ライフサイエンスコーパス: NTP

1 NTP binding to this site could promote high-fidelity pro

2 NTP hydrolysis by ABCE1 is stimulated by post-TCs and is

3 NTP hydrolysis by DHX29 is strongly stimulated by 43S co

4 NTP induced deactivation of NF-kappaB in SCCQLL1 cells,

5 NTP's research was key to the nation's first-ever drinki

6 NTP-assisted methane (CH4 ) oxidation over Pd/Al2 O3 was

7 including downstream promoter opening, +1+2 NTPs binding, and the rate of 2-mer synthesis.

8 E. coli QueD catalyzes the conversion of H(2)NTP to 6-carboxy-5,6,7,8-tetrahydropterin (CPH(4)).

9 nvert 7,8-dihydroneopterin triphosphate (H(2)NTP) to 6-pyruvoyltetrahydropterin (PPH(4)) in biopterin

10 Ps at frequencies of around one error per 30 NTPs polymerized, making it one of the least accurate po

11 ey feature that primase recognizes to bind a NTP is the 5'-gamma-phosphate since converting a NTP int

12 is the 5'-gamma-phosphate since converting a NTP into a NDP greatly compromised binding.

13 k hydrogen bonds to efficiently polymerize a NTP.

14 imase chooses whether or not to polymerize a NTP.

15 n bond formation to efficiently polymerize a NTP.

16 Our data indicate that a NTP specific for the i + 2 template position can bind to

17 In addition, NTP increased the expression level of E-cadherin, and de

18 n CTP and efficiently polymerizes additional NTPs onto the tC.

19 oductive TL conformations that persist after NTP binding but can be reversed by the elongation factor

20 her, our metabolic analyses unveil the AICAR/NTP balance as a major factor of AICAR antiproliferative

21 on, metabolite profiling points to the AICAR/NTP balance as crucial for optimal utilization of glucos

22 of corona applied, CF(2)Br(2) reacts in air NTP via a common intermediate, the CF(2)Br radical.

23 Ozone, an important product of air NTP, was never detected in experiments with CF(2)Br(2) a

24 ugh both channels have enough space to allow NTP loading, the percentage of MD conformations containi

25 y Nun in a posttranslocated register allowed NTP binding and nucleotidyl transfer but inhibited pyrop

26 w in nucleotide addition, as suggested by an NTP soaking experiment.

27 transfer through the pCF10 T4S channel by an NTP-dependent mechanism.

28 lyzes reversible phosphoryl transfer from an NTP donor to a 5'-OH polynucleotide acceptor.

29 and bottom DNA strands, respectively, in an NTP-hydrolysis dependent reaction.

30 Estimates of annual tuberculosis burden and NTP performance indicators and control variables during

31 and separation, translocation along DNA, and NTP loading to Pol II during elongation.

32 allosteric interactions between the DNA- and NTP-binding site prior to the cofactor hydrolysis step a

33 Allosteric interactions between the DNA- and NTP-binding sites of the Escherichia coli DnaB helicase

34 riboswitches can integrate both effector and NTP concentrations to generate a regulatory response app

35 s of the NIEHS's intramural, extramural, and NTP programs and establishing productive partnerships wi

36 ies by enhancing the turnover of the RNA and NTP substrates.

37 ndertaken using existing national survey and NTP data.

38 d; and we define effects of DNA topology and NTP concentration.

39 is to changes in concentrations of ppGpp and NTPs.

40 y changes in the concentrations of ppGpp and NTPs.

41 A polymerase using a RNA primer-template and NTPs as substrates) but could still bind DNA, indicating

42 ase activity using a RNA primer-template and NTPs as substrates.

43 a broad and objective approach for assessing NTP's effectiveness, including methodological needs for

44 nd over 8000 studies including all available NTP carcinogenicity, short-term toxicity and genetic tox

45 nonorthologous replacement of the bacterial NTP:AdoCbi kinase (EC 2.7.7.62)/GTP:AdoCbi-P guanylyltra

46 ding non-native pyrimidine- and purine-based NTPs as well as non-native D- and L-sugars (both alpha-

47 ata reveals the functional interplay between NTP triphosphate moiety and base pair hydrogen bonding r

48 eraction with an amino acid sequence between NTP binding motifs A and B of 2C(ATPase).

49 in pol iota is able to discriminate between NTPs and dNTPs during DNA synthesis.

50 r 43% of the proteome can theoretically bind NTP ligands.

51 tin-labeled nucleotide triphosphates (biotin-NTPs) into the 3' end of nascent RNA.

52 ins that isomerize the triphosphate of bound NTP and two Mg(2+) ions from a preinsertion state to a r

53 oside triphosphate (NTP) binding followed by NTP incorporation/pyrophosphate release, quantitatively

54 accommodate the breadth of data produced by NTP, the CEBS data collection component is an integrated

55 ct dNTPs from a nucleotide pool dominated by NTPs.

56 ) subsequent metabolic derangement, cerebral NTP, PCr and inorganic phosphate (relative to the exchan

57 The results show that with a cognate NTP, TL closing should be a spontaneous process.

58 of mismatch extension with the next cognate NTP in vitro.

59 r and is capable of binding the next cognate NTP.

60 apeutic potential of treatment that combines NTP and cetuximab in OSCC.

61 we report for the first time that combining NTP treatment with cetuximab led to inhibition of migrat

62 of the NTPase domains to form two composite NTP phosphohydrolase sites.

63 e-ligand affinity chromatography, we confirm NTP binding to 47 different proteins, of which 4 are hyp

64 and whether the reaction mixtures contained NTPs.

65 port the k(pol) and K(d) of all four correct NTP additions by T7 RNAP, which showed a range of values

66 On addition of the correct NTP to the T7 RNAP-DNA, 2-aminopurine fluorescence incre

67 replicative DNA helicase (DnaB) that couples NTP hydrolysis to 5' to 3' translocation.

68 ing faster rates than any other canonical (d)NTP.

69 tion-dependent catalytic incorporation of (d)NTP nucleotides into nucleic acids.

70 expression according to the abundance of (d)NTPs.

71 o be the most important checkpoint for deoxy-NTP discrimination.

72 3'-Deoxy-NTPs generally support faster DNA unwinding, with dTTP s

73 erase in excess of DNA, indicated that deoxy-NTPs were efficiently bound to the polymerase-DNA comple

74 These interactions dictate NTP specificity.

75 Case activity over the full four-dimensional NTP space.

76 bind NS3h with similar affinities, but each NTP supports a different unwinding rate and processivity

77 on, the RPB9 deletion substantially enhances NTP misincorporation and increases the rate of mismatch

78 ymerases have evolved to efficiently exclude NTPs while copying long stretches of undamaged DNA.

79 A polymerase predicts that ACT also executes NTP selection thereby contributing to high transcription

80 pol iota incorporates and extends NTPs opposite damaged and undamaged template bases in a

81 with the non-template DNA strand facilitates NTP sequestration through interaction with the adjacent

82 FL-NTP and FL-substrate exhibited 10-fold higher ion produc

83 z 471 (N-methoxysuccinyl-Ala-Ala-Pro-Val, FL-NTP), m/z 332 (N-succinyl-Ala-Ala-Ala, UV-NTP), m/z 176

84 asured by counting views of and requests for NTP's products by external stakeholders.

85 the secondary channel is the major route for NTP entry during Pol II transcription.

86 he "secondary channel" is the only route for NTP to reach the active site of the enzyme or if the "ma

87 MD conformations containing enough space for NTP loading through the secondary channel is twice highe

88 dNTPs in vitro, with a strong preference for NTPs, using Mn(2+) as a cofactor.

89 nding properties and interacts with all four NTPs and both RNA and DNA.

90 consistent with in vivo conditions) all four NTPs being present.

91 De novo synthesis at high NTP concentrations was shown to be preferred over primer

92 A $1 per capita (general population) higher NTP budget (including domestic and external sources) was

93 on was decreased and/or when an imbalance in NTP concentration was introduced (situations that mimic

94 ith Mg(2+) and exhibits a marked increase in NTP incorporation and extension, and surprisingly, it al

95 NS3 helicase domain plays critical roles in NTP-dependent RNA unwinding and translocation during vir

96 (Gln24) relaxed the substrate specificity in NTP hydrolysis, e.g., eliciting a gain of function as a

97 Increased investment in NTPs was significantly associated with improved performa

98 Crick base pair of template DNA and incoming NTP are critical for efficient incorporation, they are n

99 ution of the base encoding the next incoming NTP and the base encoding the 3' end of the nascent RNA,

100 nt of the 3' end of the RNA and the incoming NTP in the active site is crucial for pausing.

101 het model for elongation, where the incoming NTP is able to bind in either the pre- or posttranslocat

102 closure of the trigger loop on the incoming NTP via interaction between the C-terminal domain of Rpb

103 ather than the interaction with the incoming NTP.

104 that are partially regulated by the incoming NTP.

105 luate the ability of pol iota to incorporate NTPs during DNA synthesis.

106 Because wild-type pol iota incorporates NTPs in a template-specific manner, certain DNA sequence

107 that T7 RNAP discriminates against incorrect NTP both at the nucleotide binding and incorporation ste

108 ion constant (K(d)) of correct and incorrect NTPs and their incorporation rate constants (k(pol)).

109 correct") and noncomplementary ("incorrect") NTPs and on the local sequence of the P/T DNA.

110 more, the compact conformation of inhibitory NTP identified in this study provides precise informatio

111 efficient +1+2 melting increases the initial NTPs Kms of the AG and AT promoters relative to AA or si

112 ndicate that the binding site for initiating NTP is located on p58C.

113 ary, several distinct examples of initiating NTP-mediated gene regulation are discussed, including a

114 ketogenesis; (iv) depletion of intracellular NTPs; (v) accelerated purine biosynthesis and salvage; a

115 l Toxicology Program 1,408-compound library (NTP 1408, which contains 1,340 unique compounds) for the

116 Maximum NTP, PCr and inorganic phosphate recoveries were observe

117 ed polymerase using 3'-deoxy- or 3'-O-methyl-NTPs as substrates.

118 vealed that human primase can misincorporate NTPs via both template misreading and a primer-template

119 Even though primase misincorporates NTPs at a relatively high frequency, this likely does no

120 Mismatched NTPs also lead to conformational changes in the active s

121 s, is hindered by the presence of mismatched NTPs.

122 Similarly, primase did not incorporate most NTPs containing hydrophobic bases incapable of Watson-Cr

123 However, above 400 muM [NTP], the concentration of lysine required to elicit tra

124 virus-1 primase misincorporates the natural NTPs at frequencies of around one error per 30 NTPs poly

125 orporation, it prevented binding of the next NTP and stimulated pyrophosphorolysis of the nascent tra

126 NIEHS/NTP BPA research investments made over the past 4 years

127 e workshop and discuss activities that NIEHS/NTP is undertaking to address research recommendations.

128 ranthenes (NFLs), mw 273 nitrotriphenylenes (NTPs), nitrobenz[a]anthracenes (NBaAs), nitrochrysene (N

129 P summary and conclusion data and larger non-NTP datasets.

130 The energy density of NVPF-NTP reaches up to 486 W h kg(-1) , which is higher than

131 The prepared NVPF-NTP exhibits two high working plateaux at about 4.01 and

132 f Na3 V2 (PO4 )2 O2 F nano-tetraprisms (NVPF-NTP) is proposed to enhance the energy density of SIBs.

133 of Ragone plots further discloses that NVPF-NTP presents the best power performance among the state-

134 c voltammetry at varied scan rates, the NVPF-NTP shows long-term cycle life, superior low-temperature

135 i- or trinucleotides, however, the amount of NTP needed to achieve maximal activity dropped 10(3)- to

136 nscription initiation by the availability of NTP substrates.

137 The approach identified awareness of NTP's work on CrVI by external stakeholders (proximal ou

138 ive center that is induced by the binding of NTP, which could slow down nucleotide addition cycles an

139 eholders (proximal outcome) and citations of NTP's research in scientific publications, reports, cong

140 ese results indicate that the combination of NTP with cetuximab can decrease invasiveness in cetuxima

141 of adenosine-binding residues as couplers of NTP hydrolysis to motor activity.

142 inates the antagonistic allosteric effect of NTP and NDP on the ssDNA affinity of the enzyme.

143 ng cDNA diminished the combination effect of NTP on invasion, migration and related signals.

144 inetic studies showed that the efficiency of NTP-mediated excision was highest with ATP.

145 In addition to the hydrolysis of NTP and NDP substrates, adenylate kinase activity was de

146 mechanism in which sequential hydrolysis of NTP causes a sequential 5' to 3' movement of the subunit

147 otential drug targets, the identification of NTP binding can directly facilitate structure-based drug

148 The effect of ssDNA on the kinetics of NTP hydrolysis depends on the type of nucleotide cofacto

149 d also be supported by <0.1 microm levels of NTP.

150 The kinetic mechanism of NTP binding and hydrolysis by the Escherichia coli repli

151 n the DnaB-DnaC complex and the mechanism of NTP hydrolysis by the complex have been examined using t

152 Examining the mechanism of NTP polymerization revealed that human primase can misin

153 ecA2 domains confirmed the essential role of NTP hydrolysis for DHX29's function in initiation and va

154 We use a set of NTP binding sub-structural motifs derived from a previou

155 that can begin RNA synthesis upon binding of NTPs (nucleoside triphosphate).

156 , propose that template-dependent binding of NTPs in the main channel regulates RNA synthesis.

157 depending on the nature and concentration of NTPs in solution, such that the fastest reactions are ob

158 typically greater than the concentration of NTPs required for elongation.

159 d migration into a concentration gradient of NTPs, resembling chemotaxis.

160 e elongation complexes by a quick removal of NTPs leads to formation of RNA-DNA hybrids (R-loops).

161 that RPB9 deletion promotes sequestration of NTPs in the polymerase active center just prior to the p

162 unwinding by T7 helicase using a variety of NTPs and their analogs.

163 er with structural analysis to shed light on NTP entry pathways.

164 the effect of non-thermal plasmas (NTPs) on NTP catalytic hybrid reactions; namely, modification or

165 L mobility, suppresses the effect of Rpb9 on NTP misincorporation, consistent with a role for Rpb9 in

166 all cellular transcription occurs using only NTPs.

167 m 4 muM to 1 mM, with specificity over other NTP molecules.

168 c residue allowed the accommodation of other NTPs, resulting in the preferential use of dATP and the

169 xposure to ATP alone in the absence of other NTPs.

170 osine analogue, 1,3-diaza-2-oxophenothiazine NTP, across from a templating G but not across from A.

171 both acute insult severity and baseline PCr/NTP.

172 addition, baseline cerebral metabolism (PCr/NTP) may identify vulnerable infants prior to invasive s

173 to nonhuman primates resulted in persistent NTP levels in peripheral blood mononuclear cells (half-l

174 Nucleoside tri-phosphates (NTP) form an important class of small molecule ligands t

175 idation mechanisms in air nonthermal plasma (NTP) at room temperature and atmospheric pressure were i

176 hat non-thermal atmospheric pressure plasma (NTP) induces death of various cancer cells, including or

177 In this study, non-thermal plasma (NTP) is investigated as an innovative preparative analyt

178 o explain the effect of non-thermal plasmas (NTPs) on NTP catalytic hybrid reactions; namely, modific

179 The enzyme did not efficiently polymerize NTPs incapable of forming two Watson-Crick hydrogen bond

180 meric form and has the ability to polymerize NTPs as well as dNTPs in vitro, with a strong preference

181 ven these new data, the National TB Program (NTP), operating through a decentralized health system, i

182 ces (NIEHS) and National Toxicology Program (NTP) have developed an integrated, multipronged, consort

183 In 2011, the National Toxicology Program (NTP) organized a workshop to assess the literature for e

184 Division of the National Toxicology Program (NTP) organized a workshop to evaluate the current state

185 l data from the National Toxicology Program (NTP) testing program and other depositors into a single

186 onducted by the National Toxicology Program (NTP).

187 Primarily, it promotes NTP sequestration in the polymerase active center.

188 However, 2-pyridone NTP and 4-methyl-2-pyridone NTP provided striking except

189 ever, 2-pyridone NTP and 4-methyl-2-pyridone NTP provided striking exceptions to this rule.

190 activity was measured in vitro at 300 random NTP concentration combinations, each involving (consiste

191 fied from the authentic olive oil reference, NTP treatments of 60min (Ar/O2 0.1%) on the oil batches

192 Addition of the remaining NTPs resulted in run-off transcription, with an efficien

193 assessment of National Toxicology Program's (NTP's) effectiveness across multiple sectors and demonst

194 t role in the National Toxicology Program's (NTP) efforts to advance toxicology from a predominantly

195 ations, the effects of different active site NTPs in both open and closed trigger loop (TL) structure

196 into a hexagon, driven by the binding of six NTPs (or six nonhydrolyzable GTPgammaS analogues) that a

197 xistence of a noncatalytic template-specific NTP binding site in the main channel that is involved in

198 n was necessary at position 535 to stabilize NTP for efficient unwinding.

199 rd transcription in the presence of standard NTPs.

200 ate and inorganic PPP(i); (ii) it stimulates NTP hydrolysis; and (iii) it biases the outcome of the l

201 For validity and reliability studies, NTP apprentices and experts were asked to submit video-r

202 oying beta,gamma-bridging atom-'substituted' NTPs, we elucidate how the methylene substitution in the

203 e 2'-hydroxyl of both template and substrate NTP.

204 , with each monomer binding to one substrate NTP.

205 of the nascent transcript and the substrate NTP in the active site.

206 ed a dose-dependent decrease in both (99m)Tc-NTP 15-5 and (18)F-FDG uptake ratios versus saline-treat

207 l results bring data in favor of the (99m)Tc-NTP 15-5 radiotracer for assessing, in vivo, cartilage r

208 me course of cartilage remodeling by (99m)Tc-NTP 15-5 scintigraphy, bone damages by (99m)Tc-hydroxyme

209 (99m)Tc-NTP 15-5 showed specific tracer accumulation within RA j

210 iethylammonium)-3-propyl-[15]ane-N5 ((99m)Tc-NTP 15-5) targeting proteoglycans has a pathophysiologic

211 otifs A-F coordinate the viral RNA template, NTPs and magnesium ions to facilitate nucleotide condens

212 otifs A-F coordinate the viral RNA template, NTPs, and magnesium ions to facilitate nucleotide conden

213 athway and uncouples establishment of key TH-NTP contacts from complete TH formation and clamp moveme

214 It was assumed that NTP-induced oxidation triggers unique lipid oxidation me

215 The NTP hydrolysis step is significantly faster for the puri

216 The NTP is an educational initiative by the National Cancer

217 The NTP-binding pocket of the protein was examined by random

218 ric signal from the DNA, which activates the NTP hydrolysis, comes predominantly from the strong DNA-

219 The protein does not affect the NTP hydrolysis mechanism of the helicase.

220 ddition, we show that Archease can alter the NTP specificity of RtcB such that ATP, dGTP or ITP is us

221 pes incubated with GS-5734 in vitro, and the NTP acts as an alternative substrate and RNA-chain termi

222 vored by electrostatic repulsion between the NTP and the highly negatively charged backbones of nucle

223 The divalent metal bridging the NTP to NS3h also influences observed unwinding rates, wi

224 oduct 5' phosphate group is displaced by the NTP gamma phosphate and the local architecture of the ac

225 During the NTP binding reaction, primase tolerated a large number o

226 rick hydrogen bonding groups from either the NTP or templating bases varied from almost no effect to

227 ces on opposite sides of the protein for the NTP phosphate donor and a 5'-OH single-stranded oligonuc

228 It is however removed from the NTP processed gas by passage through a water scrubber re

229 However, the NTP did lead to an increase in the temperature of the Pd

230 However, the NTP only identified and commenced treatment for around 1

231 Here, we seek to identify the NTP binding proteome (NTPome) in M. tuberculosis (M.tb),

232 m (competition with UTP for occupancy of the NTP addition site) that differ from those of the RNAP in

233 the Watson-Crick base-pairing region of the NTP base and the nature of the functional groups attache

234 D, a region that forms the outer edge of the NTP entry channel where it may act as a nucleotide senso

235 caused by the impaired sequestration of the NTP substrate in the active center prior to catalysis.

236 ups attached to the 2' and 3' carbons of the NTP sugar.

237 nnels has revealed that the diffusion of the NTP through the main channel is greatly disfavored by el

238 Modifications to the 2' position of the NTP, including 2',3'-ddCTP, arabinose-CTP, and 2'-O-meth

239 identify the structural requirements of the NTP, we determined the efficiency of DNA unwinding by T7

240 Whether or not the base on the NTP could form a correct base pair with the template bas

241 trinucleotide also dramatically reduced the NTP levels needed to achieve efficient RNA synthesis.

242 owing the rate of elongation by reducing the NTP concentration or using a mutant RNAP increases sever

243 its RNAP through a binding site on RNAP (the NTP addition site) and mechanism (competition with UTP f

244 rease the rate of RNA synthesis and that the NTP bound to this site can be shuttled directly into the

245 polymerization absolutely required that the NTP contain a 3'-hydroxyl and an intact sugar ring.

246 r, we now demonstrate biochemically that the NTP GTP is equally capable of activating SAMHD1, but GTP

247 Results from this study suggest that the NTP must be stabilized by specific interactions within t

248 te population was further increased when the NTP concentration was decreased and/or when an imbalance

249 abilized by specific interactions within the NTP-binding site of the protein to achieve efficient hyd

250 The inhibitory effects of the NTPs were more pronounced on authentic N-RNA with the ex

251 ine Guided Search tools that allow access to NTP summary and conclusion data and larger non-NTP datas

252 ith tyrosine reduced the binding affinity to NTP and the catalysis step.

253 hat carboxyl-terminal residues contribute to NTP hydrolysis required for translocation and DNA unwind

254 for template binding; Trp-97 contributes to NTP binding and the catalysis step; and Trp-147 maintain

255 its weak binding affinity to PPi relative to NTP, suggesting a mechanism in which PPi is rapidly rele

256 In response to NTP binding, the TL undergoes large conformational chang

257 iate, distal) and applied retrospectively to NTP's research on hexavalent chromium (CrVI).

258 d with sunflower oil (1-3%) and submitted to NTP treatment.

259 ift for incoming nucleoside 5'-triphosphate (NTP), thus compromising nucleotide addition.

260 teps, TL folding on nucleoside triphosphate (NTP) binding followed by NTP incorporation/pyrophosphate

261 but not a Walker A nucleoside triphosphate (NTP) binding motif mutant, induced (i) MPB labeling of C

262 atases (NTPases) or nucleoside triphosphate (NTP) binding proteins.

263 A PcfC Walker A nucleoside triphosphate (NTP) binding site mutant (K156T) fractionated with the E

264 A PrgJ nucleoside triphosphate (NTP) binding site mutation (K471E) slightly diminished A

265 ires only an intact nucleoside triphosphate (NTP) binding site within the Rep proteins, indicating th

266 ologically relevant nucleoside triphosphate (NTP) concentrations.

267 ryl transfer from a nucleoside triphosphate (NTP) donor to a 5'-OH polynucleotide acceptor, either DN

268 template tunnel or nucleoside triphosphate (NTP) entry tunnel and the exterior of the protein, sugge

269 e P-loop-containing nucleoside triphosphate (NTP) hydrolase superfamily.

270 r competes with the nucleoside triphosphate (NTP) in the active center.

271 acologically active nucleoside triphosphate (NTP) is efficiently formed in multiple human cell types

272 usion routes of the nucleoside triphosphate (NTP) substrate through the main channel might overlap wi

273 incorporate correct nucleoside triphosphate (NTP) substrates with high efficiency and fidelity.

274 tion of the matched nucleoside triphosphate (NTP), catalysis of transcription elongation, and translo

275 At low nucleotide triphosphate (NTP) concentrations, we observe good agreement between t

276 n that contacts the nucleotide triphosphate (NTP) substrate to allow rapid nucleotide addition.

277 ent K(m) values for nucleotide triphosphate (NTP) use.

278 tely or relative to nucleotide triphosphate, NTP) following HI has been observed in cardiac and skele

279 the hydrolysis of nucleoside triphosphates (NTP).

280 the interaction of nucleoside triphosphates (NTPs) containing modified sugars to develop a better und

281 to investigate how nucleoside triphosphates (NTPs) fuel HCV helicase-catalyzed DNA unwinding.

282 Although nucleoside triphosphates (NTPs) have been seen only in the catalytic site and the

283 n of two bioactive nucleoside triphosphates (NTPs) in human hepatocytes.

284 is initiated using nucleoside triphosphates (NTPs) only.

285 nce of the cognate Nucleoside triphosphates (NTPs), Adenosine triphosphate (ATP) and Cytosine triphos

286 ription substrates nucleoside triphosphates (NTPs).

287 ed by all four ribonucleoside triphosphates (NTPs) in a nonlinear manner.

288 centrations of ribonucleoside triphosphates (NTPs), few MCMs are found.

289 amydia imports ribonucleotide triphosphates (NTPs) but not deoxyribonucleotide triphosphates (dNTPs)

290 ncreasing the rate of primer initiation (two NTPs --> pppNpN), the rate-limiting step in primer synth

291 rgo any significant structural changes under NTP conditions.

292 nging to the AAA+ superfamily of ATPases use NTP hydrolysis to remodel their versatile substrates.

293 y, the polymerase elongation complex can use NTPs to excise the terminal nucleotide in nascent RNA.

294 that all transcription in cells occur using NTPs only (i.e., de novo).

295 y DNA-dependent RNA polymerases occurs using NTPs alone.

296 FL-NTP), m/z 332 (N-succinyl-Ala-Ala-Ala, UV-NTP), m/z 176 (7-amino-4-methylcoumarin, AMC), and m/z 1

297 Various NTPs bind NS3h with similar affinities, but each NTP sup

298 energetic study based on MD simulations with NTP loaded in the channels has revealed that the diffusi

299 Studies with NTP analogs reveal that specificity is determined by the

300 cess to discriminate between right and wrong NTPs.