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1 NTD deletion reduced the cytokine-induced expression of
2 NTD vaccines face unique challenges with respect to thei
3 NTDs are associated with hyperglycemia-induced protein m
4 NTDs have been included within the Sustainable Developme
5 ural and biological properties of the TDP-43 NTD, indicating that the NTD must be stably folded for T
6 temperature conditions, we show that TDP-43(NTD) is thermodynamically stable, well-folded and underg
7 of BRCA2 that exhibits DNA binding activity (NTD) and provide evidence for NTD promoting RAD51-mediat
8 e light of the renewed global action against NTDs and the global efforts to achieve the sustainable d
10 esembled human PrP(c) The requirement for an NTD, but not for the specific human sequence, suggests t
11 alog from the same organism, we show that an NTD-CTD heterodimer forms when the domains are expressed
13 his study establishes that all four Anabaena NTD-like proteins can bind a carotenoid and the differen
15 racellular portion, comprised of the LBD and NTD, is loosely arranged, mediating complex allosteric r
16 cholesterol transfer tunnel between NPC2 and NTD cholesterol binding pockets, supporting the "hydroph
20 he pathway of multiple births, while the ART-NTD association was explained by the multiple-births pat
22 h HBc rescued NTD assembly in RRL as well as NTD expression and assembly in mammalian cells, resultin
23 eracts directly with the membrane-associated NTD, which serves as both a membrane anchor and an allos
24 PSK H23C mutant, SynAPSK fused to the AtAPSK NTD, and the fusion protein with the H23C mutation showe
25 reviously determined Euprosthenops australis NTD structures reveals subtle conformational alterations
28 h replacement of the human NTD by the bovine NTD resembled human PrP(c) The requirement for an NTD, b
29 the presence of white-tailed deer and bovine NTDs hindered seeded conversion of PrP(c), but human and
31 ns support the conclusion that the HTLV-1 CA NTD can functionally replace the HIV-1 CA CTD, but the H
32 y replace the HIV-1 CA CTD, but the HIV-1 CA NTD cannot replace the HTLV-1 CA CTD, indicating that th
34 re, chimeric Gag proteins with the HTLV-1 CA NTD produced particles phenotypically similar to HTLV-1
35 d that Gag proteins with a chimeric HIV-1 CA NTD/HTLV-1 CA CTD did not result in Gag oligomerization
36 The N-terminal and C-terminal domains of CA (NTD and CTD, respectively) engage in both homotypic and
37 NTDs, suggesting that Gldc deficiency causes NTDs through limiting supply of one-carbon units from mi
42 est that relatively little of the clomiphene-NTD association is mediated through the pathway of multi
44 ermore, treatment with PBA in vivo decreases NTD rate in the embryos of diabetic mice, as well as Cas
46 g at a rate of 11.3% for neural tube defect (NTD) formation, whereas no embryos in the control groups
48 c acid prevents neural tube closure defects (NTDs), but the causal metabolic pathways have not been e
50 rly pregnancy can cause neural tube defects (NTDs) in embryos by perturbing protein activity, causing
53 ls of folate-responsive neural tube defects (NTDs) indicate that impaired de novo thymidylate (dTMP)
54 educe the prevalence of neural tube defects (NTDs), although just how folates benefit the developing
57 n prevents up to 70% of neural tube defects (NTDs), which result from a failure of neural tube closur
60 for protection against neural tube defects (NTDs); among nonconsumers of folic acid, only 16% attain
61 tified in patients with neural tube defects (NTDs); however, the relationship between NKH and NTDs is
64 s was developed, using a needle trap device (NTD) in conjunction with thermal-desorption photoionizat
65 well established neglected tropical disease (NTD) programs have seen great progress towards disease c
68 entions against neglected tropical diseases (NTD), including lymphatic filariasis (LF), scaled up dra
72 The concept of neglected tropical diseases (NTDs) emerged more than a decade ago and has been recogn
73 iene (WASH) and neglected tropical diseases (NTDs) encourages integration, whilst maintaining existin
74 malaria and the neglected tropical diseases (NTDs) kill more than 800,000 people annually, while crea
76 isk mapping for neglected tropical diseases (NTDs), particularly to scale up preventive chemotherapy,
79 domain (CTD), an N-terminal effector domain (NTD) and a ketocarotenoid; the chromophore spans the two
80 te (NMDA) receptor GluN2B N-terminal domain (NTD) aims for the treatment of various neurologic diseas
81 sequentially folded in an N-terminal domain (NTD) and a C-terminal domain (CTD) separated by a centra
83 nding site located at the N-terminal domain (NTD) and accelerating proteasomal degradation through dy
84 ble linker connecting the N-terminal domain (NTD) and C-terminal domain (CTD) of AhpF suggests that t
85 oles of the HTLV-1 CA amino-terminal domain (NTD) and CA CTD in particle biogenesis, we generated and
86 ts of the membrane-distal N-terminal domain (NTD) and ligand-binding domain (LBD), which is fused to
87 t the junction of the amino-terminal domain (NTD) and the carboxy-terminal domain (CTD) was found to
90 highly conserved spidroin N-terminal domain (NTD) is a pH-driven self-assembly device that connects s
93 periments showed that the N-terminal domain (NTD) is intrinsically disordered and binds presequence n
95 , we show that the LCMV Z N-terminal domain (NTD) mediates the inhibition of macrophage activation an
97 s the conformation of the N-terminal domain (NTD) of DnaB to impair the ability of this DNA helicase
100 -CoV) in group A uses the N-terminal domain (NTD) of S protein to bind to its receptor, whereas the b
102 studied, the role of the N-terminal domain (NTD) of STING remains an important subject of investigat
103 sequence homology to the N-terminal domain (NTD) of the Orange Carotenoid Protein (OCP), and are ref
104 es are located within the N-terminal domain (NTD) of the Z protein and the N-terminal CARD domains of
105 crystal structure of the N-terminal domain (NTD) of YabA solved at 2.7 A resolution reveals an exten
106 te the impact of the PHF1 N-terminal domain (NTD) on the Tudor domain interaction with the nucleosome
107 idence that the conserved N-terminal domain (NTD) plays a significant role in the binding of Ltn1 to
108 Here, we show that Cet1's N-terminal domain (NTD) promotes the recruitment of FACT (facilitates chrom
111 o the tyrosines, the ClpB N-terminal domain (NTD) was suggested to provide a second substrate-binding
112 equilibrium involving the N-terminal domain (NTD) with implications for the binding of certain adapto
113 by interactions with the N-terminal domain (NTD), masking an RNA polymerase binding site until a spe
115 Sirtuins with an extended N-terminal domain (NTD), represented by yeast Sir2 and human SIRT1, harbor
116 t the extracellular AMPAR N-terminal domain (NTD), which projects midway into the synaptic cleft, pla
121 s to an integral-membrane N-terminal domain (NTD); however, how the NTD activates the C-terminal cata
122 c) amino-terminal domain (N-terminal domain [NTD], amino acids [aa] 23 to 90) in cross-species conver
123 motif (MIM), both N- and C-terminal domains (NTD and CTD) of MAD1 also contribute to mitotic checkpoi
124 more pronounced when the N-terminal domains (NTDs) of both RelA and p50 were present, even though the
125 ies established that the N-terminal domains (NTDs) of cMyBP-C (e.g., C0, C1, M, and C2) can bind to a
126 have shown that the sHSP N-terminal domains (NTDs), which have a high degree of intrinsic disorder, a
127 a critical role for eIF3 requiring the eIF3a NTD, in stabilizing mRNA interactions at the exit channe
129 tigate mechanisms underlying the established NTD allostery in NMDA-type iGluRs, as well as the fold-r
136 ave determined a crystal structure of hCDC73-NTD at 1.02 A resolution, which reveals a novel protein
137 he folding of the hydrophobic core of hCDC73-NTD, while others such as the K34Q mutant reduce its the
139 A chimera with replacement of the human NTD by the bovine NTD resembled human PrP(c) The require
141 Here, we briefly review recent work on iGluR NTD structure and dynamics, and further explore the allo
144 this article, we identify novel mutations in NTD of Sting of the MOLF strain in response to HSV and L
146 prisingly, uridine supplementation increased NTD incidence, independent of embryo genotype and dietar
150 n by methotrexate during neurulation induces NTDs by inhibiting folate interaction with its uptake sy
151 TD activated the t-SNARE complex to initiate NTD zippering with the v-SNARE, a mechanism likely share
153 beta-CoV in group A, uses the galectin-like NTD in its spike protein to bind its receptor protein, w
156 Our results have uncovered that the MAD1(NTD) and MAD1(CTD) directly interact with each other and
162 egion 4, the N-terminal domain of MotA [MotA(NTD)], and the C-terminal domain of MotA [MotA(CTD)]), m
166 ic CTD can bind carotenoid in the absence of NTD, and name this truncated variant the C-terminal doma
167 bal efforts to accelerate the development of NTD vaccines and some of the hurdles to ensuring their a
169 sults showed that energetics and kinetics of NTD self-assembly are highly conserved across spider spe
172 psid surface that (i) permits the packing of NTD domains in the outer layer of the Gag shell, (ii) di
177 s and the experience of integration of other NTDs, strengthen existing health systems, and contribute
178 Mutant embryos develop partially penetrant NTDs while surviving mice exhibit post-natal features of
180 tocopherol dietary supplementation prevented NTD almost completely (from 54% to 2%, p < 0.001) in SR-
182 file, restores embryonic growth and prevents NTDs, suggesting that Gldc deficiency causes NTDs throug
185 Mimicry leads to fluorescently labeled pyoS2(NTD) being imported into FpvAI-expressing P. aeruginosa
186 ure of the N-terminal domain of pyoS2 (pyoS2(NTD)) bound to FpvAI (Kd = 240 pM) reveals that the pyoc
187 ( approximately 10 mum) between human LCN2-R-NTD and apoNGAL suggests that the N terminus on its own
189 eriod of organogenesis significantly reduced NTDs and cell apoptosis in the embryos, compared with th
191 Coexpression of the full-length HBc rescued NTD assembly in RRL as well as NTD expression and assemb
192 a model to investigate folic acid-responsive NTDs wherein disruption of de novo thymidylate synthesis
196 , our results support the notion that Cet1's NTD promotes FACT targeting to the active gene independe
197 stinctive domains, the N-terminal domain (S1-NTD) and the C-terminal domain (S1-CTD), both of which c
201 rt the comparative investigation of spidroin NTDs originating from the major ampullate glands of the
203 etermined the crystal structure of the STAT3 NTD and identified a dimer interface responsible for coo
204 tion, whilst maintaining existing structured NTD investments, and acceleration towards Sustainable De
207 harged groove formed between the N-terminal (NTD) and C-terminal (CTD) domains of its successive N pr
208 g of Ltn1 to 60S ribosomal subunits and that NTD mutations causing defective 60S binding also lead to
211 triggered upon binding to DNA, allowing the NTD to interact with RNA polymerase to facilitate transc
212 ositions have been identified that alter the NTD equilibrium; these lie in specific regions that loca
215 ormational selectivity and plasticity at the NTD dimer interface play a role in the pH-dependent tran
217 s that localize to the interface between the NTD and the D1 nucleotide-binding domain of the complex.
218 interaction of client proteins with both the NTD and the pore-loop tyrosines in the 580-kDa ClpB hexa
219 amshell motions intrinsically favored by the NTD bilobate fold are coupled to dimeric and higher-orde
224 ns of Jak3 interacted with beta-catenin, the NTD domain of beta-catenin facilitated its interactions
228 mild L28A mutation severely destabilized the NTD, drastically reducing TDP-43's in vitro splicing act
229 her explore the allosteric potential for the NTD in AMPA-type iGluRs using coarse-grained simulations
232 ne N-terminal domain (NTD); however, how the NTD activates the C-terminal catalytic domain is unclear
233 rative deletion mapping to elucidate how the NTD of HSPB6 influences its preferential association wit
236 ted in breast cancer patients located in the NTD impairs HR stimulation on dsDNA/ssDNA junction conta
237 previously named the helical hairpin in the NTD of DnaB altered the conformation of the helical hair
242 pose that a concerted movement involving the NTD, C-terminal NADH, and FAD domains, and the flexible
246 The juxtamembrane region, which links the NTD and the catalytic domain, is necessary and sufficien
247 hich stably associated only with C-MAD2, the NTD and CTD in MAD1 surprisingly bound both O- and C-MAD
248 23C mutation showed that the addition of the NTD and cysteines recapitulated thiol-based regulation.
250 a role in the pH-dependent transition of the NTD from monomer to stably associated dimer as the spidr
251 These studies shed light on the role of the NTD in transcriptional regulation by STAT3 and provide a
253 s is likely the evolutionary ancestor of the NTD of the OCP, which arose following a domain fusion ev
255 U1, the purified C domain, downstream of the NTD, could block HKU1 virus infection of human respirato
257 vide both a detailed characterization of the NTD-substrate complex and insight into the functional re
261 hot injector, the analytes collected on the NTD were thermally desorbed and directly transferred to
263 logically low HBc concentrations in RRL, the NTD was insufficient for capsid assembly and the CTD was
264 e mutant involving an R155C substitution the NTD equilibrium can be shifted back to its wild-type pos
266 e specific human sequence, suggests that the NTD interacts with other regions of the human PrP(c) to
268 rties of the TDP-43 NTD, indicating that the NTD must be stably folded for TDP-43's physiological fun
271 ate state that builds up upon binding to the NTD and shares features from both folds, in agreement wi
273 Unlike contacts with the tyrosines, the NTD-substrate interaction is independent of the ClpB nuc
274 -OC43, another beta-CoV in group A, uses the NTD to bind to its sialic-acid containing receptor.
276 anchor Tim44 to the translocon, whereas the NTD is a dynamic arm, interacting with multiple componen
277 nding site; however, the manner in which the NTD recognizes and binds substrate proteins has remained
280 rects the maturational rearrangements of the NTDs that yield a functional core structure, and (iii) s
296 However, the molecular mechanism(s) by which NTDs modulate interaction of myosin with the TF remains
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