ライフサイエンスコーパス: Na pump

1 s phospholipid interactions that inhibit the Na pump.

2 determined and compared to inhibition of the Na pump.

3 s exclusively dependent on activation of the Na+ pump.

4 Vitreoscilla oxidase functions as a primary Na+ pump.

5 r, sustained decline to K+ uptake via axonal Na+ pumps.

6 for activity, indicating that Rnf acts as a Na(+) pump.

7 pump function has renewed interest in brain Na(+) pumps.

8 cytes; these effects were mediated by alpha2 Na(+) pumps.

9 r Na+ concentration ([Na+]i) that might link Na+ pump activation to increased Na+ reabsorption, [Na+]

10 Nevertheless, only mice with reduced alpha2 Na(+) pump activity (alpha2(+/-)), and not alpha1 (alpha

11 lating EO modulates ouabain-sensitive alpha2 Na(+) pump activity and Ca(2+) transporter expression an

12 stance and blood pressure by reducing alpha2 Na(+) pump activity and promoting Ca(2)(+) entry via NCX

13 lux criteria of light-dependent electrogenic Na(+) pumping activity in vitro, namely, light-induced p

14 ct to stimulate Na+ absorption by increasing Na+ pump activity and apical Na+ conductance (GNa+) to b

15 requires a transient 74-120-fold increase in Na+ pump activity.

16 osphorylation and inhibition of Na,K-ATPase (Na-pump) activity in the proximal tubules, which is asso

17 Blocking Na pumps alone greatly prevents action potentials from r

18 try using isoform-specific antibodies to the Na+ pump alpha subunit and labeled alpha-bungarotoxin as

19 ited the different ouabain affinities of the Na+ pump alpha subunit isoforms in rat (alpha1, low ouab

20 Three Na+ pump alpha subunit isoforms, alpha1, alpha2 and alph

21 amma but did not alter the expression of the Na+ pump alpha subunit.

22 arteries of mice with reduced expression of Na(+) pump alpha1 (alpha1(+/-)) or alpha2 (alpha2(+/-))

23 o-immunoprecipitate with NCX1, including the Na(+) pump alpha1 isoform, PM Ca(2+) pump type 1 (PMCA1)

24 bserved in cells transfected with the rodent Na+ pump alpha1 cDNA is large and sufficiently fast that

25 ial kidney cells transfected with the rodent Na+ pump alpha1 cDNA.

26 , immunoprecipitation with antibodies to the Na(+) pump alpha2 and alpha3 isoforms, but not alpha1, c

27 co-localization of beta-spectrin with NCX1, Na(+) pump alpha3, and IP(3)R-1 in neurons and of alpha-

28 propyl, and butyl diamine all inhibited the Na pump and all competed at the intracellular surface.

29 oxidation continues in the absence of active Na(+) pumping and glutamatergic transmission.

30 al phase of K+ removal to K+ uptake by glial Na+ pumps and the slower, sustained decline to K+ uptake

31 ain selectively inhibit Na+, K+ -ATPase (the Na+ pump) and, via Na+ / Ca2+ exchange (NCX), exert card

32 Thus, alpha1 Na(+) pumps are apparently excluded from the PM microdom

33 ated non-specific cation current or a Ca(2+)-Na+ pump are possible mechanisms for this effect.

34 s transmembrane conductance regulator or the Na+ pump beta subunit were unchanged.

35 When alpha4 and the Na pump beta1 subunit are coexpressed in the cells, Na,

36 pression of chimeras constructed between the Na+ pump beta1 isoform and the H,K-ATPase beta subunit i

37 For the Na pump, both TEA and TPA inhibited, but TMA did not.

38 dult mouse ventricular myocytes indicate the Na pump can modulate the influence of I(Na) on E-C coupl

39 Isoprenaline had no effect on Na+ pump capacity at PO2 levels of 23 mmHg or 100 mmHg,

40 meabilised cells showed that a small rise in Na+ pump capacity was evident 6 h after PO2 was raised a

41 s raised and is due, primarily, to increased Na+ pump capacity.

42 (50 microM), showed that high PO2 increased Na+ pump capacity.

43 luding the alpha2 and alpha3 isoforms of the Na(+) pump catalytic (alpha) subunit, and the alpha2 sub

44 h either the alpha1 or alpha2 isoform of the Na(+) pump catalytic (alpha) subunit.

45 nce over Na+ transport in FDLE cells and the Na+ pump could be an important locus at which this contr

46 arization (usAHP) mediated by an increase in Na(+) pump current.

47 SOD1, but not SOD2, partially inhibited the Na+ pump degradation.

48 hx1 Deltanha1 Deltakha1) and plasma membrane Na+ pumps (Deltaena1-4).

49 function as dual-function light-driven H(+)/Na(+) pumps, ejecting sodium ions from cells in the pres

50 Reduced smooth muscle (SM)-specific alpha2 Na(+) pump expression elevates basal blood pressure (BP)

51 ge inhibited by KB-R 7943, inhibition of the Na pump failed to increase the magnitude of the peak sys

52 voltage pulses (0.25 Hz), inhibition of the Na pump for 1.5 s immediately before and continuing duri

53 Western analysis of the Na pump from mature human erythrocyte ghosts, purified b

54 Conceivably, dopamine induces recruitment of Na+ pumps from intracellular pools to the plasma membran

55 (-)5 M DA for 15 min, probably by recruiting Na+ pumps from intracellular pools.

56 mutations and some mood disorders to altered Na(+) pump function has renewed interest in brain Na(+)

57 NCX current density and basal Na(+) pump function were not influenced by gender.

58 oton antiporter, monensin, which potentiates Na(+) pump function, induced similar effects to short in

59 ystem proves that the dual light-driven H(+)/Na(+) pumping function of IAR is intrinsic to the single

60 tions between CTSs in two indirect assays of Na+ pump function: myogenic tone (MT) in isolated, press

61 of potential models suggests that, in vivo, Na+ pumps function as tetraprotomers ((alphabeta)4) in w

62 o alkaline pH-inducible genes, including the Na+ pump gene ENA1, which is required for ion tolerance.

63 nternalization of the Na(+)/K(+)-ATPase (the Na(+) pump) has been studied in the human lung carcinoma

64 (alpha) subunit of the plasma membrane (PM) Na+ pump have been identified in the tissues of birds an

65 icroM tetrodotoxin (TTX)), inhibition of the Na pump immediately before and during a voltage pulse di

66 was not altered by abrupt inhibition of the Na pump immediately before and during a voltage pulse.

67 of its actions on the high-ouabain-affinity Na(+) pumps in both neurones and astrocytes.

68 nal to the total numbers of primary H(+) and Na(+) pumps in the cell.

69 inhibiting from the cytoplasmic side of the Na pump; in contrast, we have previously shown that TPA

70 on is that nanomolar ouabain inhibits alpha3 Na(+) pumps, increases (local) intracellular Na(+), and

71 PLM C42A but not PLM C40A inhibits the Na pump, indicating PLM palmitoylation at C40 but not C4

72 -stimulus recovery of [K+]o was sensitive to Na+ pump inhibition with 50 microM strophanthidin.

73 ered Na+-Ca2+ exchange activity secondary to Na+ pump inhibition.

74 fer in their affinities for ions and for the Na+ pump inhibitor, ouabain.

75 to previous reports, we demonstrate that the Na pump is not localized basolaterally in epithelial cel

76 Action potential amplitude falls when the Na(+) -pump is blocked, an effect speeded by warming.

77 the new steady state [Na+]i is reached, the Na+ pump is 58% activated.

78 The Na+ pump is crucial for the regulation of [Na+]i (the in

79 This study is aimed at identifying the Na pump isoform composition of human erythroid precursor

80 Thus, the Na pump isoform composition of human erythroid precursor

81 Complete inhibition of all Na+ pump isoforms (>/=100 microM ouabain) caused sustain

82 mmal distribution, the high ouabain-affinity Na+ pump isoforms may have more specific roles in neuron

83 4beta3 are, however, distinct from the other Na pump isozymes.

84 -butyl-4-hydroxybenzaldehyde) stimulated the Na+ pumping, it is unlikely that it is a secondary effec

85 , the structure of the first light-activated Na(+) pump, Krokinobacter eikastus rhodopsin 2 (KR2), wa

86 The high ouabain affinity Na+ pumps may thereby modulate reticulum Ca2+ content an

87 three important parameters (calcium fluxes, Na pumps, mitochondrial motility) at nodes of Ranvier in

88 estigate whether activity of the sarcolemmal Na pump modulates the influence of sodium current on exc

89 Linkage of certain neurological diseases to Na(+) pump mutations and some mood disorders to altered

90 The alpha (catalytic) subunit of the Na+ pump (Na+, K(+)-ATPase) has three isoforms; alpha1 i

91 The Na(+)-pumping NADH-ubiquinone oxidoreductase has six pol

92 The Na(+)-pumping NADH:quinone complex is found in Vibrio ch

93 The Na(+)-pumping NADH:quinone oxidoreductase (Na(+)-NQR) is

94 ia possess a unique respiratory complex, the Na(+)-pumping NADH:quinone oxidoreductase (Na(+)-NQR), w

95 Na(+)-pumping NADH:ubiquinone oxidoreductase (Na(+)-NQR)

96 The efficiency of the Na+ pumping was 3.93 Na+ pumped per O2 consumed when ascorbate/TMPD was used

97 zed cell lines to limit the synthesis of the Na+ pump polypeptides while expressing other vaccinia re

98 Thus, Na+ pump rate cannot explain the higher [Na+]i in rat.

99 risingly, that physiologic activation of the Na pumps retards mitochondrial motility.

100 ffects of ouabain indicate the presence of a Na+ pump that is more readily inhibited by applications

101 fect the [Na+]i of cells expressing a mutant Na+ pump that is not stimulated by PKC.

102 normal physiological levels thus allows the Na+ pump to be controlled by isoprenaline.

103 myocytes ([Na+](pip) = 15 or 0 mM) when the Na pump was activated (4.4 mM K(+)(o)) and during abrupt

104 The rate of Na+ transport by the Na+ pump was measured as a function of [Na+]i in intact

105 The efficiency of the Na+ pumping was 3.93 Na+ pumped per O2 consumed when asc

106 To elucidate its molecular mechanism for Na(+) pumping, we perform here extensive classical and q

107 e Na(+)/K(+) ATPase (also referred to as the Na pump), which is composed of a catalytic alpha subunit

108 The neurones and astrocytes express Na(+) pumps with a high-ouabain-affinity catalytic subun

109 d with subjacent S/ER; alpha1(f)GCaMP2, like Na(+) pumps with alpha1-subunits, was more uniformly dis

110 and glia PM microdomains containing NCX1 and Na(+) pumps with alpha2 or alpha3 subunits form Ca(2+) s

111 monstrated that alpha2(f)GCaMP2, like native Na(+) pumps with alpha2-subunits, sorted to PM domains t

112 TPase inhibitor that binds reversibly to the Na+ pump with high affinity and specificity.

113 Additionally, most cells express Na+ pumps with a second alpha isoform.

114 strocytes and arterial myocytes also express Na+ pumps with the alpha2 isoform.

115 s and active basolateral exit of Na(+) via a Na(+) pump, with recycling of K(+) at the basolateral me