ライフサイエンスコーパス: NPI

1 NPI domain scores after the initial open-treatment phase

2 NPI mean difference favoured memantine at weeks 6 (-6.9;

3 NPI-0052 also induces DNA fragmentation in leukemia line

4 NPI-0052 inhibited YY1 promoter activity as well as both

5 NPI-0052 plus bortezomib-induced synergistic apoptosis i

6 NPI-0052 plus lenalidomide-induced apoptosis is associat

7 NPI-0052 up-regulated DR5 reporter activity and both sur

8 NPI-0052-induced apoptosis was further probed using casp

9 NPI-0052-induced inhibition of NF-kappaB activity was in

10 NPIs cocultured with MSCs had greater cellular insulin c

11 NPIs were cotransplanted with or without MSCs in diabeti

12 ssociated with worsening DR (NPA, P = 0.001; NPI, P = 0.0003).

13 participants (n = 139) exhibited at least 1 NPI symptom from the onset of cognitive symptoms.

14 Salinosporamide A ( 1 (NPI-0052)) is a potent, monochlorinated 20S proteasome i

15 Salinosporamide A (1, NPI-0052) is a potent proteasome inhibitor in developmen

16 e nonmetastatic LNCaP cells induced EMT, (2) NPI-0052-induced repression of Snail via inhibition of N

17 In stage 2, NPI Agitation/Aggression scores were reduced from 5.8 to

18 with visual acuity (NPA, r = 0.14, P = 0.23; NPI, r = 0.24, P = 0.05).

19 ly significant macular edema (NPA, P = 0.99; NPI, P = 0.67), nor correlated with visual acuity (NPA,

20 Salinosporamide A (NPI-0052, marizomib) is a naturally occurring proteasome

21 e of BIM using siRNA significantly abrogates NPI-0052 plus lenalidomide-induced apoptosis.

22 In addition, NPI-0052 blocked rapid disease progression and death in

23 eine (NAC) also conferred protection against NPI-0052-induced apoptosis, indicating a role for oxidat

24 a/importin-alpha and hSrp1/karyopherin alpha/NPI-1, respectively, and show considerable sequence dive

25 Implementing an NPI program in a large school system to mitigate the eff

26 191.8 mm(2) vs. 306.1 mm(2); P = 0.0019) and NPI (0.25 vs. 0.43; P = 0.0003).

27 which are required for binding to NPI-1 and NPI-3, respectively.

28 Two cellular proteins, NPI-1 and NPI-3, were previously identified through their interact

29 ansmission between patient skin bacteria and NPI contamination, and a third did not find any cross-tr

30 or the proteasome inhibitors bortezomib and NPI-0052, as well as with the conventional anti-MM agent

31 NN) classifiers that predicted ER, Grade and NPI status in the test set with an average misclassifica

32 iated with estrogen receptor (ER), Grade and NPI were used to build k-nearest neighbor (KNN) classifi

33 C) score and compared it to CDR, IQCODE, and NPI scores.

34 otocol, the evaluation of UWF FA for NPA and NPI is reproducible.

35 yes without PDR (n = 52), increasing NPA and NPI was associated with worsening DR (NPA, P = 0.001; NP

36 NPA and NPI were not associated with clinically significant macu

37 ate the association of variables with PI and NPI and with in-hospital mortality.

38 A total of 68 and 50 patients with PI and NPI, respectively were included; 6 patients had incomple

39 portin alpha homologues hSRP1 alpha/Rch1 and NPI/ hSRP1.

40 Three studies explored association between NPIs contamination and patient colonization and infectio

41 ter at 24 hours compared with 1 hour in both NPI (wild-type) and AIs.

42 rfilzomib, Onyx 0912, MLN 9708] and broader [NPI-0052] proteasome inhibitors; immunoproteasome inhibi

43 Caspase-3 activation by NPI-0052 was seen in wild-type Jurkat cells, but was sig

44 erall, our results suggest that crosstalk by NPI-0052 and HDACi are contributing, along with caspase-

45 Hyperacetylation by NPI-0052 occurred to a lesser extent in caspase-8-defici

46 The direct role of Snail inhibition by NPI-0052 in sensitization was shown with Snail small int

47 s, indicating a role for oxidative stress by NPI-0052.

48 Salinosporamide A (also called NPI-0052), recently identified from the marine bacterium

49 nts in distress as measured by the caregiver NPI at 12 months; at 18 months, caregivers showed improv

50 Interestingly, combining NPI-0052 with either MS-275 or valproic acid (VPA) induc

51 Here, we demonstrate that combining NPI-0052 and bortezomb induces synergistic anti-MM activ

52 Here we demonstrate that combining NPI-0052 and lenalidomide (Revlimid) induces synergistic

53 and candidate pandemic viruses, we developed NPIs that simulated notions of protective isolation for

54 IgM and macrophages were highly specific for NPIs (alpha1,3-galactosyltransferase knockout) compared

55 Immununostaining of MM tumors from NPI-0052 plus bortezomib-treated mice showed growth inhi

56 st of the present North Patagonian Icefield (NPI), serve as 'dipsticks' that allow us to reconstruct

57 reduce its interaction with nuclear importin NPI-1, which might be responsible for its decreased nucl

58 ety of settings confirms the need to improve NPIs decontamination practices.

59 lue in Scan2 and non-planning impulsiveness (NPI) measured at follow-up.

60 the transcription factor SP-1 is involved in NPI-0052-induced HB-EGF transcription.

61 genomic instability (P = 0.019), increasing NPI score (P < 0.001), and reduced disease-free survival

62 perfusion area (NPA) and nonperfusion index (NPI; nonperfused/total gradable area).

63 American Pattern (PNA), North Pacific Index (NPI), El Nino-Southern Oscillation (ENSO)] to explain de

64 rognosis group (Nottingham Prognostic Index (NPI) <or=3.4) tumors had frequent loss of 16q24-qtel.

65 .0001), and the Nottingham Prognostic Index (NPI) score (P <.0001).

66 , which was defined as nonprimary infection (NPI) owing to the presence of highly elevated serum immu

67 nd RKIP small interfering RNA that inhibited NPI-0052-mediated sensitization.

68 The proteasome inhibitor NPI-0052 also prevented disease progression and death in

69 The novel proteasome inhibitor NPI-0052 has been shown to sensitize tumor cells to apop

70 t the second-generation proteasome inhibitor NPI-0052 induced the mRNA transcription of several EGFR

71 e hypothesized that the proteasome inhibitor NPI-0052 inhibits the transcription repressor Yin Yang 1

72 monstrated that a novel proteasome inhibitor NPI-0052 is distinct from bortezomib (Velcade) and, impo

73 monstrated that a novel proteasome inhibitor NPI-0052 triggers apoptosis in multiple myeloma (MM) cel

74 G7128) is a nucleoside polymerase inhibitor (NPI), which requires intracellular uptake and phosphoryl

75 ork found that a novel proteasome inhibitor, NPI-0052, and HDACi synergistically induce apoptosis in

76 The proteasome inhibitor, NPI-0052, induces the metastasis tumor suppressor/immune

77 teasome in WM using 2 proteasome inhibitors, NPI-0052 and bortezomib.

78 under which nonpharmaceutical interventions (NPIs) alone might prevent the introduction of a pandemic

79 Nonpharmaceutical interventions (NPIs) intended to reduce infectious contacts between per

80 tiveness of nonpharmaceutical interventions (NPIs) was uncertain.

81 number of non-pharmaceutical interventions (NPIs), including hand washing and use of hand sanitizer,

82 baseline on the Neuropsychiatric Inventory (NPI) Agitation/Aggression domain (scale range, 0 [absenc

83 m domains in the Neuropsychiatric Inventory (NPI) and relapse in the first 16-week phase after random

84 y (CMAI) and the Neuropsychiatric Inventory (NPI), ability to complete activities of daily living (AD

85 luated using the Neuropsychiatric Inventory (NPI).

86 rtaken using the Neuropsychiatric Inventory (NPI).

87 assessed by the Neuropsychiatric Inventory (NPI).

88 measured by the neuropsychiatric inventory (NPI).

89 ls completed the Neuropsychiatric Inventory (NPI); 362 were classified as having dementia, 320 as hav

90 easured with the Neuropsychiatric Inventory (NPI, 0-120 points) and the Alzheimer Disease Assessment

91 immune responses to neonatal porcine islet (NPI) xenografts compared with rhesus islet allografts at

92 Interestingly, neonatal porcine islet (NPI) xenografts uniformly survived long term (>100 days)

93 erived MSCs have on neonatal porcine islets (NPIs) in vitro and determined islet engraftment and meta

94 hanism by which a proteasome inhibitor, like NPI-0052, inhibits the transcription repressor YY1 invol

95 In cell lines, NPI-0052 inhibits all 3 proteolytic activities associate

96 unexpected, given that few cities maintained NPIs longer than 6 weeks in 1918.

97 inhibitor (-)-salinosporamide A (marizomib; NPI-0052; 1), using a regio- and stereoselective epoxide

98 In stage 1, mean NPI Agitation/Aggression scores were reduced from 7.1 to

99 r DHMEQ and (3) RKIP overexpression mimicked NPI-0052 in the inhibition of Snail and EMT.

100 he NF-kappaB inhibitor DHMEQ, which mimicked NPI-0052 in sensitization and inhibition of Snail and in

101 ed by both overexpression of RKIP (mimicking NPI-0052) and RKIP small interfering RNA that inhibited

102 In multivariate models, NPI was significantly associated with underlying psychia

103 thesis that rapid implementation of multiple NPIs can significantly reduce influenza transmission, bu

104 obtained data on the timing of 19 classes of NPI in 17 U.S. cities during the 1918 pandemic and teste

105 sis in WM cells, and that the combination of NPI-0052 and bortezomib induced synergistic cytotoxicity

106 raft model show that low dose combination of NPI-0052 and bortezomib is well tolerated and triggers s

107 tumor model studies, low-dose combination of NPI-0052 and lenalidomide is well tolerated, significant

108 bortezomib, a 400-fold less concentration of NPI-0052 was used.

109 Here, we describe effects of NPI-0052, a novel proteasome inhibitor, in leukemia mode

110 These effects of NPI-0052, alone and in combination with HDACi, warrant f

111 The underlying mechanism of NPI-0052-induced inhibition of the metastatic phenotype

112 Overall, rates of NPI contamination ranged from 23% to 100%.

113 demonstrate, for the first time, the role of NPI-0052 in the regulation of EMT via inhibition of NF-k

114 The direct role of NPI-0052-induced inhibition of YY1 and up-regulation of

115 Because the proximal targets of NPI-0052 and HDACi are inhibition of proteasome activity

116 Although the potential benefits of NPIs are supported by mathematical models, the historica

117 dUTP nick end labeling])-positive cells) of NPIs compared with AIs.

118 y 2013 on studies regarding contamination of NPIs and association to infections in non-outbreak circu

119 Cotransplantation of NPIs and MSCs resulted in significantly earlier normogly

120 We evaluated implementation of NPIs during fall 2009 in response to H1N1 pandemic influ

121 A comprehensive list of NPIs was developed, and a systematic review of these ite

122 ections with pathogens found concurrently on NPIs, one found cross-transmission between patient skin

123 and multiply resistant organisms present on NPIs in routine, non-outbreak conditions and in a variet

124 a diagnosis of primary WNV infection (PI) or NPI during 2005-2007 at Sheba Medical Center (Tel-Hashom

125 cal items potentially shared among patients (NPIs) are part of the patient's immediate surroundings a

126 Two cellular proteins, NPI-1 and NPI-3, were previously identified through thei

127 nonresponders) showed significantly reduced NPI Agitation/Aggression scores for dextromethorphan-qui

128 They compared caregiver-reported NPI scores at week 9 in patients receiving citalopram (3

129 rp1alpha and Srp1/karyopherin-alpha/alpha-S1/NPI-1) which function in nuclear transport as the import

130 Study NPI-0052-101 Part 1 enrolled relapsed or RRMM patients i

131 gest the therapeutic application of subtoxic NPI-0052 concentrations in combination with TRAIL/agonis

132 I; 6 and 12 weeks Neuropsychiatric symptoms (NPI), Clinical Global Impression Change (CGI-C), Standar

133 caspase-8 versus caspase-9 demonstrate that NPI-0052 plus lenalidomide-triggered apoptosis is primar

134 Moreover, we demonstrated that NPI-0052 and bortezomib inhibited migration and adhesion

135 We demonstrated that NPI-0052-induced cytotoxicity was completely abrogated i

136 We found that NPI-0052 inhibited proliferation and induced apoptosis i

137 We hypothesized that NPI-0052 may inhibit Snail expression and, consequently,

138 We hypothesized that NPI-0052-mediated sensitization may result from NF-kappa

139 These results indicate that NPI-0052 is eliciting caspase-8 and oxidative stress-dep

140 The possibility that NPI may be an emerging clinical entity with a high morta

141 We show that NPI-0052 inhibits both NF-kappaB and Snail and induces R

142 These findings show that NPI-0052 modifies the NF-kappaB-Snail-RKIP circuitry in

143 It appears unavoidable that NPI combinations effective against pandemics more severe

144 The NPI-0052 concentrations used for TRAIL sensitization wer

145 The NPI-0052-induced sensitization to TRAIL involved activat

146 re was a significant correlation between the NPI score and more sophisticated tests of ToM in the fvF

147 Another NLS activity not mediated by the NPI binding sites is associated with noncontiguous seque

148 pha5 and alpha6, which together comprise the NPI-1 subfamily of karyopherin alphaS.

149 antine treatment had no effect on either the NPI (mean difference 2.2, 95% CI -3.9 to 8.3, p=0.47) or

150 dness plan were more likely to implement the NPI guidelines recommended by NYC public health official

151 mbined with parameters currently used in the NPI.

152 lymph node stage, and Ki-67 LI, but not the NPI score.

153 erase inhibitors improved 1.72 points on the NPI (95% confidence interval [CI], 0.87-2.57 points), an

154 and caregiver distress scores but not on the NPI agitation subscale, ADLs, or in less use of rescue l

155 sychiatric symptoms, based on ratings on the NPI in the previous month and from the onset of cognitiv

156 specific domains on the NP that bind to the NPI proteins.

157 24 (eVP24) involves its interaction with the NPI-1 subfamily of karyopherin alpha (KPNA) nuclear tran

158 egarding schools' ability to implement these NPIs during an influenza outbreak.

159 ed that each VP24 binds to each of the three NPI-1 KPNAs.

160 d RESTV VP24 (rVP24) interactions with three NPI-1 subfamily KPNAs (KPNA1, KPNA5, and KPNA6).

161 TKRSxxxM, which are required for binding to NPI-1 and NPI-3, respectively.

162 II interferon (IFN) signaling by binding to NPI-1 subfamily karyopherin alpha (KPNA) nuclear import

163 d significant improvement on the CMAI, total NPI, and caregiver distress scores but not on the NPI ag

164 Primary endpoints were the change in total NPI score and clinical global impression of change (CGIC

165 ymptoms of dementia as measured by the total NPI score at 12 months (mean difference, -5.6; P = .01)

166 l respondents (99%) implemented at least two NPIs.

167 mortality was significantly associated with NPI (aOR, 3.86; 95% CI, 1.12-13.28; P = .032) and a high

168 Treatment of PC-3 and Ramos cells with NPI-0052 (</=2.5 nM) and TRAIL sensitizes the tumor cell

169 rotocols evaluating bortezomib together with NPI-0052 to improve patient outcome in MM.

170 tocols evaluating lenalidomide together with NPI-0052 to improve patient outcome in MM.

171 in Jurkat and CLL primary cells treated with NPI-0052, alone or in combination with various HDACi (MS

172 Cell treatment with NPI-0052 induced E-cadherin and inhibited Snail expressi

173 in vitro activities, biweekly treatment with NPI-0052 lessened total white blood cell (WBC) burden ov

174 een used to characterize viral kinetics with NPIs.

175 Cotransplantation of human MSCs with NPIs demonstrated a beneficial metabolic effect likely a