ライフサイエンスコーパス: NRG1

1 NRG1 could stimulate the stability of PSD-95 in the mann

2 NRG1 enhanced excitatory drive onto fast spiking interne

3 NRG1 enhanced the strength of excitatory synapses onto F

4 NRG1 has multiple isoforms that are generated by usage o

5 NRG1 is the ligand for ERBB3 and 4, members of the epide

6 NRG1 treatment prevents the loss of deprived eye visual

7 NRG1 type I-IV and NRG1-IVNV isoforms were evaluated wit

8 NRG1 was localized to the wound epithelium prior to blas

9 NRG1-ErbB4 signaling controls inhibitory circuit develop

10 NRG1-IVNV was expressed from 16 weeks gestation until ag

11 Neuregulin 1 (NRG1) and ErbB4, critical neurodevelopmental genes, are

12 We show that neuregulin 1 (NRG1) and hepatocyte growth factor (HGF) provide resista

13 Neuregulin 1 (NRG1) and its interneuron-specific receptor ERBB4 are cr

14 Genetic variants of Neuregulin 1 (NRG1) and its neuronal tyrosine kinase receptor ErbB4 ar

15 Neuregulin 1 (NRG1) and its receptor ErbB4 are both susceptibility gen

16 We provide evidence that neuregulin 1 (NRG1) and its receptor ErbB4 tyrosine kinase are critica

17 scued by the administration of neuregulin 1 (NRG1) and nerve growth factor (NGF) recombinant proteins

18 Neuregulin 1 (NRG1) and the gamma-secretase subunit APH1B have been pr

19 tudies revealed that the ErbB3-neuregulin 1 (NRG1) axis is a dominant pathway responsible for hematog

20 Some studies suggest that neuregulin 1 (NRG1) could be involved in the regulation of skeletal mu

21 he only autonomous receptor of neuregulin 1 (NRG1) in the basolateral amygdala (BLA), was expressed i

22 Neuregulin 1 (NRG1) is a multifunctional neurotrophin that mediates ne

23 Neuregulin 1 (NRG1) is a secreted trophic factor that activates the po

24 Neuregulin 1 (NRG1) is a trophic factor that has been implicated in ne

25 Neuregulin 1 (NRG1) is an axon-derived factor that is critical for Sch

26 protective missense variant in neuregulin 1 (NRG1) linked to schizophrenia by meta-analysis (ie, rs10

27 val, we obtained evidence that neuregulin 1 (NRG1) produced by TICs promotes their proliferation and

28 Neuregulin 1 (NRG1) signaling is critical to various aspects of neuron

29 lines of evidence suggest that neuregulin 1 (NRG1) signaling may influence cognitive function and neu

30 Neuregulin 1 (NRG1) type III is involved in myelination of the periphe

31 Neuregulin 1 (NRG1), a critical developmental neurotrophin, is associa

32 that the signalling pathway of neuregulin 1 (NRG1), a protein involved in the regulation of skeletal

33 However, the source of neuregulin 1 (NRG1), the ligand for ErbB3, is unknown.

34 ase B receptor (BDNF/TrkB) and neuregulin 1 (NRG1)/ErbB2.

35 The Neuregulin 1 (NRG1)/ErbB4 signaling pathway has been genetically and f

36 studies implicate variants of Neuregulin-1 (NRG1) and its neuronal receptor ErbB4 in schizophrenia a

37 Neuregulin-1 (NRG1) and its receptor ErbB4 influence several processes

38 is related to the abundance of neuregulin-1 (NRG1) expressed on the axon surface.

39 he neuronally secreted protein Neuregulin-1 (NRG1) fulfills all these criteria in the axolotl.

40 of Schwann cells and neuronal Neuregulin-1 (NRG1) has emerged as the pivotal signal that controls Sc

41 sed by disruption of BMP10 and Neuregulin-1 (NRG1) signaling pathways, two central mediators of myoca

42 production of the ErbB3 ligand neuregulin-1 (NRG1).

43 ance ectodomain sensitivity of neuregulin-1 (NRG1; epidermal-growth-factor) or CD44 (receptor-tyrosin

44 e critical period downregulates neuregulin-1(NRG1)/ErbB4 signaling in PV neurons, causing retraction

45 gulators, LIMK and SSH1, as end targets of a NRG1 signaling pathway and demonstrates that cofilin1 is

46 However, little is known about NRG1 isoform composition profile, whether it changes dur

47 ormation, whereas knockdown of YAP abrogates NRG1- and HBEGF-stimulated cell proliferation.

48 ACE1 is a protease needed to generate active NRG1 from the full-length form.

49 ly, we show that interneuronal DISC1 affects NRG1-ErbB4-mediated phenotypes in the fast spiking inter

50 tion and proliferation in HER2-amplified and NRG1-expressing cancer cells, and it displayed single-ag

51 In summary, Mycn acts downstream of BMP and NRG1 cardiogenic signaling pathways to promote normal my

52 ression of MYCN is regulated by both BMP and NRG1 signaling.

53 levels of ErbB3 in ovarian cancer cells and NRG1 in the omentum allowed for tumor cell localization

54 a functional relationship between DISC1 and NRG1-ErbB4 signalling in mature cortical interneurons.

55 hanism by which cross-talk between DISC1 and NRG1-ErbB4 signalling may contribute to these deficits.

56 hrenia (for example, COMT, DISC1, DTNBP1 and NRG1).

57 ession of GSTT2, CTSA, PPARG, CDA, ENPP1 and NRG1-Iis changing over time and correlates with disease

58 ter injury, probably by regulating ErbB2 and NRG1 levels, identifying a novel player in regulating re

59 ral genes (ACSM3, ERI2, IL18RAP, IL23RAP and NRG1) with left ventricular hypertrophy phenotypes.

60 rbB4 is highly abundant in interneurons, and NRG1-mediated erbB4 activation has been shown to modulat

61 NRG1 type I-IV and NRG1-IVNV isoforms were evaluated with quantitative real

62 Notch1 and NRG1 expression are associated in melanoma and inhibitio

63 autocrine signaling loop between Notch1 and NRG1 that controls melanoma growth and provide experimen

64 also demonstrate that the effects of RET and NRG1 are universal across European and Asian ancestries.

65 ue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes.

66 usceptibility variants at the RET, SEMA3 and NRG1 loci have been detected through genome-wide associa

67 susceptibility alleles at the RET, SEMA3 and NRG1 loci.

68 suggest that BRCA1-IRIS and/or BDNF/TrkB and NRG1/ErbB2 could serve as rational therapeutic targets f

69 ions between striatal gray matter volume and NRG1 genotype.

70 s required for the induction of an antisense NRG1 transcript.

71 Single-pass NRGs, such as NRG1 Types I/II and NRG2, accumulate as unprocessed prof

72 This SNP, located at NRG1, a susceptibility gene for schizophrenia, was prior

73 06030) and at SEMA3 (rs11766001), but not at NRG1.

74 transgenic mice that expressed excess axonal NRG1-III exhibited continued remodeling, in contrast to

75 hrough promoting the local release of axonal NRG1.

76 Because NRG1 and ErbB4 are susceptibility genes of schizophrenia

77 We observed epistasis between NRG1 (rs10503929; Thr286/289/294Met) and its receptor ER

78 entified biological and disease link between NRG1-ErbB4, p110delta, and AKT; and suggest that p110del

79 Both NRG1 and erbB4 have been repeatedly associated with schi

80 Both NRG1 and its receptor, ErbB4, are well-established risk

81 Because both NRG1 and ErbB4 are susceptibility genes of schizophrenia

82 ight of the association of the genes of both NRG1 and ErbB4 with schizophrenia and dysfunction of GAB

83 Considering that both NRG1 and ErbB4 are susceptibility genes of schizophrenia

84 dies have strongly implicated membrane-bound NRG1 forms (type III) in the myelination at late stages,

85 ternative splicing, and association of brain NRG1 type IV isoform expression with the schizophrenia-r

86 growth factor neuregulin-1 (Nrg1, encoded by NRG1) is a key signalling factor controlling myelination

87 e found that the glutamatergic impairment by NRG1 overexpression required LIM domain kinase 1 (LIMK1)

88 , and LTP inhibition or reversal mediated by NRG1/ErbB signaling, which requires ErbB4 receptors in P

89 regulates Rac1 activation by BDNF but not by NRG1-Type III in Schwann cells, although both ligands ac

90 We show that signaling by NRG1 and NRG2, but not NRG3, increase expression of an i

91 analysis confirms the recently reported CD74-NRG1 fusion and suggests that NRG1, NF1 and Hippo pathwa

92 nown about the function of NRG2, the closest NRG1 homolog.

93 deficits in ctoNrg1 mice require continuous NRG1 abnormality in adulthood, suggesting that relevant

94 In contrast, NRG1 treatment had no effect on either the number or siz

95 In stark contrast, NRG1 had minor effects on whole-cell potassium currents.

96 Conversely, NRG1 cleavage, ErbB4 activity and GABA transmission are

97 le (T) of rs6994992 conferred lower cortical NRG1-IVNV levels.

98 Both NRG3 and CRD-NRG1 cluster on axons through juxtacrine interactions wi

99 We furthermore show that NRG3, like CRD-NRG1, is a dual-pass transmembrane protein that harbors

100 s unprocessed proforms, axonal puncta of CRD-NRG1 and NRG3 are comprised of processed protein.

101 Mutations of CRD-NRG1 and NRG3 that render them resistant to BACE cleavag

102 By contrast, dual-pass CRD-NRG1 and NRG3 are constitutively processed by BACE and a

103 ether, our results show that nerve-dependent NRG1/ErbB2 signaling promotes blastemal proliferation in

104 protective effects of fibroblast/CAF-derived NRG1 on cell growth properties of RAF inhibitor-treated

105 y, after the switch to a well-balanced diet, NRG1 cleavage ratio and ErbB4 amount were increased.

106 These results suggest that direct NRG1-integrin interaction mediates integrin-ErbB cross-t

107 ronal deficits and involvement of the DISC1, NRG1 and ErbB4 genes in schizophrenia, respectively.

108 Finally, the expression of each NRG1 isoform is distinctly regulated by neuronal activit

109 Endogenous NRG1-ErbB4 signaling pathway in the BLA could modulate a

110 Neutralizing endogenous NRG1, inhibition, or genetic ablation of ErbB4, which wa

111 itatory synapses, suggesting that endogenous NRG1 may be critical for basal synapse formation.

112 Taken together, these data establish NRG1 type III as the activator of NF-kappaB during myeli

113 Exogenous NRG1 rapidly restores excitatory inputs onto deprived PV

114 Moreover, exogenous NRG1 also produced an anxiolytic effect in the stressed

115 ore, overexpression of transcription factors NRG1 and UME6, to maintain yeast and hyphal morphologies

116 Consistent with these findings, NRG1 effects on hippocampal long-term potentiation at CA

117 lthy individuals carrying risk genotypes for NRG1 and ERBB4, or these 2 together with AKT1, were disp

118 these results identify a novel mechanism for NRG1 cleavage and shedding.

119 four for ERBB4, three for DISC1 and one for NRG1.

120 ne kinase (RTK) since it is the receptor for NRG1 on the surface of Schwann cells.

121 targeting ERBB3 and cMET, the receptors for NRG1 and HGF, respectively, overcome resistance to trame

122 However, the specific role for NRG1 (III) in the CNS has not been established.

123 ulate interneuron function, but the role for NRG1-erbB4 signaling in regulating interneuron dendritic

124 gy, and pharmacology, we identify a role for NRG1-IV in learning, memory, and cognition and determine

125 These data demonstrate a novel role for NRG1-IV in learning, memory, and neural circuit formatio

126 results in the secretion of this domain from NRG1 type III.

127 on a molecular level, and eight genes (e.g., NRG1 and ERBB4) displayed evidence for pleiotropy, revea

128 nctional analysis revealed that three genes, NRG1, MST1 and NAT9, were strongly correlated with the p

129 ) and production of EGF-like ligands (HBEGF, NRG1 and NRG2).

130 e and absence of the ERBB3 ligand heregulin (NRG1).

131 terneurons, and offer novel insight into how NRG1/ErbB4 signaling can impact hippocampal activity.

132 h occurs in schizophrenia, understanding how NRG1-erbB4 signaling modulates interneuron dendritic mor

133 T, DRD2, DTNBP1, GAD1, GRIA1, GRIN2B, HTR2A, NRG1, RELN, SNAP-25, TNIK), brain development, myelinati

134 enic mouse model engineered to express human NRG1-IV, an isoform of the NRG1 (Neuregulin 1) gene that

135 yos demonstrated that misexpression of human NRG1 type III results in ectopic Schwann cell migration,

136 mouse model (NRG1-IV/NSE-tTA) in which human NRG1-IV is selectively overexpressed in a neuronal speci

137 Downregulating endogenous type I/II NRG1 signaling either with a targeted NRG1 antagonist or

138 Both type I and type III NRG1 improves deficits in the Morris water-maze behavior

139 uble ectodomains of both type I and type III NRG1 significantly increased expression of Abeta-degradi

140 we have identified mutations within type III NRG1 that disrupt intramembranous proteolytic processing

141 possibility, full-length type I or type III NRG1 was overexpressed via lentiviral vectors in the hip

142 Neuregulin 1 type III (NRG1 type III) is a major physiological substrate of bet

143 ow that diet-induced obesity does not impair NRG1 signalling in rat skeletal muscle.

144 TP is an insuppressible form due to impaired NRG1/ErbB signaling, possibly through the loss of PV int

145 hway and that chronic exercise could improve NRG1 signalling in rat skeletal muscle.

146 In NRG1 knockout mice, this DISC1 isoform is selectively re

147 at different ages, resulting in a change in NRG1 isoform composition.

148 ting reveals a novel association with FT4 in NRG1.

149 metalloprotease ADAM17, which is involved in NRG1 shedding.

150 vant phenotypes similar to those observed in NRG1 or ErbB4 null mutant mice, including hyperactivity,

151 isease, however, consistent with its role in NRG1 processing we find that BACE1 inhibition significan

152 by a schizophrenia candidate gene variant in NRG1.

153 ctivation of ADAM17 in rat myoblasts induced NRG1 cleavage and ErbB4 activation.

154 ough ligand-blocking HER3 antibodies inhibit NRG1-driven tumor growth, they are ineffective against H

155 se model, we demonstrate that DISC1 inhibits NRG1-induced ErbB4 activation and signalling.

156 This suggests that WT NRG1 induces integrin-NRG1-ErbB3 ternary complex formation.

157 ut the neurobiology of a novel NRG1 isoform, NRG1-IV, which is increased in the brains of individuals

158 causes significant increase in type I and IV NRG1 levels.

159 Novel splice variants of NRG1-IV (NRG1-IVNV), with predicted unique signaling capabilities

160 and fail to increase DA in response to local NRG1 infusion into the dorsal hippocampus, medial prefro

161 In human lymphoblasts, NRG1-mediated phosphatidyl-inositol,3,4,5 triphosphate [

162 iption of NRG1-IVNV, compared with the major NRG1 isoforms, across human prenatal and postnatal prefr

163 Here, we developed a transgenic mouse model (NRG1-IV/NSE-tTA) in which human NRG1-IV is selectively o

164 ," composed of the ErbB4 ligand, neuregulin (NRG1), fused to the avian viral receptor TVB (TVB-NRG1),

165 g from overexpression of HER2 or neuregulin (NRG1) in cancer leads to HER3-mediated oncogenic activat

166 Neuregulin1 (NRG1) is a single transmembrane protein that plays a cri

167 regulates the transcription of neuregulin1 (NRG1) by binding to its promoter region.

168 the levels of membrane-tethered neuregulin1 (NRG1-III), a potent activator of SCs normally presented

169 liced proteins belonging to the neuregulin1 (NRG1) gene family of growth and differentiation factors

170 e is known about the neurobiology of a novel NRG1 isoform, NRG1-IV, which is increased in the brains

171 Our data reveal the direct actions of NRG1 signaling in ErbB4-expressing interneurons, and off

172 f Glycogen synthase kinase 3, or addition of NRG1 significantly enhanced the efficiency of transdiffe

173 Addition of NRG1-beta to these cells restored their epithelial pheno

174 The administration of NRG1 into the BLA of high-anxiety mice alleviated their

175 le-phenotype analyses we find association of NRG1 with left ventricular hypertrophy phenotypes, fibri

176 t the NRG1 locus, involving a novel class of NRG1 proteins.

177 is a potent activator and key determinant of NRG1 ED cleavage and shedding.

178 ffectively reverses the protective effect of NRG1 and HGF in trametinib-treated cells.

179 These effects of NRG1 are primarily attributable to decreased voltage-gat

180 bumin-positive cells mediates the effects of NRG1 on inhibitory circuit formation in the cortex.

181 The expression of NRG1 isoforms is higher in rat brains at ages of E13 and

182 These results indicate that expression of NRG1 isoforms is regulated by distinct mechanisms, which

183 Expression of NRG1 types I, II, and III was temporally regulated durin

184 hway, which down-regulates the expression of NRG1, the major repressor of hyphal development.

185 he role of soluble, heparin-binding forms of NRG1 (type I/II) in regulating early Schwann cell develo

186 veral studies have addressed the function of NRG1 in brain, very little is known about the cleavage a

187 To understand the function of NRG1-ErbB2/3 signaling axis in adult Schwann cell biolog

188 ich may contribute to versatile functions of NRG1 and pathologic mechanisms of brain disorders such a

189 ohistochemistry and in situ hybridization of NRG1 and its active receptor ErbB2 revealed that they ar

190 The immunolocalization of NRG1 (III) suggests that it plays a novel role in the my

191 Supplementation by implantation of NRG1-soaked beads rescued regeneration to digits in dene

192 Conversely, increase of NRG1 in adulthood was sufficient to cause glutamatergic

193 are associated in melanoma and inhibition of NRG1 signaling leads to melanoma cell growth inhibition

194 ted limbs, and pharmacological inhibition of NRG1 signaling reduced cell proliferation, blocked blast

195 indings highlight the targeted inhibition of NRG1-HER3 pathways as a potential target for the treatme

196 g high levels of phospho-ErbB3, knockdown of NRG1 reduced cell viability and was associated with decr

197 hat ctoNrg1 mice, which mimic high levels of NRG1 observed in forebrain regions of schizophrenic pati

198 Given that levels of NRG1-III expression normally peak during the period of s

199 ed for the immunofluorescent localization of NRG1 (III) in the developing and adult CNS of rat.

200 At the cellular level, the majority of NRG1 isoforms (types I, II, and III) are expressed in ex

201 study provides the first quantitative map of NRG1 isoform expression during human neocortical develop

202 lecular, cellular, and circuit mechanisms of NRG1/ErbB4 in regulating the initiation of critical peri

203 Because of the hairpin nature of NRG1 type III, two membrane-bound stubs with a type 1 an

204 rophysiological and behavioral phenotypes of NRG1 mutant mice have been investigated extensively, pra

205 re we investigated proteolytic processing of NRG1 type III and demonstrate that the ectodomain can be

206 r distribution and proteolytic processing of NRG1-IVNV isoforms were also determined.

207 dependent transcriptional down-regulation of NRG1 and Sok1-mediated degradation of Nrg1 protein.

208 mechanistic perspective on the relevance of NRG1 processing in schizophrenia.

209 dings suggested a novel synaptogenic role of NRG1 in excitatory synapse development, possibly via sta

210 iched in GABAergic interneurons, the role of NRG1 in excitatory synapse formation in these neurons re

211 d cleavage is required to allow signaling of NRG1 type III.

212 Moreover, stimulation of NRG1 cleavage by calcyon was recapitulated in HEK 293 ce

213 he type 2-oriented membrane-retained stub of NRG1 type III is further processed by signal peptide pep

214 severing protein, as a downstream target of NRG1 signaling in rat Schwann cells (SCs).

215 ed the temporal dynamics of transcription of NRG1-IVNV, compared with the major NRG1 isoforms, across

216 We found that each of the six types of NRG1 has a distinct expression pattern in the brain at d

217 Novel splice variants of NRG1-IV (NRG1-IVNV), with predicted unique signaling cap

218 e that the stimulatory effects of calcyon on NRG1 cleavage and shedding depend on clathrin-mediated e

219 Neuregulin 1 (or NRG1, hereafter referred to as heregulin) increased CXCR

220 HBEGF or NRG1, in turn, activates YAP and stimulates cancer cell

221 Overall, NRG1 immunoreactivity is found predominantly at choliner

222 (which encode proteins in the WNT pathway), NRG1 (which encodes an ERBB ligand), and IL16 (which enc

223 At the end of this period, NRG1 and ErbB expression/activity in skeletal muscle was

224 tor required for cellular migration, and pro-NRG1 (ADAM17 substrate), which releases the epidermal gr

225 ErbB4 following proteolytic cleavage of pro-NRG1 precursor protein.

226 itioned medium from fibroblasts that produce NRG1 and HGF.

227 taining the levels of ErbB2 and in producing NRG1 in axons.

228 Chronic exercise training also promoted NRG1 cleavage, resulting in increased ErbB4 phosphorylat

229 On the other end, addition of recombinant NRG1 can partially restore melanoma cell growth that is

230 promoters of hypha-specific genes or reduced NRG1 expression.

231 and whether exercise and diet might restore NRG1 signalling in skeletal muscle of obese rats.

232 fit from therapeutic intervention to restore NRG1 signaling.

233 is not only controlled by membrane-retained NRG1 type III, but also in a paracrine manner via proteo

234 In isolated SCs, NRG1 promotes dephosphorylation of cofilin1 and its upst

235 se depends on the phosphorylation of several NRG1-ICD serines, in part mediated by protein kinase Cde

236 Here, we show that axon-derived soluble NRG1 translocates from axonal to Schwann cell surfaces i

237 ized, axoglial feedback loop through soluble NRG1 and BDNF critical for early Schwann cell survival a

238 ryos, which can then be rescued with soluble NRG1.

239 Overexpression of calcyon stimulates NRG1 cleavage and signaling in vivo, and as a result, GA

240 Surprisingly, NRG1 (III) was prominently expressed on dendrites and so

241 e I/II NRG1 signaling either with a targeted NRG1 antagonist or by shRNA blocks their differentiation

242 ination, our findings identify axon-tethered NRG1 as a molecular determinant for SC-driven neuromuscu

243 In this study, we demonstrate that NRG1 is highly expressed by dermal fibroblasts and cance

244 and behavioral analyses, we demonstrate that NRG1-IV/NSE-tTA mice exhibit abnormal behaviors relevant

245 We found that NRG1 acutely attenuates ErbB4-expressing interneuron exc

246 a tissue microarray analysis, we found that NRG1 expression and associated HER2 activation occurred

247 These findings support the idea that NRG1, acting in a paracrine manner, promotes resistance

248 These observations indicated that NRG1 signaling maintains high GABAergic activity in amyg

249 Together, these observations indicated that NRG1-ErbB4 signaling is critical to maintaining GABAergi

250 cortical pyramidal neurons, indicating that NRG1 effects on principal neurons are indirect.

251 ) in GABAergic interneurons, indicating that NRG1 stimulates the formation of new synapses and streng

252 Finally, we reveal that NRG1 regulates the translation of nuc-ErbB3 in rat Schwa

253 We show that NRG1 isotypes I and II, which like NRG2 are single-pass

254 Here we show that NRG1, via stimulating GABA release from interneurons, in

255 Here we show that NRG1/erbB4 promote the growth of dendrites in mature int

256 We showed that NRG1 increased both the number and size of PSD-95 puncta

257 Assays showed that NRG1-IVNV is a novel nuclear-enriched, truncated NRG1 pr

258 Our study shows that NRG1 is probably a susceptibility gene for CaD, based on

259 These results suggest that NRG1 provides beneficial effects in candidate neuropatho

260 Recent studies suggest that NRG1 signaling plays a role in remyelination of regenera

261 Our data suggest that NRG1 type III-dependent myelination is not only controll

262 reported CD74-NRG1 fusion and suggests that NRG1, NF1 and Hippo pathway fusions may play important r

263 The NRG1 ecto-domain (ED) binds and activates ErbB4 followin

264 The NRG1 gene undergoes extensive alternative splicing and,

265 The NRG1 gene undergoes extensive alternative splicing, and

266 aining and a well-balanced diet activate the NRG1 signalling in skeletal muscle of obese rats, possib

267 training and well-balanced diet activate the NRG1-ErbB4 pathway, possibly via the metalloprotease ADA

268 besity, but did not significantly affect the NRG1/ErbB signalling pathway in rat skeletal muscle.

269 developmental risk for schizophrenia at the NRG1 locus, involving a novel class of NRG1 proteins.

270 orrected P values >.05), and affected by the NRG1 genotype (higher striatal responses in controls wit

271 ost robust associations were observed in the NRG1 gene (rs6996585, P=1.08 x 10(-10)) and this SNP was

272 to express human NRG1-IV, an isoform of the NRG1 (Neuregulin 1) gene that is increased in the brains

273 d by increases in cortical expression of the NRG1 receptor, ErbB4 and the downstream signaling target

274 ced obesity could lead to alterations of the NRG1 signalling pathway and that chronic exercise could

275 d diet is associated with alterations of the NRG1 signalling pathway and whether exercise and diet mi

276 ld be partly explained by stimulation of the NRG1 signalling pathway.

277 sion of BRG1 influences the stability of the NRG1 transcript, thus controlling filamentation through

278 The mutation reduces generation of the NRG1 type III beta-peptide as well as reverses signaling

279 e conversely pharmacological blockade of the NRG1-ErbB pathway prevents myelination, providing direct

280 tify a genetic pathway that converges on the NRG1-responsive transcription factor ETV1 as a critical

281 studies support the rationale to target the NRG1-ErbB3-ErbB2 axis as a novel treatment strategy in a

282 Thus, NRG1 type III is the first protein substrate that is not

283 adhesion kinase, and paxillin in response to NRG1, but fail to increase in size possibly due to stabi

284 genesis in rat Schwann cells, in response to NRG1, TGFbeta, and laminins, three major signals implica

285 y, trametinib enhances the responsiveness to NRG1 and sustained HGF-mediated activation of AKT.

286 -IVNV is a novel nuclear-enriched, truncated NRG1 protein resistant to proteolytic processing.

287 ve inhibitory neurons infected using the TVB-NRG1 bridge protein receives inputs indiscriminately fro

288 , fused to the avian viral receptor TVB (TVB-NRG1), along with EnvB pseudotyped lentivirus (LV) and r

289 programmed cell death, whereas upregulating NRG1 rescues Schwann cells.

290 in glioblastoma, MSN-ROS1, TRIM4-BRAF, VAMP2-NRG1, TPM3-NTRK1 and RUFY2-RET in lung cancer, FGFR2-CRE

291 uminal cell signaling, controlled by p63 via NRG1, orchestrates the entire lactation program.

292 After another 8 weeks, NRG1 and ErbB expression/activity in skeletal muscle wer

293 guingly, these deficits were diminished when NRG1 expression returned to normal in adult mice, sugges

294 (-10)) and this SNP was also associated with NRG1 expression in thyroid tissues.

295 The association of rs6994992 genotype with NRG1-IVNV expression and the subcellular distribution an

296 In addition, cells were incubated with NRG1-beta, a mediator of HER2-HER3 signaling, or A83-01,

297 fact, synaptic SCs of these adult mice with NRG1-III overexpression exhibited behaviors evident in w

298 the adult rodent brain does not overlap with NRG1 and is more extensive than originally reported, inc

299 y examined the association of rs6994992 with NRG1-IVNV expression.

300 This suggests that WT NRG1 induces integrin-NRG1-ErbB3 ternary complex formati