15N and 2H
NMR relaxation methods.
190 gated using (15)N amide and deuterium methyl
NMR relaxation methods.
191 eptide complex using site-specific deuterium
NMR relaxation methods.
192 second aromatic-ring dynamics using solution
NMR relaxation methods.
193 Several lines of evidence, including (15)N
NMR relaxation,
NMR chemical shift perturbations, static
194 Results of ligand docking and heme-induced
NMR relaxation of drug protons showed that ticlopidine w
195 latus ferrocytochrome c(2) derived from (2)H
NMR relaxation of methyl group resonances is presented.
196 elaxivity (i.e., its ability to speed up the
NMR relaxation of nearby water molecules).
197 amplitudes of the vibrations, as measured by
NMR relaxation or crystallographic B-factors, remain lar
198 Measurement of (15)N
NMR relaxation parameters and backbone hydrogen/deuteriu
199 Agreement between
NMR relaxation parameters and our theoretical results hi
200 behavior of individual domains by measuring
NMR relaxation parameters and residual dipolar couplings
201 The
NMR relaxation parameters are primarily sensitive to rot
202 filtration has allowed the determination of
NMR relaxation parameters at an unprecedented number of
203 Model-free analysis of the
NMR relaxation parameters indicated significantly greate
204 Comparison of the (15)N
NMR relaxation parameters of the holo-TrpRs with those o
205 ual structure in the intermediate state, and
NMR relaxation parameters T(1) and T(2) and inverted que
206 Here,
NMR relaxation parameters were acquired for backbone 15N
207 (15)N and (13)C
NMR relaxation parameters were measured for both peptide
208 erase by recording an extensive set of (13)C
NMR relaxation parameters.
209 protein, as indicated by the analysis of the
NMR relaxation parameters.
210 ) of this oligomer have been determined from
NMR relaxation parameters.
211 -3' sequence steps have been determined from
NMR relaxation parameters.
212 Using solid-state (2)H
NMR relaxation performed on selectively deuterated methy
213 olactin were investigated by analysis of 15N
NMR relaxation phenomena and demonstrated a rigid four-h
214 The (15)N
NMR relaxation profiles of apo-L75F-TrpR were analyzed a
215 Here we introduce an approach to making the
NMR relaxation properties of large proteins amenable to
216 ions and dynamics because of their favorable
NMR relaxation properties, which lead to sharp signals i
217 ures of disordered proteins and experimental
NMR relaxation properties.
218 (PH) domain from dynamin were studied by 15N
NMR relaxation (
R1 and R2) and steady state heteronuclea
219 bindin D(9k) have been characterized by (2)H
NMR relaxation rate measurements.
220 ) was determined from its effect on the T(2)
NMR relaxation rate of either phosphite (HPO(3)(2-)) or
221 Measurement of
NMR relaxation rate of water protons in heating-cooling
222 hibit an ex vivo nuclear magnetic resonance (
NMR) relaxation rate (1/T2) as high as 24-39 s-1/mM iron
223 NMR relaxation rates ( (15)N R 1, R 2) and (1)H- (15)N h
224 Moreover, the (2)H
NMR relaxation rates are increased by the presence of om
225 residue topology was probed by measuring 19F
NMR relaxation rates for site-specifically labeled sampl
226 The paramagnetic enhancements in the
NMR relaxation rates for the fluorine in fluorophthalate
227 ISL by analyzing the power dependence of 13C
NMR relaxation rates in the rotating frame.
228 onstrate that intermoment distances based on
NMR relaxation rates provide a sensitive indicator of in
229 distance, but the distances deduced from the
NMR relaxation rates were shorter than expected for ever
230 , predictions for the amide hydrogens of the
NMR relaxation-
restrained ensemble that become exposed t
231 alysis of protein backbone dynamics based on
NMR relaxation reveals a combination of complementary ef
232 We conducted solid-state (2)H
NMR relaxation (
spin-lattice, T(1Z), and quadrupolar-ord
233 NMR relaxation studies are capable of providing "long-ra
234 NMR relaxation studies are well suited for examining cha
235 31P
NMR relaxation studies from 0.005 to 11.7 T are used to
236 Previous
NMR relaxation studies have identified exchange line bro
237 dynamic was anticipated by previous solution
NMR relaxation studies in micelles, these measurements i
238 Here, we report (13)C
NMR relaxation studies of base and ribose dynamics for t
239 NMR relaxation studies of the complex were carried out a
240 Previous
NMR relaxation studies of the isolated RNase H domain of
241 ng 1855 order parameters from 20 independent
NMR relaxation studies on proteins whose three-dimension
242 15N
NMR relaxation studies reveal that the two zinc knuckle
243 For the first time,
NMR relaxation studies show that the viscoelastic proper
244 Previously, we showed through
NMR relaxation studies that binding of the RA-GEF2 C-ter
245 Described here are 15N
NMR relaxation studies to compare the backbone dynamics
246 NMR relaxation studies were conducted to investigate the
247 ntrifugation, size-exclusion chromatography,
NMR relaxation studies, dynamic light scattering, and ci
248 Using
NMR relaxation studies, the dynamics of the backbone nit
249 xistence of this network comes from previous
NMR relaxation studies, where motions in several residue
250 with data from fluorescence polarization and
NMR relaxation studies.
251 Herein we report a
NMR relaxation study [(1)H and (13)C T(1), T(2); (13)C{(
252 Here, we report an
NMR relaxation study of dynamics over multiple timescale
253 Longitudinal (1)H(2)O
NMR relaxation time constant (T(1)) values were measured
254 conditions were also studied by 23Na and 7Li
NMR relaxation time measurements.
255 the experimentally determined dielectric and
NMR relaxation time scales.
256 ng amide hydrogen-deuterium exchange and 15N
NMR relaxation times (T1 and T2) and 15N inverted questi
257 (1)H
NMR relaxation times (T1 and T2) were measured at low fi
258 (13)C-[(1)H]
NMR relaxation times and steady-state NOE enhancements w
259 by analysis of the power dependence of (13)C
NMR relaxation times in the rotating frame (T(1)(rho)).
260 receptor substrate-1 (IRS-PTB), we have used
NMR relaxation to determine the dynamics of backbone ami
261 We used low-field
NMR relaxation to investigate CO2 and water interactions
262 This novel approach yields (19)F T2
NMR relaxation values of any fluorinated contaminant, wh
263 Nitrogen-15 backbone and carbon-13 methyl
NMR relaxation was measured to investigate the dynamical
264 NMR relaxation was used to probe motion on the backbone
265 h measurement of enzyme kinetics, main chain
NMR relaxation,
X-ray crystallographic studies, and in v