ライフサイエンスコーパス: NMR structure

1 ly identified in the CD247 TM dimer solution NMR structure.

2 hylline complex, as observed in the previous NMR structure.

3 acy and in terms of precision, with a recent NMR structure.

4 conformation similar to the high temperature NMR structure.

5 90 degrees) from the groove predicted by the NMR structure.

6 ints for refining of the currently available NMR structure.

7 inding affinities, receptor-selectivity, and NMR structure.

8 n these quadruplex crystal structures and an NMR structure.

9 tif in the disordered NS5A-D2 and report its NMR structure.

10 erver, a quality assessment tool for protein NMR structures.

11 in 1-2 A backbone RMSD relative to X-ray and NMR structures.

12 erent local sequence contexts in crystal and NMR structures.

13 lies in the pore of the crystallographic and NMR structures.

14 ssing and the same interhelix contacts as in NMR structures.

15 ve to the experimentally determined x-ray or NMR structures.

16 in close agreement with previous crystal and NMR structures.

17 howing differences with previously described NMR structures.

18 power compared to conventionally determined NMR structures.

19 lates for KCNQ1 homology-modeling) and KCNE1 NMR structures.

20 Also predicted from the NMR structures, a G2S mutant was found to relieve these

21 The NMR structures also show that the Pab PolII intein has a

22 erior locations that bind rimantadine in the NMR structure, although these sites are partially due to

23 High-resolution NMR structure analysis of AVR3a indicates that the RxLR

24 We present the solution NMR structure and conformational dynamics of the 59 nucl

25 Here we describe the NMR structure and dynamics of Ca(2+)-bound PC2-EF.

26 nction of this protein, we characterized the NMR structure and dynamics of Nop10 proteins from both a

27 closely with the interfaces observed in the NMR structure and inferred from mutational analysis of d

28 tational analysis of Yhc1, guided by the U1C NMR structure and low-resolution crystal structure of hu

29 atch is proposed on the basis of the present NMR structure and previously reported thermodynamics.

30 We determined the solution NMR structure and studied the dynamics of medaka P2ab, a

31 ymmetric unit that are highly similar to the NMR structure and support the dynamic behaviour seen nea

32 nctional 120b pRNA was generated using a 27b NMR structure and the crystal structure of the 66b prohe

33 ectrum and 2) to solve its three-dimensional NMR structure and thus gain insight into structure-funct

34 Second, NMR structures and an existing benchmark of PDB crystall

35 The NMR structures and Autodock analysis suggest that the po

36 deviate somewhat from previously determined NMR structures and indicate that very minor structural c

37 bed here can improve the accuracy of protein NMR structures and should find broad and general for stu

38 finement of their X-ray crystal and solution NMR structures and the characterization of structural an

39 hin 1 A rmsd of the traditionally determined NMR structure, and fit independently collected RDC data

40 f proteins better than individual crystal or NMR structures, and can suggest experimentally testable

41 , and 12 experimentally determined X-ray and NMR structures are nearly identical to the computational

42 antially, irrespective of using a crystal or NMR structure as the starting conformation.

43 in the available (but membrane-free) crystal/NMR structures as pointing away from the membrane (helix

44 ctural order of the beta2-alpha2 loop in the NMR structure at pH 4.5 and 20 degrees C, caused transmi

45 m a well-structured beta2-alpha2 loop in the NMR structures at 20 degrees C termed rigid-loop cellula

46 ructure solution, although there are several NMR structures available.

47 Here we describe the solution NMR structure, backbone dynamics, and heme binding prope

48 Subsequent NMR structure-based mutational analysis of the region hi

49 Together with classical automated NMR structure calculation, this allowed us to faithfully

50 However, NMR structure calculations typically use a simple repuls

51 t inclusion of (15)N R(2)/R(1) restraints in NMR structure calculations without any a priori assumpti

52 erdeuterated samples to guide RASREC Rosetta NMR structure calculations.

53 Finally, the static alpha3Y NMR structure cannot explain (i) how the phenolic proton

54 and a tool for interactive visualization of NMR structures, corresponding experimental data as well

55 lacement, such information is rarely used in NMR structure determination because it can be incorrect,

56 The pK(a) coupling and NMR structure determination demonstrate that protonated

57 han 15 kilodaltons and should enable routine NMR structure determination for larger proteins.

58 NMR structure determination further reveals that despite

59 lication as weak-alignment media in solution NMR structure determination of membrane proteins in dete

60 th identical solution conditions as used for NMR structure determination or for crystallization trial

61 ilable at the early stage of the traditional NMR structure determination process, before the collecti

62 Conventional NMR structure determination requires nearly complete ass

63 NMR structure determination reveals a symmetric dimer in

64 NMR structure determination reveals that J2a/b forms a d

65 ar masses up to 15.4 kDa, whose conventional NMR structure determination was conducted in parallel by

66 nd binding studies with peptide mutagenesis, NMR structure determination, and molecular modeling, we

67 ), residue two in our CTD construct used for NMR structure determination, but not present in the crys

68 tag was required to get spectra suitable for NMR structure determination, while the tag was required

69 provides a new direction for high-throughput NMR structure determination.

70 are important global angular restraints for NMR structure determination.

71 Despite the advances in NMR, structure determination is often slow and constitut

72 This work reports NMR structure determinations of the C-terminal domain (S

73 Finally, NMR structure determinations suggested that MTP1 would b

74 auser effect restraints, greatly simplifying NMR structure determinations.

75 NMR structures display more variability, but is this bec

76 lar to the crystal structure of apoE-NT, the NMR structure displayed an elongated four-helix bundle.

77 ll-converged and stably folded nature of the NMR structure ensemble, experimentally resolved intermol

78 The NMR structure exhibits an excellent agreement with the d

79 In this study, we present an NMR structure for the entire EAG domain, which reveals t

80 Here we present liposome fusion data and NMR structures for a complete (54-residue) disulfide-bon

81 utine determination of high-quality solution NMR structures for proteins up to 40 kDa, and should be

82 Here, we present the NMR structures for the two lobes of CaM each bound to a

83 in the middle of the channel, whereas in the NMR structure four drug molecules bind at the channel's

84 eomics Project; and (iii) static crystal and NMR structures from the Protein Data Bank.

85 igid methyl rotation barriers in a series of NMR structures from the Protein Databank.

86 ies with a NaV1.7 homology model and peptide NMR structure generated a model consistent with the key

87 Using NMR structure-guided mutagenesis, electrophoretic mobili

88 To confirm the NMR structure in a membrane-like environment, we studied

89 an be difficult to judge the precision of an NMR structure in an objective manner.

90 NMR structures in dodecylphosphocholine micelles at pH 7

91 ant differences from the previously reported NMR structures in some regions of the ShK protein molecu

92 Our NMR structures indicated that the different thermostabil

93 al flexibility (derived from the ensemble of NMR structures), interhelical hydrogen bonds, and native

94 In contrast, the NMR structure is based on a peptide/micelle construct th

95 structure-like packing in the core, but more NMR-structure-like variability in loops, may in some cas

96 his study, we determined the high-resolution NMR structure of (Aalpha(2)-L1M/L38M)(2) in the presence

97 insight into its function, we determined the NMR structure of (Ba)SrtA bound to a LPXTG sorting signa

98 The NMR structure of 1 demonstrated that compound 1 retained

99 The NMR structure of [betaCpe(34)]-NPY-(25-36) in dodecylpho

100 The solution-NMR structure of a 15-kDa biologically active C-terminal

101 ng of XPA to ERCC1 derives from the solution NMR structure of a complex between the ERCC1 central fra

102 The NMR structure of a complex of Pex5-(57-71) with the Pex1

103 in conjunction with the previously reported NMR structure of a dimeric PGN fragment, permitted ident

104 We additionally determined a solution NMR structure of a divergent fungal homolog, and compari

105 We report here the NMR structure of a domain IIa construct in complex with

106 i formation, we have determined the solution NMR structure of a double mutant of CsgE (W48A/F79A) tha

107 The solution state NMR structure of a peptide comprising the LD anchor boun

108 The NMR structure of a peptide-RNA complex reveals that thes

109 The recent NMR structure of a PLN pentamer depicts cytoplasmic heli

110 Together with the recently published NMR structure of a UCP family member, our data provide a

111 Here, we extend our recent findings on the NMR structure of A3A and report structural, biochemical

112 Here we report solution NMR structure of an 11-kDa BRCA1 C-terminus (BRCT) domai

113 Although an NMR structure of an engineered proinsulin monomer has be

114 ur knowledge, the first magic-angle spinning NMR structure of an intact filamentous virus capsid and

115 This structure represents the first NMR structure of an intercalated RNA duplex, of either b

116 The NMR structure of an OCRE-SmN peptide complex reveals a s

117 We report the NMR structure of apoE3, displaying a unique topology of

118 The NMR structure of AtraPBP1 at pH 4.5 contains seven alpha

119 gh-resolution crystal structure and solution NMR structure of AYEdesign, which show that the experime

120 The high-resolution NMR structure of C-terminal domains III and IV of the AU

121 Here we present the NMR structure of Ca(2+)-CaM bound to two molecules of ER

122 The NMR structure of Ca2+-bound Frq1 complexed to an N-termi

123 Here, we present the NMR structure of CaM bound to MA-(8-43).

124 Here, the NMR structure of CBP reveals a highly intertwined homodi

125 nliganded GAF-A with the previously reported NMR structure of cGMP-bound PDE5 revealed dramatic confo

126 The three-dimensional NMR structure of chicken AvBD2 defensin displays the str

127 Here, we present the solution NMR structure of CUG-binding protein 2 RRM3 in complex w

128 The NMR structure of Dph4 reveals two domains: a conserved J

129 We describe the NMR structure of DsbB, a polytopic helical membrane prot

130 The NMR structure of Dtrx shows a different charge repartiti

131 Here we present the 3D NMR structure of ECD1 of CRF-R2beta in complex with astr

132 Comparison of the NMR structure of free FluA with the X-ray structures of

133 Here, we report the NMR structure of full-length PriC from Cronobacter sakaz

134 ck-calculated RDCs using the high-resolution NMR structure of GlyR TM23 in trifluoroethanol as the st

135 The NMR structure of gp6 reveals a dimeric protein with a he

136 The 2D (1)H-NMR structure of HB10 revealed a beta-hairpin loop stabi

137 The NMR structure of HlyIIC reveals a novel fold, consisting

138 ween amylin and membranes, we determined the NMR structure of human amylin bound to SDS micelles.

139 Unlike the recent NMR structure of human VDAC1, the position of the voltag

140 Klebsiella oxytoca, obtained by fitting the NMR structure of its calcium-bound subunit PulG into the

141 Here we report the NMR structure of its kringle domain, NT/K.

142 The NMR structure of its RNA-binding domain shows two unusua

143 We solve the NMR structure of its transmembrane domain in micelles an

144 sulfate as a membrane model, we examined the NMR structure of K2 in the presence and absence of the m

145 However, a solution NMR structure of M2(18-60) showed four rimantadines boun

146 We have solved the solution NMR structure of micelle-bound syntaxin-1A in its prefus

147 The NMR structure of n-NafY reveals that it belongs to the s

148 Here, we report the high resolution NMR structure of N-terminal truncated ComGC revealing a

149 invisible in a previously published solution NMR structure of OmpG in n-dodecylphosphocholine micelle

150 An NMR structure of one of our most promising compounds was

151 olecular docking simulations using a refined NMR structure of rho-TIA, we identified 14 residues on t

152 Our study describes for the first time a NMR structure of SCP-2 in lepidopteran H. armigera and r

153 The NMR structure of Sdh5 represents the first eukaryotic st

154 The NMR structure of SrtA has been determined with a backbon

155 The three-dimensional NMR structure of Synechococcus OS-B' cyanobacterial Phy

156 The NMR structure of Tah1 has been solved, and this structur

157 his gap in our knowledge, we have solved the NMR structure of the 10th complement type repeat of huma

158 The NMR structure of the 21 kDa lipocalin FluA, which was pr

159 The NMR structure of the 34 -kDa ternary complex of the RNA

160 The NMR structure of the [3]catenane was determined, suggest

161 We report the NMR structure of the [W184A/M185A]-CTD mutant in its mon

162 Here, we report the NMR structure of the actin-binding domain contained in t

163 The solution NMR structure of the alpha-helical integral membrane pro

164 he secretin receptor was developed using the NMR structure of the analogous domain of the corticotrop

165 Here, we report the solution NMR structure of the autoinhibitory domain of WNK1 (WNK1

166 The differences of the current solid-state NMR structure of the bilayer-bound M2TMP from the deterg

167 The NMR structure of the bundle reveals a conserved surface-

168 The solution NMR structure of the C-terminal NlpC/P60 domain of E. co

169 Determining the NMR structure of the C. glabrata Gal11A KIX domain provi

170 tubular assembly of CA and a high-resolution NMR structure of the CA C-terminal domain (CTD) dimer.

171 Here we report the NMR structure of the CCHF virus Gn cytoplasmic tail, res

172 The NMR structure of the chicken CD3epsilondelta/gamma heter

173 We report here a high-resolution NMR structure of the complete receptor-binding domain of

174 An NMR structure of the complex between the CXCL12 dimer an

175 Here, we present an NMR structure of the complex of PI4KB and its interactin

176 nalyze biophysical properties and report the NMR structure of the complex of the C-terminal tandem he

177 in into a well-defined conformation, and the NMR structure of the complex shows the drug bound in the

178 Here we report the solution NMR structure of the core ILK.PINCH complex (28 kDa, K(D

179 In the recent solution NMR structure of the DAP12-NKG2C immunoreceptor transmem

180 We solved the NMR structure of the DNA-binding Myb domain of TbTRF, wh

181 We report a magic angle spinning (MAS) NMR structure of the drug-resistant S31N mutation of M21

182 We now report the three-dimensional NMR structure of the ECD1 of human CRF-R1 complexed with

183 ximately 45 degrees from that observed in an NMR structure of the Escherichia coli LpoA N domain.

184 ittle is known about its structure beyond an NMR structure of the extreme C-terminus, which is known

185 Here, we present a high resolution solution NMR structure of the free form of the MptpA LMW-PTP.

186 Here, we have determined the NMR structure of the functional AbbA dimer, confirmed th

187 We report the NMR structure of the G-quadruplex formed by the conserve

188 In this study, we report a high-resolution NMR structure of the G-rich element within the KRAS NHE.

189 Here, we report the 3D NMR structure of the Helianthus annuus PawS1 (preproalbu

190 al screening based on the recently published NMR structure of the hGlyR-alpha1 transmembrane domain (

191 d from molecular dynamics simulations of the NMR structure of the hGlyR-alpha1 transmembrane domain i

192 We report the solution NMR structure of the hLARP7 CTD and show that this domai

193 tural information available was the solution NMR structure of the inactive calcium-free form of the p

194 Here, we determined an NMR structure of the isolated C-terminal domain of the A

195 We have determined the solution NMR structure of the K-turn sequence element within the

196 We determined the NMR structure of the kindlin-2 PH domain bound to the he

197 The solution NMR structure of the Kluyveromyces lactis pseudoknot, pr

198 l shift differences relative to the solution NMR structure of the monomer, and mutagenesis.

199 ure overall resembles the recently published NMR structure of the murine cytomegalovirus homolog pM50

200 Here we present the NMR structure of the murine leukaemia virus recoding sig

201 Here, we report the NMR structure of the N-terminal domain (residues 1-74, c

202 The new NMR structure of the Pdx-CYP101 complex agrees well with

203 The NMR structure of the peptide establishes that there is n

204 Here, we report the high resolution solution NMR structure of the PilA protein from G. sulfurreducens

205 Here, we report the NMR structure of the PrgI needle protein of Salmonella t

206 ructures are similar to that observed in the NMR structure of the rat skeletal overlap complex.

207 Our recent study established the NMR structure of the recombinant bAalpha406-483 fragment

208 Here we report the NMR structure of the recombinant LP2086 variant B01, a r

209 Here we present the NMR structure of the reduced form of Cr-TRP16, along wit

210 The NMR structure of the resulting mutant reveals significan

211 The NMR structure of the severe acute respiratory syndrome c

212 The NMR structure of the SUMO-2.phospho-RAP80 complex reveal

213 rotein and TER domains, including a solution NMR structure of the Tetrahymena pseudoknot.

214 In this study, we have determined the NMR structure of the three individual R-modules from Alg

215 A solution NMR structure of these compounds bound to tubulin shows

216 ese observations, we determined the solution NMR structure of TRTK12 in a complex with Ca 2+-loaded S

217 Here we describe the solution NMR structure of ubiquitin in complex with an SH3 domain

218 The solution-NMR structure of VG16KRKP in lipopolysaccharide features

219 The NMR structure of XlePABP2-TRP revealed that the protein

220 oposed sst(1) pharmacophore derived from the NMR structures of a family of mono- and dicyclic undecam

221 Previously, we reported the NMR structures of Ac-18A-NH(2) (renamed as 2F because of

222 s flexibility has been observed in X-ray and NMR structures of acyl carrier proteins attached to diff

223 Together with NMR structures of amylin and the IGF and epidermal growt

224 NMR structures of both peptide-RNA complexes of Rev and

225 Here we present NMR structures of CaBP1 in both Mg2+-bound and Ca2+-boun

226 Here we present NMR structures of CaBP4 in both Mg(2+)-bound and Ca(2+)-

227 rb beta-hairpin formation, as judged by (1)H NMR structures of four peptides determined to <1 A backb

228 tose binding to gal-1 and to derive solution NMR structures of gal-1 in the lactose-bound and unbound

229 High-resolution NMR structures of hIAPP bound to zinc reveal changes in

230 g-range interresidue distances obtained from NMR structures of holo to apo transitions in calmodulin.

231 eing revealed by a combination of crystal or NMR structures of individual subunits and electron micro

232 Comparison to previous NMR structures of isolated, inactive substrates provides

233 E2 from Asticcacaulis excentricus, we solved NMR structures of its substrates astexin-2 and astexin-3

234 We determined the NMR structures of mouse and human Fas TM domains in bice

235 X-ray and NMR structures of protein-protein complexes, their assoc

236 e have developed an approach for determining NMR structures of proteins over 20 kDa that utilizes spa

237 By solving solution NMR structures of selected macrocycles and combining the

238 NMR structures of six ligands of this family (the antago

239 ect structural insights have been limited to NMR structures of soluble domains.

240 The solution NMR structures of the 20 kDa apo-YdbC dimer and YdbC:dT(

241 The 3D NMR structures of the analogues in dimethylsulfoxide are

242 Solution NMR structures of the blue light-absorbing dark state Pb

243 ted compounds enabled the elucidation of the NMR structures of the C-terminal domain of EB1 in the fr

244 different orientations in several X-ray and NMR structures of the CTD dimer and full-length CA prote

245 Recent crystal and NMR structures of the CXC chemokine receptors (CXCR) CXC

246 6-Glu22 of Abeta42) mutated forms of IDE and NMR structures of the full-length Abeta40 and Abeta42 ha

247 We report the solution NMR structures of the hyperthermophilic Pyrococcus abyss

248 We determined NMR structures of the NCS-1 homolog from fission yeast (

249 NMR structures of the regulatory domain show that its ac

250 The x-ray crystal and solution NMR structures of the transmembrane region of the M2 hom

251 High-resolution NMR structures of these acylated forms revealed that act

252 Although crystallographic or NMR structures of these DBDs and a trimerization core ha

253 gh resolution crystal structure and solution NMR structures of this motif reveal a novel and stable h

254 Here, we present the NMR structures of ToxB and its inactive homolog Ptr toxb

255 re the DNA cytidine deaminase activities and NMR structures of two A3G catalytic domain constructs.

256 Although multiple solution NMR structures of XPA(98-219) have been determined, the

257 NMR structures of zeta-subunits, which are recently disc

258 The nuclear magnetic resonance (NMR) structure of a central segment of the previously an

259 The nuclear magnetic resonance (NMR) structure of a globular domain of residues 1071 to

260 report the first nuclear magnetic resonance (NMR) structure of a synthetic agnoprotein peptide spanni

261 ent the solution nuclear magnetic resonance (NMR) structure of mouse hepatitis virus (MHV) nsp3a and

262 re we report the nuclear magnetic resonance (NMR) structure of the membrane-embedded, heterotrimeric

263 The nuclear magnetic resonance (NMR) structure of Vav1 SH2 in complex with a doubly phos

264 The nuclear magnetic resonance (NMR) structures of the I544A and L529A I544A mutants in

265 of interest in the absence of X-ray crystal/NMR structures or homology models.

266 The WSK3 NMR structure (PDB ID code 2K1E) resembles the KcsA crys

267 splay minimal fluxionality; a well-converged NMR structure rationalizes all of the large structuring

268 half of the improvement when fitting to the NMR structures relates to the amide proton deviating fro

269 stance and angle constraints, and a reliable NMR structure represented by a family of conformers.

270 helices of collagen fibers whereas solution NMR structures reveal the simpler interactions of isolat

271 The NMR structure revealed that this deletion mutant undergo

272 The NMR structure reveals an internal loop with no hydrogen

273 Our NMR structure reveals that both lobes of CaM collapse on

274 A solution NMR structure reveals that the native Pin WW beta-sheet

275 Analysis of the available crystal and NMR structures reveals specific structural mechanisms fo

276 While prior X-ray crystal and NMR structures show that DNA with oxoG lesions appears v

277 By contrast, the composite X-ray/NMR structures show that finger 1 continues to follow th

278 In the cryo-trapped meta I state, the (2)H NMR structure shows a reduction of the polyene strain, w

279 The NMR structure shows some important differences compared

280 The NMR structure shows that AGR2 consists of an unstructure

281 The NMR structure shows that the heptaloop adopts a well-org

282 A solution NMR structure shows that the homodimer exhibits parallel

283 vel of agreement approaches the precision of NMR structures solved in different membrane mimetics.

284 NMR structures solved under molecular crowding experimen

285 Thus, the NMR structure suggests a unified scheme for the initiati

286 NMR restraints yields more accurate protein NMR structures than those that have been deposited in th

287 ct of P6.1 pseudouridylation on its solution NMR structure, thermodynamic stability of folding and te

288 ted on its first ubiquitin-like domain whose NMR structure thus was determined.

289 We have found that refinement of protein NMR structures using Rosetta with experimental NMR restr

290 In addition, the NMR structure was determined for Ca(2+)-S100A1 bound to

291 Furthermore, its NMR structure was elucidated and employed in a molecular

292 rotocol for restrained refinement of protein NMR structures was also compared with restrained CS-Rose

293 fter simulation for 50 ns initiated with the NMR structure, we observed that the protein spontaneousl

294 3D NMR structures were calculated for des-AA(1,4-6,10,12,13

295 The NMR structures were determined to a backbone root mean s

296 ystal, all of the restrained Rosetta refined NMR structures were sufficiently accurate to be used for

297 not near RNA in the crystal structures or in NMR structures with RNA oligomers (aa 37-46).

298 The high-solution NMR structure, with a backbone root mean-square deviatio

299 sis of MMP-12 and allows us to determine its NMR structure without an inhibitor.

300 e modeled on the nuclear magnetic resonance (NMR) structure without significant distortion.