ライフサイエンスコーパス: NTM

1 NTM and CNTNAP4 were shown to be expressed in ocular tis

2 NTM disease was defined by 1) American Thoracic Society/

3 NTM infection was not associated with increased mortalit

4 NTM infection was not associated with increased mortalit

5 NTM otomastoiditis should be suspected if a patient has

6 NTM prevalence varies significantly among patients with

7 NTM species were unidentifiable in 29.2% [2,623 of 8,980

8 NTM were recovered from 17 of 224 sputum samples using R

9 NTM-infected patients had at least 1 positive culture fo

10 NTM-w cells also exhibited decreased levels of active Rh

11 NTMs were detected in 78% of the water samples.

12 nsisted of 3 treatments supplemented with 0 (NTM), low (LTM) and high (HTM) TM levels in the same bas

13 ica criteria for respiratory specimens or 2) NTM cultured from a sterile site with a compatible clini

14 Normal (n = 3 NTM) and glaucomatous (n = 3 GTM) human TM cell lines we

15 We report 3 NTM infections in otherwise healthy persons who received

16 From June 2009 to March 2012, 36 NTM isolates recovered from 10 (7.75%) out of 129 childr

17 In addition, NTM and GTM tissue samples were examined by immunohistoc

18 potency of tedizolid than linezolid against NTM and suggest that an evaluation of tedizolid as a pot

19 ssociated with increased mortality, although NTM disease was associated with increased mortality comp

20 Detection of an NTM helps ensure that the negative result for M. tubercu

21 Human TM cell lines NTM-5 and NTM-5 transfected to overexpress Bves (NTM-w) were evalu

22 rst time that an association between FLA and NTM is observed in water networks, highlighting the impo

23 Thus, both MTB and NTM appear to elicit a phenotypically similar T-cell res

24 2, SUR2A, and SUR2B were expressed in TM and NTM cells.

25 to naturally processed epitopes from MTB and NTMs, whereas T cells reactive to MTB-specific epitopes

26 tients with NTM, 66 (30%) were classified as NTM pulmonary disease suspects, 9 (4%) with NTM pulmonar

27 TGM2 enzyme activity between NTM and GTM cells was studied by using a biotin cadaveri

28 Both NTM and GTM cultured cells expressed prepro-ET-1 mRNA le

29 the expression of the ET(A) receptor in both NTM and GTM cells, and this was supported by the absence

30 strated the presence of TGM2 protein in both NTM and GTM cells.

31 This study demonstrated that both NTM and GTM cells express TGM2.

32 The immune response to both NTM and Mycobacterium tuberculosis is based on cellular

33 5 and NTM-5 transfected to overexpress Bves (NTM-w) were evaluated for TJ formation, and levels of oc

34 nd antibiotic resistance patterns of certain NTM isolates highlight the importance of correct diagnos

35 In children, NTM cause lymphadenitis, skin and soft tissue infections

36 Thirty-one cases of suspected or confirmed NTM inoculation from professional tattooing were uncover

37 haracterized 3 of 3 specimens that contained NTM.

38 tients re-admitted to hospital, and deaths), NTM concentrations were significantly different between

39 tive RhoA and lower levels of MLC-p than did NTM-5 cells.

40 lassify patients into NTM pulmonary disease, NTM pulmonary disease suspects, NTM disseminated disease

41 nosed, our results suggest that disseminated NTM disease may cause false-positive LF-LAM results.

42 Healthcare facilities with endemic NTM should consider similar tap water avoidance and engi

43 Finally, NTM-specific epitopes that elicit T cells that recognize

44 Thoracic Society microbiologic criteria for NTM disease (3 +/- 1, 3 +/- 2, and 5 +/- 2%, respectivel

45 years with at least one positive culture for NTM in 2011.

46 patients had at least 1 positive culture for NTM posttransplant.

47 cts with three or more positive cultures for NTM had two or more characteristic findings on entry HRC

48 r NTM, few meet a strict case definition for NTM disease.

49 ecimens from patients from areas endemic for NTM lung disease and at low risk for AIDS.

50 n total, 272 water samples were examined for NTM using a membrane filtration, culture method.

51 Multiple cultures were positive for NTM in six patients.

52 frequently have sputum cultures positive for NTM, few meet a strict case definition for NTM disease.

53 one of multiple sputum cultures positive for NTM.

54 ycobacterial cultures; 14% were positive for NTM.

55 saturated vapor pressure increased risk for NTM (odds ratio = 1.06; 95% confidence interval = 1.02-1

56 macrolide resistance, routine screening for NTM should be considered for persons with CF.

57 undertook detailed environmental testing for NTM and defined potential opportunities for transmission

58 ecipients; 18 of 43 (41.8%) were treated for NTM and 6 (13.9%) met disease criteria.

59 reported, whereas the opposite was true for NTM conserved epitopes, suggesting that intragenus conse

60 f the taps that were repeatedly positive for NTMs, the species M. avium, M. mucogenicum, and Mycobact

61 have been isolated in pulmonary samples from NTM-infected patients in the region.

62 cted and differentiated M. tuberculosis from NTM.

63 Functionally, NTM-w cells showed decreased permeability and increased

64 Agreement of GenoType NTM-DR results with sequencing and phenotypic resistance

65 Earlier reviews of global NTM epidemiology only included subject-level data from o

66 nables routine screening for rapidly growing NTM in all submitted sputum samples from patients with C

67 method for the isolation of rapidly growing NTM in this setting.

68 One hundred forty-two slowly growing NTM, including 7/7 M. marinum, 7/7 M. kansasii, and 7/11

69 124 (12%) had tuberculosis and 218 (21%) had NTM.

70 Of 3338 SOT recipients, 50 (1.5%) had NTM infection during a median 1038 days (range, 165-3706

71 iving antiretroviral therapy (ART), none had NTM disease compared with 19 (2%) of 1,009 not receiving

72 ART was associated with lower odds of having NTM disease.

73 However, NTM culture practices vary greatly, with some high-preva

74 creasing attention in recent years; however, NTM otomastoiditis is extremely rare.

75 iggering additional proteolytic cleavages in NTM, which allow its intracellular region to translocate

76 ion of Bves led to increased TJ formation in NTM-5 cells.

77 protein levels were significantly higher in NTM tissues compared to GTM tissues.

78 s was used to compare TGM2 protein levels in NTM and GTM cells.

79 We followed 60 incident NTM-positive and 99 culture-negative patients with CF fo

80 es were the least likely to develop incident NTM in 2011 (P < 0.01).

81 formed a nested case-control study: incident NTM cases were persons aged more than 5 years with at le

82 Patients with incident NTM infections from either MAC or M. abscessus were less

83 of Non-tuberculous mycobacterial infections (NTM) were sub-cultured and characterized.

84 America guidelines to classify patients into NTM pulmonary disease, NTM pulmonary disease suspects, N

85 k 7H11 agar), for their abilities to isolate NTM.

86 Human TM cell lines NTM-5 and NTM-5 transfected to overexpress Bves (NTM-w)

87 ulation are hampered by inadequate mandatory NTM reporting and the overlap of clinical presentation w

88 nd primary normal human trabecular meshwork (NTM) cells were studied by Western blot and immunohistoc

89 ultures of normal human trabecular meshwork (NTM) cells.

90 al transport and neoclassical tearing modes (NTMs) during transient nonlocal heat transport events in

91 f POAG, SNPs in two cell adhesion molecules, NTM and CNTNAP4, were identified and may increase POAG s

92 The Anyplex MTB/NTM assay demonstrates sensitivities, specificities, and

93 First, the T cells elicited by MTB/NTM cross-reactive epitopes in HCs were found mainly in

94 Second, T cells reactive to MTB/NTM-conserved epitopes responded to naturally processed

95 n of nontuberculous (atypical) mycobacteria (NTM) during the tattooing process.

96 ntification of nontuberculosis mycobacteria (NTM) in patients presumably suffering from tuberculosis

97 rculosis (TB), nontuberculosis mycobacteria (NTM), and Mycobacterium tuberculosis drug resistance are

98 entification of nontuberculous mycobacteria (NTM) and their environmental isolates in about 3 h witho

99 Nontuberculous mycobacteria (NTM) are an important cause of pulmonary disease in pati

100 Nontuberculous Mycobacteria (NTM) are opportunistic pathogens that share the same eco

101 Nontuberculous mycobacteria (NTM) are potential respiratory pathogens in cystic fibro

102 Although nontuberculous mycobacteria (NTM) are widely documented as a cause of illness among H

103 Nontuberculous mycobacteria (NTM) commonly colonize municipal water supplies and caus

104 some species of nontuberculous mycobacteria (NTM) compared with that of linezolid.

105 Studies of nontuberculous mycobacteria (NTM) described a rapid rise in the prevalence and spatia

106 5, and 1.00 for nontuberculous mycobacteria (NTM) detection, respectively, making it a suitable scree

107 ful recovery of nontuberculous mycobacteria (NTM) from cystic fibrosis (CF) patients.

108 he isolation of nontuberculous mycobacteria (NTM) from patients with CF.

109 Isolation of nontuberculous mycobacteria (NTM) from the sputum of patients with cystic fibrosis (C

110 Worldwide, nontuberculous mycobacteria (NTM) have become emergent pathogens of pulmonary infecti

111 s caused by the nontuberculous mycobacteria (NTM) have been recognized for more than 20 years and con

112 Nontuberculous mycobacteria (NTM) infection has attracted increasing attention in rec

113 e prevalence of nontuberculous mycobacteria (NTM) is high (approximately 13%) in sputum of patients w

114 berculosis from nontuberculous mycobacteria (NTM) is of primary importance for infection control and

115 C) is a form of Nontuberculous mycobacteria (NTM) of special, international concern in Cystic Fibrosi

116 C) strains from nontuberculous Mycobacteria (NTM) strains by targeting the IS6110 insertion element.

117 via aerosolized nontuberculous mycobacteria (NTM), it is important to characterize their persistence

118 mplex (MTC) and nontuberculous mycobacteria (NTM), using surface-enhanced Raman spectroscopy (SERS).

119 uberculosis and nontuberculous mycobacteria (NTM).

120 es positive for nontuberculous mycobacteria (NTM).

121 resentative of non-tuberculous mycobacteria (NTM) and other opportunistic human pathogens are enriche

122 Non-tuberculous mycobacteria (NTM) are a large family of acid-fast bacteria, widesprea

123 Nontuberculous mycobacteria (NTMs) are environmental microorganisms that can cause in

124 conservation in nontuberculous mycobacteria (NTMs), suggesting environmental exposure as an underlyin

125 h disseminated nontuberculous mycobacterial (NTM) disease.

126 t high risk of nontuberculous mycobacterial (NTM) infection, with treatment requiring prolonged multi

127 Nontuberculous mycobacterial (NTM) infections have the potential to affect outcomes in

128 reater risk of nontuberculous mycobacterial (NTM) infections than the general population.

129 68 MTBC and 97 nontuberculous mycobacterial (NTM) isolates grown on agar and 107 cultures grown in Ba

130 Pulmonary non-tuberculous mycobacterial (NTM) disease epidemiology in sub-Saharan Africa is not a

131 a slow-growing nontuberculous mycobacterium (NTM), subsequent to cardiothoracic surgery.

132 onchromogenic, nontuberculous mycobacterium (NTM).

133 rug-resistant non-tuberculous mycobacterium (NTM) Mycobacterium abscessus, which causes progressive l

134 S showed that the expression of neurotrimin (NTM) was highly upregulated, by 26.5 times (p<0.0001), i

135 dentified, rs7481514 within the neurotrimin (NTM) gene, that was significantly associated with POAG i

136 eferred to as Hain version 2 [V2]) and Nipro NTM+MDRTB detection kit 2 (referred to as Nipro), to Hai

137 e suspects, NTM disseminated disease, and no NTM categories.

138 cobacterium avium complex was seen in 75% of NTM-positive subjects.

139 sis was used to determine the association of NTM with mortality among lung transplant recipients.

140 on, and attempts to understand the burden of NTM disease and to identify risk factors in the paediatr

141 in the prevalence and spatial clustering of NTM in the United States over the past decade.

142 ignificant (P < 0.002) spatial clustering of NTM was detected, centering in Wisconsin, Arizona, Flori

143 tion phase showed that the concentrations of NTM in plasma were significantly higher in the responder

144 y and 99.9% specificity for determination of NTM identity.

145 not provide specific advice for diagnosis of NTM in children, from whom the quantity and quality of d

146 ting the importance of FLA in the ecology of NTM.

147 The epidemiology of NTM varies by world region, and attempts to understand t

148 the epidemiological and clinical features of NTM infection in children, with a specific focus on the

149 try (MALDI-TOF MS) for the identification of NTM isolated on RGM medium was also assessed.

150 Identification of NTM isolates was accomplished by polymerase chain reacti

151 Molecular identification of NTM was performed by using PCR restriction analysis targ

152 or 15 months and assessed clinical impact of NTM by FEV1 and high-resolution computed tomography (HRC

153 n of continuous and routine investigation of NTM infection or colonization in CF patients, including

154 selective brand of BCSA for the isolation of NTM from 224 sputum samples from patients with CF.

155 d highly effective tool for the isolation of NTM from patients with CF.

156 ivalent to that of the MGIT for isolation of NTM from the sputum of patients with CF.

157 most significant predictor for isolation of NTM.

158 d statistically significant higher levels of NTM in chloraminated water than in chlorinated water.

159 ntrolled trials to improve our management of NTM disease.

160 red amoebal cultures carried high numbers of NTM.

161 ic data were also obtained and predictors of NTM infection analyzed using regression analysis.

162 We investigated here the presence of NTM and FLA on a drinking water network during an all ye

163 This work investigated the presence of NTM in sputum samples of 129 CF patients (2 to 18 years

164 was collected to investigate the presence of NTM.

165 were obtained to estimate the prevalence of NTM among patients with CF 12 years of age or older by s

166 , cross-sectional study of the prevalence of NTM and clinical features of patients at 21 U.S. centers

167 world, studies describing the prevalence of NTM disease among HIV-infected people in most resource-l

168 The prevalence of NTM disease was 2% (19 of 1,060).

169 The overall prevalence of NTM in sputum was 13.0% (range by center, 7-24%).

170 The prevalence of NTM-associated diseases is increasing in the United Stat

171 cles on prevalence and clinical relevance of NTM detection in pulmonary samples in sub-Saharan Africa

172 d engineering strategies to decrease risk of NTM infection.

173 The clinical significance of NTM in CF is incompletely defined, but patients with the

174 on designed to determine the significance of NTM in CF patients were required to demonstrate proficie

175 iled to detect any potential point source of NTM infection.

176 Still, given that environmental sources of NTM are ubiquitous and PNTM disease is rare, both host s

177 mens growing the four most common species of NTM.

178 Further studies of NTM in HIV-infected individuals in tuberculosis-endemic

179 Four studies of therapy of NTM disease highlighted the pressing need for well-desig

180 Treatment of NTM infections is very different from the treatment of t

181 and identifies and determines the species of NTMs.

182 Among SOT patients, NTM were most frequently identified from lung transplant

183 detected in patients with multiple positive NTM cultures, but an abnormal HRCT was predictive of pro

184 Patients with CF and multiple positive NTM cultures, characteristic HRCT findings, and progress

185 In contrast, PrP-NTM, although membrane anchored and localized at the cel

186 N-terminal transmembrane anchored form, PrP-NTM, a double-anchored form, PrP-DA, and a truncated for

187 In conclusion, pulmonary NTM disease is a neglected and emerging public health di

188 Although risk factors for pulmonary NTM such as advanced age and low BMI are known, the mech

189 % (266 of 952) of participants had pulmonary NTM disease and M. kansasii with a prevalence of 69.2% [

190 The prevalence of pulmonary NTM colonization was 7.5% (95% CI: 7.2%-7.8%), and 75.0%

191 4.7%] was the most common cause of pulmonary NTM disease.

192 epitopes that elicit T cells that recognize NTMs but not MTB were identified.

193 All laboratories successfully recovered NTM from samples with acid-fast bacillus (AFB) smear sco

194 on of INH resistance and clinically relevant NTM are priorities.

195 The remaining NTM infected patients were classified as colonized.

196 ith chronic Pseudomonas, macrolide-resistant NTM infections are of growing concern.

197 frequent transmission of multidrug resistant NTM between patients with cystic fibrosis despite conven

198 ment agent for infections caused by selected NTM is warranted.

199 (NEC) and a transmembrane signaling subunit (NTM).

200 In summary, NTM are common in patients with CF, but neither person-t

201 ary disease, NTM pulmonary disease suspects, NTM disseminated disease, and no NTM categories.

202 Although TB-NTM coinfection may have been underdiagnosed, our result

203 These studies suggest that NTM are as likely as M. tuberculosis to be detected by f

204 Our findings suggest that NTM as a novel biomarker in heart failure will not only

205 The NTM species detected most frequently were: Mycobacterium

206 The NTM, in return, regulates the nonlocal transport by trun

207 outbreaks or pseudo-outbreaks caused by the NTM.

208 In contrast to the MTB complex cases, the NTM cases were more likely to have been diagnosed during

209 d as Mycobacterium tuberculosis complex, the NTM cross-reacts with the M. tuberculosis complex nuclei

210 rational surface and hence the onset of the NTM in relatively low beta plasmas (betaN < 1).

211 all MTBC isolates and 97.9% and 95.8% of the NTM isolates from characterized agar cultures and MGIT b

212 provides a suggestion of the identity of the NTM present, when the most commonly encountered mycobact

213 A normal primary human TM (NTM) cell line and a TM cell line derived from a glaucom

214 d FST and Act A protein levels in normal TM (NTM) and glaucomatous TM (GTM) cells.

215 Compared to NTM, LTM reduced area under the curve (AUC) of FPD lesio

216 r patients with clinical pulmonary TB due to NTM and co-infection with HIV and the likely role of the

217 ontribute to the increased susceptibility to NTM infection and its progression to pulmonary disease.

218 Exposure to NTMs occurs primarily through human interactions with wa

219 be used to characterize T-cell responses to NTMs, eliminating the confounding factor of MTB cross-re

220 Latanoprost-free acid (LFA)-treated NTM cells were analyzed for OPN gene and protein express

221 t all patients within each center had unique NTM strains.

222 for conclusive identification of the unknown NTM isolates.

223 Cambodia, where solid media alone was used, NTM was rare.

224 amples seeded with P. aeruginosa and various NTM.

225 FEV1 was not different among control versus NTM-positive subjects who did not, or did, meet American

226 Of these, 191 (4%) were NTM-positive in 2011 only (cases); 5,212 (96%) were NTM-

227 itive in 2011 only (cases); 5,212 (96%) were NTM-negative in 2010 and 2011 (control subjects).

228 NTM pulmonary disease suspects, 9 (4%) with NTM pulmonary disease, and 10 (5%) with NTM disseminated

229 with NTM pulmonary disease, and 10 (5%) with NTM disseminated disease.

230 Forty-three patients (86%) with NTM infection were lung transplant recipients; 18 of 43

231 dition, a comprehensive review of cases with NTM otomastoiditis in the literature was also performed.

232 e in TGM2 protein in GTM cells compared with NTM cells, and GTM cells also had increased in TGM2 enzy

233 reased in TGM2 enzyme activity compared with NTM cells.

234 permeability and increased TER compared with NTM-5 cells, consistent with increased TJ formation.

235 vis) and 69 (15%) were due to infection with NTM.

236 and cytokine responses between patients with NTM lung disease and demographically matched controls.

237 his study, we aimed to analyze patients with NTM otomastoiditis and establish a more efficient treatm

238 ds and temporal bone images of patients with NTM otomastoiditis were retrospectively analyzed.

239 Of 218 patients with NTM, 66 (30%) were classified as NTM pulmonary disease s

240 Three of 6 lung transplant recipients with NTM disease died compared with 6 of 37 colonized (hazard

241 Among those with NTM infection, cases 35 years or younger were more likel

242 When compared with patients with CF without NTM, culture-positive subjects were older (26 vs. 22 yea