ライフサイエンスコーパス: NOD-like receptor

1 -like receptors, C-type lectin receptors and NOD-like receptors.

2 of pathogen-associated molecular patterns by Nod-like receptors.

3 ammasome components, including caspase 1 and Nod-like receptors.

4 responses mediated by both the TLRs and the NOD-like receptors.

5 TLRs, and nucleotide oligomerization domain (NOD)-like receptors.

6 r Toll-like receptors (TLRs) 1, 2, 4, and 6; NOD-like receptor 2; and the signaling adaptor molecule

7 e nucleotide-binding oligomerization domain (NOD)-like receptor 3 (NLRP3) inflammasome has been impli

8 Furthermore, baicalein reduced NOD-like receptor 3 (NLRP3) inflammasome activation and

9 hogen-associated molecular patterns activate Nod-like receptor 3, which activates caspase-1 through t

10 AE is dependent on ASC and caspase-1 but not Nod-like receptor 3.

11 or and regulatory interactions with TLRs and Nod-like receptors, Ag presentation, naive T cell repert

12 owever, their usefulness in conjunction with NOD-like receptor agonists remains poorly studied.

13 Remarkably, a conserved fungal NOD-like receptor and prion pair can functionally recons

14 hat have common structural features with the Nod-like receptors and are essential for protection agai

15 cells as microbial sensors through TLRs and Nod-like receptors and identify Nod1 and RICK as importa

16 NF-kappaB downstream of Toll-like receptors, Nod-like receptors, and the T cell receptor.

17 complex, plant R proteins and related animal Nod-like receptors, and with the Hsp90 molecular chapero

18 d nucleotide binding oligomerization domain (NOD)-like receptors are critical for IL-1-dependent host

19 Toll-like receptors and NOD-like receptors are families of innate immune recepto

20 in leucine-rich-repeat-containing receptors; NOD-like receptors) are a class of pattern recognition r

21 e cluster also encoding a lipase (SBP) and a Nod-like receptor, both of which display the PP motif.

22 d nucleotide-binding oligomerization domain (NOD)-like receptor C4 (NLRC4) were associated with neutr

23 in receptors Toll-like receptor 5 (TLR5) and NOD-like receptor C4 (NLRC4).

24 em (T3SS) needle complex that induces NLRC4 (NOD-like receptor C4) activation, interleukin-1beta (IL-

25 Toll-like receptors and Nod-like receptors, collectively referred to as pattern

26 endent of new production of pro-IL-1beta and NOD-like receptor components.

27 beta by sterile particles is mediated by the NOD-like receptor containing a pyrin domain 3 (NLRP3) in

28 B. abortus was diminished in the absence of Nod-like receptor containing a pyrin domain 3 and absent

29 Both absent in melanoma 2 and Nod-like receptor containing a pyrin domain 3 are partia

30 ors encoding a PYD belong to the families of NOD-like receptors containing a PYD (NLRPs) or AIM2-like

31 specific angiogenic responses in a TLR- and NOD-like receptor-dependent fashion.

32 r nucleotide-binding oligomerization domain (NOD)-like receptors, detect tissue damage or microbial i

33 re, we demonstrate that double deficiency of Nod like receptor family, pyrin domain containing 3 (NLR

34 e nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 12 (NL

35 d nucleotide-binding oligomerization domain (NOD)-like receptor family, pyrin domain containing 3 act

36 Nucleotide-binding oligomerization domain (NOD)-like receptor family, pyrin domain-containing prote

37 e nucleotide-binding oligomerization domain (NOD)-like receptors family members are key for innate im

38 Members of the Nod-like receptor family (including Nlrp1, Nlrp3, and Nl

39 Nod-like receptor family card containing 4 (NLRC4)/Ipaf

40 The Nod-like receptor family in man contains proteins that r

41 e recently found that asbestos activates the nod-like receptor family member containing a pyrin domai

42 learance during IAV infection.IMPORTANCE The NOD-like receptor family member NLRC5 is known to regula

43 f caspase-1, through a process requiring the NOD-like receptor family member NLRP3 and the inflammaso

44 Here, we report that NLRX1, a NOD-like receptor family member, negatively regulates To

45 The NOD-like receptor family members and the NALP3 inflammas

46 show that NOD1 and NOD2, two members of the NOD-like receptor family of PRRs, are important mediator

47 ion-induced caspase-1 activation occurs by a Nod-like receptor family protein 3-independent mechanism

48 flow, and local tissue hypoxia activate the NOD-like receptor family pyrin domain containing 3 infla

49 tely on inhibition of the IL-1beta-producing NOD-like receptor family pyrin domain containing 3 infla

50 nt Domain (CARD)), pro-caspase-1, and NLRP3 (NOD-Like Receptor family Pyrin domain containing 3).

51 CRC development, where mice deficient in the NOD-like receptor family pyrin domain containing 6 (NLRP

52 his study aims to compare salivary levels of nod-like receptor family pyrin domain containing protein

53 to IL-1 and IL-18, suggesting a role for the NOD-like receptor family pyrin domain containing-3 infla

54 ins induced release of IL-1beta dependent on NOD-like receptor family pyrin domain-containing 3 (NLRP

55 The SREBP-induced NOD-like receptor family pyrin domain-containing protein

56 manner, which leads to the activation of the NOD-like receptor family pyrin domain-containing protein

57 NLRC4 is a cytosolic member of the NOD-like receptor family that is expressed in innate imm

58 NLRX1, a member of the Nod-like receptor family that translocates to the mitoch

59 Members of the Nod-like receptor family, including NLRP1, NLRP3 and NLR

60 ain (Nod)1, a member of the intracytoplasmic Nod-like receptor family, induced potent secretion of th

61 NLRP12, a member of the NOD-like receptor family, is expressed in myeloid and bo

62 ns of chitosan, but not chitin, activate the NOD-like receptor family, pyrin domain containing 3 (NLR

63 The NOD-like receptor family, pyrin domain containing 3 (NLR

64 of the mature IL-1beta form depended on the NOD-like receptor family, pyrin domain containing 3 (NLR

65 We hypothesized that Gal3 is a key to induce NOD-like receptor family, pyrin domain containing 3 (NLR

66 Activation of the NOD-like receptor family, pyrin domain containing 3 (NLR

67 an neutrophils express key components of the NOD-like receptor family, pyrin domain containing 3 (NLR

68 NOD-like receptor family, pyrin domain containing 3 (NLR

69 eroxide in the mechanisms tightly regulating NOD-like receptor family, pyrin domain containing 3 acti

70 The key role of the NOD-like receptor family, pyrin domain containing 3 infl

71 nt thinking, an early intervention targeting NOD-like receptor family, pyrin domain containing 3 infl

72 t transient, increase in the activity of the NOD-like receptor family, pyrin domain containing 3 infl

73 The NLRP3 (NOD-like receptor family, pyrin domain containing 3) inf

74 recent evidence that the NOD2 target, NLRP3 (NOD-like receptor family, pyrin domain containing 3) is

75 leading to enhanced Caspase-1/Caspase-4- and NOD-like receptor family, pyrin domain containing 3-depe

76 The NOD-like receptor family, pyrin domain-containing 3 (NLR

77 re we show that bee venom is detected by the NOD-like receptor family, pyrin domain-containing 3 infl

78 tidylarginine deiminase 4, and activates the NOD-like receptor family, pyrin domain-containing 3 infl

79 1 and NOD2, two members of the intracellular NOD-like receptor family, sense bacterial peptidoglycan-

80 2, the founding members of the intracellular NOD-like receptor family, sense conserved motifs in bact

81 lular stress is activation of members of the NOD-like receptor family, such as NLRP3, to assemble cas

82 best characterized members of the cytosolic NOD-like receptor family.

83 1 has long remained an elusive member of the NOD-like-receptor family of innate immune sensors.

84 The specific ligands for some NOD-like receptors have been identified.

85 omoting colon tumorigenesis, but the role of Nod-like receptors in regulating tumorigenesis remains u

86 as HMGB1 and IL-1beta, Toll-like receptors, Nod-like receptors including NLRC4, NLRP3 and NLRP4, and

87 nduces caspase 1 activation through multiple Nod-like receptors, including Ipaf and Nalp3.

88 lar endothelial growth factor inhibited TLR-/NOD-like receptor-induced HIMEC angiogenesis.

89 ror rate, FWER p-value <0.05), including the NOD-like receptor inflammasome (NLR; p < 0.001), toll-li

90 roducts in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1

91 the detection of bacterial products through Nod-like receptors leads to the secretion of mature inte

92 and plays an important role in both TLR and NOD-like receptor ligand induced inflammation.

93 MAPK, mitogen-activated protein kinase; NLR, NOD-like receptors; LRR, leucine-rich repeats; DC, dendr

94 mmune receptors, the Toll-like receptors and Nod-like receptors, many of which are upstream of nuclea

95 ment in vivo results in up-regulation of the Nod-like receptor member Nod1, which recognizes the prod

96 The Nod-like receptor NACHT, LRR, and PYD domain-containing

97 Once detected by the NOD-like receptors Naip5 and Ipaf (Nlrc4), flagellin tri

98 The NOD-like receptors NAIP5 and NLRC4 play an essential rol

99 e nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) (nucleotide-binding domain leuc

100 cleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family contribute to immune res

101 pathways and Nuclear Oligomerization Domain (NOD)-Like Receptor (NLR) pathways and Caspase networks.

102 Nucleotide-binding, oligomerization domain (NOD)-like receptor (NLR) proteins are a family of innate

103 n nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) proteins.

104 , including the Toll-like receptor (TLR) and Nod-like receptor (NLR) families.

105 agellin secreted by Salmonella activates the Nod-like receptor (NLR) family CARD domain containing pr

106 cular mechanisms promoting activation of the Nod-like Receptor (NLR) family member NLRP3 inflammasome

107 NOD2 is a NOD-like receptor (NLR) family member that senses and re

108 flammasome, a multiprotein complex formed by NOD-like receptor (NLR) family members, has recently bee

109 The Nod-like receptor (NLR) family of innate immune cell sen

110 The Nod-like receptor (NLR) family of innate immune cell sen

111 NLRC4 and NLRP3, of the NOD-like receptor (NLR) family of intracellular proteins

112 Members of the NOD-like receptor (NLR) family of pathogen recognition r

113 Nod1, a member of the Nod-like receptor (NLR) family of pattern recognition re

114 NALP1 is a member of the NOD-like receptor (NLR) family of proteins that form inf

115 h several inflammasome components, including NOD-like receptor (NLR) family pyrin domain-containing 3

116 Members of the Nod-like receptor (NLR) family, including NLRP1, NLRP3 a

117 The NOD-like receptor (NLR) family, pyrin domain-containing

118 Activating-mutations in NOD-like receptor (NLR) family, pyrin domain-containing

119 Nlrp1b belongs to the Nod-like receptor (NLR) gene family and contributes to i

120 sensed and restricted in vivo, especially by NOD-like receptor (NLR) inflammasomes, is largely unknow

121 ld be rescued by administration of bacterial Nod-like receptor (NLR) ligands (the NOD1 ligand MurNAcT

122 C)/PYCARD, a central adaptor molecule in the Nod-like receptor (NLR) pathway, regulates the IL-18/IFN

123 NOD1 and NOD2 are members of the NOD-like receptor (NLR) protein family that are involved

124 NLRC5, a member of the NOD-like receptor (NLR) protein family, has recently bee

125 previously reported inhibitory effect of the Nod-like receptor (NLR) protein NLRX1 on NF-kappaB- and

126 NLRX1 is a mitochondrial Nod-like receptor (NLR) protein whose function remains e

127 have been identified in the NACHT domains of Nod-like receptor (NLR) proteins.

128 NOD2, a NOD-like receptor (NLR), is an intracellular sensor of b

129 is activated through amyloid templating by a Nod-like receptor (NLR).

130 ing evidence highlights additional roles for Nod-like receptors (NLR) in nonhematopoietic cells.

131 Toll-like receptors and Nod-like receptors (NLR) play an important role in sensi

132 A diverse class of PRRs, the NOD-like Receptors (NLR), has recently been implicated i

133 pathogen recognition receptors, known as PYD-Nod-like receptors (NLR), PAN, PYPAF, NALP, Nod, and Cat

134 rs, such as Toll-like receptors (TLR) and/or Nod-like receptors (NLR).

135 -associated speck-like protein (ASC) and the NOD-like receptor NLRC4 are significantly down-regulated

136 in a mouse we recently described lacking the NOD-like receptor NLRP10 (NLR family, pyrin domain conta

137 The intracellular NOD-like receptor Nlrp3 is rapidly emerging as a crucial

138 als, stimulates the inflammasome through the Nod-like receptor NLRP3.

139 aureus exoproteins through activation of the NOD-like receptors NLRP3 and NLRP4 and enhanced phagocyt

140 osolic pattern recognition receptors such as NOD-like receptors, NLRP3 inflammasomes.

141 r nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) and the adaptor ASC is believ

142 r nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) and they initiate innate immu

143 e nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are a family of intracellular

144 cleotide oligomerization and binding domain (NOD)-like receptors (NLRs) are a major constituent of th

145 cleotide oligomerization and binding domain (NOD)-like receptors (NLRs) are important in the innate i

146 cleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) have shaped our current under

147 f nucleotide binding oligomerization domain (NOD)-like receptors (NLRs) in innate detection of influe

148 cleotide oligomerization and binding domain (NOD)-like receptors (NLRs), caspase-1, and in some cases

149 n nucleotide binding oligomerization domain (NOD)-like receptors (NLRs), retinoic acid-inducible prot

150 NOD-like receptors (NLRs) and caspase-1 are critical com

151 The NOD-like receptors (NLRs) are a specialized group of int

152 NOD-like receptors (NLRs) are central components of the

153 NOD-like receptors (NLRs) are increasingly implicated in

154 underway and have already revealed specific NOD-like receptors (NLRs) as inflammatory triggers.

155 In contrast, the role of NOD-like receptors (NLRs) in viral recognition and induc

156 influence of human polymorphisms in TLRs and Nod-like receptors (NLRs) on C. burnetii-induced cytokin

157 The NOD-like receptors (NLRs) were among the first innate im

158 These receptors include cytoplasmic NOD-like receptors (NLRs) whose stimulation recruits and

159 xamine the effects of glucocorticoids on the NOD-like receptors (NLRs), a central component of the in

160 ptors, including Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-1-like receptors (RLR

161 w the varied roles of one class of PRRs, the NOD-like receptors (NLRs), in immune responses and propo

162 The innate immune system encodes cytosolic Nod-like receptors (NLRs), several of which activate cas

163 Although they are among the best studied NOD-like receptors (NLRs), the therapeutic potential of

164 In order to determine the role of NOD-like receptors (NLRs), we used an experimental Esche

165 ogenous danger signals in the cytosol engage NOD-like receptors (NLRs), which assemble inflammasome c

166 bial sensors have been identified, including NOD-like receptors (NLRs).

167 nsors such as Toll-like receptors (TLRs) and NOD-like receptors (NLRs).

168 ptors (PRRs), Toll-like receptors (TLRs) and NOD-like receptors (NLRs).

169 like receptors and the more recently defined NOD-like receptors (NLRs): NODs, NALPs, NAIP and IPAF.

170 cleotide-binding and oligomerization domain (NOD)-like receptors NOD1 and NOD2 are cytosolic innate i

171 g IL-22 secretion by iNKT cells, whereas the NOD-like receptors NOD2 and NLRP3 are dispensable.

172 Among various NOD like receptors, NOD2 was significantly upregulated i

173 Nucleotide-binding oligomerization domain (NOD)-like receptors of which there are more than 20 rela

174 ins of plants (R-proteins) and the so-called NOD-like receptors of animals (NLRs) share a domain arch

175 mous substitutions in NOD-2, a member of the NOD-like receptor or NACHT-leucine-rich repeat (NLR) fam

176 ction of ASC with IFI16 but not with AIM2 or NOD-like receptor P3 (NLRP3) was detected.

177 ase of IL-1alpha, which was still high after Nod-like receptor P3 inhibition via glibenclamide.

178 reptococcus (GBS)-mediated activation of the Nod-like receptor-P3 (NLRP3) inflammasome in macrophages

179 cine-rich repeat-containing protein (NLR or (NOD-like)) receptors play a critical role in the innate

180 e nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome to rec

181 his study was that sustained activity of the Nod-like receptor protein (NLRP)-3 inflammasome in wound

182 tosis, in T lymphocytes through induction of Nod-like receptor protein 3 (NLRP3) inflammasome complex

183 whether inhibition of a major product of the Nod-like receptor protein 3 (NLRP3) inflammasome with ca

184 strong activation of innate immunity induced Nod-like receptor protein 3 (NLRP3) inflammasome-indepen

185 a in bacterial clearance, and we showed that Nod-like receptor protein 3 (NLRP3), apoptosis-associate

186 The TLR2 ligand increased Nod-like receptor protein 3, an inflammasome component,

187 Similar to Ipaf and caspase-1, the Nod-like receptor protein Naip5 restricts intracellular

188 cent studies revealed a crucial role for the NOD-like receptor protein Nlrp3 in regulating inflammati

189 review, we will summarize the centrality of Nod-like receptor proteins that assemble inflammasomes a

190 g domain, leucine-rich repeat containing, or NOD-like receptor) proteins is in inflammasome activatio

191 e nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain containing family of gen

192 We recently demonstrated that the NOD-like receptor, pyrin domain containing-3 (NLRP3) con

193 ARD4 and NOD2/CARD15 proteins are members of NOD-like receptors recognizing specific motifs within pe

194 ind specific receptors [Toll-like receptors, NOD-like receptors, RIG-I-like receptors, AIM2-like rece

195 ike receptor (TLR), RIG-I-like receptor, and NOD-like receptor signaling pathways of the innate immun

196 arity of epithelial cells acts on intestinal NOD-like receptor signaling to mediate spatial specifici

197 e of Streptococcus correlated with increased NOD-like receptor signaling.

198 d Proteobacteria phyla, we found that potent Nod-like receptor-stimulating bacteria in the upper airw

199 indings expand the potential ligands for the NOD-like receptors, suggesting that other xanthone compo

200 ng from IL-1 receptors, Toll-like receptors, NOD-like receptors, T- and B-cell receptors.

201 mprises an intracellular sensor (typically a Nod-like receptor), the precursor procaspase-1 and the a

202 n-recognition proteins) and mammals (through Nod-like receptors) to bacterial invasion.

203 cell surface (TLRs) and within the cytosol (Nod-like receptors) to promote inflammatory processes ai

204 dependent on caspase-1; however, the role of Nod-like receptors upstream of caspase-1 is unknown.

205 s of the large family of intracellular NLRs (NOD-like receptors), which also includes animal immune r

206 ncing of the newly discovered dsRNA receptor Nod-like receptor X-1 (NLRX-1), but not other previously

207 016) demonstrate in independent studies that Nod-like receptor X1 (NLRX1) may facilitate early system