ライフサイエンスコーパス: NRSE

1 ictive silencer element/repressor element 1 (NRSE/RE-1) sequence within the cholinergic gene.

2 1/neuron-restrictive silencing element (RE-1/NRSE) mediates transcriptional repression by the repress

3 essor of Crh transcription, via the Crh RE-1/NRSE, and an enhancer of Crh transcription, via a mechan

4 ts was down-regulated by REST/NRSF in a RE-1/NRSE-dependent fashion in both muscle-derived L6 and RES

5 While the RE-1/NRSE-mediated repressive influence of REST/NRSF is well

6 lated by REST/NRSF, in part through the RE-1/NRSE.

7 on from constructs containing an intact RE-1/NRSE.

8 levels of constructs lacking an intact RE-1/NRSE.

9 via a mechanism independent of the Crh RE-1/NRSE.

10 This cis-activating NRSE element also confers NRSF-dependent modulation in t

11 arches reveal that over 800 genes contain an NRSE.

12 domain of dimethylated histone H3-K9 around NRSEs, but H3-K27 remains unmethylated.

13 um channel H6, another gene with a bipartite NRSE, were up-regulated by dominant-negative REST in C6-

14 mputational analysis revealed many bipartite NRSE variants conserved between mouse and human genomes.

15 juxtaposition of the two halves of bipartite NRSE.

16 We confirmed that this bipartite NRSE permits transcriptional repression by REST identica

17 termed NRSF or XBR) to the RE1 (also called NRSE) sequence in the type II sodium channel gene.

18 al repression by REST identical to canonical NRSE in rat C6-glioma cells.

19 erformed data base searches with a composite NRSE to identify additional candidate NRSF target genes.

20 sed mainly in neurons, were found to contain NRSE-like sequences.

21 neuronal transcription factor genes contain NRSEs, suggesting that NRSF may repress neuronal differe

22 In vivo, decoy NRSE ODN treatment restored theta rhythm and altered the

23 e to that using Neutron Resonance Spin Echo (NRSE) coils.

24 hat the neuron-restrictive silencer element (NRSE) of MOR functions as a critical regulator to repres

25 hat the neuron-restrictive silencer element (NRSE) of mu opioid receptor (MOR) functions as a critica

26 that a neural restrictive silencer element (NRSE) was critical for preventing ectopic expression of

27 that a neuron restrictive silencer element (NRSE) was implicated in transcriptional repression of th

28 that a neural restrictive silencer element (NRSE) within the second intron prevented expression of L

29 to the neuron-restrictive silencer element (NRSE) within this fragment.

30 as the neuron-restrictive silencer element (NRSE).

31 led the neuron-restrictive silencer element (NRSE).

32 led the neuron-restrictive silencer element (NRSE).

33 ce (RE1/neuron-restrictive silencer element [NRSE]) present in their regulatory regions.

34 quence (neuron restrictive silencer element [NRSE]), in vitro and in vivo, reduced NRSF binding to Hc

35 f experimentally validated binding sites for NRSE can be found at http://www.cse.ucsd.edu/groups/bioi

36 Functional NRSEs were also found in several nonneuronal genes, impl

37 ved in pancreas development that also harbor NRSE-like motifs, including pdx-1, Beta2/NeuroD, and pax

38 The sequence defined by this dsRNA is NRSE/RE1, which is recognized by NRSF/REST, known primar

39 cells, via a mechanism dependent on the MOR NRSE.

40 Statistically significant enrichment of NRSE-associated genes was found for neuron-specific Gene

41 ism for both ancient and modern dispersal of NRSEs through vertebrate genomes.

42 A potential NRSE/RE-1 site is located nearby.

43 Many of these putative NRSEs bound NRSF in vitro and repressed transcription in

44 An RE1/NRSE element is not necessary for NR2A neuron specificit

45 We utilized an RE1/NRSE transgenic reporter system to dynamically monitor R

46 se in the acetylation of histones around RE1/NRSE and that this decrease requires the N-terminal Sin3

47 in the brain contain a silencer element (RE1/NRSE) that limits transcription in nonneuronal cells by

48 ite/neuron-restrictive enhancer element (RE1/NRSE), activate plasmid-encoded neuronal promoters in va

49 1/neuron-restrictive silencing element (RE1/NRSE).

50 REST-VP16 binds to the same RE1/NRSE, but activates these REST/NRSF target genes.

51 We show that REST/NRSF binding to RE1/NRSE is accompanied by a decrease in the acetylation of

52 om yeast promoters engineered to contain RE1/NRSEs.

53 re cross-competed with a characterized SCG10 NRSE probe and do not bind to the AVP probe with a speci

54 re extensive evolutionary survey showed that NRSE sites matching the PSFM model exist in roughly simi

55 The NRSE dsRNA can trigger gene expression of neuron-specifi

56 The NRSE in TPH2 is a novel bipartite variant interrupted by

57 The NRSE-like motif identified in the upstream pax4 promoter

58 dulation of normal repressor activity at the NRSE.

59 g transcription factor (REST)/NRSF, both the NRSE and sequences in the first intron were required.

60 timal silencing of L1 gene expression by the NRSE-binding factor RE-1-silencing transcription factor

61 s through a canonical 21-bp motif called the NRSE (neuron-restrictive silencing element).

62 In gel mobility shift experiments, the NRSE formed DNA-protein complexes with nuclear extracts

63 he AVP probe with a specific mutation in the NRSE.

64 In contrast, a similar construct lacking the NRSE produced precocious expression in the peripheral ne

65 lacZ) and another (L1lacZDeltaN) lacking the NRSE.

66 study, we have investigated the role of the NRSE in the regulation of L1 expression during postnatal

67 To examine the influence of the NRSE on postnatal patterns of L1 expression in vivo, we

68 small nucleolar RNAs, retrotransposons, the NRSE small modulatory RNA, and BC1/BC200 in the CNS.

69 These experiments show that the NRSE and REST/NRSF are important components in restricti

70 These data support the conclusion that the NRSE not only plays a role in the silencing of L1 expres

71 co-transfection studies, we showed that the NRSE of the MOR promoter is functional in NRSF-positive

72 NRSF binds to the NRSE of the MOR gene in a sequence-specific manner confi

73 enic mice, an L1lacZ gene construct with the NRSE generated a neurally restricted expression pattern

74 The NRSEs are also associated with HP1.

75 NRSF/REST from A126.1B2 exhibited binding to NRSE/RE-1, nuclear extracts from PC12 cells did not.

76 restrictive silencer factor (NRSF) binds to NRSE.

77 ST), the transcription factor which binds to NRSE/RE-1, was expressed at similar levels in both PC12

78 we identify a conserved GC sequence next to NRSE region in the mouse MOR gene.

79 REST4 inhibited binding of NRSF/REST to NRSE/RE-1 as determined by gel mobility shift assays.

80 functionally synergic repressor element with NRSE in NS20Y cells, but not in the NRSF negative PC12 c